Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases

作     者：Syed Aoun Mehmood Sherazi Asim Abbasi Abdullah Jamil Mohammad Uzair Ayesha Ikram Shanzay Qamar Adediji Ayomide Olamide Muhammad Arshad Peter J.Fried Milos Ljubisavljevic Ran Wang Shahid Bashir Syed Aoun Mehmood Sherazi;Asim Abbasi;Abdullah Jamil;Mohammad Uzair;Ayesha Ikram;Shanzay Qamar;Adediji Ayomide Olamide;Muhammad Arshad;Peter J.Fried;Milos Ljubisavljevic;Ran Wang;Shahid Bashir

作者机构：Department of Biological SciencesFaculty of Basic&Applied SciencesInternational Islamic UniversityIslamabadPakistan Department of Biological SciencesUniversity of ArkansasFayettevilleARUSA Department of PharmacologyGovernment College UniversityFaisalabadPakistan Department of Bioinformatics and BiotechnologyGovernment College UniversityFaisalabadPakistan Department of ChemistryChulalongkorn UniversityThailand Department of NeurologyBerenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive NeurologyBeth Israel Deaconess Medical Center(KS 158)Harvard Medical SchoolBostonMAUSA Department of PhysiologyCollege of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates Department of PsychiatryThe First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第5期

页      面：959-968页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

主　　题：aging Alzheimer’s disease DNA sequence epigenetics immune non-coding RNA oligonucleotides telomere-associated 

摘      要：Aging is linked to the deterioration of many physical and cognitive abilities and is the leading risk factor for Alzheimer’s disease. The growing aging population is a significant healthcare problem globally that researchers must investigate to better understand the underlying aging processes. Advances in microarrays and sequencing techniques have resulted in deeper analyses of diverse essential genomes(e.g., mouse, human, and rat) and their corresponding cell types, their organ-specific transcriptomes, and the tissue involved in aging. Traditional gene controllers such as DNA-and RNA-binding proteins significantly influence such programs, causing the need to sort out long non-coding RNAs, a new class of powerful gene regulatory elements. However, their functional significance in the aging process and senescence has yet to be investigated and identified. Several recent researchers have associated the initiation and development of senescence and aging in mammals with several well-reported and novel long non-coding RNAs. In this review article, we identified and analyzed the evolving functions of long non-coding RNAs in cellular processes, including cellular senescence, aging, and age-related pathogenesis, which are the major hallmarks of long non-coding RNAs in aging.