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The role of nitric oxide in the dorsomedial periaqueductal gray(dmPAG)column in cardiovascular responses in urethane-anesthetized male rats

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Animal Models and Experimental Medicine 2022年第6期5卷 557-564页

作者： mohammad Najaftomaraei Atiyeh Ghorbani Alireza rahimi Reza Mohebbati Sogol Sherkat mohammad Naser Shafei Department of Physiology Faculty of MedicineMashhad University of Medical SciencesMashhadIran Material Science and Metallurgy Engineering Islamic Azad University-Karaj BranchKarajIran Department of Physiology Faculty of MedicineGonabad University of Medical SciencesGonabadIran Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran Department of Physiology School of MedicineSabzevar University of Medical SciencesSabzevarIran Division of Neurocognitive Sciences Psychiatry and Behavioral Sciences Research CenterMashhad University of Medical SciencesMashhadIran

Background:The dorsomedial periaqueductal gray(dmPAG)is a mesencephalic area and has numerous functions including cardiovascular *** nitric oxide(NO)is present in the dmPAG,here we investigate,the probable cardiovascular effect of NO in the ***:Five groups(n=6 for each group)were used as follows:(1)control;(2)L-NAME(N^(G)-nitro-L-arginine methyl ester,a NO synthase inhibitor,90 nmol);(3)Larginine(L-Arg,a precursor for NO,60 nmol);(4)Sodium nitroprusside(SNP,a NO donor,27 nmol);and(5)L-Arg+*** cardiovascular parameters were recorded by a Power Lab device after cannulation of the femoral *** were injected using a stereotaxic *** changes(Δ)in systolic blood pressure(SBP),mean arterial pressure(MAP),and heart rate(HR)were calculated at different times and compared to the control ***:Microinjection of L-NAME significantly increased ΔSBP,ΔMAP,and ΔHR more than saline(from p<0.05 to p<0.001).L-Arg only significantly increased ΔHR(p<0.05).In the L-Arg+L-NAME group,the above parameters also significantly increased(from p<0.01 to p<0.05)but not as significantly as with L-NAME *** of SNP significantly decreased ΔSBP and ΔMAP more than in the control and L-NAME groups(from p<0.01 to p<0.001),but ΔHR did not change ***:The results indicated that NO in dmPAG has an inhibitory effect on cardiovascular responses in anesthetized rats.

关键词： blood pressure dorsomedial periaqueductal gray L-arginine L-NAME nitric oxide

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The research and development on the antioxidants in prevention of diabetic complications

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 801-808页

作者： mohammad rahimi-Madiseh Afsaneh Malekpour-Tehrani Mahmoud Bahmani Mahmud Rafieian-kopaei Medical Plants Research Center Shahrekord University of Medical Sciences Department of Social Medicine Shahrekord University of Medical Sciences Faculty of Medicine and Clinical Microbiology Research Center

Diabetes mellitus can damage the eyes,kidneys,nerves and *** and macrovascular disorders are the leading causes of morbidity and mortality in diabetic *** can increase the indicators of lipid peroxidation and oxidative stress in which free radicals have the main role in the pathogenesis of these ***,antioxidants which combat oxidative stress should be able to prevent and repair free radicals induced *** free radicals contribute to kidney damage,atherosclerosis,diabetes,heart disease,nephrotoxicity and hepatotoxicity; however,clinical trials do not uniquely confirm a substantial impact on diabetic *** seems that antioxidants in vegetables,fruits and grains help preventing diabetes complications; however,there is little evidence that taking single antioxidants such as vitamin E or vitamin C protect these *** findings about combination antioxidants are also complicated and not entirely *** this review paper we tried to present the role of oxidative stress on microvascular complications of type2 diabetes *** objective of this paper is to review the new findings about the role of various antioxidants on prevention and treatment of diabetes mellitus as well as its complications including retinopathy,nephropathy and neuropathy.

关键词： Diabetic Nephropathy Natural antioxidants Diabetes complications Nephropathy Neuropathy Retinopathy

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Relationship between Temperaments of Medicinal Plants and Their Major Chemical Compounds

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Journal of Traditional Chinese Medicine 2011年第1期31卷 27-31页

作者： mohammad Reza Shams Ardekani Roja rahimi Behjat Javadi Leila Abdi Mahnaz Khanavi Department of Traditional Pharmacy Faculty of Traditional Iranian Medicine Tehran University of Medical Sciences Department of Pharmacognosy Faculty of Pharmacy Tehran University of Medical Sciences

Objective: To determine any relationship between temperaments of medicinal plants referred to traditional Iranian manuscripts and their major chemical compounds. Methods: Plants used in traditional Iranian medicine were categorized based on their major chemical compounds including alkaloids, phenolic compounds, and essential oils. Their temperaments were extracted from traditional herbal pharmacopeias of Iran. The possible relationship between major chemical compounds and temperaments of each group were evaluated. Results: Plants containing phenolic compounds as their major constituents are hot and dry temperaments except those contain tannins with cold and dry temperaments. Plants containing essential oils have hot and dry temperaments except those whose major essential oils with alcoholic structure which have cold and dry temperaments. Alkaloid-containing plants have cold and dry or hot and dry temperaments based on their alkaloidal structures. Conclusions: There is a close relationship between major chemical compounds of medicinal plants and their temperaments mentioned in traditional Iranian manuscripts.

关键词： traditional Iranian medicine " temperament " alkaloids " phenolic compounds " volatile oils

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Sb(Ⅴ) removal from copper electrorefining electrolyte: Comparative study by different sorbents

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Transactions of Nonferrous Metals Society of China 2017年第2期27卷 440-449页

作者： Katereh SALARI Saeedeh HASHEMIAN mohammad taghi BAEI Department of Chemistry Islamic Azad UniversityYazd BrunchP.O.Box 89195-155YazdIran Department of Chemistry Islamic Azad UniversityAzadshahr BranchAzadshahrP.O.Box 49617-89985 GolestanIran

Removal of Sb（V） from copper electrolyte by different sorbents such as activated carbon, bentonite, kaolin, resin, zeolite and white sand was investigated. Adsorption capacity of Sb（V） removal from copper electrolyte was as follows： white sand 〈 anionic resin 〈 zeolite 〈 kaolin 〈 activated carbon 〈 bentonite. Bentonite was characterized using FTIR, XRF, XRD, SEM and BET methods. The results show specific surface area of 95 m2/g and particles size of 175 nm for bentonite. The optimum conditions for the maximum removal of Sb are contact time 10 min, 4 g bentonite and temperature of 40 ° C. The adsorption of Sb（V） on bentonite is followed by pseudo-second-order kinetic （R2=0.996 and k=9×10？5 g/（mg· min））. Thermodynamic results reveal that the adsorption of Sb（V） onto bentonite from copper electrolyte is endothermic and spontaneous process （ΔGΘ=？4806 kJ/（mol· K）. The adsorption data fit both the Freundlich and Langmuir isotherm models. Bentonite has the maximum adsorption capacity of 10000 mg/g for adsorption of Sb（V） in copper electrolyte. The adsorption of Zn, Co, Cu and Bi that present in the copper electrolyte is very low and insignificant.

关键词： antimony (V) bentonite copper electrolyte sorbent removal

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Transient thermal behavior of radial fins of rectangular,triangular and hyperbolic profiles with temperature-dependent properties using DTM-FDM

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Journal of Central South University 2017年第3期24卷 675-682页

作者： Sobhan Mosayebidorcheh mohammad rahimi-Gorji D.D Ganji Taha Moayebidorcheh O Pourmehran M.Biglarian Young Researchers and Elite Club Najafabad BranchIslamic Azad UniversityNajafabadIran Young Researchers and Elite Club Gorgan BranchIslamic Azad UniversityGorganIran Mechanical Engineering Department Babol University of TechnologyBabolMazandaranIran Department of Mechanical Engineering Sharif University of TechnologyTehranIran

This work focuses on transient thermal behavior of radial fins of rectangular,triangular and hyperbolic profiles with temperature-dependent properties.A hybrid numerical algorithm which combines differential transformation(DTM) and finite difference(FDM) methods is utilized to theoretically study the present *** and FDM are applied to the time and space domains of the problem,*** accuracy of this method solution is checked against the numerical ***,the effects of some applicable parameters were studied *** a broad range of governing parameters are investigated,the results could be useful in a number of industrial and engineering applications.

关键词： transient thermal behavior radial fin thermal conductivity temperature-dependent property hybrid differential transformation-finite difference (DTM-FDM)

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A comparative study of optimization algorithms for wavefront shaping

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Journal of Innovative Optical Health Sciences 2019年第4期12卷 74-82页

作者： Zahra Fayyaz Nafiseh mohammadian M.Reza rahimi Tabar Rayyan Manwar Kamran(mohammad)Avanaki Department of Physics Sharif University of Technology Tehran 11365-9161 Iran Biomedical Engineering Department Wayne State University DetroitMI 48201USA Department of Dermatology Wayne State University School of Medicine DetroitMI 48202USA Barbara Ann Karmanos Cancer Institute Detroit MI 48202USA

By manipulating the phase map of a wavefront of light using a spatial light modulator,the scattered light can be sharply focused on a specific *** iterative optimization algo-rithrns for obtaining the optimumn phase map have been ***,there has not been a comparative study on the performance of these *** this paper,six optimization algorithms for wavefront shaping inchuding continuous sequential,partitioning algorithm,transmission matrix estimation method,particle swarm optimization,genetic algorithm(GA),and simulated annealing(SA)are discussed and compared based on their efficiency when introduced with various measurement noise levels.

关键词： Wave front shaping algorithms optimization turbid media wavefront shaping

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Dill tablet: a potential antioxidant and anti-diabetic medicine

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Asian Pacific Journal of Tropical Biomedicine 2015年第9期5卷 696-702页

作者： Ebrahim Abbasi Oshaghi Heidar Tavilani Iraj Khodadadi mohammad taghi Goodarzi Department of Clinical Biochemistry School of Medicine Hamadan University of Medical Sciences Research Center for Molecular Medicine Hamadan University of Medical Sciences

Objective:To evaluate the antiglycation and antioxidant properties of the dill tablet, an herbal product used in Iran as a hypolipidemic medicine. Methods: In this descriptive study, the antioxidant and antiradical properties of dill tablet at dif erent concentration(0.032, 0.065, 0.125, 0.25, 0.5 and 1 mg/m L) were measured. The total phenolic, l avonols and l avonoid, alkaloids, anthocyanin, tannin and saponin contents in dill tablet were determined. Furthermore, antiglycation properties of dill tablet were assayed. In the in vivo experiments, male rats were randomly divided into three groups(n = 6): Group 1: normal rats; Group 2: diabetic rats; Group 3: diabetic rats + 300 mg/kg dill tablet, and Group 4: diabetic rats + 100 mg/kg dill tablet. After 2 months, the blood glucose was measured enzymatically and advanced glycation end-products(AGEs) formation was determined using a l uorometric ***: Our results illustrated that different concentrations of dill tablet had significant antioxidant activity. Dill tablet markedly declined AGEs formation and fructosamine levels(P < 0.001) compared with glycated sample. Oxidation of protein carbonyl and thiol group was signii cantly reduced by dill tablet in a dose dependent manner(P < 0.001). Formation of amyloid cross-β and fragmentation were markedly inhibited by dill tablet(P < 0.001) compared with glycated sample. After 2 months, fasting blood glucose levels(P < 0.001) and AGEs formation(P < 0.05) were signii cantly reduced by dill tablet in diabetic animals. Conclusions: Dill tablet exhibited significant antiglycation and antioxidant activities. This study provides a scientii c basis for using dill in treatment of diabetic patients.

关键词： Anethum graveolens Antioxidants Flavonoids Hypoglycemic agents Herbal medicine Dill

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Efficacy and safety of Hemoheal cream in patients with hemorrhoids:a randomized double-blind placebo controlled clinical trial

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Journal of Traditional Chinese Medicine 2021年第2期41卷 301-307页

作者： Mehdi Zobeiri Fatemeh Parvizi Roja rahimi Fatemeh Heydarpour Hamid Reza Sheikhan Jafar Navabi mohammad Hosein Farzaei Internal Medicine Department Imam Reza HospitalKermanshah University of Medical SciencesKermanshah ***Iran Pharmaceutical Sciences Research Center Kermanshah University of Medical SciencesKermanshah ***Iran Department of Traditional Pharmacy School of Persian MedicineTehran University of Medical SciencesTehran ***Iran Medical Biology Research Center Health Technology InstituteKermanshah University of Medical SciencesKermanshah ***Iran Clinical Research Development Center Imam Khomeini Hospital and Department of Internal MedicineKermanshah University of Medical SciencesKermanshah ***Iran Medical Technology Research Center Health Technology InstituteKermanshah University of Medical SciencesKermanshah ***Iran

OBJECTIVE:To evaluate the efficacy and safety of Hemoheal cream,an anti-hemorrhoid herbal preparation,(inspired by Persian medicine literatures in a double-blind,randomized placebo-controlled ***:Hemoheal cream consists of aqueous extract of Allium ampeloprasum L.,Commiphora mukul(*** Stocks)Engl and the oil of Sesamum indicum ***-two patients with symptomatic hemorrhoids were randomized to receive hemoheal cream or placebo for 3 *** patients were evaluated before and after the intervention in terms of the severity of anal irritation,bleeding,anal itching,pain,defecation discomfort and swelling sense,and overall subjective improvement(%),as well as any reported adverse ***:The results showed that after 3 weeks of treatment,distribution of anal irritation,bleeding,pain as well as swelling sense were significantly different(P0.05).Furthermore,a significant difference was observed between the overall subjective improvement of Hemoheal cream and placebo groups(P=0.012).One patient in the treatment group complained of rashes on the application ***:The present study showed a positive effect of Hemoheal cream in improving clinical signs and symptoms in patients with hemorrhoids.

关键词： Hemorrhoids Allium Commiphora Sesamum Medicine,Iranain traditional Controlled clinical trial

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Sustainability criteria of apicultural industry:evidence from Iran

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Ecosystem Health and Sustainability 2020年第1期6卷 617-629,616页

作者： mohammad Kazem rahimi Enayat Abbasi Masoud Bijani Gholamhosein Tahmasbi Ali Akbar Azimi Dezfouli Department of Agricultural Extension and Education College of AgricultureTarbiat Modares University(TMU)TehranIran Animal Science Research Institute(ASRI) Agricultural ResearchEducation and Extension Organization(AREEO)KarajIran Agricultural Planning Economicsand Rural Development Research Institute(APERDRI)Ministry of Agriculture-JihadTehranIran

This study aimed to determine the sustainability criteria of the beekeeping industry in Iran,which was performed using three-stage classical Delphi *** participants were 32 experts in beekeeping industry who were purposefully selected using the snowball sampling *** criteria identified,after three Delphi stages,consisted of 70 items,which were categorized into 13 general criteria and into four economic,environmental,social,and institutional *** general criteria were presented in the form of a conceptual model,including:farmers’environmental behavior quality,beekeepers'environmental behavior quality,the quality of marketing and sales of beekeeping productions,productivity and performance improvement,amount of monetization from pollinations'right,the amount of monetization of byproducts and value added,employment rate and job stability,the level of social development of stakeholders,the quality of the role-playing of non-governmental stakeholders,the quality of extension and education new sciences and technologies to stakeholders,comprehensiveness of laws and programs,quality of role-playing of stakeholder non-governmental organizations,and the quality of the roleplaying of governmental institutions *** them,a comprehensive perception of the necessary criteria for the sustainability of Iran's beekeeping industry can be obtained and a comprehensive program can be designed for its implementation.

关键词： Sustainable apiculture agricultural sustainability conceptual model Delphi technique

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Complementary and alternative medicine use in Iranian patients with diabetes mellitus

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Journal of Integrative Medicine 2015年第5期13卷 319-325页

作者： mohammad Hashem Hashempur Mojtaba Heydari Seyed Hamdollah Mosavat Seyyed taghi Heydari Mesbah Shams Noncommunicable Diseases Research Center Fasa University of Medical Sciences Department of Traditional Medicine School of Medicine Fasa University of Medical Sciences Research Center for Traditional Medicine and History of Medicine Department of Traditional Persian Medicine School of Medicine Shiraz University of Medical Sciences Essence of Parsiyan Wisdom Institute Traditional Medicine and Medicinal Plant Incubator Shiraz University of Medical Sciences Health Policy Research Center Shiraz University of Medical Sciences Endocrine and Metabolism Research Center Nemazee Hospital Shiraz University of Medical Sciences

OBJECTIVE： There is increasing interest in complementary and alternative medicine generally, and especially by those affected by chronic diseases, such as diabetes mellitus. We aimed to determine the prevalence and pattern of complementary and altemative medicine use among patients suffering from diabetes mellitus in Shiraz, southern Iran. Another objective was to explore associated factors for use of complementary and alternative medicine among patients with diabetes mellitus. METHODS： A 19-item semi-structured questionnaire （open- and close-ended） was administered to 239 patients with diabetes mellitus in this cross-sectional study. It was carried out in two outpatient diabetes clinics affiliated with the Shiraz University of Medical Sciences, Shiraz, Iran. RESULTS： One hundred and eighty patients （75.3%） used at least one type of complementary and alternative medicine in the last year prior to the interview. Patients with diabetes mellitus who were living in a large family （〉 5 members）, not taking insulin, and believed that complementary and alternative medicine have synergistic effects with conventional medicine, were independently and significantly （P values： 0.02, 0.04, and 0.01, respectively） more likely to use complementary and alternative medicine. Most of the users （97.7%） reported use of herbal preparations, and 89.4% of users did not change their medication, neither in medication schedule nor its dosage. CONCLUSION： The use of complementary and alternative medicine, especially herbal remedies, is popular among diabetes patients in Shiraz, Iran. This use is associated with patients＇ family size, type of conventional medications and their view about concomitant use of complementary and conventional medicine.

关键词： diabetes mellitus complementary therapies prevalence medicine, herbal Iran.

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