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Effects of apical sodium-bile acid transporter inhibitor and obeticholic acid co-treatment in experimental non-alcoholic steatohepatitis

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Liver Research 2022年第4期6卷 276-283页

作者： David J.Matye Xuan Qin mohammad nazmul hasan Lijie Gu Yung Dai Clayton Feng Li Tiangang Li Harold Hamm Diabetes Center Department of PhysiologyUniversity of Oklahoma Health Sciences CenterOklahoma CityOKUSA Department of Pathology and Immunology Baylor College of MedicineHoustonTXUSA NMR and Drug Metabolism Core Baylor College of MedicineHoustonTXUSA

Background and aims:Several bile acids-based monotherapies have been developed for non-alcoholic steatohepatitis(NASH)treatment but clinical trial findings suggest that they do not satisfactorily improve NASH and liver fibrosis in many ***,we have shown that combining a gut-restricted apical sodium-bile acid transporter(ASBT)inhibitor GSK2330672(GSK)with adeno-associated virus(AAV)-mediated liver fibroblast growth factor 15(FGF15)overexpression provides significantly improved efficacy than either single treatment against NASH and liver fibrosis in a high fat,cholesterol,and fructose(HFCFr)diet-induced NASH mouse *** beneficial effects of the com-bined treatment can be attributed to the markedly reduced bile acid pool that reduces liver bile acid burden and intestinal lipid *** aim of this study is to further investigate if combining GSK treatment with the orally bioavailable obeticholic acid(OCA),which induces endogenous FGF15 and inhibits hepatic bile acid synthesis,can achieve similar anti-NASH effect as the GSKþAAV-FGF15 co-treatment in HFCFr-diet-fed *** and methods:Male C57BL/6J mice were fed HFCFr diet to induce NASH and liver *** effect of GSK,OCA,and GSKþOCA treatments on NASH development was compared and contrasted among all ***:Findings from this study showed that the GSKþOCA co-treatment did not cause persistent reduction of obesity over a 12-week treatment *** single treatment nor the GSKþOCA co-treatment reduce hepatic steatosis,but all three treatments reduced hepatic inflammatory cytokines and fibrosis by a similar *** GSKþOCA co-treatment caused a higher degree of total bile acid pool reduction(~55%)than either GSK or OCA treatment ***,such bile acid pool reduction was insufficient to cause increased fecal lipid *** GSKþOCA co-treatment prevented GSK-mediated induction of hepatic cholesterol 7alpha-hydroxylase but failed to induce ileal FGF15 expression.

关键词： Bile acids Farnesoid X receptor(FXR) Fibroblast growth factor 15(FGF15) Apical sodium-bile acid transporter(ASBT) Non-alcoholic steatohepatitis(NASH) Liver fibrosis

Systematic mutational analysis of epitope-grafted ED3 immunogenicity reveals a DENV3-DENV4 bi-serospecific ED3 mutant

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Asian Pacific Journal of Tropical Medicine 2022年第2期15卷 63-70,I0001-I0004页

作者： Mamtaz Sultana nazmul hasan Mamunur R.Mahib mohammad M.Islam Department of Biochemistry and Molecular Biology University of ChittagongChittagong-4331Bangladesh

Objective:To identify the residue determinants of the serospecificity and sero-cross-reactivity of dengue virus(DENV)envelope protein domain 3(ED3),which contains two major putative epitopes of ***:We constructed ED3 from DENV3(3ED3)and DENV4(4ED3),and six epitope-grafted variants,where we transferred epitope 1(L304I,K305D,V309M,and S310A)and/or epitope 2(D383N,K384S,K387T,and N389H)of 4ED3 onto 3ED3 and *** albino mice aged 3-4 weeks were immunized against wildtype and epitope-grafted ED3 variants and anti-ED3 IgG antibody responses were determined using ***:Mouse immunization using 3ED3 and 4ED3 generated serotype-specific antisera,as ***,most epitope-grafted ED3s produced antisera serospecific to the template ED3 with little or no cross-recognition of ED3 of the serotype from which the epitopes were *** indicated that a mere grafting of the epitope was not sufficient to transfer serospecificity,contrary to our ***,one epitope-grafted ED3 mutant,where epitope 1 of 3ED3 was grafted onto 4ED3(4ED3^(epi1)),generated antisera that was serospecific to both 4ED3 and ***:The 4ED3^(epi1)is a chimeric ED3 that produces antisera possessing serospecificity to both 3ED3 and 4ED3 onto a common 4ED3 *** 4ED3^(epi1),therefore,provides a unique tool for analyzing serospecificity and sero-cross-reactivity in *** believe that chimeric ED3 may provide a template for future recombinant ED3 possessing serospecificity of multiple DENVs onto a single scaffold and may pave a way developing tri-and/or tetravalent anti-DENV antisera.

关键词： Dengue virus serospecificity Sero-cross-recognition Anti-ED3 antibodies Epitope-grafting Chimeric ED3

Secure Channel Estimation Using Norm Estimation Model for 5G Next Generation Wireless Networks

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Computers, Materials & Continua 2025年第1期82卷 1151-1169页

作者： Khalil Ullah Song Jian Muhammad Naeem Ul Hassan Suliman Khan mohammad Babar Arshad Ahmad Shafiq Ahmad Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming650500China Department of Computer Science Abbottabad University of Science and TechnologyHavelianAbbottabad22500Pakistan Department of Computing and Electronics Engineering Middle East CollegeMuscat124Oman Department of CS&IT Pak-Austria Fachhochschule Institute of Applied Sciences and Technology MangHaripur22621Pakistan Industrial Engineering Department College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia

The emergence of next generation networks(NextG),including 5G and beyond,is reshaping the technological landscape of cellular and mobile *** networks are sufficiently scaled to interconnect billions of users and *** in academia and industry are focusing on technological advancements to achieve highspeed transmission,cell planning,and latency reduction to facilitate emerging applications such as virtual reality,the metaverse,smart cities,smart health,and autonomous *** continuously improves its network functionality to support these *** input multiple output(MIMO)technology offers spectral efficiency,dependability,and overall performance in *** article proposes a secure channel estimation technique in MIMO topology using a norm-estimation model to provide comprehensive insights into protecting NextG network components against adversarial *** technique aims to create long-lasting and secure NextG networks using this extended *** viability of MIMO applications and modern AI-driven methodologies to combat cybersecurity threats are explored in this ***,the proposed model demonstrates high performance in terms of reliability and accuracy,with a 20%reduction in the MalOut-RealOut-Diff metric compared to existing state-of-the-art techniques.

关键词： Next generation networks massive mimo communication network artificial intelligence 5G adversarial attacks channel estimation information security

Engendered nanoparticles for treatment of brain tumors

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Oncology Research 2025年第1期33卷 15-26页

作者： SOROUSH SOLEYMANI mohammad DOROUDIAN MAHDIEH SOEZI ALI BELADI KIARASH ASGARI ASO MOBARAKSHAHI ARYANA AGHAEIPOUR RONAN MACLOUGHLIN Department of Cell and Molecular Biology School of Biological SciencesUniversity of LeicesterLeicesterLE17RHUK Department of Cell and Molecular Biology Faculty of Biological SciencesKharazmi UniversityTehran15719-14911Iran Cancer Epidemiology Research Center Aja University of Medical SciencesTehran14117-18541Iran Medical Biotechnology Research Center Aja University of Medical SciencesTehran14117-18541Iran Department of Life Sciences Faculty of Natural SciencesImperial College LondonLondonSW72AZUK School of Pharmacy and Biomolecular Sciences Royal College of Surgeons in Ireland(RCSI)DublinD02 YN77Ireland Research and Development Science and Emerging TechnologiesAerogen Ltd.Galway Business ParkGalwayH91 HE94Ireland School of Pharmacy and Pharmaceutical Sciences Trinity CollegeDublinD02 PN40Ireland

Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain *** median survival time is typically less than a year after *** of the major challenges in treating these cancers is the efficiency of the transport of drugs to the central nervous *** blood-brain barrier is cooperating with advanced stages of *** blood-brain barrier poses a significant challenge to delivering systemic medications to brain *** delivery systems have emerged as promising tools for effectively crossing this ***,the development of smart nanoparticles brings new hope for cancer diagnosis and *** nanoparticles improve drug delivery efficiency,allowing for the creation of targeted and stimuli-responsive delivery *** review highlights recent advancements in nanoparticle and smart nanoparticle technologies for brain cancer treatment,exploring the range of nanoparticles under development,their applications,targeting strategies,and the latest progress in enhancing transport across the blood-brain *** also addresses the ongoing challenges and potential benefits of these innovative approaches.

关键词： Nanoparticles Smart nanoparticles Stimuli responsive nanoparticles Targeted nanoparticles Blood-brain barrier(BBB) Brain cancer

Efficient Wind Turbine Generation Planning for Decreasing Distribution System Company Payments in Real Applications

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 81-90页

作者： mohammad hasan Hemmatpour mohammad Hossein Rezaeian Koochi Electrical Engineering Department Faculty of EngineeringJahrom UniversityJahromIran Department of Electrical Engineering Shahid Bahonar University of KermanKermanIran

Wind energy has posed new challenges in both transmission and distribution systems owing to its uncertain nature. The effect of wind turbines (WTs) on the actual payments charged by upstream networks to distribution system companies (DISCOs) is one challenge. Moreover, when the grid-connected inverters of WT operate in the lead or lag modes, WTs absorb or inject reactive power from the system. This paper proposes an approach to assess the importance of operation modes of WTs to minimize the costs by DISCOs in the presence of system uncertainties. Accordingly, an optimization problem is formulated to minimize the costs to DISCO by determining the optimal locations and sizes of WTs in optimally reconfigured distribution systems. In addition, an improved vector-based swarm optimization (IVBSO) algorithm is proposed because it is highly suitable for vector-based problems. Two distribution systems are used in the simulations to evaluate the proposed algorithm. Firstly, the capabilities of the IVBSO algorithm to determine better solutions over other heuristic algorithms are confirmed using the IEEE 33-bus test system. Secondly, the BijanAbad distribution system (BDS) is used to demonstrate the effectiveness of the proposed optimization problem. Accordingly, the distribution system model, cumulative distribution function of wind speed, and load profile are all extracted from the actual data of the BijanAbad region. Finally, the optimization problem is applied to BDS in both the lead and lag modes of WTs. Results indicate that the total costs of DISCO are lower when WTs operate in the lag mode than in the lead mode.

关键词： Distribution system companies(DISCOs) improved vector-based swarm optimization(IVBSO) reconfiguration wind turbine operation mode

Reliability and sensitivity analysis of wedge stability in the abutments of an arch dam using artificial neural network

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Earthquake Engineering and Engineering Vibration 2022年第4期21卷 1019-1033页

作者： hasan Mostafaei Farhad Behnamfar mohammad Alembagheri Department of Civil Engineering Isfahan University of TechnologyIsfahan 84156-83111Iran Department of Civil and Environmental Engineering Tarbiat Modares UniversityTehran 11155-9313Iran

In this study,the seismic stability of arch dam abutments is investigated within the framework of the probabilistic method.A large concrete arch dam is considered with six wedges for each *** seismic safety of the dam abutments is studied with quasi-static analysis for different hazard *** Londe limit equilibrium method is utilized to calculate the stability of the wedges in the *** the finite element method is time-consuming,the neural network is used as an alternative for calculating the wedge safety *** training the neural network,1000 random samples are generated and the dam response is *** direction of applied acceleration is changed within 5-degree intervals to reveal the critical direction corresponding to the minimum safety *** Latin hypercube sampling(LHS)is employed for sample generation,and the safety level is determined with reliability *** sample numbers of 1000,2000 and 4000 are used to examine the average and standard deviation of the *** global sensitivity analysis is used to identify the effects of random variables on the abutment *** is shown that friction,cohesion and uplift pressure have the most significant effects on the wedge stability variance.

关键词： arch dam seismic reliability artificial neural network Latin hypercube sampling sensitivity analysis wedge abutment

Effect of microstructure on the breakage of tin bronze machining chips during pulverization via jet milling

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International Journal of Minerals,Metallurgy and Materials 2016年第11期23卷 1323-1332页

作者： Elham Afshari mohammad Ghambari hasan Farhangi School of Metallurgy and Materials Engineering University College of EngineeringUniversity of Tehran

In this study, jet milling was used to recycle tin bronze machining chips into powder. The main purpose of this study was to assess the effect of the microstructure of tin bronze machining chips on their breakage behavior. An experimental target jet mill was used to pulverize machining chips of three different tin bronze alloys containing 7wt%, 10wt%, and 12wt% of tin. Optical and electron microscopy, as well as sieve analysis, were used to follow the trend of pulverization. Each alloy exhibited a distinct rate of size reduction, particle size distribution, and fracture surface appearance. The results showed that the degree of pulverization substantially increased with increasing tin content. This behavior was attributed to the higher number of machining cracks as well as the increased volume fraction of brittle δ phase in the alloys with higher tin contents. The δ phase was observed to strongly influence the creation of machining cracks as well as the nucleation and propagation of cracks during jet milling. In addition, a direct relationship was observed between the mean δ-phase spacing and the mean size of the jet-milled product; i.e., a decrease in the δ-phase spacing resulted in smaller particles.

关键词： bronze chips microstructure cracks pulverization

HIGH ORDER FINITE DIFFERENCE/SPECTRAL METHODS TO A WATER WAVE MODEL WITH NONLOCAL VISCOSITY

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Journal of Computational Mathematics 2020年第4期38卷 580-605页

作者： mohammad Tanzil hasan Chuanju Xu School of Mathematical Sciences and Fujian Provincial Key Laboratory of Mathematical Modeling and High Performance Scientific Computing Xiamen UniversityXiamen 361005China

In this paper,efficient numerical scheme is proposed for solving the water wave model with nonlocal viscous term that describe the propagation of surface water *** using the Caputo fractional derivative definition to approximate the nonlocal fractional operator,finite difference method in time and spectral method in space are constructed for the considered *** proposed method employs known 5/2 order scheme for fractional derivative and a mixed linearization for the nonlinear *** analysis shows that the proposed numerical scheme is unconditionally stable and error estimates are provided to predict that the second order backward differentiation plus 5/2 order scheme converges with order 2 in time,and spectral accuracy in *** numerical results are provided to verify the efficiency and accuracy of our theoretical ***,the decay rate of solutions are investigated.

关键词： Water waves Nonlocal viscosity Finite difference Spectral method Conver-gence order Decay rate

Chaos suppression of uncertain gyros in a given finite time

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Chinese Physics B 2012年第11期21卷 126-131页

作者： mohammad Pourmahmood Aghababa hasan Pourmahmood Aghababa Electrical Engineering Department Urmia University of Technology Department of Mathematics University of Tabriz Research Center for Industrial Mathematics of University of Tabriz

The gyro is one of the most interesting and everlasting nonlinear dynamical systems, which displays very rich and complex dynamics, such as sub-harmonic and chaotic behaviors. We study the chaos suppression of the chaotic gyros in a given finite time. Considering the effects of model uncertainties, external disturbances, and fully unknown parameters, we design a robust adaptive finite-time controller to suppress the chaotic vibration of the uncertain gyro as quickly as possible. Using the finite-time control technique, we give the exact value of the chaos suppression time. A mathematical theorem is presented to prove the finite-time stability of the proposed scheme. The numerical simulation shows the efficiency and usefulness of the proposed finite-time chaos suppression strategy.

关键词： chaos suppression chaotic gyro finite-time stability robustness