检索结果-南通市图书馆

High-throughput computational screening and in vitro evaluation identifies 5-(4-oxo-4H-3,1-benzoxazin-2-yl)-2-[3-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-1H-isoindole-1,3(2H)-dione(C3),as a novel EGFR—HER2 dual inhibitor in gastric tumors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第2期32卷 251-259页

作者： MESFER AL SHAHRANI REEM GAHTANI mohammad ABOHASSAN mohammad ALSHAHRANI YASSER ALRAEY AYED DERA mohammad RAJEH ASIRI PRASANNA RAJAGOPALAN Department of Clinical Laboratory Sciences College of Applied Medical SciencesKing Khalid UniversityAbhaSaudi Arabia

Gastric cancers are caused primarily due to the activation and amplification of the EGFR or HER2 kinases resulting in cell proliferation,adhesion,angiogenesis,and *** therapies are ineffective due to the intra-tumoral heterogeneity and concomitant genetic ***,dual inhibition strategies are recommended to increase potency and reduce *** this study,we have conducted computational high-throughput screening of the ChemBridge library followed by in vitro assays and identified novel selective inhibitors that have a dual impediment of EGFR/HER2 kinase ***-based High-throughput Virtual Screening(D-HTVS)was used to screen the whole ChemBridge small molecular library against EGFR and *** atomistic molecular dynamic simulation was conducted to understand the dynamics and stability of the protein-ligand ***/HER2 kinase enzymes,KATOIII,and Snu-5 cells were used for in vitro *** atomistic Molecular Dynamics simulations followed by solvent-based Gibbs binding free energy calculation of top molecules,identified compound C3(5-(4-oxo-4H-3,1-benzoxazin-2-yl)-2-[3-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-1H-isoindole-1,3(2H)-dione)to have a good affinity for both EGFR and *** predicted compound,C3,was promising with better binding energy,good binding pose,and optimum interactions with the EGFR and HER2 residues.C3 inhibited EGFR and HER2 kinases with IC50 values of 37.24 and 45.83 nM,*** GI50 values of C3 to inhibit KATOIII and Snu-5 cells were 84.76 and 48.26 nM,*** on these findings,we conclude that the identified compound C3 showed a conceivable dual inhibitory activity on EGFR/HER2 kinase,and therefore can be considered as a plausible lead-like molecule for treating gastric cancers with minimal side effects,though testing in higher models with pharmacokinetic approach is required.

关键词： Dual inhibitor Drug discovery EGFR/HER2 kinase Gastric cancer High-throughput screening

Improving the Segmentation of Arabic Handwriting Using Ligature Detection Technique

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第5期79卷 2015-2034页

作者： Husam Ahmad Al Hamad mohammad Shehab College of Computer Sciences and Informatics Amman Arab UniversityAmman11953Jordan

Recognizing handwritten characters remains a critical and formidable challenge within the realm of computervision. Although considerable strides have been made in enhancing English handwritten character recognitionthrough various techniques, deciphering Arabic handwritten characters is particularly intricate. This complexityarises from the diverse array of writing styles among individuals, coupled with the various shapes that a singlecharacter can take when positioned differently within document images, rendering the task more perplexing. Inthis study, a novel segmentation method for Arabic handwritten scripts is suggested. This work aims to locatethe local minima of the vertical and diagonal word image densities to precisely identify the segmentation pointsbetween the cursive letters. The proposed method starts with pre-processing the word image without affectingits main features, then calculates the directions pixel density of the word image by scanning it vertically and fromangles 30° to 90° to count the pixel density fromall directions and address the problem of overlapping letters, whichis a commonly attitude in writing Arabic texts by many people. Local minima and thresholds are also determinedto identify the ideal segmentation area. The proposed technique is tested on samples obtained fromtwo datasets: Aself-curated image dataset and the IFN/ENIT dataset. The results demonstrate that the proposed method achievesa significant improvement in the proportions of cursive segmentation of 92.96% on our dataset, as well as 89.37%on the IFN/ENIT dataset.

关键词： Arabic handwritten segmentation image processing ligature detection technique intelligent recognition

Distributed Energy and Reserve Scheduling in Local Energy Communities Using L-BFGS Optimization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第3期10卷 942-952页

作者： mohammad Dolatabadi Alireza Zakariazadeh Alberto Borghetti Pierluigi Siano Department of Management&Innovation Systems University of SalernoSalernoItaly Department of Electrical Electronicand Information EngineeringUniversity of BolognaBolognaItaly University of Science and Technology of Mazandaran BehshahrIran Department of Power Systems National University of Science and Technology POLITEHNICA BucharestBucharestRomania IEEE

Encouraging citizens to invest in small-scale renewable resources is crucial for transitioning towards a sustainable and clean energy *** energy communities(LECs)are expected to play a vital role in this ***,energy scheduling in LECs presents various challenges,including the preservation of customer privacy,adherence to distribution network constraints,and the management of computational *** paper introduces a novel approach for energy scheduling in renewable-based LECs using a decentralized optimization *** proposed approach uses the Limitedmemory Broyden–Fletcher–Goldfarb–Shanno(L-BFGS)method,significantly reducing the computational effort required for solving the mixed integer programming(MIP)*** incorporates network constraints,evaluates energy losses,and enables community participants to provide ancillary services like a regulation reserve to the grid *** assess its robustness and efficiency,the proposed approach is tested on an 84-bus radial distribution *** indicate that the proposed distributed approach not only matches the accuracy of the corresponding centralized model but also exhibits scalability and preserves participant privacy.

关键词： Distributed optimization flexibility services L-BFGS method local energy community renewables reserve

Normal Crossings Singularities for Symplectic Topology:Structures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第1期40卷 107-160页

作者： mohammad FARAJZADEH-TEHRANI Mark MCLEAN Aleksey ZINGER The University of Iowa MacLean HallIowa CityIA 52241 Department of Mathematics Stony Brook UniversityStony BrookNY 11794

Our previous papers introduce topological notions of normal crossings symplectic divisor and variety,show that they are equivalent,in a suitable sense,to the corresponding geometric notions,and establish a topological smoothability criterion for normal crossings symplectic *** present paper constructs a blowup,a complex line bundle,and a logarithmic tangent bundle naturally associated with a normal crossings symplectic divisor and determines the Chern class of the last *** structures have applications in constructions and analysis of various moduli *** a corollary of the Chern class formula for the logarithmic tangent bundle,we refine Aluffi’s formula for the Chern class of the tangent bundle of the blowup at a complete intersection to account for the torsion and extend it to the blowup at the deepest stratum of an arbitrary normal crossings divisor.

关键词： Normal crossings divisor Chern class Logarithmic tangent bundle

Time-dependent effects in transient liquid phase bonding of 304L and Cp-Ti using an Ag-Cu interlayer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2024年第7期31卷 2237-2255页

作者： Saeed VAZIRIAN mohammad MOSHKBAR BAKHSHAYESH Ali FARZADI Department of Materials and Metallurgical Engineering Amirkabir University of Technology(Tehran Polytechnic)Tehran 15916-34311Iran

One of the challenges for bimetal manufacturing is the joining ***,transient liquid phase(TLP)bonding was performed between 304L stainless steel and Cp-Ti using an Ag-Cu interlayer with a thickness of 75μm for bonding time of 20,40,60,and 90 *** bonding temperature of 860℃ was considered,which is under the β transus temperature of *** TLP bonding,various intermetallic compounds(IMCs),including Ti_(5)Cr_(7)Fe_(17),(Cr,Fe)_(2)Ti,Ti(Cu,Fe),Ti_(2)(Cu,Ag),and Ti_(2)Cu from 304L toward Cp-Ti formed in the ***,on the one side,with the increase in time,further diffusion of elements decreases the blocky IMCs such as Ti_(5)Cr_(7)Fe_(17),(Cr,Fe)_(2)Ti,Ti(Cu,Fe)in the 304L diffusion-affected zone(DAZ)and reaction zone,and on the other side,Ti_(2)(Cu,Ag)IMC transformed into fine morphology toward Cp-Ti *** microhardness test also demonstrated that the(Cr,Fe)_(2)Ti+Ti_(5)Cr_(7)Fe_(17) IMCs in the DAZ on the side of 304L have a hardness value of HV 564,making it the hardest *** maximum and minimum shear strength values are equal to 78.84 and 29.0 MPa,*** cleavage pattern dominated fracture surfaces due to the formation of brittle phases in dissimilar joints.

关键词： diffusion brazing transient liquid phase bonding dissimilar material joints microstructural evolution mechanical properties grade 2 titanium

An Improved Binary Quantum-based Avian Navigation Optimizer Algorithm to Select Effective Feature Subset from Medical Data:A COVID-19 Case Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2024年第1期21卷 426-446页

作者： Ali Fatahi mohammad H.Nadimi-Shahraki Hoda Zamani Faculty of Computer Engineering Najafabad BranchIslamic Azad UniversityNajafabad ***Iran Big Data Research Center Najafabad BranchIslamic Azad UniversityNajafabad ***Iran

Feature Subset Selection(FSS)is an NP-hard problem to remove redundant and irrelevant features particularly from medical data,and it can be effectively addressed by metaheuristic ***,existing binary versions of metaheuristic algorithms have issues with convergence and lack an effective binarization method,resulting in suboptimal solutions that hinder diagnosis and prediction *** paper aims to propose an Improved Binary Quantum-based Avian Navigation Optimizer Algorithm(IBQANA)for FSS in medical data preprocessing to address the suboptimal solutions arising from binary versions of metaheuristic *** proposed IBQANA’s contributions include the Hybrid Binary Operator(HBO)and the Distance-based Binary Search Strategy(DBSS).HBO is designed to convert continuous values into binary solutions,even for values outside the[0,1]range,ensuring accurate binary *** the other hand,DBSS is a two-phase search strategy that enhances the performance of inferior search agents and accelerates *** combining exploration and exploitation phases based on an adaptive probability function,DBSS effectively avoids local *** effectiveness of applying HBO is compared with five transfer function families and thresholding on 12 medical datasets,with feature numbers ranging from 8 to 10,***'s effectiveness is evaluated regarding the accuracy,fitness,and selected features and compared with seven binary metaheuristic ***,IBQANA is utilized to detect *** results reveal that the proposed IBQANA outperforms all comparative algorithms on COVID-19 and 11 other medical *** proposed method presents a promising solution to the FSS problem in medical data preprocessing.

关键词： Feature subset selection Optimization Binary metaheuristic algorithms Bioinspired Machine learning Medical datasets

Advances in Manta Ray Foraging Optimization:A Comprehensive Survey

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2024年第2期21卷 953-990页

作者： Farhad Soleimanian Gharehchopogh Shafi Ghafouri mohammad Namazi Bahman Arasteh Department of Computer Engineering Urmia BranchIslamic Azad UniversityUrmiaIran Department of Computer Engineering Tabriz BranchIslamic Azad UniversityTabrizIran Department of Computer Engineering Maybod BranchIslamic Azad UniversityMaybodIran Department of Software Engineering Faculty of Engineering and Natural ScienceIstinye UniversityIstanbulTurkey

This paper comprehensively analyzes the Manta Ray Foraging Optimization(MRFO)algorithm and its integration into diverse academic *** in 2020,the MRFO stands as a novel metaheuristic algorithm,drawing inspiration from manta rays’unique foraging behaviors—specifically cyclone,chain,and somersault *** biologically inspired strategies allow for effective solutions to intricate physical *** its potent exploitation and exploration capabilities,MRFO has emerged as a promising solution for complex optimization *** utility and benefits have found traction in numerous academic *** its inception in 2020,a plethora of MRFO-based research has been featured in esteemed international journals such as IEEE,Wiley,Elsevier,Springer,MDPI,Hindawi,and Taylor&Francis,as well as at international conference *** paper consolidates the available literature on MRFO applications,covering various adaptations like hybridized,improved,and other MRFO variants,alongside optimization *** trends indicate that 12%,31%,8%,and 49%of MRFO studies are distributed across these four categories respectively.

关键词： Manta ray foraging optimization Metaheuristic algorithms Hybridization Improved Optimization

Towards implementation of alloy-specific thermo-fluid modelling for laser powder-bed fusion of Mg alloys

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第6期12卷 2327-2344页

作者： mohammad Hoseini-Athar Mikael Ersson Peter Hedström Department of Material Science and Engineering KTH Royal Institute of TechnologyStockholmSE-10044 Sweden

Multi-physics thermo-fluid modeling has been extensively used as an approach to understand melt pool dynamics and defect formation as well as optimizing the process-related parameters of laser powder-bed fusion(L-PBF).However,its capabilities for being implemented as a reliable tool for material design,where minor changes in material-related parameters must be accurately captured,is still in *** the present research,first,a thermo-fluid computational fluid dynamics(CFD)model is developed and validated against experimental *** the predicted material properties of the pure Mg and commercial ZK60 and WE43 Mg alloys,parametric studies are done attempting to elucidate how the difference in some of the material properties,i.e.,saturated vapor pressure,viscosity,and solidification range,can influence the melt pool *** is found that a higher saturated vapor pressure,associated with the ZK60 alloy,leads to a deeper unstable keyhole,increasing the keyhole-induced porosity and evaporation mass *** viscosity and wider solidification range can increase the non-uniformity of temperature and velocity distribution on the keyhole walls,resulting in increased keyhole instability and formation of ***,the WE43 alloy showed the best behavior in terms of defect formation and evaporation mass loss,providing theoretical support to the extensive use of this alloy in *** summary,this study suggests an approach to investigate the effect of materials-related parameters on L-PBF melting and solidification,which can be extremely helpful for future design of new alloys suitable for L-PBF.

关键词： Mg alloys Laser powder-bed fusion(L-PBF) Melt pool dynamics Computational fluid dynamics Fluid flow

Movement Trend Alterations in the Periaqueductal Gray(PAG)-Employed Ratbot Navigation Are Correlated with Stimulation Parameters

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2024年第2期21卷 866-876页

作者： Sina Khajei Abed Khorasani mohammad Reza Afarinesh Vahid Sheibani Neuroscience Research Center Institute of NeuropharmacologyKerman University of Medical SciencesKerman***Iran Cognitive Neuroscience Research Center Institute of NeuropharmacologyKerman University of Medical SciencesKerman***Iran

In previous studies,Periaqueductal Gray(PAG)stimulation was used to stop ratbots from *** to the homology between the PAG and the intercollicular nucleus,which has been used for forward movement in birds,we investigated the possibility of PAG application to induce forward locomotion for the first *** a corridor maze,the traveled distances via PAG electrical stimulation were examined in nine Wistar male rats during three sessions.A custom-designed stimulator was developed to apply the *** results showed reductions in responses to stimulation over ***,the traveled distances had negative slopes during the consecutive trials(in 8 out of the 9 rats),and the slope mean was significantly different from *** was a strong correlation between the stimulation parameters(electric Charge per Phase(CPP)and the Number of Pulses(NP))and the observed *** negative Movement Slopes(MS)were highly correlated with the CPP and the NP,as the Pearson's linear correlation coefficients were−0.87 and−0.79,*** MS-CPP coefficients of determination(R-squared)were also between 0.76 and *** addition,the MS-NP coefficients of determination were between 0.63 and ***,it is concluded that the electrical stimulation parameters influence the behavioral outcomes ***,the PAG area may be considered a suitable candidate for forward locomotion control in the future if the area is harnessed effectively to prevent undesirable chaotic behaviors.

关键词： Periaqueductal Gray(PAG) Navigation Ratbot Animal-robot Forward locomotion Movement slope