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The Evolution of Iron-Related Comorbidities and Hospitalization in Patients with Hemochromatosis:An Analysis of the Nationwide Inpatient Sample

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Blood Science 2023年第2期5卷 131-135页

作者： Ahmad Abou Yassine Kira MacDougall Roula Sasso Youssef Shammaa Mira Alsheikh mohammad Abureesh Loai Dahabra mohammad alshami Stephen Mulrooney Department of Internal Medicine Zucker School of Medicine at Hofstra/Northwell at Staten Island University HospitalNew YorkNYUSA Department of Gastroenterology Zucker School of Medicine at Hofstra/Northwell at Staten Island University HospitalNew YorkNYUSA

Hemochromatosis,either hereditary hemochromatosis(HH)or secondary hemochromatosis,consists of the accumulation of iron in the liver,heart,and other *** leads to end-organ damage in a proportion of affected *** liver-related morbidity(cirrhosis and hepatocellular carcinoma[HCC])and mortality are well established,the frequency of these complications remains *** aim of this study is to examine the rate of hospitalization and the incidence of iron overload-related comorbidities in patients with hemochromatosis between the years of 2002 and *** queried the Nationwide Inpatient Sample(NIS)database from the year 2002 to *** included adults(age≥18 years)and used the ICD-CM 9 code 275.0x to identify hospitalized patients with a diagnosis of *** analysis for this study was generated using SAS software version 9.4.A total of 168,614 hospitalized patients between 2002 and 2010 had a diagnosis of *** majority were males(57%)with a median age of 54 years(37–68),with a predominance of white patients(63.3%)followed by black(26.8%).The rate of hospitalization among patients with hemochromatosis increased by 79%between the years 2002 and 2010(34.5/100,000 in 2002 vs 61.4/100,000 in 2010).The main associated diagnoses were diabetes mellitus(20.2%),cardiac disease,including arrhythmias(14%)and cardiomyopathy(dilated 3.8%;peri-,endo-,myocarditis 1.3%),liver cirrhosis(8.6%),HCC(1.6%),and acute liver failure(0.81%).Of note,HCC was associated with cirrhosis in 1188 patients(43%of HCC patients)and male sex(87%).Diagnostic biopsies were performed in 6023(3.6%)of those patients and liver transplant was performed in 881(0.5%).In-hospital mortality occurred in 3638(2.16%)*** this large database study,we found a rising trend in hospitalization for hemochromatosis,possibly due to the increased recognition of this entity and billing for the *** incidence of cirrhosis in hemochromatosis was found to be simi

关键词： Diabetes mellitus Hemochromatosis Hepatocellular carcinoma Hospitalization Iron overload Liver cirrhosis

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Auto-tuning PVT data using multi-objective optimization: Application of NSGA-Ⅱ algorithm

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Petroleum 2024年第1期10卷 135-149页

作者： Abdolhadi Zarifi mohammad Madani mohammad Jafarzadegan Reservoir Engineering Systems Petroleum Engineering Department Main Office Building of National Iranian South Oil Company (NISOC) Combined Planning Management National Iranian Oil Company (NIOC) Reservoir Engineering Division Petroleum Engineering Department Petroleum Engineering and Development Company (PEDEC)

Reservoir simulation is known as perhaps the most widely used, accurate, and reliable method for field development in the petroleum industry. An integral part of a reliable reservoir simulation process is to consider robust and rigorous tuned EOS models. Traditionally, EOS models are tuned iteratively through arduous workflows against experimental PVT data. However, this comes with a number of drawbacks such as forcingly using weight factors, which upon alteration adversely affects the optimization *** objective of the current work is thus to introduce an auto-tune PVT matching tool using NSGA-II multi-objective optimization. In order to illustrate the robustness of the presented technique, three different PVT samples are used, including two black-oil and one gas condensate sample. We utilize PengRobinson EOS during all the manual and auto-tuning processes. Comparison of auto-tuned EOS-generated results with those of experimental and computed statistical error values for these samples clearly show that the proposed method is robust. In addition, the proposed method, contrary to the manual matching process, provides the engineer with several matched solutions, which allows them to select a match based on the engineering background to be best amenable to the problem at hand. In addition, the proposed technique is fast, and can output several solutions within less time compared to the traditional manual matching method.

关键词： Auto-tuning PVT Equation of state NSGA-II Multi-objective optimization

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Investigation of material composition,design,and performance of open-graded asphalt mixtures for semi-flexible pavement:A comprehensive experimental study

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 92-116页

作者： mohammad Taghipoor Abolfazl Hassani mohammad M.Karimi Department of Civil and Environmental Engineering Tarbiat Modares UniversityTehranIran

The primary goal of this study is the design and construction of semi-flexible pavement(SFP)mixture in accordance with the engineering and mechanical *** study involves the use of a range of gradation curves,air void contents,cellulose and synthesized fibers,and neat and modified asphalt binders to prepare the open-graded asphalt(OGA)*** analyze the characteristics of these mixtures,a variety of test,namely binder drainage,semi-circular bending(SCB),Cantabro,wheel tracking,indirect tensile strength(ITS),and permeability tests were ***,to analyze the prepared grouting material,flexural strength,compressive strength,and fluidity tests were *** the final stage,SFP was compared to HMA in terms of engineering characteristics and *** to the results,SFP was more resistant to skid,rutting,fire,and moisture damage,while HMA had a better performance in fracture tests,including SCB *** to the results of the mechanical performance tests conducted on OGA mixtures,the highest and lowest values for air void content to achieve the highest mechanical performance level were 30%-35%and 25%,***,based on the laboratory results,it was determined that the required void ratio for constructing OGA mixtures was 24%-26%based on the bitumen type and fibers amount in the ***,SFP mixture can be regarded as a viable alternative to common pavements thanks to its high resistance to rutting and moisture damage,long freezing-thawing fatigue life,and adequate fire and skid resistance.

关键词： Semi-flexible pavement mixture Open-graded asphalt mixture Engineering properties Cantabro test Hot mix asphalt

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Recent Progress in Bionic Hydrogels for Articular Cartilage:Tribological and Mechanical Characteristics

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Journal of Bionic Engineering 2024年第2期21卷 653-673页

作者： mohammad Javan Almasi Dangsheng Xiong School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing210094China

Cartilage regeneration and repair are considered clinical challenges since cartilage has limited capability for *** tissue-engineered materials have the ability to repair cartilage,they have weak mechanical characteristics and cannot resist long-term *** the other hand,surgery to replace the joint is frequently done to treat significant cartilage deterioration these ***,the materials that are being used for replacement have high friction coefficients,lack shock absorption functions,and lack *** research on natural articular cartilage structure and function may lead to bionic hydrogels,which have suitable physicochemical and biological characteristics(e.g.,tribological and mechanical properties and the ability to support loadbearing capability),but need *** on their tribological and mechanical characteristics,the current review highlights the most recent advancements of bionic hydrogels used for articular cartilage,highlighting both the field's recent progress and its potential for future *** this reason,firstly,some important property improvement methods of bionic hydrogels are discussed and then,the recent findings of various research on the making of those bionic materials are provided and *** seems that by using some modifications such as product design,surface treatments,animal tests,controlling the isoelectric point of hydrogels,and computer simulation,the intended mechanical and tribological characteristics of natural articular cartilage may be attained by the bionic hydrogels.

关键词： Bionic hydrogel Articular cartilage Mechanical property Tribological property Lubrication

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Ultrasensitive plasmonic sensor based on MDM waveguide containing Persian Orsi window cavities for refractive index and blood plasma sensing

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Optoelectronics Letters 2024年第7期20卷 406-411页

作者： mohammad Ghanavati mohammad Azim Karami School of Electrical Engineering Iran University of Science and TechnologyTehran 16846-13114Iran12

We developed a plasmonic refractive index(RI)with a metal-dielectric-metal(MDM)structure that utilizes two Persian Orsi windows-like separated cavities with a high figure of merit(FoM)and *** simulated and optimized Ag-air-Ag MDM sensor for surface plasmon resonance(SPR)offers high RI sensitivity(SRI)and the ability to detect blood plasma concentration(BPC).The results verified that structural parameters have an effect on SRI,full width at half maximum(FWHM),FoM,sensitivity of blood plasma(S_(p))for right and left peaks,whose values are 1345.45 nm·RIU^(−1),32 nm,42.04 RIU^(−1),0.26 and 0.19 nm·L·g^(-1),*** proposed design opens a new horizon in sensor development.

关键词： index utilize MDM

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Enhanced adaptive nonlinear extended state observer for pure feedback systems with matched and mismatched disturbances

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Control Theory and Technology 2024年第2期22卷 254-268页

作者： Mahtab Delpasand mohammad Farrokhi School of Electrical Engineering Iran University of Science and TechnologyTehran16846-13114Iran Center of Excellence for Modelling and Control of Complex Systems Iran University of Science and TechnologyTehran16846-13114Iran

In this paper, an enhanced adaptive nonlinear extended state observer (EANESO) for single-input single-output pure feedback systems in the presence of external time-varying disturbances is proposed. In this paper, a nonlinear system with matched and mismatched disturbances is considered. The conventional extended state observer (ESO) can only be applied to systems that are in the form of integral chains. Moreover, this method has limitations in the face of mismatched disturbances. In the presence of time-varying disturbances, the traditional ESOs cannot estimate the disturbances accurately. To overcome this limitation, an EANESO is proposed in this paper. The main idea is to design the nonlinear ESO (NESO) to estimate the states of the system and multiple disturbances simultaneously. The observer gains are considered time-varying and adjusted with adaptation laws to improve the estimation accuracy and overcome the peaking phenomenon. Next, the proposed controller is designed based on output feedback to eliminate the effects of multiple disturbances and stabilize the closed-loop system. Subsequently, the stability analysis of the closed-loop system and convergence of the observer error are discussed. Finally, the proposed method is applied to the inverted pendulum system. The simulated results show good performance of the proposed method as compared with a recently published scheme in the related literature.

关键词： Nonlinear extended state observer Enhanced adaptive extended state observer Adaptation law Multiple-channel disturbances Inverted pendulum system Time-varying gain

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The modeling non-sequential double ionization of helium atom under highintensity femtosecond laser pulses with shielding charge approximation

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Communications in Theoretical Physics 2024年第2期76卷 151-156页

作者： Marjan Zakavi mohammad Sabaeian Department of Physics Faculty of ScienceShahid Chamran University of AhvazIran Center for Research on Laser and Plasma Shahid Chamran University of AhvazIran

In this study,we successfully extracted the‘knee structure’for non-sequential double ionization(NSDI)in the helium *** achieve this,for the first time,we solved the time-dependent Schrödinger equation in three dimensions for the helium atom,utilizing the shielding charge *** findings corroborate prior observations by Wang et al[Wang and Eberly,***.105,083001(2010)],demonstrating that NSDI occurs within a narrower time window in circular polarization compared to linear *** a result,the yield of linear polarization was higher than that of circular polarization,aligning with the previously reported ***,in the case of circular polarization,the time window further narrows with increasing intensity,attributed to a decrease in the time-of-flight.

关键词： NSDI knee structure TDSE shielding charge helium 3D-TDSE

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Bending results of graphene origami reinforced doubly curved shell

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Defence Technology（防务技术） 2024年第5期35卷 198-210页

作者： Nan Yang Yunhe Zou mohammad Arefi School of Architecture and Civil Engineering Qiqihar UniversityQiqihar 161006HeilongjiangChina School of Mechanical Engineering Inner Mongolia University of TechnologyHohhot 010051Inner MongoliaChina Inner Mongolia Key Laboratory of Special Service Intelligent Robotics Hohhot 010051Inner MongoliaChina Faculty of Mechanical Engineering Department of Solid MechanicsUniversity of KashanKashan87317-51167Iran

The present work investigates higher order stress,strain and deformation analyses of a shear deformable doubly curved shell manufactures by a Copper(Cu)core reinforced with graphene origami auxetic metamaterial subjected to mechanical and thermal *** effective material properties of the graphene origami auxetic reinforced Cu matrix are developed using micromechanical models cooperate both material properties of graphene and Cu in terms of temperature,volume fraction and folding *** principle of virtual work is used to derive governing equations with accounting thermal *** numerical results are analytically obtained using Navier's technique to investigate impact of significant parameters such as thermal loading,graphene amount,folding degree and directional coordinate on the stress,strain and deformation responses of the *** graphene origami materials may be used in aerospace vehicles and structures and defence technology because of their low weight and high stiffness.A verification study is presented for approving the formulation,solution methodology and numerical results.

关键词： Graphene origami Copper matrix Doubly curved Shear deformable Auxetic metamaterial

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Direct scaling of residual displacements for bilinear and pinching oscillators

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 129-149页

作者： mohammad Saifullah Vinay K.Gupta Department of Civil Engineering Indian Institute of Technology KanpurKanpur 208016India

The estimation of residual displacements in a structure due to an anticipated earthquake event has increasingly become an important component of performance-based earthquake engineering because controlling these displacements plays an important role in ensuring cost-feasible or cost-effective repairs in a damaged structure after the *** attempt is made in this study to obtain statistical estimates of constant-ductility residual displacement spectra for bilinear and pinching oscillators with 5%initial damping,directly in terms of easily available seismological,site,and model *** of the available models for the bilinear and pinching oscillators are useful when design spectra for a seismic hazard at a site are not *** statistical estimates of a residual displacement spectrum are proposed in terms of earthquake magnitude,epicentral distance,site geology parameter,and three model parameters for a given set of ductility demand and a hysteretic energy capacity coefficient in the case of bilinear and pinching models,as well as for a given set of pinching parameters for displacement and strength at the breakpoint in the case of pinching model *** proposed scaling model is applicable to horizontal ground motions in the western *** earthquake magnitudes less than 7 or epicentral distances greater than 20 km.

关键词： residual displacement spectrum bilinear hysteresis model pinching hysteresis model nonlinear analysis scaling model

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Interpretable Detection of Malicious Behavior in Windows Portable Executables Using Multi-Head 2D Transformers

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Big Data Mining and Analytics 2024年第2期7卷 485-499页

作者： Sohail Khan mohammad Nauman Computer Science Department Effat College of EngineeringEffat UniversityJeddah 23341Kingdom of Saudi Arabia

Windows malware is becoming an increasingly pressing problem as the amount of malware continues to grow and more sensitive information is stored on *** of the major challenges in tackling this problem is the complexity of malware analysis,which requires expertise from human *** developments in machine learning have led to the creation of deep models for malware ***,these models often lack transparency,making it difficult to understand the reasoning behind the model’s decisions,otherwise known as the black-box *** address these limitations,this paper presents a novel model for malware detection,utilizing vision transformers to analyze the Operation Code(OpCode)sequences of more than 350000 Windows portable executable malware samples from real-world *** model achieves a high accuracy of 0.9864,not only surpassing the previous results but also providing valuable insights into the reasoning behind the *** model is able to pinpoint specific instructions that lead to malicious behavior in malware samples,aiding human experts in their analysis and driving further advancements in the *** report our findings and show how causality can be established between malicious code and actual classification by a deep learning model,thus opening up this black-box problem for deeper analysis.

关键词： machine learning malware vision transformers Windows Protable Executable(PE)

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