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Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms

Journal of Coastal Life Medicine 2014年第1期 70-75页

作者： Nurul Huda Syed Ibrahim Muhammad Taher Deny Susanti mohamed zaffarali mohamed amiroudine Qamar Uddin Ahmed Department of Biomedical Science Faculty of ScienceInternational Islamic University Malaysia25200 KuantanPahangMalaysia Department of Pharmaceutical Technology Faculty of PharmacyInternational Islamic University Malaysia25200 KuantanPahangMalaysia Department of Chemistry Faculty of ScienceInternational Islamic University Malaysia25200 KuantanPahangMalaysia Department of Pharmaceutical Chemistry Faculty of PharmacyInternational Islamic University Malaysia25200 KuantanPahangMalaysia

Objective:To test direct and indirect antimicrobial properties of α-mangostin towards a number of bacteria and ***:Activity of α-mangostin paired with an antibiotic was studied by calculating its fractional inhibitory concentration(FIC).Results:The experiment was carried out using broth microdilution and checkerboards *** showed no interaction with the combination withα-mangostin where the FIC indexes were between the range of 0.5*** of doxycycline on Pseudomonas aeruginosa fell into other set of range,FIC_(index)≥4 which is an *** activity of all four bacteria towards ampicillin,penicillin G,streptomycin and Conclusions:The FIC index is far away in the *** coupled antibiotic andα-mangostin is considered synergy in action if it lies in FIC_(index)≤0.5 and it was found that the isolated compound,α-mangostin revealed very low synergistic antimicrobial effects when coupled with antibiotics.

关键词： α-mangostin Direct Indirect Antimicrobial FIC index

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Antioxidant and antimicrobial activities of Shorea kunstleri

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Journal of Coastal Life Medicine 2014年第8期 638-644页

作者： Siti Suria Daud Muhammad Taher Deny Susanti mohamed Zaffar Ali mohamed amiroudine Tengku Muhamad Faris Syafiq Tengku Zakaria Department of Biomedical Science Faculty of ScienceInternational Islamic University Malaysia25200 KuantanPahangMalaysia Department of Pharmaceutical Technology Faculty of PharmacyInternational Islamic University Malaysia25200 KuantanPahangMalaysia Department of Chemistry Faculty of ScienceInternational Islamic University Malaysia25200 KuantanPahangMalaysia

Objective:To evaluate antioxidant and antimicrobial activities of stembark of Shorea kunstleri(***)together with analysis of phytochemical and total phenolic ***:Extraction was conducted with different solvent polarity of n-hexane,dichloromethane(DCM)and methanol by using Soxhlet *** phenolic content was determined using Folin-Ciocalteu *** radical scavenging activity and inhibition of lipid peroxidation were evaluated with DPPH radical scavenging and ferric thiocyanate assays,*** activities were performed using disc diffusion method,minimum inhibition concentration(MIC),minimum bactericidal concentration(MBC),and minimum fungicidal ***:*** stembark extracts revealed presence of steroids,terpenoids,saponins,flavonoids,and phenolic *** extract exhibited the highest total phenolic content and free radical scavenging activity resulting in phenolic content of(8.340±0.003)g GAE/100 g of extract and(95.90±1.07)%DPPH inhibition(IC_(50)value of 18.6μg/mL),*** thiocyanate assay of n-hexane,DCM,and methanol extracts indicated lipid peroxidation inhibitory activity of(74.20±0.35)%,(74.00±0.10)%,and(72.80±0.27)%,*** antimicrobial and antifungal tests,methanol extract showed inhibition against Staphylococcus aureus(***),Candida albicans,and Candida tropicalis with inhibition zones of 10-12,18-22,and 18-19 mm,*** MIC test of methanol extract showed highest inhibition against Candida albicans and ***(0.04 and 0.08 mg/mL,respectively)while DCM extract exhibited the highest activity towards Candida tropicalis(MIC value of 0.63 mg/mL).Taken together,MBC test of methanol extract strongly demonstrated bactericidal effect against *** with MBC value of 0.08 mg/***:The study demonstrated that stembark extracts of *** possessed antioxidant and antimicrobial properties.

关键词： Shorea kunstleri Phytochemicals Antioxidant Antimicrobial

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