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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Comparative study of three types of controllers for dFIG in wind energy conversion system

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Protection and Control of Modern Power Systems 2018年第1期3卷 223-234页

作者： sa.d Boubzizi Hafedh Abid Ahmed El hajjaji mohamed Chaabane Lab-STA Laboratory National Engineering School of SfaxRoute de la Soukra3029 SfaxTunisia MIS Laboratory University of Picardie Jules Verne33Rue Saint-Leu80039 AmiensFrance

This paper presents an enhanced control strategy for Wind Energy Conversion System(WECS)using doubly-Fed Induction Generator(dFIG).A robust Super-Twisting(STW)sliding mode control for variable speed wind turbine is developed to produce the optimal aerodynamic torque and improve the dynamic performance of the *** electromagnetic torque of the dFIG is directly tracked using the proposed control to achieve maximum power *** performance and the effectiveness of the STW control strategy are compared to conventional Sliding Mode(SM)and Proportional-Integral(PI)*** proposed STW algorithm shows interesting features in terms of chattering reduction,finite convergence time and robustness against parameters variations and system disturbances.

关键词： Wind turbine(WT) doubly-fed induction generator(dFIG) Power generation STW(super-twisting) Second order sliding mode control(SOSMC) PI controller

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An Abstract Reachability Approach by Combining HOL Induction and Multiway decision Graphs

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Journal of Computer Science & Technology 2009年第1期24卷 76-95页

作者： sa'ed Abed Otmane Ait mohamed Ghiath Al-sammane ECE department Concordia UniversityMontrealCanada

In this paper, we provide a necessary infrastructure to define an abstract state exploration in the HOL theorem prover. Our infrastructure is based on a deep embedding of the Multiway decision Graphs （MdGs） theory in HOL. MdGs generalize Reduced Ordered Binary decision diagrams （ROBdds） to represent and manipulate a subset of first-order logic formulae. The MdGs embedding is based on the logical formulation of an MdG as directed Formulae （dF）. Then, the MdGs operations are defined and the correctness proof of each operation is provided. The MdG teachability algorithm is then defined as a conversion that uses our MdG theory within HOL. Finally, a set of experimentations over benchmark circuits has been conducted to ensure the applicability and to measure the performance of our approach.

关键词： HOL theorem prover multiway decision graphs correctness reachability analysis

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NuMdG:A New Tool for Multiway decision Graphs Construction

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Journal of Computer Science & Technology 2011年第1期26卷 139-152页

作者： sa'ed Abed Yassine Mokhtari Otmane Ait-mohamed Sofiene Tahar department of Computer Engineering Hashemite UniversityZarqaJordan department of Electrical and Computer Engineering Concordia UniversityMontrealCanada

Multiway decision Graphs （MdGs） are a canonical representation of a subset of many-sorted first-order logic. This subset generalizes the logic of equality with abstract types and uninterpreted function symbols. The distinction between abstract and concrete sorts mirrors the hardware distinction between data path and control. Here we consider ways to improve MdGs construction. Efficiency is achieved through the use of the Generalized-If-Then-Else （GITE） commonly operator in Binary decision diagram packages. Consequently, we review the main algorithms used for MdGs verification techniques. In particular, Relational Product and Pruning by Subsumption are algorithms defined uniformly through this single CITE operator which will lead to a more efficient implementation. Moreover, we provide their correctness proof. This work can be viewed as a way to accommodate the ROBBd algorithms to the realm of abstract sorts and uninterpreted functions. The new tool, called NuMdG, accepts an extended SMV language, supporting abstract data sorts. Finally, we present experimental results demonstrating the efficiency of the NuMdG tool and evaluating its performance using a set of benchmarks from the SMV package.

关键词： infinite state model checking multiway decision graphs uninterpreted functions

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Apatite phosphate doped by cobalt as hight efficient catalyst of multi-component synthesis of therapeutic spiropyrimidine compound

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Natural Products and Bioprospecting 2022年第1期12卷 567-572页

作者： Abdallah Rhihil Youness Aichi mohamed Zahouily sa.d Sebti mohamed El Guendouzi Laboratory of Chemistry Physics Materials and Catalysis(LCPMC) Faculty of Sciences Ben M’sik of CasablancaHassan II University of CasablancaCasablancaMorocco Financial Engineering Governance and Development LaboratoryNational School of Business and Management of CasablancaHassan II University of CasablancaCasablancaMorocco Laboratory of Materials Catalysis and Valorization of Natural ResourcesFaculty of Sciences and Technology of MohammediaHassan II University of CasablancaCasablancaMorocco

Spiropyrimidines vanquish a significant situation in the field of heterocyclic chemistry, they are broadly utilized as an antibacterial, an inhibitor of multidrug opposition, or an antiplatelet and antithrombotic drug. Phosphate, the principal Moroccan mineral wealth occupies a vital spot in the economic sector and its valuation is a goal continually looked for. Among the conceivable outcomes of valorization, its utilization in heterogeneous catalysis which thought about an exceptionally encouraging new way. In this context, the focus on the reaction of the synthesis of spiropy-rimidine, catalyzed by natural phosphate (NP) and by fluoroapatite (Fap), are used alone or doped by cobalt. These phosphate catalysts were characterized by XRd, IR and SEM, while the synthesized spiropyrimidine was identified by IR, GC-MS and NMR. The obtained yield with fluorapatite doped by cobalt (Co/Fap), at room temperature in ethanol is very high and shows a high impact performance induced by a synergistic effect compared to that of NP alone.

关键词： Spiropyrimidine Natural phosphate Co/Fap Heterogeneous catalysis Multicomponent reaction

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Effects of human disturbance on nest placement of the woodpigeon (Columba palumbus): a case study from the Middle Atlas, Morocco

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Integrative Zoology 2014年第3期9卷 349-359页

作者： sa.d HANANE Forest Research Center High Commissariat for WaterForests and Desertification ControlRabat-AgdalMorocco

The woodpigeon(Columba palumbus)is a common and widespread bird in Morocco(North Africa).I examined,over 2 years(2010 and 2011),the breeding density and nest placement of this game species in relation to nest site habitat and degree of human *** study area was in the Middle Atlas Tighboula mountain forest,Morocco,in a disturbed and an undisturbed *** data collected in the 2 study sites,I aimed to identify the factors influencing the placement of nests within holm oak trees(Quercus rotundifolia)and their densities.I found that habitat structures,influenced by grazing disturbance,have affected nesting density and the location of nests of this *** place their nests in a higher position(3.42±0.19 m)when disturbance intensity is high and lower(1.68±0.1 m)when disturbance intensity is low,and show higher nesting density in less disturbed zone(3.1±0.4 nests/ha)than in highly disturbed zones(1.4±0.2 nests/ha).Grazing disturbance could pose a threat to population persistence at a broader scale and could potentially reduce the abundance of this species by altering the composition and the structure of the forest nesting *** multi-scale studies are needed to assess the effects of different levels of grazing disturbance on woodpigeon nest density and placement,and to enhance our knowledge of the breeding behavior of this game species under variable environments.

关键词： breeding density Columba palumbus holm oak Middle Atlas Morocco nest location woodpigeon

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PYRIdINATION OF POLY(VINYL CHLORIdE) via A HOMOLYTIC PATHWAY

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Chinese Journal of Polymer Science 2007年第3期25卷 297-302页

作者： sa.d Moulay Zakia Zeffouni Laboratoire de Chimie-Physique Moléculaire et Macromoléculaire Faculté des Sciences de l'Ingénieur Département de Chimie IndustrielleUniversité Sad Dahlab de BlidaRoute de SoumaB. P. 270Blida 09000Algeria

PVC was subjected to a chemical modification aiming at replacing the chlorine atoms by pyridine groups via a homolytic route. Pyridine groups were peculiarly affixed to the PVC matrix via a carbon-carbon bond rather than a carbonnitrogen one. PVC was first iodinated using the Conant-Finkelstein reaction, followed by the application of the homolytic conditions of Minisci to generate pyridinated PVC with a varying degree of substitution. The extent of substitution was not high; the reaction on 30% iodinated PVC afforded a degree of modification no greater than 3%.

关键词： Conditions of Minisci Iodinated PVC Pyridinated PVC

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HALOMETHYLATION OF POLYSTYRENE ANd SUBSEQUENT PYRIdINATION VIA A HOMOLYTIC PATHWAY

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Chinese Journal of Polymer Science 2006年第6期24卷 627-635页

作者： sa.d Moulay Nadia Mehdi Laboratoire de Chimie-Physique Moléculaire et Macromoléculaire Faculté des Sciences de l'Ingénieur Departement de Chimie IndustrielleUniversité de BlidaRoute de SoumaB. P. 270Blida 09000Algeria

Chloromethylation of polystyrene （PS） with two different chloromethylating systems methylal/thionyl chloride and paraformaldehyde/trimethylchlorosilane was studied. Soluble chloromethylated polystyrene with a degree of substitution of 89% was obtained. The Conant-Finkelstein reaction on the chloromethylated PS afforded soluble iodomethylated polystyrene with a degree of substitution as high as 96%. The reaction conditions of Minisci were employed to radically pyridinate PS via its iodomethylated derivative. Polyelectrolytes were formed which could be converted to normal polymers by treatment with a 20% aqueous solution of NaOH.

关键词： Chloromethylated polystyrene Conditions of Minisci Iodomethylated polystyrene Pyridinated polystyrene.

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Online Postcolumn Indirect detection for determination of Ibandronate in Pharmaceutical Tablets by HPLC/dAd

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Journal of Analysis and Testing 2019年第4期3卷 322-330页

作者： Mokhtar Mabrouk Sherin F.Hammad mohamed A.Abdelaziz Fotouh R.mansour department of Pharmaceutical Analytical Chemistry Faculty of PharmacyTanta UniversityElgeish StreetTanta 31111Egypt Pharmaceutical Services Center Faculty of PharmacyTanta UniversityTanta 31111Egypt department of Pharmaceutical Analytical Chemistry Faculty of PharmacyKafrelsheikh UniversityKafrelsheikh 33511Egypt

Ibandronate sodium monohydrate is a highly polar aliphatic compound that belongs to the bisphosphonate class,a widely used bone resorption *** aliphatic nature of ibandronate precludes direct photometric detection and its high polar-ity urged analysts to use ion-pairing agents in the mobile phase to promote retention in reversed-phase *** this work,a reversed-phase method for determination of ibandronate sodium monohydrate in pharmaceutical tablets is introduced by employing an online postcolumn ligand exchange reaction to enable photometric *** method offers for the first time the ability to separate the drug from its well-known impurities on conventional reversed-phase *** detection reac-tion depends on the ability of ibandronate and its degradation products to displace salicylate in the iron(III)salicylate complex,forming various colorless iron(III)complexes and showing a negative chromatographic signal for ibandronate and its degra-dants atλ_(max)=525 *** chromatographic separation was achieved using a Hypersil BdS C_(8) column(5μm particle size,150 mm×4.6 mm i.d.)and a mobile phase consisting of a mixture of aqueous formate buffer pH 3(pH 3,5 mM)and methanol in a ratio of 80:20%(v/v),delivered at a flow rate of 0.8 mL/*** postcolumn iron(III)salicylate reagent was prepared at 250μM in aqueous formate buffer,delivered using a syringe pump at a flow rate of 0.5 mL/*** proposed method was validated as per the guidelines of the International Conference on Harmonization Q2(R1)and was found linear over the range 40-120μg/mL(r=0.9995)with a limit of detection of 3.19μg/*** to currently reported methods,the proposed method is considerably simpler,faster,cheaper,and adequately sensitive and makes use of the most popular LC detectors.

关键词： Bisphosphonates Non-chromophoric drugs Highly polar compounds High-performance liquid chromatography Reversed phase

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Artificial Intelligence-driven FVM-ANNModel for Entropy Analysis ofMHd Natural Bioconvection in Nanofluid-Filled Porous Cavities

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Frontiers in Heat and Mass Transfer 2024年第5期22卷 1277-1307页

作者： Noura Alsedais mohamed Ahmed mansour Abdelraheem M.Aly sara I.Abdelsalam department of Mathematical Sciences College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Mathematics department Faculty of SciencesAssiut UniversityAssiut71515Egypt department of Mathematics College of ScienceKing Khalid UniversityAbha62529Saudi Arabia Basic Science Faculty of EngineeringThe British University in EgyptAl-Shorouk CityCairo11837Egypt Instituto de Ciencias Matemáticas ICMAT CSICUAMUCMUC3MMadrid28049Spain

The research examines fluid behavior in a porous box-shaped *** fluid contains nanoscale particles and swimming microbes and is subject to magnetic forces at an *** circulation driven by biological factors is *** analysis combines a traditional numerical approach with machine learning *** equations describing the system are transformed into a dimensionless form and then solved using computational *** artificial neural network(ANN)model,trained with the Levenberg-Marquardt method,accurately predicts(Nu)values,showing high correlation(R=1),low mean squared error(MSE),and minimal error *** analysis reveals significant effects of parameters,length and location of source(B),(d),heat generation/absorption coefficient(Q),and porosity parameter(ε).Increasing the cooling area length(B)reduces streamline intensity and local Nusselt and Sherwood numbers,while decreasing isotherms,isoconcentrations,and *** Bejan number(Be+)decreases with increasing(B),whereas(Be+++),and global entropy(e+++)*** in(Q)slightly affect streamlines but reduce isotherm intensity and average Nusselt ***(d)significantly impacts isotherms,iso-concentrations,andmicro-rotation,altering streamline contours and local Bejan number ***(ε)enhances streamline strength and local Nusselt number profiles but has mixed effects on average Nusselt *** findings highlight the complex interactions between cooling area length,fluid flow,and heat transfer *** combining finite volume method(FVM)with machine learning technique,this study provides valuable insights into the complex interactions between key parameters and heat transfer,contributing to the development of more efficient designs in applications such as cooling systems,energy storage,and bioengineering.

关键词： ANN model finite volume method natural bioconvection flow magnetohydrodynamics(MHd) porous media

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