检索结果-南通市图书馆

Right Ventricular Mechanical Changes after Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy: Vector Velocity Imaging Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiovascular Diseases 2019年第7期9卷 467-488页

作者： Hala Mahfouz Badran Ghada Soltan Naglaa Faheem mohamed ezzat enait Magdi H. Yacoub Cardiology Department Menoufia University Al Minufya Egypt The BAHCM National Program Aswan Heart Center Egypt Imperial College London UK

Objectives: The impairment of right ventricular (RV) myocardial mechanics is evident in hypertrophic cardiomyopathy (HCM). It is independently influenced by LV mechanics and correlated to the severity of LV phenotype. We investigated the changes in RV global and regional deformation following surgical septal myectomy using vector velocity imaging (VVI). Methods: 25 HCM patients, 68% males with mean age (34.5 ± 12 years) were examined before and within two months after surgical myectomy using VVI. In addition to conventional echocardiographic parameters, peak systolic strain (εsys), strain rate (SR) and time to peak εsys (TTP) of regional RV free wall (RVFW) & septal walls were analyzed in longitudinal (long) directions from apical four-chamber view and their (Δ) changes were calculated. Similar parameters were quantified in LV from apical 2 & 4 CH views. Intra-V-delay was defined as SD of TTP and inter-V dyssynchrony was estimated from TTP difference between the most delayed LV segment & RVFW. Results: All study patients showed improvement of their functional class from NYHA class III to class I and reduction of LVOT gradient to below 20 mmHg except one patient who had 30 mmHg gradients at rest. There was significant reduction of septal thickness, left atrial diameter & volume, LVOT gradient, LVMI, severity of mitral regurgitation, tricuspid annular velocities (P < 0.0001), RV diameter (P < 0.02) and increase in LV internal dimensions(P < 0.001) post myectomy. However, there was significant reduction of RV and LV systolic mechanics;RV global εsys % (from -16.1% ± 4.4% to -12.9% ± 2.9%, P < 0.0001) and LV global εsys %: from -11.6% ± 2.8% to -9.4% ± 2.2%, P < 0.0001) respectively. The magnitude of reduction of RV strain (ΔRV εsys %, ΔSRsys) was directly correlated LV maximal wall thickness (r = 0.46, P < 0.01) and ΔRV dyssynchrony (TTP-SD) (r = 0.4, P < 0.05) and negatively correlated to age (r = -0.46, P sys (r = -0.52, P < 0.01) and pre-op LV EF % (r = -0.43, P , t

关键词： Right Ventricle Deformation Imaging Hypertrophic Cardiomyopathy

Right Ventricular Mechanical Changes after Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy: Vector Velocity Imaging Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unique situation of hepatocellular carcinoma in Egypt:A review of epidemiology and control measures

World Journal of Cardiovascular Diseases（心血管病） 2019年第7期

作者： Hala Mahfouz Badran1 Ghada Soltan1 Naglaa Faheem mohamed ezzat enait1 Magdi H. Yacoub

来源：评论

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2021年第12期13卷 1919-1938页

作者： Reem ezzat mohamed Eltabbakh mohamed El Kassas Internal Medicine Department Faculty of MedicineAssiut UniversityAssiut 71515Egypt Tropical Medicine Department Faculty of MedicineAin Shams UniversityCairo 11566Egypt Endemic Medicine Department Faculty of MedicineHelwan UniversityCairo 11795CairoEgypt

Hepatocellular carcinoma(HCC)is the sixth most common primary malignancy worldwide,and the third most common cause of death among cancers *** occurs in several pre-existing conditions,including hepatitis C,hepatitis B virus,and non-alcoholic *** used to be the country with the heaviest hepatitis C virus(HCV)*** relationship between HCV and HCC is an important research *** Egypt,HCC is a significant public health problem.A possible cause for the increasing rates of detection of HCC in Egypt is the mass screening program that was carried by the government for detecting and treating HCV.A multidisciplinary approach is now widely applied to HCC management in health centers all over *** treatment modalities are available in Egypt,with success rates comparable to global *** Egyptian health authorities have made the elimination of HCV from Egypt a special priority,and this approach should lead to a decrease in number of HCC cases in the near *** this article we review the current situation of HCC in Egypt,including epidemiological aspects,relevant risk factors for HCC development,strategies,and efforts established by health authorities for the screening and prevention of both HCV and HCC in *** highlight the different modalities for HCC treatment.

关键词： Hepatocellular carcinoma Liver cancer Hepatitis C virus Hepatitis B virus Screening Egypt

Molecular detection of virulence genes in Campylobacter species isolated from livestock production systems in South Africa

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2020年第6期19卷 1656-1670页

作者： Bongekile NGOBESE Oliver Tendayi ZISHIRI mohamed ezzat EL ZOWALATY Discipline of Genetics School of Life SciencesUniversity of KwaZulu-NatalDurban 4000South Africa Zoonosis Science Center Department of Medical Biochemistry and MicrobiologyUppsala UniversityUppsala SE-75185Sweden Infectious Diseases and Anti-Infective Therapy Research Group College of Pharmacy and Sharjah Medical Research InstituteUniversity of SharjahSharjah 27272UAE

Campylobacter species are a major cause of foodborne bacterial infections in both developed and developing countries *** jejuni is responsible for the majority of infectio *** study was con ducted to identify virule nceassociated genes in Campylobacter species isolated from livestock production systems in South Africa.A total of 250 fecal samples consisting of cattle(n=50),chickens(n=50),goats(n=50),sheep(n=50)and pigs(n=50)were randomly collected from livestock in Eastern Cape and KwaZulu-Natal provinces of South Africa between April and October *** samples were an a lyzed for the presence of virule nee genes in Campylobacter species using molecular PCR-based *** was found that 77 and 23%of Campylobacter jejuni and Campylobacter coli respectively were isolated from all the livestock *** were positive significant(P<0.05)correlations amongst all the virulenee genes that were *** and Fisher's exact tests were implemented to test for the effect of livestock species on the presenee or absenee of virule nee gen *** study dem on strated that most of livestock species can pote ntially cause zoonotic infecti on s and food pois oning due to the high prevale nee of *** high prevale nee of virule nee genes highlights the sign ifica nee of Campylobacter\r\livestock production systems in South *** requires the implementation of one-health approaches to reduce the impact of foodborne and zoonotic diseases for the welfare of human and animal health.

关键词： Campylobacter zoonotic cytotoxicity pathogenicity virulenee campylobacteriosis foodbome livestock PCR one-health

Predictors of long-term survival after pancreaticoduodenectomy for peri-ampullary adenocarcinoma: A retrospective study of 5-year survivors

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 443-449页

作者： Ayman El Nakeeb mohamed El Sorogy Helmy ezzat Rami Said mohamed El Dosoky mohamed Abd El Gawad Ahmed M Elsabagh Ehab El Hanafy Gastroenterology Surgical Center Mansoura University

Background: Pancreaticoduodenectomy(PD) is the standard curative treatment for periampullary tumors. The aim of this study is to report the incidence and predictors of long-term survival( ≥ 5 years) after PD. Methods: This study included patients who underwent PD for pathologically proven periampullary adenocarcinomas. Patients were divided into 2 groups: group(I) patients who survived less than 5 years and group(II) patients who survived ≥ 5 years. Results: There were 47(20.6%) long-term survivors( ≥ 5 years) among 228 patients underwent PD for periampullary adenocarcinoma. Patients with ampullary adenocarcinoma represented 31(66.0%) of the long-term survivors. Primary analysis showed that favourable factors for long-term survival include age < 60 years old, serum CEA < 5 ng/mL, serum CA 19-9 < 37 U/mL, non-cirrhotic liver, tumor size < 2 cm, site of primary tumor, postoperative pancreatic fistula, R0 resection, postoperative chemotherapy, and no recurrence. Multivariate analysis demonstrated that CA 19-9 < 37 U/mL [OR(95% CI) = 1.712(1.24 8–2.34 8), P = 0.001], smaller tumor size [OR(95% CI) = 1.335(1.032–1.726), P = 0.028] and R0 resection [OR(95% CI) = 3.098(2.095–4.582), P < 0.001] were independent factors for survival ≥ 5 years. The prognosis was best for ampullary adenocarcinoma, for which the median survival was 54 months and 5-year survival rate was 39.0%, and the poorest was pancreatic head adenocarcinoma, for which the median survival was 27 months and 5-year survival rate was 7%. Conclusions: The majority of long-term survivors after PD for periampullary adenocarcinoma are patients with ampullary tumor. CA 19-9 < 37 U/mL, smaller tumor size, and R0 resection were found to be independent factors for long-term survival ≥ 5 years.

关键词： Pancreatic carcinoma Pancreatic head carcinoma Pancreaticodudenectomy Long-term survival

Impact of referral pattern and timing of repair on surgical outcome after reconstruction of post-cholecystectomy bile duct injury:A multicenter study

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 53-60页

作者： Ayman El Nakeeb Ahmad Sultan Helmy ezzat mohamed Attia mohamed Abd ElWahab Taha Kayed Ayman Hassanen Ahmad AlMalki Ahmed Alqarni Mohammed M Mohammed Gastrointestinal Surgical Center Mansoura UniversityMansouraEgypt Minia University Hospital MiniaEgypt Aseer Central Hospital Aseer regionSaudi Arabia

Background:Bile duct injury(BDI)after cholecystectomy remains a significant surgical *** guideline exists to guide the timing of repair,while few studies compare early versus late repair *** study aimed to analyze the outcomes in patients undergoing immediate,intermediate,and delayed repair of ***:We retrospectively analyzed 412 patients with BDI from March 2015 to January *** patients were divided into three groups based on the time of BDI *** 1 underwent an immediate reconstruction(within the first 72 hours post-cholecystectomy,n=156);group 2 underwent an intermediate reconstruction(from 4 days to 6 weeks post-cholecystectomy,n=75),and group 3 underwent delayed reconstruction(after 6 weeks post-cholecystectomy,n=181).Results:Patients in group 2 had significantly more early complications including anastomotic leakage and intra-abdominal collection and late complications including anastomotic stricture and secondary liver cirrhosis compared with groups 1 and *** outcome was observed in 111(71.2%)patients in group 1,31(41.3%)patients in group 2,and 157(86.7%)patients in group 3(P=0.0001).Multivariate analysis identified that complete ligation of the bile duct,level E1 BDI and the use of external stent were independent factors of favorable outcome in group 1,the use of external stent was an independent factor of favorable outcome in group 2,and level E4 BDI was an independent factor of unfavorable outcome in group *** BDI and level E4 BDI were independent factors of unfavorable ***:Favorable outcomes were more frequently observed in the immediate and delayed reconstruction of post-cholecystectomy *** ligation of the bile duct,level E1 BDI and the use of external stent were independent factors of a favorable outcome.

关键词： Bile duct injury Hepaticojejunostomy Anastomotic stricture Biloma Biliary peritonitis

Problem of living liver donation in the absence of deceased liver transplantation program:Mansoura experience

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第37期20卷 13607-13614页

作者： mohamed Abdel Wahab Hosam Hamed Tarek Salah Waleed Elsarraf mohamed Elshobary Ahmed mohamed Sultan Ahmed Shehta Omar Fathy Helmy ezzat Amr Yassen mohamed Elmorshedi mohamed Elsaadany Usama Shiha Gatrointestinal Surgery Liver Transplantation Unit Gastrointestinal Surgical Center Mansoura University Daqahlia 35516 Egypt Anesthesia Intensive Care Department Gastrointestinal Surgical Center Mansoura Faculty of Medicine Mansoura University Daqahlia 35516 Egypt Internal Medicine Department Mansoura Faculty of Medicine Mansoura University Daqahlia 35516 Egypt Radiology Department Gastrointestinal Surgical Center Mansoura University Daqahlia 35516 Egypt

We report our experience with potential donors for living donor liver transplantation(LDLT), which is the first report from an area where there is no legalized deceased donation program. This is a single center retrospective analysis of potential living donors(n = 1004) between May 2004 and December 2012. This report focuses on the analysis of causes, duration, cost, and various implications of donor exclusion(n = 792).Most of the transplant candidates(82.3%) had an experience with more than one excluded donor(median = 3). Some recipients travelled abroad for a deceased donor transplant(n = 12) and some died before finding a suitable donor(n = 14). The evaluation of an excluded donor is a time-consuming process(median = 3 d, range 1 d to 47 d). It is also a costly process with a median cost of approximately 70 USD(range 35 USD to 885 USD). From these results, living donor exclusion has negative implications on the patients and transplant program with ethical dilemmas and an economic impact. Many strategies are adopted by other centers to expand the donor pool; however, they are not all applicable in our locality. We conclude that an active legalized deceased donor transplantation program is necessary to overcome the shortage of available liver grafts in Egypt.

关键词： Living donor Liver transplantation Excluded donors Deceased donor Liver disease

Biliary leakage following pancreaticoduodenectomy:Prevalence,risk factors and management

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 67-72页

作者： Ayman El Nakeeb mohamed El Sorogy Hosam Hamed Rami Said Mohamad Elrefai Helmy ezzat Waleed Askar Ahmed M Elsabbagh Gastroenterology Surgical Center Mansoura University

Background: Few studies investigated biliary leakage after pancreaticoduodenectomy(PD) especially when compared to postoperative pancreatic fistula(POPF). This study was to determine the incidence of biliary leakage after PD, predisposing factors of biliary leakage, and its management. Methods: We retrospectively studied all patients who underwent PD from January 2008 to December 2017 at Gastrointestinal Surgery Center, Mansoura University, Egypt. According to occurrence of postoperative biliary leakage, patients were divided into two groups. Group(1) included patients who developed biliary leakage and group(2) included patients without identified biliary leakage. The preoperative data, operative details, and postoperative morbidity and mortality were analyzed. Results: The study included 555 patients. Forty-four patients(7.9%) developed biliary leakage. Ten patients(1.8%) had concomitant POPF. Multivariate analysis identified obesity and time needed for hepaticojejunostomy reconstruction as independent risk factors of biliary leakage, and no history of preoperative endoscopic retrograde cholangiopancreatiography(ERCP) as protective factor. Biliary leakage from hepaticojejunostomy after PD leads to a significant increase in development of delayed gastric emptying, and wound infection. The median hospital stay and time to resume oral intake were significantly greater in the biliary leakage group. Non-surgical management was needed in 40 patients(90.9%). Only 4 patients(9.1%) required re-exploration due to biliary peritonitis and associated POPF. The mortality rate in the biliary leakage group was significantly higher than that of the non-biliary leakage group(6.8% vs 3.9%, P = 0.05). Conclusions: Obesity and time needed for hepaticojejunostomy reconstruction are independent risk factors of biliary leakage, and no history of preoperative ERCP is protective factor. Biliary leakage increases the risk of morbidity and mortality especially if concomitant with POPF. Howeve

关键词： Pancreatic head carcinoma Pancreaticodudenetomy Postoperative pancreatic fistula Biliary leakage

Outcomes of pancreaticoduodenectomy in elderly patients

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2016年第4期15卷 419-427页

作者： Ayman El Nakeeb Ehab Atef Ehab El Hanafy Ali Salem Waleed Askar Helmy ezzat Ahmed Shehta mohamed Abdel Wahab Gastroenterology Surgical Center Mansoura University

BACKGROUND： Although the mortality and morbidity of pancreaticoduodenectomy（PD） have improved significantly over the past years, the concerns for elderly patients undergoing PD are still present. Furthermore, the frequency of PD is increasing because of the increasing proportion of elderly patients and the increasing incidence of periampullary tumors. This study aimed to analyze the outcomes of PD in elderly ***： We studied all patients who had undergone PD in our center between January 1995 and February 2015. The patients were divided into three groups based on age： group I（patients aged 〈60 years）, group II（those aged 60 to 69 years） and group III（those aged ≥70 years）. The primary outcome was the rate of total postoperative complications. Secondary endpoint included total operative time, hospital mortality, length of postoperative hospital stay, delayed gastric emptying, re-exploration, and survival ***： A total of 828 patients who had undergone PD for resection of periampullary tumor were included in this study. There were 579（69.9%） patients in group I, 201（24.3%） in group II, and 48（5.8%） in group III. The overall incidence of complications was higher in elderly patients（25.9% in group I, 36.8% in group II, and 37.5% in group III; P=0.006）. There were more patients complicated with delayed gastric emptying in group II compared with the other two groups. There was no significant difference in the incidence of postoperative pancreatic fistula, biliary leakage, pancreatitis, pulmonary complications and hospital ***： PD can be performed safely in selected elderly patients. Advanced age alone should not be a contraindication for PD. The outcome of elderly patients who have undergone PD is similar to that of younger patients, and the increased rate of complications is due to the presence of associated comorbidities.

关键词： pancreaticoduodenectomy elderly pancreatic fistula delayed gastric emptying