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Mesuaferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways

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Chinese Journal of Natural Medicines 2017年第7期15卷 505-514页

作者： Muhammad Asif Armaghan Shafaei Aman Shah Abdul Majid Mohammed Oday Ezzat saad S Dahham mohamed B.Khadeer Ahamed Chern Ein Oon Amin Malik Shah Abdul Majid EMAN Testing and Research Laboratory Department of Pharmacology School of Pharmaceutical Sciences Universiti Sains Malaysia Penang 11800 Malaysia Department of Pharmaceutical Chemistry School of Pharmaceutical Sciences Universiti Sains Malaysia Penang 11800 Malaysia Department of Pharmacology School of Medical Sciences Quest International University Perak Malaysia Centre for Drug Research Universiti Sains Malaysia Penang 11800 Malaysia Institute for Research in Molecular Medicine (INFORMM) Universiti Sains Malaysia Penang 11800 Malaysia

Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based on MTT assay results, bioactive sub-fraction(SF-3) was selected for further studies using HCT 116 cells. Repeated column chromatography resulted in isolation of less active α-amyrin from SF-3, which was identified and characterized by GC-MS and HPLC methods. α-amyrin and betulinic acid contents of SF-3 were measured by HPLC methods. Fluorescent assays revealed characteristic apoptotic features, including cell shrinkage, nuclear condensation, and marked decrease in mitochondrial membrane potential in SF-3 treated cells. In addition, increased levels of caspases-9 and-3/7 levels were also observed in SF-3 treated cells. SF-3 showed promising antimetastatic properties in multiple in vitro assays. Multi-pathway analysis revealed significant down-regulation of WNT, HIF-1α, and EGFR with simultaneous up-regulation of p53, Myc/Max, and TGF-β signalling pathways in SF-3 treated cells. In addition, promising growth inhibitory effects were observed in SF-3 treated HCT 116 tumour spheroids, which give a hint about in vivo antitumor efficacy of SF-3 phytoconstituents. In conclusion, these results demonstrated that anticancer effects of SF-3 towards colon cancer are through modulation of multiple molecular pathways.

关键词： Mesua ferrea a-Amyrin Apoptotic Antimetastatic Molecular pathways

Model Atmosphere Analysis of Some B-Type Stars

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International Journal of Astronomy and Astrophysics 2011年第2期1卷 45-51页

作者： Somaya M. saad mohamed I. Nouh 不详

We present model atmosphere analysis for a sample of B-type stars in optical region to obtain their fundamental parameters e.g. effective temperature, surface gravities, and rotational velocities. Approximate masses for the sample of stars under study are obtained by comparing the resulted effective temperatures and surface gravities with the evolutionary tracks. Comparison between these masses and the empirical effective temperatures-mass relation revealed good agreement.

关键词： B-Type Stars Model Atmosphere Analysis Fundamental Parameters

The Diagnostic Role of Brain MRI in Detection of Multiple Sclerosis Related Cognitive Impairment

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Journal of Behavioral and Brain Science 2019年第8期9卷 313-324页

作者： mohamed saad Maha Bilal Wael Gabr Aymen Abd Elnaby Neurology Department Mansoura University Mansoura Egypt Radiology Department Mansoura University Mansoura Egypt Internal Medicine Department Tiabah University Madina KSA

Background: Cognitive impairment (CI) is a common manifestation of multiple sclerosis (MS), which can severely affect patients’ and their families’ life. Early suspicion and detection of CI can improve general medical management of MS patients. Objectives: To correlate MS related CI to cortical brain lesions using brain magnetic resonance imaging (MRI). Materials and Methods: Cognitive impairment was detected using mini mental state examination (MMSE);Neurological examination and brain MRI were performed for all patients. Correlation was calculated between disease cortical burden detected by MRI and CI. Results: Fifty-three patients with proven MS were scanned by brain MRI;69.8% of them had cognitive impairment diagnosed with MMSE. The presence and severity of cognitive impairment was correlated to cortical brain lesion. Cognitive impairment was not correlated with non-cortical brain lesions or neurological physical disability measured by Expanded Disability Status Scale (EDSS). Conclusions: Presence of brain frontal cortical lesions detected by MRI in MS patients can predict subsequent development of MS-related CI.

关键词： Multiple Sclerosis Cognitive Impairment MRI Cortical Brain Lesion MS Related CI

The Role of HER2/Neu and BRCA1 Genes in the Diagnosis of Breast Cancer among Sudanese Women

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Journal of Cancer Therapy 2020年第8期11卷 491-496页

作者： mohamed Ahmed Osman Faris Merghani Eltom mohamed Elzubier Abdallah saad Ali S. Aljohani Department of Histopathology and Cytology Faculty of Medical Laboratory Science Al-Neelain University Khartoum Sudan Department of Anatomy and Histology Faculty of Medicine Batterjee Medical College Jeddah KSA Department of Histology College of Medicine Alrayan Colleges Almadinah Almunawwarah KSA Department of Biochemistry Faculty of Medicine Umm Al-Qura University Makkah KSA Department of Biochemistry and Molecular Biology Faculty of Science and Technology Al-Neelain University Khartoum Sudan Department of Basic Medical Science Faculty of Medicine Alrayan Colleges Almadinah Almunawarah KSA

Background: Knowledge of HER2/Neu and BRCA1 Genes might be helpful for development of strategies for decreasing the burden of risk of breast cancer. Therefore, the aim of this study to detect the role of HER2/Neu and BRCA1 Genes expression in diagnosis of breast cancer in Sudanese women. Methodology: A total of 100 tissue samples obtained from patients with breast cancer in addition to 50 tissue samples obtained from patients with benign breast lesions, were detected the expression of HER2/Neu and BRCA1 Genes by Polymerase Chain Reaction (PCR). Results: The prevalence of HER2/Neu and BRCA1 Genes, among cases was 6%, and 10% respectively. Conclusion: HER2/Neu and BRCA1 Genes have a considerable contribution to etiology of breast cancer in Sudan that requires further consideration.

关键词： HER2/Neu and BRCA1 Genes Breast Cancer Sudan

Methods for in vitro evaluating antimicrobial activity： A review

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Journal of Pharmaceutical Analysis 2016年第2期6卷 71-79页

作者： mounyr balouiri moulay sadiki saad koraichi ibnsouda Laboratory of Microbial Biotechnology Faculty of Sciences and Techniques University Sidi Mohamed Ben Abdellah B.P.. 2202 lmouzzer Road Fez Morocco

In recent years, there has been a growing interest in researching and developing new antimicrobial agents from various sources to combat microbial resistance. Therefore, a greater attention has been paid to antimicrobial activity screening and evaluating methods. Several bioassays such as disk-diffusion, well diffusion and broth or agar dilution are well known and commonly used, but others such as flow cy- tofluorometric and bioluminescent methods are not widely used because they require specified equip- ment and further evaluation for reproducibility and standardization, even if they can provide rapid re- sults of the antimicrobial agent＇s effects and a better understanding of their impact on the viability and cell damage inflicted to the tested microorganism. In this review article, an exhaustive list of in vitro antimicrobial susceptibility testing methods and detailed information on their advantages and limita- tions are reported.

关键词： Thin-layer chromatography (TLC)-bioautography Time-kill test Antimicrobial gradient method Agar diffusion method

Maximum Power Point Tracker Controller Using Fuzzy Logic Control with Battery Load for Photovoltaics Systems

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Smart Grid and Renewable Energy 2021年第10期12卷 163-181页

作者： Mazen Yeselam Baramadeh mohamed Abd Almonem Abouelela saad Mubarak Alghuwainem Electrical Engineering Department King Saud University Riyadh Saudi Arabia

The target of this paper is to model a Maximum Power Point Tracker (MPPT) using a Fuzzy Logic Control (FLC) algorithm and to investigate its behavior with a battery load. The advantage of this study over other studies in this field is that it considers a battery load rather than the commonly used resistive load especially when we deal with the relationship between MPPT and system load. The system is about 60 kW which is simulated under various environmental conditions by Matlab/Simulink program. For this type of non-linear application, FLC naturally offers a superior controller for the real load case. The artificial intelligence approach also benefits from this method for overcoming the complexity of nonlinear system modelling. The results show that FLC provides high performance for MPPT of PV system with battery load due to its low settling time and limited oscillation around the steady state value. These are assistant factors for increasing battery life.

关键词： MPPT Controller Fuzzy Logic Control PV System Matlab Simulink

Nutrient Fluxes and Sediments Composition in El Mex Bay and Surround Drains, Alexandria, Egypt

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American Journal of Analytical Chemistry 2015年第6期6卷 513-527页

作者： mohamed Attia Shreadah Mamdouh saad Masoud Abdel-Rhman Mosaad Khattab Gehan mohamed El Zokm National Institute of Oceanography and Fisheries Alexandria Egypt Faculty of Science Alexandria University Alexandria Egypt Faculty of Science Al-Azhar University Cairo Egypt

The regeneration of pore water (PW) nutrients was investigated and the contribution of benthic nutrient fluxes to the overlying bottom water (BW) was examined. Dissolved inorganic nutrients (NO-2, NO-3, PO3-4 and SIO4-4) were measured in PW and BW in El Mex Bay and surround drains during spring 2010. Nutrient concentrations gradiance in PW with overlying seawater were evaluated according to Fick’s Law. Average inorganic nutrient fluxes were estimated using the pore water gradient concentration across the sediment-water interface. Calculated nutrient fluxes had averages of ﹣7.24, ﹣1.36, ﹣7.86 and ﹣1.33 in El Mex Bay. Additionally, the fluxes in the drains were ﹣34.39, ﹣32.28, ﹣53.20 and ﹣117.6 mg·m﹣2·day﹣1 for NO-3, NO-2, PO3-4 and SIO4-4, respectively. Mineralogical studies of sediment samples by using IR, X-ray analysis were carried out to identify the chemical structure of sediments. The results revealed that calcite, aragonite and quartz are the dominant minerals. On the other hand, differential thermal analysis (DTA) was used to evaluate and discuss different kinetic parameters such as Ea#, ΔG#, ΔH#, ΔS#, Z and Tm support the view of the extra stability of these sediments.

关键词： Nutrient Fluxes IR-X-Ray-DTA Sediments El Mex Bay Alexandria Egypt

Influence of Sn Low Doping on the Morphological, Structural and Optical Properties of ZnO Films Deposited by Sol Gel Dip-Coating

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Advances in Materials Physics and Chemistry 2014年第5期4卷 93-104页

作者： Chewki Zegadi Khalil Abdelkebir Denis Chaumont mohamed Adnane saad Hamzaoui Laboratory of Electron Microscopy and Materials Sciences University of Science and Technology of Oran El-Mnaouer Oran Algeria Nanoform—ICB Université de Bourgogne Dijon France

In this work, Undoped Zinc Oxide (ZnO) and Sndoped Zinc Oxide (ZnO:Sn) films have been deposited by sol-gel dip coating method, where the Sn/Zn atomic ratio was 3% and 5% in the solution. The effects of Sn incorporation on morphological, structural and optical properties of ZnO films were investigated. The Scanning Electron Microscopy (SEM) showed that the morphological surface of the films was affected by Sn low doping. The X-Ray Diffraction (XRD) patterns showed that all films have polycrystalline structures, and the doping incorporation has not lead to substantial changes in the structural characteristics of ZnO films. The crystallite size was calculated using the well-known Scherrer’s formula and found to be in the range of 23 - 40 nm. The measurements from UV-Visible Spectrophotometer (U-Vis) indicated that the highest average optical transmittance in the visible region was related to Undoped ZnO film, then the optical band gap and Urbach energy values of thin films were calculated. The X-Ray Photoelectron Spectroscopy (XPS) has demonstrated that Sn is incorporated in ZnO lattice.

关键词： Sol-Gel Dip-Coating ZnO Films Sn Low Doping SEM Micrographs X-Rays Patterns Optical Properties XPS Spectrum

Correlation of Magnetoresistance and Thermoelectric Power in La1-xLixMnOy Compounds

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Journal of Electromagnetic Analysis and Applications 2011年第1期3卷 27-32页

作者： Ahmed mohamed Ahmed Abed El Rahman Ahmed saad Mahrous Rashad Ahmed 不详

The temperature dependences of the thermoelectric power, TEP, (S) and magnetoresistance (MR) effect of La1-xLixMnOy (x = 0.05, 0.1, 0.15, 0.2 & 0.25 at %) fixed valence doped compounds were studied between 80K and 320K. X-ray powder diffraction (XRD) showed that the samples are single phase. We found the correlation of structures to the mag-netoresistance (MR) and the thermoelectric power (S) which we assigned to change the specific branches of the magnon /phonon spectra with x. We also observed a splitting of the Curie and the metal insulating temperature TC > Tms.

关键词： Thermoelectric Power Magnetoresistance the Curie Temperature