The Role of HER2/Neu and BRCA1 Genes in the Diagnosis of Breast Cancer among Sudanese Women

作     者：Mohamed Ahmed Osman Faris Merghani Eltom Mohamed Elzubier Abdallah Saad Ali S. Aljohani Mohamed Ahmed Osman;Faris Merghani Eltom;Mohamed Elzubier Abdallah;Saad Ali S. Aljohani

作者机构：Department of Histopathology and Cytology Faculty of Medical Laboratory Science Al-Neelain University Khartoum Sudan Department of Anatomy and Histology Faculty of Medicine Batterjee Medical College Jeddah KSA Department of Histology College of Medicine Alrayan Colleges Almadinah Almunawwarah KSA Department of Biochemistry Faculty of Medicine Umm Al-Qura University Makkah KSA Department of Biochemistry and Molecular Biology Faculty of Science and Technology Al-Neelain University Khartoum Sudan Department of Basic Medical Science Faculty of Medicine Alrayan Colleges Almadinah Almunawarah KSA 

出 版 物：《Journal of Cancer Therapy》 (癌症治疗（英文）)

年 卷 期：2020年第11卷第8期

页      面：491-496页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：HER2/Neu and BRCA1 Genes Breast Cancer Sudan 

摘      要：Background: Knowledge of HER2/Neu and BRCA1 Genes might be helpful for development of strategies for decreasing the burden of risk of breast cancer. Therefore, the aim of this study to detect the role of HER2/Neu and BRCA1 Genes expression in diagnosis of breast cancer in Sudanese women. Methodology: A total of 100 tissue samples obtained from patients with breast cancer in addition to 50 tissue samples obtained from patients with benign breast lesions, were detected the expression of HER2/Neu and BRCA1 Genes by Polymerase Chain Reaction (PCR). Results: The prevalence of HER2/Neu and BRCA1 Genes, among cases was 6%, and 10% respectively. Conclusion: HER2/Neu and BRCA1 Genes have a considerable contribution to etiology of breast cancer in Sudan that requires further consideration.