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Calculus bovis in hepatocellular carcinoma:Tumor molecular basis,Wnt/β-catenin pathway role,and protective mechanism

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World Journal of Gastroenterology 2024年第35期30卷 3959-3964页

作者： Khaled mohamed mohamed Koriem Department of Medical physiology Medical Research and Clinical Studies InstituteNational Research CentreGiza 12622Egypt

In this editorial,we comment on the recent article by Huang et *** editorial focuses specifically on the molecular mechanisms of hepatocellular carcinoma(HCC),mechanism of Wnt/β-catenin pathway in HCC,and protective mechanism of Calculus bovis(CB)in *** cancer is the fourth most common cause of cancer-related deaths *** most prevalent kind of primary liver cancer,HCC,is typically brought on by long-term viral infections(hepatitis B and C),non-alcoholic steatohepatitis,e.ce.sive alcohol consumption,and other conditions that can cause the liver to become chronically inflamed and *** is a wellknown traditional remedy in China and Japan and has been used extensively to treat a variety of diseases,such as high fever,convulsions,and *** in lipid metabolism,cholesterol metabolism,bile acid metabolism,alcohol metabolism,and xenobiotic detoxification lead to fatty liver disease and liver ***,which is a tricarboxylic acid cycle intermediate,is vital to energy production and mitochondrial *** is also thought to be a signaling molecule in metabolism and in the development and spread of liver *** Wnt/β-catenin pathway is made up of a group of proteins that are essential for both adult tissue homeostasis and embryonic *** is frequently caused by the dysregulation of the Wnt/β-catenin signaling *** HCC liver carcinogenesis,Wnt/β-catenin signaling is activated by the expression of downstream target *** between the liver and the gut exists via the portal vein,biliary tract,and systemic ***"gutliver axis"controls intestinal *** of the main factors contributing to the development,progression,and treatment resistance of HCC is the abnormal activation of the Wnt/β-Catenin signaling ***,understanding this pathway is essential to treating *** ingredients of CB,particularly oleanolic acid,ergosterol,and ursolic acid,have anti-p

关键词： Hepatocellular carcinoma MicroRNAs Wnt/β-catenin pathway Calculus bovis Apoptosis

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3D static modeling and seque.ce.stratigraphy using well logs and seismic data:An example of Abu Roash G member in Bahga oilfield

Energy Geoscience

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energy Geoscience 2024年第3期5卷 362-377页

作者： mohamed Reda mohamed Fathy mohamed Mosaad Fahad Alshehri mohamed S.Ahmed Geology Department Faculty of ScienceAl-Azhar UniversityP.O.Box 11884Nasr CityCairoEgypt Abdullah Alrushaid Chair for earth Scie.ce.Remote Sensing Research Geology and Geophysics DepartmentCollege of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

This research uses both three-dimensional(3D)modeling and geologic well control to piece back together the architectural parts of the Late Cretaceous *** goal is to figure out the sizes,directions,locations,and controls of the layers of the fluvial sandstone *** stratigraphy is essential for 3D reservoir modeling and petroleum geology understanding in the Bahga *** purpose of this work is to create a static model that shows the layers and facies distribution in the reservoir *** will use data from nine well logs and 22 seismic lines calibrated by the Abu Roash G Member reservoir core intervals to accomplish *** petrophysical study discovered three parts in the Abu Roash G Member reservoir rock:channel fill that is affected by tides,channel fill that is dominated by tides(intertidal sands),and channel top with lenticular bedded *** model's findings point to the existe.ce.of an NNW-oriented sand body,which could be a prime location to produce *** original oil in place(OOIp)is about 3,438,279 Stock Tank Barrels(STB),and the oil reserve reaches up to 1,031,484(STB).Seque.ce.stratigraphic analysis using seismic and well log information(SB)reveals that the Upper Cretaceous AR/G reservoir of the Bahga field is characterized by third-and fourth-order stratigraphic seque.ce.,which are constrained by three Maximum Flooding Surfaces(MFS)and two Seque.ce.*** integration of the derived geological model and seque.ce.stratigraphic results can lower future extraction risk by identifying the locations and trends of the geologic facies with the necessary petrophysical properties for the hydrocarbon accumulations.

关键词： Three-dimensional reservoir modeling Seque.ce.stratigraphy Reservoir characterization Abu Roash reservoir Abu Gharadig Basin

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Oil-source correlation and paleozoic source rock analysis in the Siwa Basin,Western Desert:Insights from well-logs,Rock-eval pyrolysis,and biomarker data

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energy Geoscience 2024年第3期5卷 313-327页

作者： mohamed I.abde.-Fattah mohamed Reda mohamed Fathy Diaa A.Saadawi Fahad Alshehri mohamed S.Ahmed petroleum Geoscie.ce. and Remote Sensing program Department of Applied Physics and AstronomyCollege of SciencesUniversity of SharjahSharjah27272United Arab Emirates Geology Department Faculty of ScienceSuez Canal UniversityIsmailiaEgypt Faculty of Science Geology DepartmentAl-Azhar UniversityP.O.Box 11884Nasr CityCairoEgypt Abdullah Alrushaid Chair for earth Scie.ce.Remote Sensing Research Geology and Geophysics DepartmentCollege of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

Understanding the origins of potential source rocks and unraveling the intricate connections between reservoir oils and their source formations in the Siwa Basin(Western Desert,egypt)necessitate a thorough oil-source correlation *** objective is achieved through a meticulous analysis of well-log responses,Rock-eval pyrolysis,and biomarker *** analysis of Total Organic Carbon across 31 samples representing paleozoic formations in the Siwa A-1X well reveals a spectrum of organic richness ranging from 0.17 wt%to 2.04 wt%,thereby highlighting diverse levels of organic content and the prese.ce.of both Type II and Type III *** of the fingerprint characteristics of eight samples from the well suggests that the Dhiffah Formation comprises a blend of terrestrial and marine organic ***,a significant contribution from more oxidized residual organic matter and gas-prone Type III kerogen is ***,the Desouky and Zeitoun formations exhibit mixed organic matter indicative of a transitional environment,and thus featuring a pronounced marine influe.ce.within a more reducing setting,which is associated with Type II *** analysis of five oil samples from different wells—SIWA L-1X,SIWA R-3X,SIWA D-1X,pTAH 5X,and pTAH 6X,it is evident that terrestrial organic matter,augmented by considerable marine input,was deposited in an oxidizing environment,and contains Type III *** scrutiny confirms the coexiste.ce.of mixed terrestrial organic matter within varying redox *** is the uniformity of identified kerogen Types II and III across all samples,known to have potential for hydrocarbon *** discovery presented in this paper unveils captivating prospects concerning the genesis of oil in the Jurassic Safa reservoir,suggesting potential links to paleozoic sources or even originating from the Safa Member *** revelations mark a substantial advancement in understanding source

关键词： Biomarker data Oil-source correlation Rock-eval pyrolysis Source rocks Siwa Basin

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effect of stress-dependent microannulus aperture on well leakage

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Journal of Rock Mechanics and Geotechnical engineering 2024年第6期16卷 1967-1976页

作者： Meng Meng Luke p.Frash J.William Carey mohamed Mehana Wenfeng Li Bailian Chen earth and environmental Scie.ce. Los Alamos National LaboratoryLos AlamosNMUSA

Debonding at the.ce.ent-casing interface is recognized as a principal failure mechanism leading to CO_(2) leakage in *** detachment gives rise to a microannulus,which notably possesses greater permeability than undamaged cement,undermining its sealing ***,the permeability of the microannulus is regarded as a uniform value throughout the ***,fundamentally,a microannulus is one type of fracture,and its gap or aperture size is affected by the effective *** this work,we developed a unique experimental *** equipment facilitates the curing of cement inside a steel casing,the formation of a microannulus between the casing and the.ce.ent,and the investigation of the fluid flow dynamics along the microannulus under laboratory-replicated in situ *** microannulus was formed by injecting fluid from one end of the setup,and receiving similar amount of fluid on the other end signified the development of the leakage ***,strain gauges affixed to the casing’s external surface yielded key information on the microannulus’s opening and *** observed a noticeable decline in microannulus hydraulic aperture(or permeability)in relation to effective stress and an exponential equation fits their *** findings also indicate a distinct behavior when comparing liquid CO_(2) with ***,it is easier for liquid CO_(2) to create the ***,the hydraulic aperture range for this microannulus(0.7-6 mm)is considerably smaller than that created by water flow(2-17 mm).Finally,we integrated the stressdependent microannulus aperture size into the combined analysis of well mechanical integrity and well *** outcomes consistently demonstrated that when factoring in the stress-dependent aperture sizes,the leakage rates are 3e5 times compared to a fixed aperture *** traditional assumption of a constant aperture significantly underestimates fluid leakage risks.

关键词： Microannulus Leakage assessment Aperture size Triaxial experiment Carbon sequestration

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explainable Conformer Network for Detection of COVID-19 pneumonia from Chest CT Scan: From Concepts toward Clinical explainability

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Computers, Materials & Continua 2024年第1期78卷 1171-1187页

作者： mohamed abde.-Basset Hossam Hawash mohamed Abouhawwash S.S.Askar Alshaimaa A.Tantawy Faculty of Computers and Informatics Zagazig UniversityZagazig44519Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Statistics and Operations Research College of ScienceKing Saud UniversityP.O.Box 2455Riyadh11451Saudi Arabia

The early implementation of treatment therapies necessitates the swift and precise identification of COVID-19 pneumonia by the analysis of chest CT *** study aims to investigate the indispensable need for precise and interpretable diagnostic tools for improving clinical decision-making for COVID-19 *** paper proposes a novel deep learning approach,called Conformer Network,for explainable discrimination of viral pneumonia depending on the lung Region of Infections(ROI)within a single modality radiographic CT ***,an efficient U-shaped transformer network is integrated for lung image ***,a robust transfer learning technique is introduced to design a robust feature extractor based on pre-trained lightweight Big Transfer(BiT-L)and finetuned on medical data to effectively learn the patterns of infection in the input ***,this work presents a visual explanation method to guarantee clinical explainability for decisions made by Conformer *** evaluation of real-world CT data demonstrated that the diagnostic accuracy of ourmodel outperforms cutting-edge studies with statistical *** Conformer Network achieves 97.40% of detection accuracy under cross-validation *** model not only achieves high sensitivity and specificity but also affords visualizations of salient features contributing to each classification decision,enhancing the overall transparency and trustworthiness of our *** findings provide obvious implications for the ability of our model to empower clinical staff by generating transparent intuitions about the features driving diagnostic decisions.

关键词： Deep learning COVID-19 multi-modal medical image fusion diagnostic image fusion

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Treatment-induced neuroendocrine prostate cancer and de novo neuroendocrine prostate cancer:Identification,prognosis and survival,genetic and epigenetic factors

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World Journal of Clinical Cases 2024年第13期12卷 2143-2146页

作者： mohamed Wishahi Department of Urology Theodor Bilharz Research InstituteCairo 12411Egypt

Neuroendocrine prostate cancer(NepC)shows an aggressive behavior compared to prostate cancer(pCa),also known as prostate *** foci in pCa can harbor genetic alternation that can arise in a heterogeneity of prostate *** may arise de novo or develop following androgen deprivation therapy(ADT).NepC that arise following ADT has the nomenclature“treatmentemerging/induced NepC(t-NepC)”.t-NepC would be anticipated in castration resistant prostate cancer(CRpC)and metastatic pCa.t-NepC is characterized by low or absent androgen receptor(AR)expression,independe.ce.of AR signaling,and gain of neuroendocrine phenotype.t-NepC is an aggressive metastatic tumor,develops from pCa in response to drug induced ADT,and shows very short response to conventional therapy.t-NepC occurs in 10%-17%of patients with *** novo NepC is rare and is accounting for less than 2%of all *** molecular mechanisms underlying the trans-differentiation from CRpC to t-NepC are not fully *** kinase 1 plays a significant role in t-NepC *** neuroendocrine markers:Synaptophysin,chromogranin A,and insulinoma associated protein 1(INSM1)are expressed in t-NepC,they are non-specific for diagnosis,prognosis,and follow-up of therapy.t-NepC shows enriched genomic alteration in tumor protein p53(Tp53)and retinoblastoma 1(RB1).There are evide.ce. suggest that t-NepC might develop through epigenetic *** are genomic,epigenetic,and transcriptional alterations that are reported to be involved in development of ***-outs of Tp53 and RB1 were found to contribute in development of *** is resistant to immunotherapy,and at present there are running trials to approach immunotherapy for pCa,CRpC,and t-NepC.

关键词： prostate cancer Neuroendocrine carcinoma Treatment induced neuroendocrine prostate cancer Androgen deprivation therapy Genetic and epigenetic factors Castration resistant prostate cancer De novo neuroendocrine prostate cancer

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Ligand-controlled NiH-catalyzed regiodivergent hydroalkylation of 2-alkenylazaarenes

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Scie.ce.China Chemistry 2024年第6期67卷 1935-1940页

作者： Ya-ping Shao Zhuo-min Chi Yong-min Liang State Key Laboratory of Applied Organic Chemistry School of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000China

A nickel-hydride(Ni H)-catalyzed migratory and nonmigratory hydroalkylation reaction of 2-alkenyl azaarenes with alkyl iodines has been established through strategic modulation of N-or p-donor *** method enables the synthesis of diverseβ-orγ-branched aromatic *** mild regiodivergent protocols exhibit wide substrate scope,e.ce.lent functional tolerance,and great reaction yield with remarkable ***,deuterium labeling studies reveal Ni H-catalyzed interrupted chain-walking mode as the mechanism behind remotedβ-selective hydroalkylation reaction—an interesting phenomenon mediated through aromatic imine directing groups.

关键词： NiH regiodivergent hydroalkylation azaarenes interrupted chain-walking

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pseudomonotonicity of Nonlinear Transformations on euclidean Jordan Algebras

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 192-204页

作者： Yuan-min Li School of Mathematics and Statistics Xidian UniversityXi’an710071China

In this paper, we have introduced the concepts of pseudomonotonicity properties for nonlinear transformations defined on euclidean Jordan algebras. The implications between this property and other p-properties have been studied. More importantly, we have solved the solvability problem of the nonlinear pseudomonotone complementarity problems over symmetric cones.

关键词： euclidean Jordan algebra nonlinear transformation complementarity problem pseudomonotone

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Timing impact on the initiation of pirfenidone therapy on idiopathic pulmonary fibrosis disease progression

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World Journal of Clinical Cases 2024年第32期12卷 6538-6542页

作者： Basma M e mohamed mohamed e A abde.rahim Department of Clinical pharmacy Faculty of PharmacyBeni-Suef UniversityBeni-Suef 343433Egypt

In this editorial,we comment on the article by Lei et al,with a specific focus on the timing of the initiation of the antifibrotic agent pirfenidone(pFD)in the management of idiopathic pulmonary fibrosis(IpF)and its impact on lung function of IpF *** is an antifibrotic agent that is widely used in the management of IpF in both early and advanced *** inhibits various pathways and has antifibrotic,anti-inflammatory,and antioxidant *** dosage lowering,pFD slowed IpF progression and maintained functional *** 6-min walk distance test indicated that patients tolerated adverse events well,and pFD significantly reduced the incide.ce.of progression episodes and *** when a single disease-progression event occurred,continuing pFD treatment had benefits.

关键词： Idiopathic pulmonary fibrosis pirfenidone pirfenidone anti-inflammatory mechanism pirfenidone antifibrotic activity Timing impact

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Unknown environment Measurement Mapping by Unmanned Aerial Vehicle Using Kalman Filter-Based Low-Cost estimated parallel 8-Beam LIDAR

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Computers, Materials & Continua 2024年第9期80卷 4263-4279页

作者： mohamed Rabik mohamed Ismail Muthuramalingam Thangaraj Khaja Moiduddin Zeyad Almutairi Mustufa Haider Abidi Department of Mechatronics engineering SRM Institute of Science and TechnologySRM NagarKattankulathurChengalpattu DistrictTamil Nadu603203India Advanced Manufacturing Institute King Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia Department of Mechanical engineering College of EngineeringKing Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia

The measurement and mapping of objects in the outer environment have traditionally been conducted using ground-based monitoring systems,as well as *** recently,unmanned aerial vehicles have also been employed for this *** accurate detection and mapping of a target such as buildings,trees,and terrains are of utmost importance in various applications of unmanned aerial vehicles(UAVs),including search and rescue operations,object transportation,object detection,inspection tasks,and mapping ***,the rapid measurement and mapping of the object are not currently achievable due to factors such as the object’s size,the intricate nature of the sites,and the complexity of mapping *** present system introduces a costeffective solution for measurement and mapping by utilizing a small unmanned aerial vehicle(UAV)equipped with an 8-beam Light Detection and Ranging(LiDAR)*** approach offers advantages over traditional methods that rely on expensive cameras and complex algorithm-based *** reflective properties of laser beams have also been *** system provides prompt results in comparison to traditional camerabased surveillance,with minimal latency and the need for complex *** Kalman estimation method demonstrates improved performance in the prese.ce.of *** measurement and mapping of external objects have been successfully conducted at varying distances,utilizing different resolutions.

关键词： 8 beam LiDAR UAV measurement mapping Kalman filter

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