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Memristor initial-boosted coexisting plane bifurcations and its extreme multi-stability reconstitution in two-memristor-based dynamical system

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Science China(Technological Sciences) 2020年第4期63卷 603-613页

作者： BAO Han chen mo WU HuaGan BAO Bocheng School of Information Science and Engineering Changzhou UniversityChangzhou 213164China

Initial-dependent extreme multi-stability and offset-boosted coexisting attractors have been significantly concerned *** paper constructs a novel five-dimensional(5-D)two-memristor-based dynamical system by introducing two memristors with cosine memductance into a three-dimensional(3-D)linear autonomous dissipative *** theoretical analyses and numerical plots,the memristor initial-boosted coexisting plane bifurcations are found and the memristor initial-dependent extreme multi-stability is revealed in such a two-memristor-based dynamical system with plane ***,a dimensionality reduction model with the determined equilibrium is established via an integral transformation method,upon which the memristor initial-dependent extreme multi-stability is reconstituted theoretically and expounded ***,physically circuit-implemented PSIM(power simulation)simulations are carried out to validate the plane offset-boosted coexisting behaviors.

关键词： memristor-based system memristor initial coexisting plane bifurcations extreme multi-stability

2nd-order spline wavelet convolution method in resolving chemical overlapped peaks

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Science China Chemistry 2004年第1期47卷 50-58页

作者： WANG Ying mo Jinyuan chen Xiaoyan School of Chemistry and Chemical Engineering Zhongshan University Guangzhou 510275 China School of Chemistry and Chemical Engineering Zhongshan University Guangzhou 510275 China School of Chemistry and Chemical Engineering Zhongshan University Guangzhou 510275 China

A 2nd-order spline wavelet convolution method in resolving overlapped peaks is developed. It determines the number of peaks, peak positions and width through wavelet? convolution, then uses spline function to construct the resoluter, which is used to resolve overlapped peaks. Theoretical proof is given, and the selections of wavelets and parameters are discussed. It is proven that baseline separation can be achieved after processed, the relative errors of peak position and area are less than 0.2% and 4.0% respectively. It can be directly applied to seriously overlapped signals, noisy signals and multi-component signals, and the results are satisfactory. It is a novel effective method for resolution.

关键词： 2nd-order spline wavelet, convolution, resolve, chemical signal, overlapped peaks.

New observation on the key schedule of RECTANGLE

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Science China(Information Sciences) 2019年第3期62卷 106-118页

作者： Hailun YAN Yiyuan LUO mo chen Xuejia LAI Department of Computer Science and Engineering Shanghai Jiao Tong University School of Electronics and Information Shanghai Dianji University

We evaluate the security of RECTANGLE from the perspective of actual key information(AKI).Insufficient AKI permits the attackers to deduce some subkey bits from some other subkey bits, thereby lowering the overall attack complexity or getting more attacked rounds. By considering the interaction between the key schedule’s diffusion and the round function’s diffusion, we find there exists AKI insufficiency in 4 consecutive rounds for RECTANGLE-80 and 6 consecutive rounds for RECTANGLE-128, although the master key bits achieve complete diffusion in 2 and 4 rounds, respectively. With such weakness of the key schedule, we give a generic meet-in-the-middle attack on 12-round reduced RECTANGLE-128 with only 8 known plaintexts. moreover, we calculate AKI of variants of RECTANGLE as well as *** we find that both RECTANGLE-128 and PRESENT-128 with no key schedule involve more AKI than the original one. Based on this finding, we slightly modify the key schedule of *** with the original one, this new key schedule matches better with the round function in terms of maximizing AKI. Our work adds more insight to the design of block ciphers’ key schedule.

关键词： lightweight block cipher RECTANGLE key schedule round function diffusion

Tracking the in vivo spatio-temporal patterns of neovascularization via NIR-II fluorescence imaging

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Nano Research 2020年第11期13卷 3123-3129页

作者： mo chen Sijia Feng Yimeng Yang Yunxia Li Jian Zhang Shiyi chen Jun chen Institute of Sports Medicine of Fudan University Department of Orthopaedic Sports MedicineHuashan HospitalFudan UniversityShanghai200041China

The in vivo spatio-temporal patterns of neovascularization are still poorly understood because it is limited to multi-scale techniques from the cellular level to living animal *** to deep tissue-penetration and zero autofluorescence background,the second near-infrared(NIR-II,1,000–1,700 nm)fluorescence imaging recently shows promise in breaking through this dilemma by dynamically tracking the pathophysiological process of neovascularization in ***,NIR-II fluorescence imaging was recruited for monitoring blood vessels in order to visualize the vascular injury and quantitively assess neovascularization in mouse models of acute skeleton muscle contusion and hindlimb *** temporal analysis of real-time NIR-II fluorescence intensity demonstrated that the blood flow perfusion of ischemia area was able to rapidly restore to 96%of pre-ischemic state within one ***,the spatial analysis revealed that the lower and outer quadrants of ischemia area in the mouse model of hindlimb ischemia always had relatively high blood flow perfusion compared with other quadrants during three weeks post-ischemia,and even exceeded pre-ischemic quantity at 21 days *** conclusion,this in vivo imaging technique has significant potential utility for studying the spatio-temporal patterns of neovascularization in vivo.

关键词： bioimaging second near-infrared(NIR-II)fluorescence nanoprobes spatio-temporal neovascularization

Bifurcation analyses and hardware experiments for bursting dynamics in non-autonomous memristive FitzHugh-Nagumo circuit

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Science China(Technological Sciences) 2020年第6期63卷 1035-1044页

作者： chen mo QI JianWei WU HuaGan XU Quan BAO Bocheng School of Information Science and Engineering Changzhou UniversityChangzhou 213164China

In this paper,a non-autonomous memristive Fitz Hugh-Nagumo(FHN)circuit is constructed using a second-order memristive diode bridge with LC *** convenience of circuit implementation,an AC voltage source is adopted to substitute the original AC current *** by the slowly varying AC voltage source,the number,locations and stabilities of the equilibrium points slowly evolve with the time,which are thus indicated as the AC equilibrium *** sequences of fold and/or Hopf bifurcations are encountered in a full period of time series evolutions,leading to various kinds of chaotic or periodic bursting *** figure out the related bifurcation mechanisms,the fold and Hopf bifurcation sets are mathematically formulated to locate the critical bifurcation *** this basis,the transitions between the resting and repetitive spiking states are clearly illustrated by the time series of the AC equilibrium points and state variables,from which Hopf/sub Hopf,Hopf/Hopf,and Hopf/fold bursting oscillations are identified in the specified parameter ***,based on a fabricated hardware circuit,the experimental measurements are *** results verify that the presented memristive FHN circuit indeed exhibits complex bursting activities,which enriches the family of memristor-based FHN circuits with bursting dynamics.

关键词： Fitz Hugh-Nagumo circuit memristive diode bridge bursting AC equilibrium point

A process study of electron beam nano-lithography and deep etching with an ICP system

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Science China(Technological Sciences) 2009年第6期52卷 1665-1671页

作者： LI QunQing ZHANG LiHui chen mo FAN ShouShan Department of Physics and Tsinghua-Foxconn Nanotechnology Research Center Tsinghua UniversityBeijing 100084China

A systemic process study on an electron beam nanolithography system operating at 100kV was *** exposure conditions were optimized for resist *** structures with line/space of 50nm/50nm were obtained in a reasonably thick resist which is beneficial to the subsequent pattern transfer *** ICP etching process conditions was *** role of etching parameters such as source power,gas pressure,and gas flow rate on the etching result was also discussed.A grating structure with line widths as small as 100nm,duty cycles of 0.5,depth of 900nm,and the side-wall scalloping as small as 5nm on a silicon substrate was *** silicon deep etching technique for structure sizes smaller than 100nm is very important for the fabrication of nano-optical devices working in the visible regime.

关键词： electron beam lithography ZEP520A resist reactive ion etching nanofabrication

Flow cytometric assessment of the effects of chlorine, chloramine, and UV on bacteria by using nucleic acid stains and 5-cyano-2,3-ditolyltetrazolium chloride

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Frontiers of Environmental Science & Engineering 2016年第6期10卷 83-91页

作者： Xuebiao Nie Wenjun Liu mo chen Minmin Liu Lu Ao School of Environment Tsinghua University Beijing 100084 China China Gezhouba Group Real Estate Corporation Beijing 100020 China Department of Architecture and Environmental Engineering Logistic Engineering University of PLA Chongqing 401331 China

Flow cytometry （FCM） has been widely used in multi-parametric assessment of cells in various research fields, especially in environmental sciences. This study detected the metabolic activity of Escherichia coli and Staphylococcus aureus by using an FCM method based on 5-cyano-2,3-ditolyltetrazolium chloride （CTC）; the accuracy of this method was enhanced by adding SYTO 9 and 10% R2A broth. The disinfection effects of chlorine, chloramine, and UV were subsequently evaluated by FCM methods. Chlorine demonstrated stronger and faster destructive effects on cytomembrane than chloramine, and nucleic acids decomposed afterwards. The metabolic activity of the bacteria persisted after the cytomembmnewas damaged as detected using CTC. Low-pressure （LP） UV or medium-oressure （MP） UV treatments exerted no significant effects on membrane permeability. The metabolic activityof the bacteria decreased with increasing UV dosage, and MP-UV was a stronger inhibitor of metabolic activity than LP-UV. Furthermore, the membrane of Gram-positive S. aureus was more resistant to chlorine/chloramine than that of Gram-negative E. coil In addition, S. aureus showed higher resistance to UV irradiation than E. coli.

关键词： Flow cytometry Escherichia coli Staphylococcus aureus UV CTC SYTO 9

Optical Properties of Dye Based on Hydroxamate Improved with Designed Tridentate Ligands for Dye Sensitized Solar Cell： a Theoretical Study

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Chemical Research in Chinese Universities 2015年第5期31卷 830-834页

作者： XIE mo chen Jie WANG Jian ZHANG Hongxing Institute of Theoretical Chemistry Jilin University Changehun 130021 P. R. China

A density function theory（DFT） study was made on three dyes based on hydroxamate with different ligands[terpyridine, isothiocyanate（NCS） and 2,2＇-bis（thienyl）-tripyrrinate（2-BTTP）] to investigtate their device performance optimization in dye sensitized solar cell（DSSC）. Based on the adsorbed dye on TiO2 （101） surface, the ground state geometry structures, electronic structures, absorption spectra and correspongding charge transfer properties were analysed in detail. The results indicate that the ligand replacement of terpyridine by NCS and 2-BTTP improves the low-energy region absorption of hydroxamate based dyes significantly. The electron injection and light harvesting capability of hydroxamate based dyes are enhanced by NCS and 2-BTTP ligands as well. In the visible region, hydroxamate based dyes have the potentials to become panchromatic light absorbers according to our research.

关键词： Dye sensitized solar cell Density functional theory Hydroxamate based dye Absorption spectrum

Bioresponsive and immunotherapeutic nanomaterials to remodel tumor microenvironment for enhanced immune checkpoint blockade

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Bioactive Materials 2024年第2期32卷 530-542页

作者： Tianxu Fang Xiaona Cao Li Wang mo chen Yueyang Deng Guojun chen Department of Biomedical Engineering McGill UniversityMontrealQCH3G 0B1Canada Rosalind&morris Goodman Cancer Institute McGill UniversityMontrealQCH3G 0B1Canada

Immune checkpoint blockade(ICB)therapy is a revolutionary approach to treat cancers,but still have limited clinical *** evidence pinpoints the immunosuppressive characteristics of the tumor microenvironment(TME)as one major *** TME,characterized by acidity,hypoxia and elevated ROS levels,exerts its detrimental effects on infiltrating anti-tumor immune ***,we developed a TME-responsive and immunotherapeutic catalase-loaded calcium carbonate nanoparticles(termed as CAT@CaCO_(3) NPs)as the simple yet versatile multi-modulator for TME ***_(3) NPs can consume protons in the acidic TME to normalize the TME *** catalyzed the decomposition of ROS and thus generated *** released Ca^(2+)led to Ca^(2+)overload in the tumor cells which then triggered the release of damage-associated molecular patterns(DAMP)signals to initiate anti-tumor immune responses,including tumor antigen presentation by dendritic ***,CAT@CaCO_(3) NPs-induced immunosupportive TME also promoted the polarization of the M2 tumor-associated macrophages to the M1 phenotype,further enhancing tumor antigen ***,T cell-mediated anti-tumor responses were activated,the efficacy of which was further boosted by aPD-1 immune checkpoint *** study demonstrated that local treatment of CAT@CaCO_(3) NPs and aPD-1 combination can effectively evoke local and systemic anti-tumor immune responses,inhibiting the growth of treated tumors and distant diseases.

关键词： Tumor microenvironment Immune modulation Calcium carbonate nanoparticles Cancer immunotherapy Immune checkpoint inhibitor Drug delivery