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Genes & Diseases 2024年第3期11卷 34-38页

作者： mj mahesh kumar Shailendra Arindkar Masum Saini Perumal Nagarajan National Institute of Immunology New Delhi 100067India Center for Cellular and Molecular Biology Hyderabad 500007India Regional Center for Biotechnology Faridabad 121001India

Non-alcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM)are two disease conditions for which obesity is a risk factor.^(1)Due to the close relationship between the three pathologies,researchers frequently use the same mouse models to identify the underlying processes of obesity,NAFLD,and *** instance,leptin(Lep)-null(ob/ob)and leptin receptor(Lepr)-deficient(db/db)mice spontaneously develop NAFLD and show different phenotypes of extreme obesity and diabetes,respectively.

关键词： obesity NAFLD Lep

Techno-Economic Optimization of Novel Stand-Alone Renewable Based Electric Vehicle Charging Station near Bahria Town Karachi,Sindh Pakistan

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Energy Engineering 2024年第6期121卷 1439-1457页

作者： Aneel kumar mahesh kumar Amir Mahmood Soomro Laveet kumar Department of Electrical Engineering Mehran University of Engineering and TechnologyJamshoroPakistan Department of Mechanical Engineering Mehran University of Engineering and TechnologyJamshoroPakistan

Electric vehicles (EVs) are the most interesting and innovative technology in the 21st century because of theirenormous advantages, both technically and economically. Their emissions rate compared to fuel-based vehicles isnegligible as they do not consume fuel and hence do not emit any harmful gases. However, their bulk production,adoption and lack of charging stations increase the stress of power stations due to modern-day lifestyles. If Electricvehicles demand increases drastically then conventional power stations will not bear their demand and if theygenerate electricity by conventional means it will be very costly and may further add greenhouse gases. Therefore,this research provides the techno-economic assessment of a stand-alone renewable-dependent electric vehiclecharging station, excluding any burden on electrical utility. The proposed study is carried out in Bahria Town,Karachi, a city in Pakistan. In this study, HOMER Pro software was utilized for techno-economic assessment. Ahybrid system comprising solar Photovoltaic/Wind Turbine/Fuel cells and battery storage is included in the *** and wind resources were taken from NASA’s website, where charging stations will be integrated. The overallresults show promising in terms of total Net Present Cost and the Cost of Energy which are 2.72M $ and 0.237 $,respectively. The total system generation is 3,598 Megawatt hours per year, and the total energy consumption is 885Megawatt hours per year.

关键词： Electrical vehicle techno economic analysis solar energy wind energy hydrogen energy

Spatial Attention Integrated EfficientNet Architecture for Breast Cancer Classification with Explainable AI

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Computers, Materials & Continua 2024年第9期80卷 5029-5045页

作者： Sannasi Chakravarthy Bharanidharan Nagarajan Surbhi Bhatia Khan Vinoth kumar Venkatesan mahesh Thyluru Ramakrishna Ahlam AlMusharraf Khursheed Aurungzeb Department of Electronics and Communication Engineering Bannari Amman Institute of TechnologySathyamangalam638402India School of Computer Science Engineering and Information Systems(SCORE) Vellore Institute of TechnologyVellore632014India School of Science Engineering and EnvironmentUniversity of SalfordManchesterM54WTUK Department of Computer Science&Engineering Faculty of Engineering and TechnologyJAIN(Deemed-to-be University)Bengaluru562112India Department of Management College of Business AdministrationPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Adjunct Research Faculty Centre for Research Impact&OutcomeChitkara UniversityRajpura140401India

Breast cancer is a type of cancer responsible for higher mortality rates among *** cruelty of breast cancer always requires a promising approach for its earlier *** light of this,the proposed research leverages the representation ability of pretrained EfficientNet-B0 model and the classification ability of the XGBoost model for the binary classification of breast *** addition,the above transfer learning model is modified in such a way that it will focus more on tumor cells in the input ***,the work proposed an EfficientNet-B0 having a Spatial Attention Layer with XGBoost(ESA-XGBNet)for binary classification of *** this,the work is trained,tested,and validated using original and augmented mammogram images of three public datasets namely CBIS-DDSM,INbreast,and MIAS *** accuracy of 97.585%(CBISDDSM),98.255%(INbreast),and 98.91%(MIAS)is obtained using the proposed ESA-XGBNet architecture as compared with the existing ***,the decision-making of the proposed ESA-XGBNet architecture is visualized and validated using the Attention Guided GradCAM-based Explainable AI technique.

关键词： EfficientNet mammograms breast cancer Explainable AI deep-learning transfer learning

Emergence of taurine as a therapeutic agent for neurological disorders

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Neural Regeneration Research 2024年第1期19卷 62-68页

作者： Ashok Jangra Priyanka Gola Jiten Singh Pooja Gond Swarnabha Ghosh mahesh Rachamalla Abhijit Dey Danish Iqbal Mehnaz Kamal Punya Sachdeva Saurabh kumar Jha Shreesh Ojha Dinesh kumar Niraj kumar Jha Hitesh Chopra Shing Cheng Tan Department of Pharmaceutical Sciences Central University of HaryanaMahendergarhHaryanaIndia Department of Biology University of SaskatchewanSaskatoonSKCanada Department of Life Sciences Presidency UniversityKolkataWest BengalIndia Department of Health Information Management College of Applied Medical SciencesBuraydah Private CollegesBuraydahSaudi Arabia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia GloNeuro Vishwakarma RoadNoidaIndia Department of Biotechnology School of Engineering&Technology(SET)Sharda UniversityGreater NoidaUttar PradeshIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates School of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradunIndia Chitkara College of Pharmacy Chitkara UniversityPunjabIndia UKM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia

Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the *** alternates between inflammation and oxidative stress-mediated injury in various disease *** part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular *** effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord *** various therapies are available,effective management of these disorders remains a global *** 30 million people are affected *** design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system *** general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this *** article is a good resource for understanding the general effects of taurine on various *** the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.

关键词： antioxidant epilepsy γ-amino butyric acid neurodegenerative disorders neuroprotection oxidative stress spinal cord injury taurine

Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3661-3679页

作者： Baolong Liu Phuong Linh Nguyen Han Yu Xingzhi Li Huiren Wang Tram Gia Bao Nguyen Prakash kumar Sahoo Meghna Sur Jay Reddy Sarah Sillman Stephen D.Kachman Bara Altartouri Guoqing Lu Sathish kumar Natarajan mahesh Pattabiraman Jiujiu Yu Department of Nutrition and Health Sciences University of Nebraska-LincolnLincolnNE 68583USA Shaanxi Key Laboratory of Molecular Biology for Agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA School of Veterinary Medicine and Biomedical Sciences University of Nebraska-LincolnLincolnNE 68583USA Department of Statistics University of Nebraska-LincolnLincolnNE 68583USA Center for Biotechnology University of Nebraska-LincolnLincolnNE 68588USA Department of Biology University of Nebraska OmahaOmahaNE 68182USA Department of Chemistry University of Nebraska-KearneyKearneyNE 68849USA

Non-alcoholic steatohepatitis(NASH),an advanced form of non-alcoholic fatty liver disease(NAFLD),has emerged as the leading cause of liver failure and related ***,no medication is specifically approved to treat NAFLD or *** we report that oral administration of honey vesiclelike nanoparticles(H-VLNs)to naturally aged mice protects the liver from NASH development.H-VLNs are dominantly taken up by Kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged *** their reported antiinflammasome function,H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa B(NF-κB).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-kB ***,oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

关键词： Honey Extracellular vesicles Exosomes Nanoparticles microRNAs Aging Inflammation Non-alcoholic steatohepatitis

Comprehensive analysis of uncertainty quantification for the^(58)Ni(n,p)^(58)Co reaction cross section

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Chinese Physics C 2024年第9期48卷 170-175页

作者： mahesh Choudhary Aman Sharma Namrata Singh Mahima Upadhyay Punit Dubey A.Gandhi Akash Hingu G Mishra Sukanya De L.S.Danu Ajay kumar R.G.Thomas Saurav Sood Sajin Prasad S.Mukherjee I.N.Ruskov Yu.N.Kopatch A.kumar Department of Physics Banaras Hindu UniversityVaranasi 221005India Horia Hulubei National Institute of Physics and Nuclear Engineering-IFIN-HH Bucharest 077125Romania Department of Physics The Maharaja Sayajirao University of BarodaVadodara 390002India Nuclear Physics Division Bhabha Atomic Research CentreMumbai 400085India Health Physics Division Bhabha Atomic Research CentreMumbai 400085India Department of Electrical Power Engineering Brno University of TechnologyBrno 61600Czech Republic Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of SciencesSofia 1784Bulgaria Joint Institute for Nuclear Research(JINR) Dubna 141980Russia

In this study,we measured the^(58)Ni(n,p)^(58)Co reaction cross section with neutron energies of 1.06,1.86,and 2.85 *** cross section was measured using neutron activation techniques andγ-ray spectroscopy,and it was compared with cross section data available in the ***,we calculated the covariance matrix of the measured cross section for the aforementioned nuclear *** uncertainties of the theoretical calculation for^(58)Ni(n,p)^(58)Co reaction cross section were calculated via Monte Carlo *** this study,we used uncertainties in the optical model and level density parameters to calculate uncertainties in the theoretical cross *** theoretical calculations were performed by using *** this study,we aim to analyze the effect of uncertainties of the nuclear model input as well as different experimental variables used to obtain the values of reaction cross section.

关键词： ^(58)Ni(n p)^(58)Co reaction γ-ray spectroscopy uncertainty quantification of cross section covariance analysis

Single-atom catalysts boosted ultrathin film sensors

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Rare Metals 2020年第10期39卷 1110-1112页

作者： Rahul kumar mahesh kumar Department of Electrical Engineering Indian Institute of Technology JodhpurJodhpur 342037India

Nowadays,demand for fast and accurate detection of toxic and flammable gases is increasing for human health safety,industrial process and environmental ***,gas sensor technology has become a requisite in our daily *** nanoscience and nanotechnology propel fabrication of a gas sensor at the miniaturization level for burgeoning Internet of things applications.

关键词： film nanotechnology gases

Investigation of 58Ni(n, p)58Co reaction cross-section with covariance analysis

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Chinese Physics C 2024年第2期48卷 78-90页

作者： Akash Hingu S.Mukherjee Siddharth Parashari Arora Sangeeta A.Gandhi Mahima Upadhyay mahesh Choudhary Sumit Bamal Namrata Singh G.Mishra Sukanya De Saurav Sood Sajin Prasad G.Saxena Ajay kumar R.G.Thomas B.K.Agrawal K.Katovsky A.kumar Department of Physics Faculty of ScienceThe M.S.University of BarodaVadodara 390002India Faculty of Electrical Engineering and Communication Brno University of TechnologyBrnoCzech Republic Department of Physics Faculty of ScienceUniversity of ZagrebBijenička c.32Zagreb 10000Croatia Department of Physics University Institute of SciencesChandigarh UniversityGharuanMohali 140413PunjabIndia Department of Physics Banaras Hindu UniversityVaranasi 221005India Horia Hulubei National Institute for Physics and Nuclear Engineering Măgurele 077125Romania Nuclear Physics Division Bhabha Atomic Research CentreMumbai 400085India Health Physics Division Bhabha Atomic Research CentreMumbai 400085India Department of Physics(H&S) Government Women Engineering CollegeAjmer 305002India Saha Institute of Nuclear Physics Kolkata 700064India Homi Bhabha National Institute Anushakti NagarMumbai 400094India

The excitation function of the 58Ni(n,p)58Co reaction was measured using the well-established neutron activation technique andγ-ray *** in the energy range of 1.7 to 2.7 MeV were generated using the 7Li(p,n)*** neutron flux was measured using the standard 115In(n,n’)115mIn monitor *** results of the neutron spectrum averaged cross-section of 58Ni(n,p)58Co reactions were compared with existing cross-section data available in the EXFOR data library as well as with various evaluated data libraries such as ENDF/B-VIII.0,JEFF-3.3,JENDL-4.0,and *** calculations were performed using the nuclear reaction code *** nuclear level density(NLD)models were tested,and their results were compared with the present *** NLDs were also obtained through the spectral distribution method(SDM).The cross-section results,along with the absolute errors,were obtained by investigating the uncertainty propagation and using the covariance *** forγ-ray true coincidence summing,low-energy background neutrons,andγ-ray self attenuation were *** experimental cross-section obtained in the present study is consistent with previously published experimental data,evaluated libraries,and theoretical calculations carried out using the TALYS code.

关键词： nuclear reactions (n,p)reaction cross-section measurement covariance analysis nuclear level density

A comprehensive review of greenhouse shapes and its applications

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Frontiers in Energy 2019年第3期13卷 427-438页

作者： Ravinder kumar SAHDEV mahesh kumar Ashwani kumar DHINGRA Mechanical Engineering University Institute of Engineering & TechnologyMaharshi Dayanand UniversityRohtakHaryana 124001India Mechanical Engineering Guru Jambheshwar University of Sciences and TechnologyHisarHaryana 125001India

Greenhouse technology is a practical option for the production and drying of agricultural products in controlled environment. For the successful design of a greenhouse, the selection of a suitable shape and orientation is of great importance. Of various shapes of greenhouses, the even-span roof and the Quonset shape greenhouses are the most commonly used for crop cultivation and drying. The orientation of greenhouses is kept east-west for maximum utilization of solar radiations. Hybrid and modified greenhouse dryers have been proposed for drying of products. The agricultural products dried in greenhouses are found to be better in quality as compared to open sun drying because they are protected from dust, rain, insects, birds and animals. Moreover, various greenhouses shapes along with their applications have been reviewed.

关键词： greenhouse shapes drying solar energy agriculture products orientation

Room-Temperature Gas Sensors Under Photoactivation:From Metal Oxides to 2D Materials

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Nano-Micro Letters 2020年第11期12卷 292-328页

作者： Rahul kumar Xianghong Liu Jun Zhang mahesh kumar Department of Electrical Engineering Indian Institute of Technology JodhpurJodhpur 342037India College of Physics Center for Marine Observation and CommunicationsQingdao UniversityQingdao 266071People’s Republic of China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071People’s Republic of China

Room-temperature gas sensors have aroused great attention in current gas sensor technology because of deemed demand of cheap,low power consumption and portable sensors for rapidly growing Internet of things *** an important approach,light illumination has been exploited for room-temperature operation with improving gas sensor's attributes including sensitivity,speed and *** review provides an overview of the utilization of photoactivated nanomaterials in gas sensing ***,recent advances in gas sensing of some exciting different nanostructures and hybrids of metal oxide semiconductors under light illumination are ***,excellent gas sensing performance of emerging two-dimensional materialsbased sensors under light illumination is discussed in details with proposed gas sensing *** impressive features from the interaction of photons with sensing materials are elucidated in the context of modulating sensing ***,the review concludes with key and constructive insights into current and future perspectives in the light-activated nanomaterials for optoelectronic gas sensor applications.

关键词： Gas sensor Room temperature Photoactivation Metal oxide 2D materials