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Caspase-11 mediated inflammasome activation in macrophages by systemic infection of *** exacerbates arthritis

International Journal of Oral Science 2024年第3期16卷 499-514页

作者： Tokuju Okano Hiroshi Ashida Noriko Komatsu Masayuki Tsukasaki Tamako Iida Marie Iwasawa Yuto Takahashi Yasuo Takeuchi Takanori Iwata miwa sasai Masahiro Yamamoto Hiroshi Takayanagi Toshihiko Suzuki Department of Bacterial Pathogenesis Infection and Host ResponseGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Lifetime Oral Health Care Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Immunoparasitology Research Institute for Microbial DiseasesOsaka UniversityOsakaJapan

Clinical studies have shown that Aggregatibacter actinomycetemcomitans(***)is associated with aggressive periodontitis and can potentially trigger or exacerbate rheumatoid arthritis(RA).However,the mechanism is poorly ***,we show that systemic infection with *** triggers the progression of arthritis in mice anti-collagen antibody-induced arthritis(CAIA)model following IL-1βsecretion and cell infiltration in paws in a manner that is dependent on caspase-11-mediated inflammasome activation in *** administration of polymyxin B(PMB),chloroquine,and anti-CD11b antibody suppressed inflammasome activation in macrophages and arthritis in mice,suggesting that the recognition of lipopolysaccharide(LPS)in the cytosol after bacterial degradation by lysosomes and invasion via CD11b are needed to trigger arthritis following inflammasome activation in *** data reveal that the inhibition of caspase-11-mediated inflammasome activation potentiates aggravation of RA induced by infection with *** work highlights how RA can be progressed by inflammasome activation as a result of periodontitis-associated bacterial infection and discusses the mechanism of inflammasome activation in response to infection with ***.

关键词： CD11b inflam infection

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Experimental investigation on effective aerosol scavenging using different spray configurations with pre-injection of water mist for Fukushima Daiichi decommissioning

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Nuclear Science and Techniques 2024年第5期35卷 154-172页

作者： Rui-Cong Xu Avadhesh Kumar Sharma Erdal Ozdemir Shuichiro miwa Shunichi Suzuki Department of Nuclear Engineering and Management The University of Tokyo7‑3‑1 HongoBunkyo‑KuTokyo 113‑8656Japan Nuclear Professional School The University of Tokyo2‑2

During the decommissioning of the Fukushima Daiichi nuclear power plant,it is important to consider the retrieval of resolidified debris both in air and underwater *** the subsequent retrieval of debris from the reactor building,the resolidified debris must be cut into smaller pieces using various cutting *** the cutting process,aerosol particles are expected to be generated at the submicron *** has been noted that such aerosols sizing within the Greenfield gap(0.1-1μm)are difficult to remove effectively using traditional spraying ***,to improve the aerosol removal efficiency of the spray system,a new aerosol agglomeration method was recently proposed,which involves injecting water mist to enlarge the sizes of the aerosol particles before removing them using water *** this study,a series of experiments were performed to clarify the proper spray configurations for effective aerosol scavenging and to improve the performance of the water *** experimental results showed that the spray flow rate and droplet characteristics are important factors for the aerosol-scavenging efficiency and performance of the water *** results obtained from this study will be helpful for the optimization of the spray system design for effective aerosol scavenging during the decommissioning of the Fukushima Daiichi plant.

关键词： Fukushima Daiichi decommissioning Aerosol scavenging Multiphase flow Spray system Aerosol-mist agglomeration

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Can early precut reduce post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with difficult bile duct cannulation?

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World Journal of Gastrointestinal Endoscopy 2024年第9期16卷 519-525页

作者： Tomohiro Tanikawa Keisuke Miyake Mayuko Kawada Katsunori Ishii Takashi Fushimi Noriyo Urata Nozomu Wada Ken Nishino Mitsuhiko Suehiro miwa Kawanaka Hidenori Shiraha Ken Haruma Hirofumi Kawamoto Department of General Internal Medicine 2 Kawasaki Medical SchoolOkayama 7008505Japan

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is associated with a variety of adverse events(AEs).One of the most important AEs is post-ERCP pancreatitis(PEP),which is most common in cases of difficult biliary *** the precut technique has been reported as a PEP risk factor,recent studies indicate that early precut could reduce PEP,and that precut itself is not a risk *** To evaluate the safety of the precut technique,especially in terms of *** We conducted a retrospective study,spanning the period from November 2011 through December *** included 1556 patients,aged≥20 years,who underwent their initial ERCP attempt for biliary disease with a naïve papilla at the Kawasaki University General Medical *** compared the PEP risk between the early precut and the delayed precut *** The PEP incidence rate did not significantly differ between the precut and nonprecut ***,the PEP incidence was significantly lower in the early precut group than the delayed precut group(3.5%vs 10.5%;P=0.02).The PEP incidence in the delayed precut group without pancreatic stent insertion(17.3%)was significantly higher compared to other cases(P<0.01).CONCLUSION Our findings indicate that early precut may reduce PEP *** the precut decision is delayed,a pancreatic stent should be inserted to prevent PEP.

关键词： Endoscopic retrograde cholangiopancreatography Post-endoscopic retrograde cholangiopancreatography pancreatitis Precut Needle-knife precut papillotomy

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EXPERIMENTAL STUDY ON THE RELATION OF BED MORPHOLOGY WITH SURFACE FLOW IN MEANDER CHANNELS

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International Journal of Sediment Research 2006年第1期21卷 1-12页

作者： Hajime miwa Faculty of Agriculture Iwate University Japan Prof.

Alternate bars have the property that they migrate downstream whenever floods occur. However, in meander channels whose bend angles are larger than a critical value, the migration of bars can be suppressed, and the positions of bank erosion and flood attack also will be steady. In this study, the bed morphology in flume channels with bends of various lengths and angles is investigated at various flow discharges, and the relation of bed morphology to surface flow is investigated in detail using fluid measuring software. An effort is made to obtain guidelines for the plane shape design of meander channels. Based on the experimental results of bed topography and measurement of surface flow direction and velocity distribution, from the viewpoint of bank erosion and the concentration and dispersion of flood flow the most suitable plane shape for meandering channels is suggested through which the migration of alternate bars is suppressed.

关键词： Meander channel Alternate bars Particle Tracking Velocimetry (PTV) Particle Image Velocimetry (PIV)

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Telomerase and mTOR in the brain:the mitochondria connection

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Neural Regeneration Research 2017年第3期12卷 358-361页

作者： Satomi miwa Gabriele Saretzki Ageing Biology Centre and Institute for Cell and Molecular Biosciences Campus for Ageing and VitalityNewcastle UniversityNewcastle upon TyneUK

Telomerase is an enzyme that maintains telomeres in dividing cells using a template on its inherent RNA ***,the protein part TERT（Telomerase Reverse Transcriptase） has various non-canonical *** example,it can localize to mitochondria under increased stress and protect cells in vitro from oxidative stress,DNA damage and *** it has been demonstrated that TERT protein persists in adult neurons in the brain and data emerge suggesting that it might have a protective function in these post-mitotic cells as *** have recently published that TERT protein accumulated in mitochondria from brain tissue of mice that have undergone short-term dietary restriction（DR） and rapamycin *** localization correlated to lower levels of oxidative stress in these brain *** rapamycin treatment decreases mTOR signaling which is also thought to play an important role for the beneficial effects of DR,we conclude that the mTOR pathway might be involved in the TERT localization and its effects in brain mitochondria in *** data are in line with previous findings from our group about increased mitochondrial localization of TERT in Alzheimer＇s disease（AD） brains and a protective function of TERT protein in neurons in vitro against pathological tau.

关键词： telomerase brain neuron mitochondria roTOR ROS dietary restriction rapamycin

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A Fine-Grained Runtime Power/Performance Optimization Method for Processors with Adaptive Pipeline Depth

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Journal of Computer Science & Technology 2011年第2期26卷 292-301页

作者：姚骏 Shinobu miwa Hajime Shimada Shinji Tomita Graduate School of Information Science Nara Institute of Science and Technology School of Engineering Tokyo University of Agriculture and Technology Graduate School of Informatics Kyoto University Institute for Integrated Cell-Material Sciences Kyoto University

Recently, a method known as pipeline stage unification （PSU） has been proposed to alleviate the increasing energy consumption problem in modern microprocessors. PSU achieves a high energy efficiency by employing a changeable pipeline depth and its working scheme is eligible for a fine control method. In this paper, we propose a dynamic method to study fine-grained program interval behaviors based on some easy-to-get runtime processor metrics. Using this method to determine the proper PSU configurations during the program execution, we are able to achieve an averaged 13.5% energydelay-product （EDP） reduction for SPEC CPU2000 integer benchmarks, compared to the baseline processor. This value is only 0.14% larger than the theoretically idealized controlling. Our hardware synthesis result indicates that the proposed method can largely decrease the hardware overhead in both area and delay costs, as compared to a previous program study method which is based on working set signatures.

关键词： dynamic optimization energy saving fine-grained pipeline stage unification workload analysis

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Numerical simulation of low-flow channel evolution due to sediment augmentation

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International Journal of Sediment Research 2012年第3期27卷 351-361页

作者： Hiroshi miwa Gary PARKER Department of Civil Engineering Maizuru National College of Technology Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign

For the conservation and restoration of river environment,a sediment replenishment technique, which conveys a part of the sediments excavated and/or dredged from reservoirs to the river below dams is developed and has been implemented tentatively in several *** placed as replenishment can be flushed out and transported downstream by floodwater or dam *** flushed sediments are expected to contribute to the control of degradation and the variation of the low-flow ***,this technique is in the development stage because there are many unknown ***,systematic investigations are necessary for practical management of the *** this study,the effects of the location of replenishment sediment on sediment flushing and on control of degradation were investigated by means of flume experiments.A two-dimensional numerical model was also developed to further investigate the effects of sediment augmentation on river *** numerical model treats bank erosion and sediment transport over fixed beds. The simulation results were verified against the experimental *** flushing process of replenishment sediment was investigated first,and then its effect as a countermeasure for river bed degradation was *** are summarized as follows:(1) Augmentation at upper riffles is effective for flushing of replenishment sediment and variation of low-flow channel.(2) Amelioration of degradation can be found in the cases of two types of *** amelioration effect of upper riffle placement was larger than that of lower riffle placement(3) Aggradation rate of the bed near the replenishment site in the fixed bed is large in the lower riffle placement compared with the upper riffle placement.(4) The numerical model was found to be generally successful as a predictive tool.

关键词： River restoration Low-flow channel Degradation Sediment replenishment Numerical simulation

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Effects of Kampo medicine hangebyakujutsutemmato on persistent postural-perceptual dizziness:A retrospective pilot study

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World Journal of Clinical Cases 2022年第20期10卷 6811-6824页

作者： Toru miwa Shin-ichi Kanemaru Department of Otolaryngology-Head and Neck Surgery Osaka Metropolitan UniversityOsaka 5458585Japan Department of Otolaryngology-Head and Neck Surgery Tazuke Kofukai Medical Research InstituteKitano HospitalOsaka 5308480Japan Department of Otolaryngology-Head and Neck Surgery Kyoto UniversityKyoto 7507501Japan

BACKGROUND Persistent postural-perceptual dizziness(PPPD)is a functional disorder,typically preceded by acute vestibular *** is characterized by a shift in processing spatial orientation information,to favor visual over vestibular and somatosensory inputs,and a failure of higher cortical *** date,no therapies for PPPD have been *** medicine hangebyakujutsutemmato(HBT)has been reported to alleviate disturbances of *** hypothesized that HBT would be a beneficial treatment for *** To examine the efficacy of HBT for the treatment of *** Patients with PPPD were enrolled and divided into two groups:The HBT group(n=24)and the non-HBT group(n=14).The participants completed questionnaire surveys[Niigata PPPD questionnaire(NPQ),dizziness handicap inventory,hospital anxiety and depression scale(HADS),orthostatic dysregulation questionnaire,pittsburg sleep quality index(PSQI),and motion sickness scores]before and after HBT ***,to identify HBT responders,multivariate regression analysis was performed using the results of the ques-tionnaire surveys and equilibrium tests;including stabilometry,and caloric,vestibular evoked myogenic response,and head-up tilt *** Thirty-eight outpatients were included in this study,of which 14 patients(3 men,11 women;mean age,63.5±15.9 years)received treatment without HBT,and 24(1 man,23 women;mean age,58.2±18.7 years)received combination treatment with *** HBT treatment,NPQ scores decreased significantly(baseline 40.1±10.0 vs 2 mo 24.6±17.7,P<0.001).No statistically significant changes were observed in the NPQ scores in the non-HBT group(baseline 38.6±12.2 vs 2 mo 39.4±14.4,P=0.92).Multivariable regression analysis revealed that the results of stabilometry(P=0.02)and the caloric(P=0.03),and head-up tilt tests(P<0.001),HADS(P=0.003),and PSQI(P=0.01)were associated with HBT responsiveness in PPPD *** HBT may be an effective adjunct therapy fo

关键词： Hangebyakujutsutemmato Kampo medicine Persistent postural-perceptual dizziness Niigata persistent postural-perceptual dizziness questionnaire score Sensory reweighting Treatment responder

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Application of semisolid process to Zr-based metallic glass matrix composites

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中国有色金属学会会刊：英文版 2010年第S3期20卷 719-722页

作者： T.TAMURA A.MAKAYA K.miwa Solidification Processing Group Materials Research Institute for Sustainable DevelopmentNational Institute of Advanced Industrial Science and Technology(AIST)

The effect of the cooling slope on the structure of Zr-based metallic glass matrix composites was investigated by changing the cooling *** synthesis of bulk metallic glass composites was made by a process combining cooling slope casting and Cu mold casting for Zr66.4Nb6.4Cu10.5Ni8.7Al8 *** results show that the semisolid slurry which consists of the spheroidal or rosette-type BCC crystals and the liquid phase which forms metallic glass phase can be formed by the cooling slope process in this alloy ***,the semisolid slurry cannot reach to the *** is considered that higher viscosity of the liquid phase which forms metallic glass phase causes this ***,parameters of the cooling slope have to be examined further.

关键词： semisolid processing bulk metallic glass composite crystal particle cooling slope casting

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Hepatitis B:Who should be treated?-managing patients with chronic hepatitis B during the immune-tolerant and immunoactive phases

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World Journal of Gastroenterology 2021年第43期27卷 7497-7508页

作者： miwa Kawanaka Ken Nishino Hirofumi Kawamoto Ken Haruma Department of General Internal Medicine 2 General Medical CenterKawasaki Medical SchoolOkayama 700-8505Japan

New hepatitis B virus(HBV)infections are decreasing owing to improved antiviral therapy and increased HBV vaccination worldwide;however,the number of HBV infections remains a major cause of liver *** triggers cytotoxic immunity to eliminate HBV-infected ***,the HBV pathophysiology changes in persistently infected individuals depending on host immune responses and HBV DNA proliferation *** prevent liver cirrhosis and carcinogenesis caused by HBV,it is important to treat HBV infection at an early *** treatment is recommended for the immunoactive hepatitis B surface-antigen-positive and-negative phase,but not during the immune-inactive phase or immune-tolerant phase;instead,follow-up is ***,these patients should be monitored through regular blood tests to accurately diagnose the immune-inactive or-tolerant *** treatment regimen should be determined based on the age,sex,family history of liver cancer,and liver fibrosis status of *** treatment is often recommended due to various problems during the immune-tolerant *** review compares the four major international practice guidelines,including those from the Japanese Society of Hepatology,and discusses strategies for chronic hepatitis B treatment during the immune-tolerant,immune-inactive,and resolved ***,recommended hepatitis B antiviral therapy and follow-up protocols are discussed.

关键词： Hepatitis B Immune tolerance Immune-inactive Anti-viral therapy Hepatocellular carcinoma Cirrhosis

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