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Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy

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World Journal of Gastroenterology 2020年第42期26卷 6669-6678页

作者： Yoshiki Niwa Masanao nakamura Hiroki Kawashima Takeshi Yamamura Keiko Maeda Tsunaki Sawada Yasuyuki Mizutani Eri Ishikawa Takuya Ishikawa Naomi Kakushima Kazuhiro Furukawa Eizaburo Ohno Takashi Honda Masatoshi Ishigami mitsuhiro Fujishiro Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoya 466-8560Japan Department of Endoscopy Nagoya University HospitalNagoya 466-8560Japan

BACKGROUND Retrograde cholangiopancreatography using double-balloon endoscopic retrograde cholangiography(DBERC)is a valuable technique to treat biliary stone and jejunobiliary anastomotic stenosis in patients with altered gastrointestinal *** accurate selection of the route at the anastomosis branch is one of the most important factors in reaching the target in a timely *** To determine the accuracy of carbon dioxide insufflation enterography(CDE)at the branch for selecting the correct route during *** We enrolled 52 consecutive patients scheduled for DBERC at our institution from June 2015 to November *** selection via two methods(visual observation and CDE)was performed in each *** determined the correct rate of route selection using *** Thirty-three patients had a jejunojejunal anastomosis and 19 patients had a gastrojejunal *** therapeutic target region was reached in 50 *** mean procedure times from the teeth to the target(total insertion time),from the teeth to the branch,and from the branch to the target,and the mean total examination time were 15.2,5.0,8.2,and 60.3 min,*** rate of correct route selection using visual observation and CDE were 36/52(69.2%)and 48/52(92.3%),respectively(P=0.002).The rate of correct route selection using CDE in patients with a jejunojejunal anastomosis was 29/33(87.8%),and the rate in patients with a gastrojejunal anastomosis was 19/19(100%).CONCLUSION CDE is helpful in selecting the route at the branch in the anastomosis for more timely access to the target in patients with altered gastrointestinal anatomy undergoing DBERC.

关键词： Retrograde cholangiopancreatography Double-balloon endoscopy Carbon dioxide insufflation Anastomosis Accuracy Prospective study

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THE LOCAL WELL-POSEDNESS OF A CHEMOTAXIS-SHALLOW WATER SYSTEM WITH VACUUM

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Acta Mathematica Scientia 2021年第1期41卷 231-240页

作者： Jishan FAN Fucai LI Gen nakamura Department of Applied Mathematics Nanjing Forestry UniversityNanjing 210037China Department of Mathematics Nanjing UniversityNanjing 210093China Department of Mathematics Hokkaido UniversitySapporo 060-0810Japan

In this paper we prove the local well-posedness of strong solutions to a chemotaxisshallow water system with initial vacuum in a bounded domainΩ■R^(2)without the standard compatibility condition for the initial *** ... 详细信息

关键词： chemotaxis shallow water vacuum local well-posedness strong solution

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Attenuation and Distortion of Compression Waves Propagating in Very Long Tube

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Journal of Thermal Science 2011年第1期20卷 53-57页

作者： Shinya nakamura Daisuke SASA Toshiyuki AOKI Graduate School of Engineering Sciences Kyushu UniversityKasugaFukuoka816-8580Japan

A lot of phenomena related to propagating various waves are seen when the high-speed train goes through the tunnel,the gas pipeline is broken due to an accident or the air brake of the wagon *** instance,a compression wave generated ahead of a high-speed train entering a tunnel propagates to the tunnel exit and spouts as a micro pressure wave,which causes an exploding *** order to estimate the magnitude correctly,the mechanism of the attenuation and distortion of a compression wave propagating along a very long tunnel must be understood and the experimental information on these phenomena is *** experimental investigation is carried out to clarify the attenuation and distortion of the propagating compression wave in a very long *** results show that the strength of a compression wave decreases with *** attenuation and distortion of compression waves are affected by the initial waveform of the compression wave and by the unsteady boundary layer induced by the propagating *** shape of a compression wave becomes different with the propagating distance;that is,a shock wave appears just head of a wavefront and an overshoot on pressure distribution is observed behind a shock wave due to the transition of the unsteady boundary layer.

关键词： Propagating Compression Wave Very Long Tube Micro-pressure Wave High-Speed Train

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A new cascade-less engine operated from subsonic to hypersonic conditions: designed by computational fluid dynamics of compressible turbulence with chemical reactions

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Journal of Thermal Science 2010年第6期19卷 481-485页

作者： Ken Naitoh Kazushi nakamura Takehiro Emoto Waseda University Faculty of Science and Engineering

By using our computational fluid dynamic models, a new type of single engine capable of operating over a wide range of Mach numbers from subsonic to hypersonic regimes is proposed for airplanes, whereas traditional piston engines, turbojet engines, and scram engines work only under a narrower range of operating conditions. The new engine has no compressors or turbines such as those used in conventional turbojet engines. An important point is its system of super multijets that collide to compress gas for the transonic regime. Computational fluid dynamics is applied to clarify the potential of this engine. The peak pressure at the combustion center is over 2.5 MPa, while that just before ignition is over 1.0 MPa. The maximum power of this engine will be sufficient for actual use. Under the conditions of higher Mach numbers, the main intake passage located in front of the super multijet nozzles, takes in air more. That results in a ram or scramjet engine for supersonic and hypersonic conditions.

关键词： Aircraft engine multijets twister system compressible flow

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Personalized immunotherapy in cancer precision medicine

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Cancer Biology & Medicine 2021年第4期18卷 955-965页

作者： Kazuma Kiyotani Yujiro Toyoshima Yusuke nakamura Project for Immunogenomics Cancer Precision Medicine CenterJapanese Foundation for Cancer ResearchTokyo 135-8550Japan

With the significant advances in cancer genomics using next-generation sequencing technologies,genomic and molecular profilingbased precision medicine is used as a part of routine clinical test for guiding and selecting the most appropriate treatments for individual cancer *** many molecular-targeted therapies for a number of actionable genomic alterations have been developed,the clinical application of such information is still limited to a small proportion of cancer *** this review,we summarize the current status of personalized drug selection based on genomic and molecular profiling and highlight the challenges how we can further utilize the individual genomic *** immunotherapies,including immune checkpoint inhibitors,would be one of the potential approaches to apply the results of genomic sequencing most *** cancer-specific antigens derived from somatic mutations,the so-called neoantigens,occurring in individual cancers have been in focus *** immunotherapies,which target neoantigens,could lead to a precise treatment for cancer patients,despite the challenge in accurately predicting neoantigens that can induce cytotoxic T cells in individual *** prediction of neoantigens should accelerate the development of personalized immunotherapy including cancer vaccines and T-cell receptor-engineered T-cell therapy for a broader range of cancer patients.

关键词： Personalized medicine cancer precision medicine neoantigen personalized immunotherapy immune checkpoint blockade cancer vaccine adoptive T cell therapy

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钢管混凝土KK型节点疲劳性能试验

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交通运输工程学报 2024年第1期24卷 100-116页

作者：吴庆雄罗健平杨益伦陈康明缪承谕中村聖三福州大学土木工程学院福建福州350116 福州大学福建省土木工程多灾害防治重点实验室福建福州350116 福州大学福建省高校工程结构重点实验室福建福州350116 长崎大学工学部长崎长崎852-8521

为研究钢管混凝土KK(CFST-KK)型节点疲劳性能,开展了CFST-KK型节点模型疲劳试验,分析了CFST-KK型节点热点应力分布规律和疲劳性能演化过程;建立了CFST-KK型节点实体有限元模型,结合试验和有限元结果,分析了CFST-KK型节点与钢管混凝土K(C... 详细信息

为研究钢管混凝土KK(CFST-KK)型节点疲劳性能,开展了CFST-KK型节点模型疲劳试验,分析了CFST-KK型节点热点应力分布规律和疲劳性能演化过程;建立了CFST-KK型节点实体有限元模型,结合试验和有限元结果,分析了CFST-KK型节点与钢管混凝土K(CFST-K)型节点疲劳性能的差异性;研究了不同参数对KK型节点疲劳性能影响,探讨了适用于CFST-KK型节点疲劳寿命的评价方法。研究结果表明:采用二次外推方式计算的CFST-KK型节点,最大热点应力位于受拉支管相贯焊缝的主管侧冠点偏外鞍点15°处;计算CFST-KK型节点应力集中系数时,支管名义应力可仅考虑轴力和面内弯矩的影响而不考虑面外弯矩的影响,其应力集中系数为6.36,比CFST-K型节点大80.2%;CFST-KK型节点的疲劳裂纹萌生于最大热点应力处,在反复加载过程中裂纹沿焊趾根部向两侧与主管壁厚方向延伸,裂纹向外鞍点扩展的速度要略快于向内鞍点扩展的速度,停止反复加载后裂纹并未贯穿主管管壁;受支管面外弯矩与支管间空间效应的影响,CFST-KK型节点的抗疲劳性能与CFST-K型节点有明显差异;主管内填混凝土能提升CFST-KK型节点径向刚度,缓解应力集中情况;支管面外夹角增大会增大支管间空间效应的影响;考虑钢管内混凝土影响的CFST-K型节点的热力应力与疲劳寿命曲线在评价CFST-KK型节点疲劳寿命时具有良好的精度。

关键词：桥梁工程钢管混凝土KK型节点疲劳性能试验热点应力应力集中系数疲劳寿命

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The effect of interface roughness on the perpendicular exchange bias of NiO/CoPt/Pt stacking structure

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Science China(Technological Sciences) 2021年第3期64卷 605-610页

作者： GAO Ying HARUMOTO Takashi nakamura Yoshio SHI Ji Department of Materials Science and Engineering Tokyo Institute of Technology2-12-1OokayamaMeguro-kuTokyo 152-8550Japan

An orthogonal coupling structure of NiO/CoPt/Pt/glass with perpendicular exchange bias effect has been *** exchange bias is found to be strongly dependent on the interface roughness between NiO and CoPt *** conventional inverse proportionality of the exchange bias field with the ferromagnetic thickness is not applicable to this top-pinned stacking ***,an anomalous ferromagnetic thickness dependence of blocking temperature is also observed.A simulation on the basis of a spin configuration model with defects at the interface agrees well with the experimental *** findings suggest considerable contribution of the interface roughness to the perpendicular exchange bias.

关键词： perpendicular exchange bias interface roughness FM thickness blocking temperature

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Helicobacter pylori and gastric mucosa-associated lymphoid tissue lymphoma:Recent progress in pathogenesis and management

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World Journal of Gastroenterology 2013年第45期19卷 8181-8187页

作者： Shotaro nakamura Takayuki Matsumoto Department of R/D for Surgical Support System Center for Advanced Medical Innovation Kyushu University Fukuoka 812-8582 Japan Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu UniversityFukuoka 812-8582 Japan Division of Gastroenterology Department of Internal Medicine Iwate Medical University Morioka 020-8505 Japan

Recent progress in the research regarding the molecular pathogenesis and management of gastric mucosa-associated lymphoid tissue (MALT) lymphoma is reviewed. In approximately 90% of cases, Helicobacter pylori (H. pylori) infection plays the causative role in the pathogenesis, and H. pylori eradication is nowadays the first-line treatment for this disease, which leads to complete disease remission in 50%-90% of cases. In H. pylori-dependent cases, microbe-generated immune responses, including interaction between B and T cells involving CD40 and CD40L co-stimulatory molecules, are considered to induce the development of MALT lymphoma. In H. pylori-independent cases, activation of the nuclear factor-κB pathway by oncogenic products of specific chromosomal translocations such as t(11;18)/API2-MALT1, or inactivation of tumor necrosis factor alpha-induced protein 3 (A20) are considered to contribute to the lymphomagenesis. Recently, a large-scale Japanese multicenter study confirmed that the long-term clinical outcome of gastric MALT lymphoma after H. pylori eradication is excellent. Treatment modalities for patients not responding to H. pylori eradication include a “watch and wait” strategy, radiotherapy, chemotherapy, rituximab immunotherapy, and a combination of these. Because of the indolent behavior of MALT lymphoma, second-line treatment should be tailored in consideration of the clinical stage and extent of the disease in each patient.

关键词： Gastric lymphoma, Mucosa-associated lymphoid tissue lymphoma, Helicobacter pylori, Nuclear factor κ B

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Miniaturization of Bubbles by Shock Waves in Gas-Liquid Two-phase Flow in the Venturi Tube

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Journal of Thermal Science 2021年第3期30卷 1068-1076页

作者： JIANG Xin YASUNOBU Tsuyoshi nakamura Arisa SHIMAZU Masaki National Institute of Technology Kitakyushu College KitakyushuFukuoka 802-0985Japan

Fine bubbles have been widely applied in many fields such as industry,medical engineering and ***,many attentions have been paid to the study of fine bubble generations in order to increase the yield while decrease the ***,the generation process of fine bubbles is a quite complicated process in which multiple hydrodynamic forces are interacted in the gas-liquid two-phase *** studies focus on the techniques of the converging-diverging nozzle(venturi tube)generator,which is famous for its simple and cheap features,and generates fine bubbles by using the miniaturization phenomenon of bubbles occurring in the venturi ***,the impact conditions on the amount and size of bubbles such as nozzle geometry and bleed air haven’t been investigated *** this work,we implement many experiments on the venturi tube fine bubble generators with different geometries and generating conditions,and evaluate different factors impacting the production components such as the volume and the bubble *** experimental results show that the supersonic flow filed in the venturi tube promotes the miniaturization of the bubbles,and the convergent angle of the nozzle and air bleed have a great impact on the size and volume of bubbles.

关键词： fine bubble shock wave gas-liquid two-phase flow venturi tube

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Large deformation simulations of geomaterials using moving particle semi-implicit method

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第6期10卷 1122-1132页

作者： Shintaro Nohara Hiroshi Suenaga Kunihiko nakamura Central Research Institute of Electric Power Industry ChibaJapan

Numerical simulation tools are required to describe large deformations of geomaterials for evaluating the risk of geo-disasters. This study focused on moving particle semi-implicit(MPS) method, which is a Lagrangian gridless particle method, and investigated its performance and stability to simulate large deformation of geomaterials. A calculation method was developed using geomaterials modeled as Bingham fluids to improve the original MPS method and enhance its stability. Two numerical tests showed that results from the improved MPS method was in good agreement with the theoretical ***, numerical simulations were calibrated by laboratory experiments. It showed that the simulation results matched well with the experimentally observed free-surface configurations for flowing sand. In addition, the model could generally predict the time-history of the impact force. The MPS method could be a useful tool to evaluate large deformation of geomaterials.

关键词： Particle method Moving particle semi-implicit(MPS) method Large deformation analysis Geomaterials Bingham model

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