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Environmental levels and toxicological potencies of a novel mixed halogenated carbazole

Emerging Contaminants 2016年第3期2卷 166-172页

作者： miren pena-abaurrea Matthew Robson Sri Chaudhuri Nicole Riddell Robert McCrindle Brock Chittim Robert Parette Un-Ho Jin Stephen Safe David Poirier Ralph Ruffolo Richard Dyer Rachael Fletcher Paul A..Helm Eric J.Reiner Department of Analysis CEPSA Research CenterAlcala de Henares28805Spain Department of Chemistry University of TorontoTorontoONM5S 3H6Canada Ontario Ministry of the Environment and Climate Change TorontoONM9P 3V6Canada Conservation Ontario NewmarketONL3Y 2P5Canada Department of Chemistry Brock UniversitySt.CatharinesONL2S 3A1Canada Wellington Laboratories Inc. GuelphONN1G 3M5Canada Department of Chemistry University of GuelphGuelphONN1G 2W1Canada Matson&Associates Inc.State CollegePA16801USA Veterinary Medicine&Biomedical Sciences Texas A&M UniversityTexasTX77843e4461USA Ministry of Northern Development and Mines SudburyONP3E 6B5Canada School of the Environment University of TorontoONM5S 3EBCanada

The present work involves an extensive analytical and toxicological description of a recently identified mixed halogenated carbazole found in sediment samples,1,8-dibromo-3,6-dichloro-9H-carbazole(BCCZ).Concentrations and the relative effect potency(REP)were calculated for the target BCCZ in a set of stream sediments collected in 2008 in Ontario,*** levels calculated for BCCZ as compared to those previously assessed for legacy persistent organic pollutants(POPs)in the same samples revealed a significant contribution of BCCZ to the total organic chemical contamination(<1%e95%;average 37%).The corresponding dioxin toxic equivalencies(TEQs)of BCCZ in the sediment extracts were estimated from experimental REP *** experimental data presented supports the classification of this emerging halogenated chemical as a contaminant of emerging environmental *** potential emission sources could not be identified,this study highlights the importance of on-going research for complete characterization of halogenated carbazoles and related compounds.

关键词： Halogenated carbazoles Levels GC×GC REP TEQ Dioxin-like Risk assessment Regulation

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Cannabinoid Modulation of Monoamine Levels in Mouse Brain:Unveiling Neurochemical Dynamics through an Innovative High-performance Liquid Chromatography-Fluorescence Detection Bioanalysis

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Journal of Analysis and Testing 2024年第3期8卷 300-314页

作者： Fonseca Carla Cunha Susana Ferreira Ricardo Lapo Pais Mariana Gon?alves Joana Camins Antoni Ettcheto miren Barbosa Rui Fortuna Ana Laboratory of Pharmacology Faculty of Pharmacy University of Coimbra CIBIT/ICNAS-Coimbra Institute for Biomedical Imaging and Translational Research University of Coimbra Department of Pharmacology Toxicology and Therapeutic Chemistry Faculty of Pharmacy and Food ScienceUniversitat de Barcelona Institute of Neurosciences Universitat de Barcelona CIBIT/ICNAS-Coimbra Institute for Biomedical Imaging and Translational Research University of Coimbra Faculty of Sciences and Technology Doctoral Program in Biomedical Engineering University of Coimbra Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED) Carlos Ⅲ Health Institute Institut d’Investigació Sanitària Pere Virgili (IISPV) CNC-Center for Neuroscience and Cell Biology University of Coimbra

Homeostasis of monoaminergic pathways is compromised in aging and neurodegenerative/neurological diseases such as Alzheimer's disease and depression. On the other hand, their modulation has also been linked to the mechanism of action of several drugs. Therefore, monitoring the levels of noradrenaline(NA), adrenaline(AD), dopamine(DA), and serotonin(5-HT), as well as those of tryptophan(TRYP), the precursor of 5-HT, and DA metabolites, namely 3,4-dihydroxyphenylaceticacid(DOPAC) and homovanillicacid(HVA), is fundamental for assessing disease severity and progression. This work aimed to develop and validate the first High-Performance Liquid Chromatography(HPLC) coupled with fluorescence detector(FLD) method that simultaneously and accurately quantifies NA, AD, DA, DOPAC, HVA, 5-HT and TRYP in mouse brain and prefrontal cortex(PFC) matrices. Previous sample preparation by protein precipitation was required to extract the compounds. Calibration curves were plotted using the background subtraction approach to reduce the interference of the endogenous analytes. Intra and inter-day accuracy and precision were within the ranges defined by ICH(The International Council for Harmonisation) guideline for bioanalytical method validation. Following validation, the impact of cannabidiol(CBD), cannabigerol(CBG), and cannabidivarin(CBDV) was explored in mice brains post-administration,revealing significant alterations in specific neurotransmitter levels upon cannabinoid exposure and shedding light on the complex modulation of neurochemical dynamics by cannabinoids. This research highlights the fit-for-purpose of the HPLC-FLD method and provides insights into potential mechanisms underlying phytocannabinoid actions in the central nervous system(CNS).

关键词： Brain Cannabinoid HPLC Mice Neurotransmitter Prefrontal cortex

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Competitive effect, but not competitive response, varies along a climatic gradient depending on tree species identity

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Forest Ecosystems 2024年第2期11卷 142-151页

作者： Teresa Valor Lluís Coll David I.Forrester Hans Pretzsch miren del Río Kamil Bielak Bogdan Brzeziecki Franz Binder Torben Hilmers Zuzana Sitková Roberto Tognetti Aitor Ameztegui Department of Agricultural and Forest Sciences and Engineering(DCEFA) University of LleidaAv.Alcalde Rovira Roure 191E25198 LleidaSpain Joint Research Unit CTFC-AGROTECNIO-CERCA Ctra.Sant LlorençKm.225280SolsonaSpain Swiss Federal Institute of Forest Snow and Landscape Research WSLZürcherstrasse 1118903BirmensdorfSwitzerland CSIRO Land and Water GPO Box 1700CanberraACT2601Australia Chair of Forest Growth and Yield Science School of Life Sciences WeihenstephanTechnical University of MunichHans-Carl-Von-Carlowitz-Platz 285354FreisingGermany Forest Research Center INIA-CSICCtra.A Coruña Km 7.528040MadridSpain IuFOR Sustainable Forest Management Research InstituteUniversity of Valladolid&INIASpain Department of Silviculture Institute of Forest SciencesWarsaw University of Life SciencesNowoursynowska 159/3402776WarsawPoland Bavarian State Institute of Forestry(LWF) Hans-Carl-von-Carlowitz-Platz 1D-85354FreisingGermany National Forest Centre Forest Research InstituteT.G.Masaryka 2296001ZvolenSlovakia Faculty of Agricultural Environmental and Food SciencesFree University of Bozen-Bolzano Piazza Università1 I-39100Bolzano

Background: Understanding the role of species identity in interactions among individuals is crucial for assessing the productivity and stability of mixed forests over time. However, there is limited knowledge concerning the variation in competitive effect and response of different species along climatic gradients. In this study, we investigated the importance of climate, tree size, and competition on the growth of three tree species: spruce(Picea abies), fir(Abies alba), and beech(Fagus sylvatica), and examined their competitive response and effect along a climatic ***: We selected 39 plots distributed across the European mountains with records of the position and growth of 5,759 individuals. For each target species, models relating tree growth to tree size, climate and competition were proposed. Competition was modelled using a neighbourhood competition index that considered the effects of inter-and intraspecific competition on target trees. Competitive responses and effects were related to *** methods and information theory were used to select the best ***: Our findings revealed that competition had a greater impact on target species growth than tree size or climate. Climate did influence the competitive effects of neighbouring species, but it did not affect the target species? response to competition. The strength of competitive effects varied along the gradient, contingent on the identity of the interacting species. When the target species exhibited an intermediate competitive effect relative to neighbouring species, both higher inter-than intraspecific competitive effects and competition reduction occurred along the gradient. Notably, species competitive effects were most pronounced when the target species' growth was at its peak and weakest when growing conditions were far from their ***: Climate modulates the effects of competition from neighbouring trees on the target tree and not the susceptibility of th

关键词： Competition coefficient Competition reduction Interspecific competition Intraspecific competition Mixing effects Mixed species forest Neighbourhood models Plant-plant interactions

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The Iberian Roma Population Variant Server(IRPVS)

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Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana María Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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Potential preventive disease-modifying pharmacological strategies to delay late onset Alzheimer’s disease

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Neural Regeneration Research 2019年第10期14卷 1721-1725页

作者： miren Ettcheto Oriol Busquets Antoni Camins Departament de Farmacologia Toxicologia i Química TerapèuticaFacultat de Farmàcia i Ciències de l’AlimentacióUniversitat de BarcelonaBarcelonaSpain Departament de Bioquímica i Biotecnologia Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain Institut de Neurociències Universitat de BarcelonaBarcelonaSpain Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED) MadridSpain

Alzheimer’s disease(AD)is a progressive neurodegenerative disease that was histopathologically characterized in the brain by the presence of extracellular senile plaques made of amyloid β peptides and intracellular neurofibrillary tangles composed of hyperphosphorylated Tau *** the years,AD has been classified in two subgroups:early onset or familial AD and late onset or sporadic *** the one hand,familial AD has been described to be the result of genetic mutations that cause,in some cases,for the overproduction of amyloid β.On the other,the cause of late onset or sporadic AD is still unclear even though several hypotheses have been proposed to explain the process of severe and progressive memory and cognitive *** the present review,some of the current hypotheses that try to explain the origin of late onset or sporadic AD have been ***,their potential implication in the development of new drugs for the presymptomatic treatment of late onset or sporadic AD has been considered.

关键词： Alzheimer's disease beta-secretase neuroinflammation Tau amyloid N-methyl-D-aspartate glutamate

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Implications of denitrification in the ecological status of an urban river using enzymatic activities in sediments as an indicator

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Journal of Environmental Sciences 2019年第1期31卷 255-268页

作者： Jessica Unda-Calvo miren Martínez-Santos Estilita Ruiz-Romera Juan Luis Lechuga-Crespo Department of Chemical and Environmental Engineering University of the Basque Country

A better understanding of the effects of a number of environmental factors on denitrification is vital for analyzing its role as nitrogen sink and providing deeper knowledge about the ecological status of a nitrate-rich ecosystem. Since few studies have addressed the occurrence and implications of denitrification in river sediments, and complexity of interactions among all these environmental factors makes comprehension of the process difficult, the potential of sediments from the Deba River to attenuate nitrate excess through denitrification was investigated. For this purpose, we adapted an in vitro method to measure activities of two enzymes contributing to the entire multiple-step nitrate reduction: Nitrate Reductase and Nitrite Reductase. The environmental features that influence both or single enzymatic activities were identified as oxygen availability,regulated directly by the moisture content or indirectly through the aerobic respiration,organic matter and nitrate content of sediments, and electrical conductivity and exchangeable sodium percentage of water. Additionally, our results showed that Nitrate Reductase catalyzes the principal limiting step of denitrification in sediments. Therefore,taking this enzymatic activity as an indicator, the southern part of the Deba River catchment presented low potential to denitrify but nitrate-limited sediments, whereas the middle and northern parts were characterized by high denitrification potential but nitraterich sediments. In general, this study on denitrifying enzymatic activities in sediments evaluates the suitability of the management of the effluents from wastewater treatment plants and municipal sewages to ensure a good ecological status of the Deba River.

关键词： Urban catchment Sediments Denitrification Enzymatic activity Ecological status

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Stand-level biomass models for predicting C stock for the main Spanish pine species

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Forest Ecosystems 2021年第2期8卷 387-402页

作者： Ana Aguirre miren del Río Ricardo Ruiz-Peinado Sonia Condés Department of Natural Systems and Resources School of Forest Engineering and Natural ResourcesUniversidad Politécnica de MadridMadridSpain INIA Forest Research CenterDepartment of Forest Dynamics and ManagementMadridSpain iuFOR Sustainable Forest Management Research InstituteUniversity of Valladolid and INIAValladolidSpain

Background:National and international institutions periodically demand information on forest indicators that are used for global *** other aspects,the carbon accumulated in the biomass of forest species must be *** this purpose,one of the main sources of data is the National Forest Inventory(NFI),which together with statistical empirical approaches and updating procedures can even allow annual estimates of the requested ***:Stand level biomass models,relating the dry weight of the biomass with the stand volume were developed for the five main pine species in the Iberian Peninsula(Pinus sylvestris,Pinus pinea,Pinus halepensis,Pinus nigra and Pinus pinaster).The dependence of the model on aridity and/or mean tree size was explored,as well as the importance of including the stand form factor to correct model ***,the capability of the models to estimate forest carbon stocks,updated for a given year,was also ***:The strong relationship between stand dry weight biomass and stand volume was modulated by the mean tree size,although the effect varied among the five pine *** humidity,measured using the Martonne aridity index,increased the biomass for a given volume in the cases of Pinus sylvestris,Pinus halepensis and Pinus *** that consider both mean tree size and stand form factor were more accurate and less biased than those that do *** models developed allow carbon stocks in the main Iberian Peninsula pine forests to be estimated at stand level with biases of less than 0.2 Mg·ha^(-1).Conclusions:The results of this study reveal the importance of considering variables related with environmental conditions and stand structure when developing stand dry weight biomass *** described methodology together with the models developed provide a precise tool that can be used for quantifying biomass and carbon stored in the Spanish pine forests in specific years when no field data are available.

关键词： Martonne aridity index Dry weight biomass Carbon stock National Forest Inventory Peninsular pine forest Biomass expansion factor

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泥质含量对隧道断层破碎带注浆加固体的力学性能影响试验研究

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电力学报 2024年第3期39卷 264-271页

作者：戎密仁庞银萍马骁耿东阳冯超河北地质大学城市地质与工程学院石家庄050031 河北省地下人工环境智慧开发与管控技术创新中心石家庄050031 石家庄职业技术学院石家庄050087 大连交通大学国际教育学院辽宁大连116028

为研究隧道断层破碎带注浆加固体中泥质含量对其加固效果的影响,根据泥质体积与试件体积占比制备不同泥质含量的试件,通过单轴压缩试验分析其力学性质,利用高速摄像技术记录压缩过程中试件裂纹演化规律,并从裂纹扩展角度探讨泥质体积含... 详细信息

为研究隧道断层破碎带注浆加固体中泥质含量对其加固效果的影响,根据泥质体积与试件体积占比制备不同泥质含量的试件,通过单轴压缩试验分析其力学性质,利用高速摄像技术记录压缩过程中试件裂纹演化规律,并从裂纹扩展角度探讨泥质体积含量对加固体强度的影响原因。研究表明:(1)加固体的强度并非是泥质含量越少就越高,单轴抗压强度最大值为泥质体积占试件体积1/4时。(2)加固体试件破坏过程可分为2个阶段,①无贯穿骨料产生阶段,此时裂纹扩展路径和总长度与抗压强度呈正相关;②贯穿裂纹产生阶段,贯穿骨料裂纹总长度与抗压强度呈正相关,与裂纹总长度相关性很小。

关键词：断层破碎带注浆加固体力学性能变化规律泥质含量

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Hitting a moving target:inhibition of the nuclear export receptor XPO1/CRM1 as a therapeutic approach in cancer

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Cancer Drug Resistance 2018年第3期1卷 139-163页

作者： Maria Sendino miren Josu Omaetxebarria Jose Antonio Rodríguez Department of Genetics Physical Anthropology and Animal PhysiologyUniversity of the Basque Country(UPV/EHU)Leioa48940Spain. Department of Biochemistry and Molecular Biology University of the Basque Country(UPV/EHU)Leioa 48940Spain

Cellular homeostasis crucially relies on the correct nucleocytoplasmic distribution of a vast number of proteins and RNA molecules,which are shuttled in and out of the nucleus by specialized transport *** nuclear export receptor XPO1,also called CRM1,mediates the translocation of hundreds of proteins and several classes of RNA to the cytoplasm,and thus regulates critical signaling pathways and cellular *** normal function of XPO1 appears to be often disrupted in malignant cells due to gene mutations or,most commonly,aberrant *** to its important physiological roles and its frequent alteration in human tumors,XPO1 is a promising target for cancer ***1 inhibitors have undergone extensive testing as therapeutic agents in preclinical models of cancer,with promising *** of these inhibitors,Selinexor,is currently being evaluated in multiple clinical trials of different types of solid tumors and hematological ***,we review several key aspects of XPO1 function,as well as the mechanisms that may lead to its alteration in cancer,and provide an update on the status of XPO1 inhibitors being developed as drugs for cancer therapy,including the definitive results of the first clinical trials with Selinexor that have been recently published.

关键词： XPO1 CRM1 nucleocytoplasmic transport Selinexor

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AASLD practice guidance on drug,herbal,and dietary supplement-induced liver injury:also useful for hepatobiliary surgeons

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 746-751页

作者： Jose María Pinazo-Bandera miren García-Cortés Raúl J.Andrade Service of Gastroenterology and Hepatology University Hospital Virgen de la VictoriaInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BionandUniversidad de MálagaMálagaSpain Centro de Investigación Biomédico en Red Enfermedades Hepáticas y Digestivas(CIBERehd) MadridSpain

Drug-induced liver injury(DILI)is a term used to describe an unexpected liver reaction to drugs,but also to herbal products and dietary supplements(HDS).In the current therapeutic armamentarium,only a small number of available drugs are still capable of causing liver damage in *** include,in addition to paracetamol-the prototypical example of this group-niacin(now rarely used to treat hypercholesterolaemia),intravenous methotrexate and probably ketamine(an intravenous hypnotic used in critically ill patients for rapid sequence induction)(1).

关键词： Drug-induced liver injury(DILI) hepatotoxicity causality assessment Revised Electronic Causality Assessment Method(RECAM)

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