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基于TMT技术的香芹酚和丁香酚杀螨机制分析

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黑龙江畜牧兽医 2024年第6期 72-79页

作者：封申瑞李美林师敏敏黄思怡方芳广西大学动物科学技术学院南宁530003 陆军军医大学基础医学院重庆400038

为了探究香芹酚和丁香酚的杀螨机制,试验首先设置香芹酚组、丁香酚组和阴性对照组共3组,每组3个重复,香芹酚组、丁香酚组和阴性对照组分别用0.15%丁香酚、0.05%香芹酚和液体石蜡处理疥螨4 h后提取疥螨蛋白质,蛋白质经还原烷基化、酶解... 详细信息

为了探究香芹酚和丁香酚的杀螨机制,试验首先设置香芹酚组、丁香酚组和阴性对照组共3组,每组3个重复,香芹酚组、丁香酚组和阴性对照组分别用0.15%丁香酚、0.05%香芹酚和液体石蜡处理疥螨4 h后提取疥螨蛋白质,蛋白质经还原烷基化、酶解及串联质谱标记(tandem mass tag, TMT)后进行高效液相色谱分离和液相色谱串联质谱分析;然后对香芹酚组/阴性对照组及丁香酚组/阴性对照组的差异表达蛋白进行分析,并对差异表达蛋白进行GO功能富集分析和KEGG信号通路富集分析;最后筛选与香芹酚、丁香酚杀螨相关的差异表达蛋白。结果表明:香芹酚组/阴性对照组共有蛋白4 692个,其中差异表达蛋白235个(上调蛋白113个,下调蛋白122个);丁香酚组/阴性对照组共有蛋白4 824个,其中差异表达蛋白103个(上调蛋白43个,下调蛋白60个)。香芹酚组/阴性对照组差异表达蛋白极显著富集(P<0.01)的GO二级条目包括平滑信号通路、从细胞核输出的蛋白质调节、氧化磷酸化等;显著富集(P<0.05)的GO二级条目包括核质转运的调节、细胞内蛋白质运输的调节、甘油酯生物合成过程等。丁香酚组/阴性对照组差异表达蛋白极显著富集(P<0.01)的GO二级条目包括tRNA修饰、ncRNA处理;显著富集(P<0.05)的GO二级条目包括细胞酰胺代谢过程、正向调节蛋白定位到细胞核、含蝶啶化合物分解代谢过程等。香芹酚组/阴性对照组差异表达蛋白显著富集(P<0.05)的KEGG信号通路包括α-亚麻酸代谢、卟啉与叶绿素代谢、癌症蛋白聚糖等。丁香酚组/阴性对照组差异表达蛋白显著富集(P<0.05)的KEGG信号通路包括核糖体、军团杆菌病。与香芹酚杀螨机制相关的GO二级条目为氧化磷酸化,磷脂酰甘油磷酸合成酶和细胞色素C氧化酶亚基1注释到这一过程中;与阴性对照组比较,香芹酚组的磷脂酰甘油磷酸合成酶显著上调(P<0.05),细胞色素C氧化酶亚基1显著下调(P<0.05)。与丁香酚杀螨机制相关的KEGG信号通路为核糖体,核糖体L23蛋白60S亚基、核糖体L32蛋白39S亚基、核糖体L3蛋白39S亚基、核糖体S16蛋白28S亚基、核糖体L1蛋白39S亚基注释到这一KEGG信号通路中;与阴性对照组比较,丁香酚组的上述蛋白均显著下调(P<0.05)。说明香芹酚杀螨机制与氧化磷酸化这一过程相关,丁香酚杀螨机制与核糖体蛋白表达相关。

关键词：疥螨香芹酚丁香酚蛋白质组学串联质谱标记(TMT)

Crystal Growth and Characterization of Fluorinated Perylene Diimides

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Chemical Research in Chinese Universities 2014年第1期30卷 63-67页

作者： HUANG Jiachi LI Hanying MO Xiong shi minmin WANG Mang CHEN Hongzheng State Key Laboratory of Silicon Materials Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of Education Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 P. R. China

One-dimensional crystals of fluorinated perylene diimides were achieved by the self-assembly of them via solvent-nonsolvent *** π-conjugated fluorinated perylene diimides were assembled into highly-ordered nanostructures of well-defined morphologies in organic solvents due to the π-π interaction between the aromatic *** was found that with more introduced F atoms,perylene diimides showed remarkably improved solubility and thus were much easier to grow into crystals,due to the increased polarity induced by the strong electron-withdrawing F *** importantly,single crystal of N,N＇-diperfluorophenyl-3,4,9,10-perylenetetracarboxylic diimide（DPFPP）was obtained,and the unit cell-dimensions of triclinic structure were determined by the selected area electron diffraction（SAED） pattems to be a=0.712 nm,b=1.072 nm,c=2.914 nm,a=97.0°,β=89.6°,γ=93.4°.Owing to most of the longest c-axis orienting nearly vertically to the long axis of the needle crystal,the molecular planes are expected to be vertical to the needle axis.

关键词： Perylene diimide Fluorination Crystal growth

Design of Non-fused Ring Acceptors toward High-Performance,Stable,and Low-Cost Organic Photovoltaics

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Accounts of Materials Research 2022年第6期3卷 644-657页

作者： Qing Shen Chengliang He Shuixing Li Lijian Zuo minmin shi Hongzheng Chen State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationInternational Research Center for X PolymersDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027P.R.China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Hangzhou 310027P.R.China

Toward future commercial applications of organic solar cells(OSCs),organic photovoltaic materials that enable high efficiency,excellent stability,and low cost should be ***-ring electron acceptors(FREAs)have declared that OSCs are capable of showing efficiencies over 19%,whereas stability and cost are not solved *** the counterparts of FREAs,non-fused ring electron acceptors(NFREAs)are more flexible in molecular *** have better stability because of the reduction of intramolecular tension via breaking fused backbone and have more advantages in cost with the reduction of synthetic ***,the challenge for NFREAs is the relatively lower efficiencies(around 15%at current stage),which require better molecular designs for addressing the issues of conformational unicity and effective molecular *** this Account,we comprehensively summarize works about NFREAs carried out in our group from three main frameworks,including molecular design and efficiency optimization,material cost,and ***,in the part of molecular design and efficiency optimization,the existing rotatable single bond in NFREAs will bring the problem of conformational uncertainty,but it can be solved through proper molecular design,which also regulates the energy levels,light absorption range,and the packing mode of the molecule for obtaining higher ***,in this part,we discuss the evolution of NFREAs in three aspects,including molecular skeleton optimization,terminal modification,and side chain *** strategies are used in the design of a molecular skeleton,such as utilizing the quinoid effect,introducing functional groups with the electron push−pulling effect,and using multiple conformational ***,simplifying the skeleton is also the preferred development *** for the terminal,the main modification strategy is adjusting the conjugation length and halogen *** is more,by adjusting the side chain to induce appropr

关键词： stability fused stability

Efficient and 1,8-diiodooctane-free ternary organic solar cells fabricated via nanoscale morphology tuning using small-molecule dye additive

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Nano Research 2017年第11期10卷 3765-3774页

作者： Shuhua Zhang Muhammad Naeem Shah Feng Liu Zhongqiang Zhang Qin Hu Thomas P. Russell minmin shi Chang-Zhi Li Hongzheng Chen MOE Key Laboratory of Macromolecular Synthesis and Functionalization State Key Laboratory of Silicon Materials Department of Polymer Science amp Engineering Zhejiang University Hangzhou 310027 China Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai 200240 China Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA

The ternary strategy for incorporating multiple photon-sensitive components into a single junction has emerged as an effective method for optimizing the nanoscale morphology and improving the device performance of organic solar cells （OSCs）.In this study,efficient and stable ternary OSCs were achieved by introducing the small-molecule dye （5E,5＆#39;E）-5,5＆#39;-（4＆#39;,4″-（1,2-diphenylethene-1,2-diyl）bis（biphenyl-4＆#39;,4-diyl））bis（methan-1-yl-1-ylidene）bis（3-ethyl-2-thioxothia zolidin-4-one）（BTPERn） into poly[4,8-bis（5-（2-ethylhexyl）thiophen-2-yl）benzo[1,2-b：4,5-b＆#39;]dithiopheneco-3-fluorothieno[3,4-b]thiophene-2-carboxylate] （PTB7-Th）：[6,6]-phenyl C71 butyric acid methyl ester （PC71BM） blend films processed using a 1,8-diiodooctane （DIO）-free *** incorporation of BTPE-Rn enhanced the short-circuit current density and fill factor of the ternary OSCs compared with those of binary *** investigation of the optical,electronic,and morphological properties of the ternary blends indicated that the third component of BTPE-Rn not only promoted the photon utilization of blends through the energy-transfer process but also improved the electron mobility of the blends owing to the fullerene-rich nanophase *** importantly,this ternary strategy of utilizing a small-molecule dye to replace the photounstable DIO additive enhanced the operational stability of the OSCs.

关键词： ternary organic solar cell energy transfer mobility 1 8-diiodooctane (DIO)-free

A non-fullerene acceptor enables efficient P3HT-based organic solar cells with small voltage loss and thickness insensitivity

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Chinese Chemical Letters 2019年第6期30卷 1277-1281页

作者： Ning Wang Weitao Yang Shuixing Li minmin shi Tsz-Ki Lau Xinhui Lu Rafi shikler Chang-Zhi Li Hongzheng Chen MOE Key Laboratory of Macromolecular Synthesis and Functionalization State Key Laboratory of Silicon Materials Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China Department of Physics The Chinese University of Hong Kong Hong Kong 999077 China Department of Electrical and Computer Engineering Ben-Gurion University of the Negev Beer-Sheva 8410501 Israel

Poly(3-hexylthiophene)(P3HT) is a low-cost polymer donor for organic solar cells (OSCs). However, the P3HT-based OSCs usually give low power conversion efficiencies (PCEs) due to the wide bandgap and the high-lying energy levels of P3HT. To solve this problem, in this work, we design and synthesize a new A-D-A type non-fullerene acceptor, DFPCBR, which owns an electron-donating (D) core constructed by linking a 2,5-difluorobenzene ring with two cyclopentadithiophene moieties, and two electron-accepting (A) end-groups of benzo[c][1,2,5]thiadiazole connected with 3-ethyl-2-thioxothiazolidin-4-one. Because of the strong electron-donating ability and large conjugation effect of D core, DFPCBR shows appropriate energy levels and a narrow bandgap matching well with those of P3HT. Therefore, with P3HT as the donor and DFPCBR as the acceptor, the OSCs possess broad absorption range from 350 nm to 780 nm and the reduced energy loss (Eloss) of 0.79 eV (compared with ~1.40 eV for the P3HT:PC61BM device), providing a good PCE of 5.34% with a high open-circuit voltage (VOC) of 0.80 V. Besides, we observe that the photovoltaic performances of these devices are insensitive to the thickness of the active layers:even if the active layer is as thick as 320 nm,~80%of the best PCE is maintained, which is rarely reported for fullerene-free P3HT-based OSCs, suggesting that DFPCBR has the potential application in commercial OSCs in the future.

关键词： Poly(3-hexylthiophene) Non-fullerene acceptors Organic solar cells Energy loss Thickness insensitivity

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论莫尔特曼的上帝观典范

宗教学研究 2005年第3期 67-71页

作者：石敏敏浙江工商大学

本文讨论了莫尔特曼的经世三一的上帝观典范。作者从莫尔特曼与拉纳的上帝观神学的关系出发,指出莫尔特曼的理论意图在于从新教的十字架神学出发来消解拉纳理论中所包含的内在三一和经世三一的张力。莫尔特曼的上帝观旨在于塑造一个“... 详细信息

本文讨论了莫尔特曼的经世三一的上帝观典范。作者从莫尔特曼与拉纳的上帝观神学的关系出发,指出莫尔特曼的理论意图在于从新教的十字架神学出发来消解拉纳理论中所包含的内在三一和经世三一的张力。莫尔特曼的上帝观旨在于塑造一个“位格关系”中的上帝受苦的真实性,凸显上帝的“为我们”的特征。以此为基点,作者探讨了莫尔特曼对于基督教上帝观传统的批评,以及他的贡献所在。

关键词：经世三一内在三一位格关系受苦

内在三一和经世三一--论卡尔·巴特和T.F.托伦斯的三位一体神学

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宗教学研究 2008年第1期 122-126页

作者：石敏敏浙江工商大学公共管理学院副教授

本文讨论了现代基督教三位一体神学的巴特和托伦斯的基本框架。从三个方面阐释了其上帝观的基本(1)自我启示的上帝与内在三一/经世三一的关系;(2)内在三一/经世三一和homoousia(本质同一)的关系;(3)现代基督教上帝观与古典基督教上帝观... 详细信息

本文讨论了现代基督教三位一体神学的巴特和托伦斯的基本框架。从三个方面阐释了其上帝观的基本(1)自我启示的上帝与内在三一/经世三一的关系;(2)内在三一/经世三一和homoousia(本质同一)的关系;(3)现代基督教上帝观与古典基督教上帝观的视界融合。

关键词：内在三一经世三一本质同一

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氟代苝酰亚胺掺杂聚噻吩薄膜的光伏性能

太阳能学报 2006年第6期27卷 525-529页

作者：施敏敏陈红征汪茫浙江大学高分子科学与工程学系

将两种新型有机n型材料N,N’—二(五氟代苯基)—3,4,9,10—四羧基二酰亚胺(DFPP)和N,N’—二(1,1—二氢十五氟代辛基)—3,4,9,10—四羧基二酰亚胺(DFOP),分别与有机p型材料———聚(3—己基噻吩)(P3HT)共混,制备有机太阳电池。结果发现,... 详细信息

将两种新型有机n型材料N,N’—二(五氟代苯基)—3,4,9,10—四羧基二酰亚胺(DFPP)和N,N’—二(1,1—二氢十五氟代辛基)—3,4,9,10—四羧基二酰亚胺(DFOP),分别与有机p型材料———聚(3—己基噻吩)(P3HT)共混,制备有机太阳电池。结果发现,当DFPP或DFOP的含量很少(1 wt%)时,氟代酰亚胺可以作为电子受体,通过与聚噻吩之间有效的光致电荷转移作用,提高有机太阳电池的光电流,但使光电压下降;当氟代酰亚胺与P3HT的比例为1:1(重量比)时,有机太阳电池的光电流和光电压都下降。

关键词：苝酰亚胺氟代作用聚噻吩掺杂有机太阳电池光伏效应光致电荷转移

Recent development of organic electron transport materials

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Progress in Natural Science:Materials International 2003年第2期 3-9页

作者： YE Jian, CHEN Hongzheng, shi minmin and WANG Mang(Department of Polymer Science & Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China) Department of Polymer Science & Engineering State Key Laboratory of Silicon Materials Zhejiang University Hangzhou 310027 China

Abstract This article reviews the recent development of organic electron transport materials applied in the fields of organic photo-conductors, light-emitting diodes, field-effect transistors and solar cells. Several technologies for charge carrer mobility measurement aresummarized and compared, and a series of basic pareiples for designing high-performance organic electron transport materials are suggestedas well.

关键词： electron transport charge carrier mobility organic semiconductors.