检索结果-南通市图书馆

Low-frequency Stimulation at the Subiculum Prevents Extensive Secondary Epileptogenesis in Temporal Lobe Epilepsy

Neuroscience Bulletin 2024年第5期40卷 564-576页

作者： Yujia Shen Yiwei Gong Xiaoli Da Shajing Gao Shuo Zhang minjuan sun Yuanzhi Yang Xiaoyun Qiu Menghan Li Yang Zheng Fan Fei Yi Wang Zhong Chen Cenglin Xu Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou310053China Institute of Pharmacology and Toxicology NHC and CAMS Key Laboratory of Medical NeurobiologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Department of Neurology First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310003China Department of Pharmacy The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310003China

Secondary epileptogenesis is characterized by increased epileptic susceptibility and a tendency to generate epileptiform activities outside the primary *** is one of the major resultants of pharmacoresistance and failure of surgical outcomes in epilepsy,but still lacks effective ***,we aimed to test the effects of low-frequency stimulation(LFS)at the subiculum for secondary epileptogenesis in a mouse ***,secondary epileptogenesis was simulated at regions both contralateral and ipsilateral to the primary focus by applying successive kindling *** kindled at the right CA3 showed higher seizure susceptibilities at both the contralateral CA3 and the ipsilateral entorhinal cortex and had accelerated kindling processes compared with naive *** at the ipsilateral subiculum during the primary kindling progress at the right CA3 effectively prevented secondary epileptogenesis at both the contralateral CA3 and the ipsilateral entorhinal cortex,characterized by decreased seizure susceptibilities and a retarded kindling process at those secondary *** application along with the primary epileptogenesis was ***,the effects of LFS on secondary epileptogenesis were associated with its inhibitory effect at the secondary focus through interfering with the enhancement of synaptic connections between the primary and secondary *** results imply that LFS at the subiculum is an effective preventive strategy for extensive secondary epileptogenesis in temporal lobe epilepsy and present the subiculum as a target with potential translational importance.

关键词： Secondary epileptogenesis Low-frequency stimulation Subiculum Temporal lobe epilepsy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fluoride Ion Adsorption Effect and Adsorption Mechanism of Self-Supported Adsorbent Materials Based on Desulfurization Gypsum-Aluminate Cement

引用

Journal of Renewable Materials 2023年第12期11卷 4079-4095页

作者： Xuefeng Song minjuan sun Juan He Lei Wang College of Materials Science and Engineering Xi’an University of Architecture and TechnologyXi’an710055China

The adsorption method has the advantages of low cost,high efficiency,and environmental friendliness in treating fluorinated wastewater,and the adsorbent material is the *** study combines the inherent anion-exchange adsorption properties of layered double hydroxides(LDHs).Self-supported porous adsorbent materials loaded with AFm and AFt were prepared from a composite cementitious system consisting of calcium aluminate cement(CAC)and flue gas desulfurization gypsum(FGDG)by chemical foaming *** mineral composition of the adsorbent material was characterized by X-ray diffraction(XRD)and Scanning electron microscopy(SEM).Through the static adsorption experiment,the adsorption effect of the mineral composition of the adsorbent on fluoride ions was deeply analyzed,and the adsorption mechanism was *** and SEM showed that the main hydration phases of the composite cementitious system consisting of CAC and FGDG are AFm,AFt,AH_(3),and CaSO_(4)·2H_(2)*** accelerates the hydration process of CAC and inhibits the transformation of AFt to *** AFt content increased,and the AFm content decreased or even disappeared as the amount of FGDG *** adsorption experiment results showed that AFm and AFt in adsorbent materials could significantly enhance the adsorption of fluoride *** adsorption of F^(−)in aqueous solution by PAG tends more towards monolayer adsorption with a theoretical maximum capacity of 108.70 mg/g and is similar to the measured value of 112.77 mg/g.

关键词： Flue gas desulfurization gypsum(FGDG) Calcium aluminate cement(CAC) AFm AFt Fluoride ions adsorption

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

One Small Step for Neurotechnology,One Giant Leap for an In-Depth Understanding of the Brain

引用

Neuroscience Bulletin 2023年第6期39卷 1034-1036页

作者： Xiaoyun Qiu minjuan sun Cenglin Xu Yingying Tang Zhong Chen Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou310053China Department of Pharmacy Women’s HospitalSchool of MedicineZhejiang UniversityHangzhou310000China

Is science mostly driven by ideas or by tools?The answers to the everlasting question remain *** the advances in techniques undoubtedly push forward scientific research to investigate both more in-breadth and in-depth... 详细信息

关键词： Leap One doubt

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acceptance and Factors Associated With Participation in Functional Cure–Related Trials Among People Living With HIV: A Cross-sectional Study in Southern China

引用

Infectious Microbes & Diseases 2024年第1期6卷 11-19页

作者： Zhaomin Deng minjuan Shi Yue Yuan GuangjinCao Chunyan Wen Lijuan Chen Xueying Fan Linan Wu Jianhui Yuan Huachun Zou Linghua Li Caijun sun School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenChina Department of Diseases Control Panyu District Center for Disease Control and PreventionGuangzhouChina Infectious Disease Center Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhouChina Nanshan District Center for Disease Control and Prevention ShenzhenChina Key Laboratory of Tropical Disease Control(sun Yat-sen University) Ministry of EducationGuangzhouChina

HIV remains a global health challenge,and research efforts directed towards a functional cure require people living with HIV(PLHIV)in-volvement in clinical *** study assessed willingness to participate in HIV functional cure–related clinical trials and associated factors among PLHIV in Guangzhou,China,using a questionnaire survey *** analyzed responses from 718 questionnaires,finding that 71.2%were willing to participate in Phase Ⅲtrials,while 51.7%were willing to participate in Phase I trials and 42.9%expressed acceptability for analytic treatment *** logistic regression demonstrated that male PLHIV,those with awareness of functional cure,and PLHIV,who had been on antiretroviral therapy(ART)for less than 1 year,were more willing to partic-ipate in Phase Ⅲ*** with a body mass index greater than 24,and those without resistance to ART drug were more willing to participate in Phase I *** major motivations for participation in Phase Ⅲtrials were access to cutting-edge treatments(62.6%)and supporting research(55.3%).Safety was the main concern contributing to *** study revealed a high willingness to participate in HIV functional cure–related trials among PLHIV in Guangzhou,China,and willingness varied across different trial phases and was influenced by multiple *** study provides valuable references for future clinical trial recruitment strategies and public health policy formulation.

关键词： people living with HIV functional cure clinical trials willingness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anticonvulsant Effect of Xingnaojing Injection on Acute Seizure Models in Mice

引用

Clinical Complementary Medicine and Pharmacology 2023年第3期3卷 31-39页

作者： minjuan sun Xiaoyun Qiu Zhijian Yuan Shuo Zhang Qi Zhang Xiaoli Da Xuming Ji Xuhong Jiang Cenglin Xu Zhong Chen Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 311402ZhejiangChina Department of Pharmacy The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310003ZhejiangChina School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina Department of Neurology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310003ZhejiangChina

Background:Epilepsy is characterized by acute recurrent *** control of seizures is largely hampered by the tolerance to current anti-seizure *** anti-convulsant pharmacotherapies are urgently ***:Here,we aimed to investigate the anti-convulsant effects of Xingnaojing Injection(XNJ)which is an approved Traditional Chinese Medicine injection on different acute seizure models in ***:The effects of XNJ were tested on the maximal electroshock(MES),pentylenetetrazol(PTZ)and kainic acid(KA)acute seizure ***,whether XNJ can directly inhibit hippocampal neuronal firings were exam-ined by in vitro ***:XNJ could shorten the durations of generalized tonic-clonic seizures in the MES *** also significantly prolonged the latencies to generalized myo-clonic seizures in the PTZ *** the KA model,XNJ showed various efficacies including inhibiting the seizure stages,prolonging the latency to the occurrence of the first seizures or generalized seizures,shortening the seizure durations,decreasing the numbers of generalized *** vitro electrophysiological recordings further verified XNJ directly inhibited both the spontaneous and evoked action potentials of hippocampal pyramidal neurons,but did not influence the excitatory or inhibitory synaptic ***:These findings proposed XNJ as an alternative anti-convulsant pharmacotherapy for controlling acute epileptic seizures.

关键词： Xingnaojing Injection Epileptic seizure Neuronal excitability Traditional Chinese Medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

脊髓型颈椎病的术式选择及术后神经功能恢复效果比较

引用

中国实用医刊 2018年第12期45卷 57-59页

作者：孙敏娟姜霞山西省运城市中心医院神经内科 044000

目的探讨不同手术方式在脊髓型颈椎病治疗中的应用，分析患者神经功能恢复情况。方法对130例脊髓型脊椎病患者进行研究，随机分为研究组和对照组，每组65例。研究组行前路椎问盘切除植骨融合并钛板置入内固定（ACDF）术，对照组行前路... 详细信息

目的探讨不同手术方式在脊髓型颈椎病治疗中的应用，分析患者神经功能恢复情况。方法对130例脊髓型脊椎病患者进行研究，随机分为研究组和对照组，每组65例。研究组行前路椎问盘切除植骨融合并钛板置入内固定（ACDF）术，对照组行前路椎体次全切除植骨融合并钛板置入内固定（ACCF）术，比较两组术后神经功能恢复情况、生活质量、出血量、住院及手术时间、并发症发生率。结果研究组术后5个月神经功能评分为（13．12±2．05）分，高于对照组的（11．01±2．14）分，差异有统计学意义（P〈0．05）；研究组各项生活质量评分高于对照组，差异有统计学意义（P〈0．05）；研究组出血量、住院与手术时间均少于对照组，差异有统计学意义（P〈0．05）；研究组并发症发生率为4．62％，低于对照组（16．92％），差异有统计学意义（P〈0．05）。结论ACDF与ACCF两种术式均可改善脊髓型颈椎病患者病情，其中ACDF能降低术后并发症率，进一步改善患者颈部神经功能，疗效更确切，值得临床推广。

关键词：脊髓型颈椎病手术恢复神经功能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SiC_f/TC17复合材料残余应力及界面力学性能研究

引用

稀有金属 2024年第06期48卷 822-832页

作者：王敏涓杨光戚继球孟庆坤孙光耀黄浩中国航发北京航空材料研究院中国航空发动机集团有限公司先进钛合金重点实验室中国矿业大学材料与物理学院

采用基体涂层法制备出SiC连续纤维增强钛基（SiC_f/Ti）复合材料，通过纤维顶出试验和有限元模拟研究复合材料的热残余应力分布特征与界面力学性能的影响因素。SiC_f/TC17复合材料中SiC纤维呈近似六方排布，均匀分布在钛合金基体中。根... 详细信息

采用基体涂层法制备出SiC连续纤维增强钛基（SiC_f/Ti）复合材料，通过纤维顶出试验和有限元模拟研究复合材料的热残余应力分布特征与界面力学性能的影响因素。SiC_f/TC17复合材料中SiC纤维呈近似六方排布，均匀分布在钛合金基体中。根据单纤维顶出试验的载荷-位移曲线计算出SiC_f/TC17复合材料的平均界面剪切强度和摩擦应力分别为49 MPa和34 MPa。有限元模拟结果表明，随SiC_f/TC17复合材料中热残余应力的增加，顶出试验的摩擦力显著增加，而界面脱粘力先降后升；随摩擦系数的增加，脱粘力和摩擦力都增加；随本征界面剪切强度增加，脱粘力增加而摩擦力不变。结合顶出试验和有限元模拟结果，确定SiC_f/TC17复合材料的界面摩擦系数和本征界面剪切强度分别为0.17和390 MPa。单纤维顶出试验中，SiC_f/TC17复合材料在C涂层和反应层之间脱粘，顶出载荷在界面产生的剪切应力与支撑端的剪切残余应力方向一致，导致界面脱粘首先发生在支撑端，而后脱粘区域沿着纤维/基体界面向加载端扩展，当载荷-位移曲线达到最大值时界面完全脱粘。

关键词： SiC纤维 Ti基复合材料残余应力界面剪切强度有限元

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

齿板连接节点试验及承载能力分析

引用

特种结构 2008年第1期25卷 1-5页

作者：何敏娟孙永良同济大学土木工程学院建筑工程系同济大学土木工程学院建筑工程系上海200092

轻型木桁架是轻型木结构中一种常见的结构形式,其节点一般由齿板钉接而成,而该齿板节点可能是桁架的薄弱环节,其承载力决定着整个桁架的承载能力,因此齿板连接承载力的确定十分重要。近年随着轻型木结构的引进,齿板连接应用较多,但是国... 详细信息

轻型木桁架是轻型木结构中一种常见的结构形式,其节点一般由齿板钉接而成,而该齿板节点可能是桁架的薄弱环节,其承载力决定着整个桁架的承载能力,因此齿板连接承载力的确定十分重要。近年随着轻型木结构的引进,齿板连接应用较多,但是国内对于齿板连接的研究较少,对这种连接的承载能力、破坏形式缺乏感性认识。本文参照我国现行木结构设计规范中有关'齿板连接节点试验'的要求,针对两种类型齿板的齿极限承载力、齿抗滑移承载力以及齿板极限受拉承载力进行了试验,并将试验结果与国外产品承载力推荐值进行了比较。

关键词：轻型木桁架齿板连接承载能力试验

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

偏轴载荷下连续SiC纤维增强钛基复合材料的拉伸行为研究

引用

航空制造技术 2024年第8期67卷 45-53页

作者：王敏涓陈永刚齐金磊孙光耀王宝黄旭黄浩中国航发北京航空材料研究院北京100095 中国航空发动机集团先进钛合金重点实验室北京100095 泰科信(北京)科技有限公司北京100085

连续SiC纤维增强钛基(SiCf/Ti)复合材料是未来高性能动力装置的关键材料之一。针对SiCf/Ti复合材料中纤维与试样轴向载荷常存在一定偏轴角度的问题,通过室温拉伸、有限元模拟和断口表征研究了偏轴角度对SiCf/TC17复合材料力学性能和失... 详细信息

连续SiC纤维增强钛基(SiCf/Ti)复合材料是未来高性能动力装置的关键材料之一。针对SiCf/Ti复合材料中纤维与试样轴向载荷常存在一定偏轴角度的问题,通过室温拉伸、有限元模拟和断口表征研究了偏轴角度对SiCf/TC17复合材料力学性能和失效机理的影响。根据SiCf/TC17复合材料力学性能、断口形貌和应力分布可以定义一个临界偏轴角度,其数值约为1°。结果表明,随偏轴角度的增加,复合材料试样的抗拉强度下降,且当偏轴角度超过临界值时,抗拉强度下降速率增加。复合材料的失效机制与偏轴角度相关,当偏轴角度小于临界值时,试样断口由数个平坦的断面组成,纤维拔出和界面开裂程度都较低,纤维断面基本垂直于轴线,为典型的正应力断裂形貌;当偏轴角度大于临界值时,断口的起伏程度增加,纤维拔出和界面开裂现象都更加明显,部分纤维开始出现剪切断裂,表明拉剪耦合在断裂中起到重要作用。因此,对于SiCf/TC17复合材料轴向试样而言,应将纤维与试样整体的偏轴角度控制在临界值内,以获得有效的性能测试数据。

关键词：钛基复合材料 SiC纤维偏轴拉伸断口形貌临界偏轴角度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

青岛某工业园区重点监管企业土壤重金属污染特征及源解析

引用

环境卫生工程 2024年第5期32卷 28-35页

作者：雒宇孙翰林康敏娟李厚恩北京市勘察设计研究院有限公司北京100038

青岛市是推动黄河流域生态保护和高质量发展的核心区之一,研究该区域表层土壤重金属污染状况、来源及潜在风险具有十分重要的意义。基于青岛某工业园区厂区内表层土壤(0~20 cm)中6种重金属元素(As、Cd、Cu、Pb、Hg、Ni)的含量及污染特征... 详细信息

青岛市是推动黄河流域生态保护和高质量发展的核心区之一,研究该区域表层土壤重金属污染状况、来源及潜在风险具有十分重要的意义。基于青岛某工业园区厂区内表层土壤(0~20 cm)中6种重金属元素(As、Cd、Cu、Pb、Hg、Ni)的含量及污染特征,利用相关性分析和正定矩阵因子分解(PMF)模型对土壤重金属进行源解析。结果表明:表层土壤中各重金属元素均未超GB 36600—2018土壤环境质量建设用地土壤污染风险管控标准(试行)中第二类建设用地筛选值;但相比山东省背景值,各重金属元素均有不同程度的富集,其中Cd、Hg分别为背景值的6.38倍、4.85倍,呈明显富集;Cd和Hg的变异系数大于100%,属于强变异,其余重金属均为中等变异,As、Cu和Pb的变异系数略大于50%,Ni的变异系数最小为32%。根据地累积指数评价结果显示,Ni、Cu和As为无污染(I_(geo)<0),Pb和Cd为轻度污染(0≤I_(geo)<1),Hg为偏中度污染(1≤I_(geo)<2)。源解析结果显示,园区内表层土壤中重金属来源受农药和化肥生产活动、工业排放、大气沉降以及自然来源的影响,其贡献率分别为15.99%、37.32%、30.35%、16.34%。

关键词：工业园区重金属污染特征源解析

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：