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PI3K/Akt/mTOR Signaling as Targets for Developing Anticancer Agents from Marine Organisms

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Journal of Ocean University of China 2021年第3期20卷 688-694页

作者： guo mingyue ZUO Ling QIAO Gan LIU Minghua CAO Shousong LIN Xiukun Department of Pharmacology School of PharmacySouthwest Medical UniversityLuzhou 646000China Central Nervous System Drug Key Laboratory of Sichuan Province Luzhou 646000China

The PI3K/Akt/mTOR signaling pathway is one of the most frequently dysregulated pathways in *** the PI3K-mediated pathway has been an important strategy for developing novel anticancer *** the past decades,more than 40 inhibitors of the PI3K/Akt/mTOR pathway have been developed at different clinical ***,everolimus,idelalisib,and copanlisib have been approved for clinical use by the Food and Drug Administration of the United States(FDA).However,the toxic-ity and drug resistance limit their efficiency in the *** compounds with greater potency and selectivity,as well as im-proved therapeutic indices with reduced toxicity,are clearly *** the past three decades,a lot of bioactive ingredients with anticancer effects by affecting the PI3K-mediated pathways have been found from marine *** the present mini-review,anticancer compounds from marine source that target the PI3K/Akt/mTOR signaling were *** molecular entities and their modes of action were *** marine compounds targeting special factors of the PI3K/Akt/mTOR were highlighted.

关键词： marine organisms PI3K/Akt/mTOR pathway anticancer activity

A Multilevel Framework for Nonlinear Surface Registration

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Wuhan University Journal of Natural Sciences 2013年第3期18卷 272-276页

作者： MA Xiaoyan DONG Wangyuan guo mingyue Science College Huazhong Agricultural University

In this paper,we discuss a new multilevel method for the vascular surface *** registration is used for hemodynamic *** care is given to the discretization of the distance function and regularizer,as well as to the sur... 详细信息

关键词： multilevel nonlinear surface registration vascular surface

Oxidative stress,the blood-brain barrier and neurodegenerative diseases:The critical beneficial role of dietary antioxidants

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Acta Pharmaceutica Sinica B 2023年第10期13卷 3988-4024页

作者： Jin Feng Youle Zheng mingyue guo Irma Ares Marta Martínez Bernardo Lopez-Torres María-Rosa Martínez-Larran aga Xu Wang Arturo Anadon María-Aranzazu Martínez National Reference Laboratory of Veterinary Drug Residues(HZAU)and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural UniversityWuhan 430070China MAO Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products Huazhong Agricultural UniversityWuhan 430070China Department of Pharmacology and Toxicology Faculty of Veterinary MedicineUniversidad Complutense de Madrid(UCM)And Research Institute Hospital 12 de Octubre(i+12)Madrid 28040Spain

In recent years,growing awareness of the role of oxidative stress in brain health has prompted antioxidants,especially dietary antioxidants,to receive growing attention as possible treatments strategies for patients with neurodegenerative diseases(NDs).The most widely studied dietary antioxidants include active substances such as vitamins,carotenoids,flavonoids and *** antioxidants are found in usually consumed foods such as fresh fruits,vegetables,nuts and oils and are gaining popularity due to recently growing awareness of their potential for preventive and protective agents against NDs,as well as their abundant natural sources,generally non-toxic nature,and ease of long-term *** review article examines the role of oxidative stress in the development of NDs,explores the‘two-sidedness’of the blood-brain barrier(BBB)as a protective barrier to the nervous system and an impeding barrier to the use of antioxidants as drug medicinal products and/or dietary antioxidants supplements for prevention and therapy and reviews the BBB permeability of common dietary antioxidant suplements and their potential efficacy in the prevention and treatment of ***,current challenges and future directions for the prevention and treatment of NDs using dietary antioxidants are discussed,and useful information on the prevention and treatment of NDs is provided.

关键词： Dietary antioxidant supplements Oxidative stress Blood-brain barrier Neurodegenerative diseases Vitamins Carotenoids Flavonoids Polyphenols

Magnetocardiograph as a noninvasive and radiation-free diagnostic device for myocardial infarction:a systematic review and meta-analysis

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Emergency and Critical Care Medicine 2023年第2期3卷 70-77页

作者： Yansong Xu Xiaole Han mingyue guo Ruochuan Li Yiming Dong Jiaxin Fan Xiaofei Yin Fei Xie Jiaojiao Pang Yuguo Chen Department of Emergency Medicine Qilu Hospital of Shandong UniversityJinanShandongChina Shandong Key Laboratory for Magnetic Field-free Medicine and Functional Imaging Institute of Magnetic Field-free Medicine and Functional ImagingShandong UniversityJinanShandongChina Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityChest Pain CenterQilu Hospital of Shandong UniversityJinanShandongChina NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug Qilu Hospital of Shandong UniversityJinanShandongChina The National Medical Science and Technology Industry-Education Integration Innovation Platform Qilu Hospital of Shandong UniversityJinanShandongChina Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology Ministry of EducationSchool of Instrumentation and Optoelectronic EngineeringBeihang UniversityBeijingChina

Background:This study aimed to evaluate the diagnostic accuracy of magnetocardiograph,a relatively new noninvasive device,in patients with myocardial infarction(MI).Methods:To identify studies assessing the diagnostic accuracy of magnetocardiography for MI,we searched four databases on November 7,2022,the Cochrane Central Register of Controlled Trials,MEDLINE,EMBASE,and Web of Science,plus *** reviewers screened the studies independently and emailed the authors for more precise data when *** Quality Assessment of Diagnostic Accuracy Studies 2 tool was used to evaluate the quality of the included ***(version 17;Stata Corporation,College Station,TX,USA)was used for meta-analysis of 22 contingency table ***:A total of 6 articles were included in this *** diagnostic parameters of all included studies were summarized as follows:the pooled sensitivity was 0.91(95%confidence intervals[95%CIs]:0.81–0.96;I 2=88.54);specificity was 0.83(95%CI:0.75–0.89;I 2=83);positive likelihood ratio was 5.3(95%CI:3.5–8.2);negative likelihood ratio was 0.1(95%CI:0.04–0.24);and diagnostic odds ratio was 51(95%CI:16–161).The area under the curve for the receiver operating characteristic curve was 0.92(95%CI:0.89–0.94).After metaregression analysis,we found that the number of channels and the way of environmental magnetic noise elimination were heterogeneous ***:In summary,our meta-analysis shows that magnetocardiography holds a high accuracy in diagnosing MI and takes the advantages of noninvasive,radiation-free,and ***,further high-quality studies to confirm its usefulness in diagnosing MI are warranted.

关键词： Diagnosis Magnetocardiograph Meta-analysis Myocardial infarction Systematic review

Survey on Deep Learning for Human Action Recognition

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国际计算机前沿大会会议论文集 2019年第2期 16-21页

作者： Zirui Qiu Jun Sun mingyue guo Mantao Wang Dejun Zhang Sichuan Agricultural University Yaan 625014 China China University of Geosciences Wuhan 430074 China

Human action recognition has gained popularity because of its worldwide applications such as video surveillance, video retrieval and human– computer interaction. This paper provides a comprehensive overview of notable advances made by deep neural networks in this field. Firstly, the basic conception of action recognition and its common applications were introduced. Secondly, action recognition was categorized as action classification and action detection according to its respective research goals. And various deep learning frameworks for recognition tasks were discussed in detail and the most challenging datasets and taxonomies were briefly reviewed. Finally, the limitations of the state-of-the-art and promising directions of the research were briefly outlined.

关键词： Action recognition Deep neural network Action classification Action detection

Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm

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Protein & Cell 2023年第4期14卷 262-278页

作者： Kuisheng Liu Xiaocui Xu Dandan Bai Yanhe Li Yalin Zhang Yanping Jia mingyue guo Xiaoxiao Han Yingdong Liu Yifan Sheng Xiaochen Kou Yanhong Zhao jiqing Yin Sheng Liu jiayu Chen Hong Wang Yixuan Wang Wenqiang Liu Shaorong Gao Shanghai Key Laboratory of Matemal Fetal Medicine Clinical and Translational Research Center of Shanghai First Matemity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Shanghai Institute of Matermal-Fetal Medicine and Gynecologic Oncology Shanghai First Matermity and Infant HospitalTongji UniversityShanghai 200092China

Self-organized blastoids from extended pluripotent stem(EPs)cells possess enormous potential for investigating postimplantation embryo development and related ***,the limited ability of postimplantation development of Eps-blastoids hinders its further *** this study,single-cell transcriptomic analysis indicated that the“trophectoderm(TE)-like structure”of EPSblastoids was primarily composed of primitive endoderm(PrE)-related cells instead of TE-related *** further identified PrE-like cells in EPS cell culture that contribute to the blastoid formation with TE-like *** of PrE cell differentiation by inhibiting MEK signaling or knockout of Gata6 in EPS cells markedly suppressed EPS-blastoid ***,we demonstrated that blastocyst-like structures reconstituted by combining the EPs-derived bilineage embryo-like structure(BLEs)with either tetraploid embryos or tetraploid TE cells could implant normally and develop into live *** summary,our study reveals that TE improvement is critical for constructing a functional embryo using stem cells in vitro.

关键词： EPS cells blastoid primitive endoderm(PrE) trophectoderm(TE) Gata6

溃疡性结肠炎患者肠道脂肪酸氧化和肉碱代谢相关基因表达变化

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中华医学杂志 2024年第36期104卷 3422-3429页

作者：江玲娟国明月杨红中国医学科学院北京协和医学院北京协和医院临床医学研究所北京100730 中国医学科学院北京协和医学院北京协和医院消化内科北京100730

目的分析溃疡性结肠炎(UC)患者肠道脂肪酸氧化和肉碱代谢相关基因表达变化。方法回顾性纳入2018年1月1日至2023年12月31日北京协和医院就诊的UC患者(UC组)和定期行结肠镜检查排除息肉的非UC对照者(对照组),收集2组结肠组织样本并提取RNA... 详细信息

目的分析溃疡性结肠炎(UC)患者肠道脂肪酸氧化和肉碱代谢相关基因表达变化。方法回顾性纳入2018年1月1日至2023年12月31日北京协和医院就诊的UC患者(UC组)和定期行结肠镜检查排除息肉的非UC对照者(对照组),收集2组结肠组织样本并提取RNA,采用实时荧光定量聚合酶链反应技术检测脂肪酸氧化和肉碱代谢相关基因的mRNA表达水平,并分析其与炎症基因表达的相关性。利用高通量基因表达数据库(GEO)中UC患者和对照者结肠黏膜转录组数据,分析脂肪酸氧化和肉碱代谢相关基因的表达情况。免疫组化检测2组肠道组织中肉碱转运蛋白SLC6A14的表达水平。选择8周龄雄性C57BL/6小鼠,分为饮水组(饮用日常水)及葡聚糖硫酸钠(DSS)组(饮用2.5%DSS溶液),每组各4只,利用DSS诱导小鼠急性结肠炎模型,检测2组小鼠肠道组织中的SLC6A14和白细胞介素-6(IL-6)的mRNA表达水平的差异。结果UC组共纳入22例患者,男12例,女10例,年龄16~64(40±12)岁;对照组10名,男3名,女7名,年龄43~72(64±8)岁。UC组肠道中与脂肪酸氧化及转运有关的基因mRNA表达水平低于对照组,如CD36[0.40(0.27,0.55)比0.93(0.39,2.93)]、CPT1A[0.39(0.07,0.54)比0.93(0.41,1.71)]、CPT1B(0.37±0.36比1.37±0.89)、CPT2[0.36(0.30,0.43)比1.14(0.68,1.34)]、CRAT[0.31(0.25,0.41)比1.06(0.64,1.73)]、CROT[0.14(0.10,0.21)比0.95(0.77,1.27)](均P<0.05);UC组肠道中与肉碱转运相关基因mRNA表达水平低于对照组,如OCTN1[0.18(0.10,0.41)比0.83(0.41,1.47)]、OCTN2[0.01(0.00,0.01)比0.47(0.35,2.15)](均P<0.05)。UC患者肠道中肉碱转运蛋白编码基因SLC6A14的mRNA表达水平高于对照组[11.31(5.34,23.50)比0.78(0.07,3.70),P<0.001],且与炎症基因IL-6表达呈正相关(r=0.425,95%CI:0.076~0.681,P=0.019)。GEO数据库分析发现,UC组与脂肪酸氧化、转运有关基因CD36、CPT1A、CPT2、CRAT、CROT的表达水平低于对照组(均P<0.05),而SLC6A14表达水平高于对照组(P<0.05)。UC组结肠组织中SLC6A14蛋白表达水平高于对照组(0.45±0.07比0.30±0.01,P=0.019)。DSS组小鼠肠道中基因SLC6A14的mRNA表达水平高于饮水组(1.83±0.90比0.60±0.10,P=0.035)。结论UC患者肠道中与脂肪酸氧化和肉碱代谢相关的基因CD36、CPT1A、CPT1B、CPT2、CRAT、CROT、OCTN1和OCTN2的表达水平降低,且同时转运氨基酸和肉碱的基因SLC6A14的表达水平升高。

关键词：结肠炎,溃疡性脂肪酸转运脂肪酸氧化肉碱代谢白细胞介素6

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炎症性肠病合并神经系统疾病诊治策略

中华炎性肠病杂志（中英文） 2021年第1期5卷 27-31页

作者：国明月杨红中国医学科学院北京协和医学院北京协和医院消化内科北京100730

炎症性肠病(IBD)是一类累及肠道的慢性炎症性疾病,自然病程中常伴随发生多种肠外疾病,神经系统为肠外受累器官之一。IBD合并神经系统疾病会干扰疾病的诊断和治疗,且有些患者预后欠佳,影响生活质量,因此近年来越来越受到关注。本文从神... 详细信息

炎症性肠病(IBD)是一类累及肠道的慢性炎症性疾病,自然病程中常伴随发生多种肠外疾病,神经系统为肠外受累器官之一。IBD合并神经系统疾病会干扰疾病的诊断和治疗,且有些患者预后欠佳,影响生活质量,因此近年来越来越受到关注。本文从神经系统肠外表现、IBD与神经系统特殊共患病以及IBD合并神经系统并发症和药物不良反应等方面解读IBD合并神经系统疾病的分类以及诊疗思路,期望临床医生对IBD合并肠外疾病有更深入的认识。

关键词：炎症性肠病神经系统疾病肠外表现共患病并发症

基本公共服务能有效提升脱贫质量吗?——基于多维贫困和多维贫困脆弱性的视角

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财政研究 2021年第12期37卷 48-62页

作者：乔俊峰郭明悦河南师范大学商学院

有效提升脱贫质量是"十四五"时期巩固拓展脱贫攻坚成果,实现稳定可持续脱贫的关键。利用中国家庭追踪调查(CFPS)数据,本文从多维贫困和多维贫困脆弱性的视角衡量脱贫质量,分析基本公共服务减缓家庭多维贫困及多维贫困脆弱性进而影响脱... 详细信息

有效提升脱贫质量是"十四五"时期巩固拓展脱贫攻坚成果,实现稳定可持续脱贫的关键。利用中国家庭追踪调查(CFPS)数据,本文从多维贫困和多维贫困脆弱性的视角衡量脱贫质量,分析基本公共服务减缓家庭多维贫困及多维贫困脆弱性进而影响脱贫质量的作用机制。研究发现基本公共服务能够显著降低家庭发生多维贫困与多维贫困脆弱性的概率,因此可以有效提升脱贫质量。机制分析表明,能力提升与不确定性风险冲击缓解是基本公共服务提升脱贫质量的重要传导机制。进一步研究发现基本公共服务对多维贫困高分位点家庭的脱贫质量提升效应更大,起到安全网作用。基本公共服务将显著降低家庭由于协同性风险冲击导致多维贫困脆弱性的概率,且在农村发挥的作用相较于城市更突出。文章结论为巩固脱贫攻坚成果,提升脱贫质量提供了可靠的政策依据。

关键词：基本公共服务多维贫困多维贫困脆弱性脱贫质量