PI3K/Akt/mTOR Signaling as Targets for Developing Anticancer Agents from Marine Organisms

作     者：GUO Mingyue ZUO Ling QIAO Gan LIU Minghua CAO Shousong LIN Xiukun GUO Mingyue;ZUO Ling;QIAO Gan;LIU Minghua;CAO Shousong;LIN Xiukun

作者机构：Department of PharmacologySchool of PharmacySouthwest Medical UniversityLuzhou 646000China Central Nervous System Drug Key Laboratory of Sichuan ProvinceLuzhou 646000China 

出 版 物：《Journal of Ocean University of China》 (中国海洋大学学报（英文版）)

年 卷 期：2021年第20卷第3期

页      面：688-694页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100701[医学-药物化学] 10[医学] 

基　　金：The study was supported by the National Natural Sci-ence Foundation of China(Nos.81573457 and 81773776) We are also grateful to the support from the Taishan Talents Project of Shandong Province and the Department of Science and Technology in Shandong Province of China(Nos.ZR2017MH117,2018YYSP025,and ZR2017MH 027) Department of Science and Technology of Si-chuan Province,China(Nos.2017HH0104 and 2019YFS 0116) 

主　　题：marine organisms PI3K/Akt/mTOR pathway anticancer activity 

摘      要：The PI3K/Akt/mTOR signaling pathway is one of the most frequently dysregulated pathways in *** the PI3K-mediated pathway has been an important strategy for developing novel anticancer *** the past decades,more than 40 inhibitors of the PI3K/Akt/mTOR pathway have been developed at different clinical ***,everolimus,idelalisib,and copanlisib have been approved for clinical use by the Food and Drug Administration of the United States(FDA).However,the toxic-ity and drug resistance limit their efficiency in the *** compounds with greater potency and selectivity,as well as im-proved therapeutic indices with reduced toxicity,are clearly *** the past three decades,a lot of bioactive ingredients with anticancer effects by affecting the PI3K-mediated pathways have been found from marine *** the present mini-review,anticancer compounds from marine source that target the PI3K/Akt/mTOR signaling were *** molecular entities and their modes of action were *** marine compounds targeting special factors of the PI3K/Akt/mTOR were highlighted.