检索结果-南通市图书馆

Chick chorioallantoic membrane model to investigate role of migrasome in angiogenensis

在线全文

学校读者我要写书评

暂无评论

Biophysics Reports 2023年第5期9卷 241-254页

作者： Cuifang Zhang Helen He Shuyao Yin mingyi gao Li Yu The State Key Laboratory of Membrane Biology Tsinghua University-Peking University Joint Centre for Life Sciences Beijing Frontier Research Center for Biological Structure Xiamen Cardiovascular Hospital Xiamen University

The development of the vascular system is essential for embryonic development, including processes such as angiogenesis. Angiogenesis plays a critical role in many normal physiological and pathological processes. It is driven by a set of angiogenic proteins, including angiogenic growth factors, chemokines,and extracellular matrix proteins. Among various animal model systems, the chorioallantoic membrane(CAM), a specialized and highly vascularized tissue of the avian embryo, has proven to be a valuable tool for analyzing the angiogenic potential of candidate cells or factors. In this protocol, we provide detailed procedures for establishing the CAM model to evaluate the function and mechanism of migrasomes in embryonic angiogenesis. This includes the CAM nylon mesh assay and CAM ex vivo sprouting assay to assess CAM angiogenesis, as well as the observation, purification, and delivery of migrasomes. Additionally, we describe the generation of T4-KO-m Cherry-KI embryos using the CRISPR system within the CAM tissue to investigate the role of migrasomes in angiogenesis.

关键词： Angiogenesis Chorioallantoic membrane (CAM) Chick CAM model

Flexible Broad-Range Pressure Sensors Enabled by Deformation-Induced Conductive Channels in 3D Graphene Foam@Polydimethylsiloxane Composite for Precise Vibrational Signal Detection

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第7期39卷 775-775页

作者： Jiankun Miao Yayuan Shi Hongfei Zhu mingyi gao Zhong Jin MOE Key Laboratory of Mesoscopic Chemistry Jiangsu Key Laboratory of Ad-vanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu 210023China Shenzhen Research Institute of Nanjing University ShenzhenGuangdong 518063China Suzhou Key Laboratory of Advanced Optical Communication Network Technology School of Electronic and Information EngineeringSoochow UniversitySuzhouJiangsu 215006China Department of Chemistry Rowey Intelligent Technology(Suzhou)Ltd.Co.High-tech ZoneSuzhouJiangsu 215011China

Here we report the design and fabrication of high-performance pressure sensors based on three- dimensional (3D) graphene foam filled polydimethylsiloxane (GF@PDMS) composite with a broad sensing range spaning from 0.05 kPa to 130 kPa. The interpretation of device functioning mechanism can be classified into low and high pressure sensing regions. In the low pressure region (<15 kPa), the pressure loading leads to the temporal connection of micro-cracks in GF scaffold and forming conductive channels. In the high pressure region (15 kPa to 130 kPa), the pressure induced deformation of GF results in the better connections among micro-cracks and the shortening of conductive pathway to further decrease the electrical resistance. The GF@PDMS sensors exhibited accuracy, sensibility and reproducibility to detect pressure signals with remarkable stability for over 16000 loading-unloading cycles, indicating its great potential for practical applications. Moreover, the GF@PDMS sensors also showed high performances in the detection of dynamic pressures, such as subtle mechanical vibration signals, as well as physiology vibrational signals generated by human throats. We expect this technology could be integrated into different sensing systems for the applications in wearable smart electronics and human-machine communications.

关键词： Vibrational signal detection Flexible broad-range Sensors Conducting materials Polymers

The effectiveness of physical activity interventions on blood pressure in children and adolescents:A systematic review and network meta-analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第5期13卷 699-708页

作者： Mohamed A.Hassan Wanjiang Zhou mingyi Ye Hui He Zan gao School of Kinesiology University of Minnesota-Twin CitiesMinneapolisMN 55455USA Department of Methods and Curriculum Physical Education College for MenHelwan UniversityCairo 12552Egypt China Institute of Sport and Health Science Beijing Sport UniversityBeijing 100084China Department of Kinesiology Recreationand Sport StudiesUniversity of TennesseeKnoxvilleTN 37996USA

Background:High blood pressure(BP)is a major contributor to mortality and cardiovascular diseases.Despite the known benefits of exercise for reducing BP,it is crucial to identify the most effective physical activity(PA)intervention.This systematic review and network meta-analysis(NMA)aimed to evaluate the available evidence on the effectiveness of various PA interventions for reducing BP and to determine their hierarchy based on their impact on BP.Methods:A search of PubMed,SPORTDiscus,PsycINFO,Web of Science,CINAHL,Cochrane,and Eric databases was conducted up to December 2022 for this systematic review and NMA.Randomized controlled trials and quasi-experimental studies targeting healthy children and adolescents aged 6-12 years old were included in this study.Only studies that compared controlled and intervention groups using PA or exercise as the major influence were included.We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines.Three independent investigators performed the literature screening,data extraction,and risk of bias assessment.We used Bayesian arm-based NMA to synthesize the data.The primary outcomes were systolic BP and diastolic BP.We calculated the mean differences(MDs)in systolic BP and diastolic BP before and after treatment.Mean treatment differences were estimated using NMA and random-effect models.Results:We synthesized 27 studies involving 15,220 children and adolescents.PA combined with nutrition and behavior change was the most effective intervention for reducing both systolic BP and diastolic BP(MD=-8.64,95%credible interval(95%CI):-11.44 to-5.84;MD=-6.75,95%CI:-10.44 to-3.11),followed by interventions with multiple components(MD=-1.39,95%CI:-1.94 to-0.84;MD=-2.54,95%CI:-4.89 to-0.29).Conclusion:Our findings suggest that PA interventions incorporating nutrition and behavior change,followed by interventions with multiple components,are most effective for reducing both systolic BP and diastolic BP in children and adolescents.

关键词： Children Diastolic blood pressure Physical activity Systolic blood pressure

NaGd0.4Eu0.6Mg1-xZnxWO6 solid solution red phosphors:Microstructure variation and luminescence enhancement induced by Zn2+-doping

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第7期42卷 1224-1232页

作者： Yu gao Jiayang Liao mingyi Zhang Qingmei Tang Ting Zhou Mengjiao Liu Yan Zhao Xin Lai Daojiang gao College of Chemistry and Materials Science Sichuan Normal University

Red phosphor is an important component of the phosphor-converted white light-emitting diodes（pcWLEDs）.The development of the novel red phosphor with excellent luminescence properties is of great significance for high performance WLEDs.In this study,NaGd0.4Eu0.6Mg1-xZnxWO6red phosphors with excellent luminescence properties were successfully synthesized and systematically investigated.Our results show that the Zn2+-doping concentration has significant effect on the microstructures and luminescence properties of the NaGd0.4Eu0.6Mg1-xZnxWO6phosphors.The NaGd0.4Eu0.6Mg1-xZnxWO6（0≤x≤0.7） samples are well crystallized pure solid solution sub-microcrystals,whereas the phase purity gradually decreases at 0.70.4Eu0.6Mg1-xZnxWO6（00.4Eu0.6MgWO6,and the optimized NaGd0.4Eu0.6Mg0.9Zn0.1WO6phosphor possesses the best luminescence properties including thermal stability,CIE chromaticity coordinate,life time and quantum yield.The packaged WLED using NaGd0.4Eu0.6Mg0.9Zn0.1WO6phosphor emits bright white light with higher CRI,lower CCT,and chromaticity coordinate close to the pure white light.The developed NaGd0.4Eu0.6Mg1-xZnxWO6phosphors have potential application in lighting and display.This work can offer an effective strategy for boosting luminescence properties of tungstate phosphors with the double perovskite structure.

关键词： Double perovskite Luminescence Microstructure Rare earths Tungstate phosphor Zn2+-doping

Optimized blind equalization for probabilistically shaped high-order QAM signals

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Optics Letters 2022年第8期20卷 1-5页

作者：曹凤楚高明义王鹏飞由骁迪沈纲祥 Jiangsu Engineering Research Center of Novel Optical Fiber Technology and Communication Network Suzhou Key Laboratory of Advanced Optical Communication Network TechnologySchool of Electronic and Information EngineeringSoochow UniversitySuzhou 215006China

Probabilistically shaped(PS)high-order quadrature amplitude modulation(QAM)signals are attractive to coherent optical communication due to increased spectral efficiency.However,standard digital signal processing algorithms are not optimal to demodulate PS high-order QAM signals.Therefore,a compromise equalization is indispensable to compensate the residual distortion.Meanwhile,the performance of conventional blind equalization highly depends on the accurate amplitude radius and distribution of the signals.The PS high-order QAM signals make the issue worsen because of indistinct amplitude distributions.In this work,we proposed an optimized blind equalization by utilizing a peak-density K-means clustering algorithm to accurately track the amplitude radius and distribution.We experimentally demonstrated the proposed method in a PS 256-QAM coherent optical transmission system and achieved approximately 1 dB optical signal-to-noise ratio improvement at the bit error rate of 1×10^(−3).

关键词： coherent optical communication probabilistic shaping blind equalization

Orthogonal Combinatorial Raman Codes Enable Rapid High-Throughput-Out Library Screening of Cell-Targeting Ligands

在线全文

学校读者我要写书评

暂无评论

Research 2024年第1期2023卷 199-208页

作者： Yuchen Tang Xingxing Zheng Tingjuan gao China Key Laboratory of Pesticide and Chemical Biology of Ministry of Education College of ChemistryCentral China Normal UniversityWuhan 430079China

High-throughput assays play an important role in the fields of drug discovery,genetic analysis,and clinical diagnostics.Although super-capacity coding strategies may facilitate labeling and detecting large numbers of targets in a single assay,practically,the constructed large-capacity codes have to be decoded with complicated procedures or are lack of survivability under the required reaction conditions.This challenge results in either inaccurate or insufficient decoding outputs.Here,we identified chemical-resistant Raman compounds to build a combinatorial coding system for the high-throughput screening of cell-targeting ligands from a focused 8-mer cyclic peptide library.The accurate in situ decoding results proved the signal,synthetic,and functional orthogonality for this Raman coding strategy.The orthogonal Raman codes allowed for a rapid identification of 63 positive hits at one time,evidencing a high-throughput-out capability in the screening process.We anticipate this orthogonal Raman coding strategy being generalized to enable efficient high-throughput-out screening of more useful ligands for cell targeting and drug discovery.

关键词： enable throughput allowed

Evolution of HIV/AIDS Prevention and Control Policies in China:A Grounded Theory Approach

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China CDC weekly 2024年第1期6卷 12-22页

作者： Huang Li Rui gao Chichen Zhang School of Public Health Southern Medical UniversityGuangzhou CityGuangdong ProvinceChina School of Health Management Southern Medical UniversityGuangzhou CityGuangdong ProvinceChina Key Laboratory of Philosophy and Social Sciences of Colleges and Universities in Guangdong Province for Collaborative Innovation of Health Management Policy and Precision Health Service Southern Medical UniversityGuangzhou CityGuangdong ProvinceChina Graduate School Xi’an Jiaotong-Liverpool UniversitySuzhou CityJiangsu ProvinceChina School of Political Science and Public Administration Soochow UniversitySuzhou CityJiangsu ProvinceChina

Objective:This study aims to provide a theoretical foundation for the development and practical application of human immunodeficiency virus(HIV)/acquired immunodeficiency syndrome(AIDS)prevention and control policy systems in China by scrutinizing,analyzing,and synthesizing the evolution of Chinese policies in this domain.Methods:Utilizing grounded theory,we employed NVivo12 software to perform text content analysis,mining,and coding classification,along with visualization techniques,on policy texts sourced from Chinese government platforms,including the official website of China’s State Council.We considered four analytical dimensions—time,subject,type,and object.Results:The National Health Commission and the State Council emerged as the primary entities engaged in policymaking for HIV/AIDS in China.We identified four distinct stages in the evolution of these policies,culminating in a novel‘sun-shaped’HIV/AIDS prevention and control policy network model with an emphasis on‘knowledge,attitude,and practice’at its nucleus,which aligns with national conditions and societal progress.Furthermore,the focal groups of these policies have been dynamically refined and updated over time.Conclusions:Our findings introduce a‘sunshaped’HIV/AIDS prevention and control policy network model specific to China.We observed a conceptual policy shift towards prioritizing overall human health rather than confining the focus to disease treatment.Additionally,in light of China’s growing elderly population,the imperative to address HIV/AIDS prevention and control among older adults is an issue that warrants increased attention.

关键词： prevention HIV/AIDS policy

Thermal and mechanical behavior of casting copper alloy wheel during wheel and belt continuous casting process

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Foundry 2024年第1期21卷 82-90页

作者： Kun gao Yan Peng School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina

To investigate the thermal and mechanical behavior of casting wheel,a two-dimensional thermoelastic-plastic finite element model was used to predict the temperature,stress and distortion distribution of the casting wheel during the wheel and belt continuous casting process.The effects of grinding thickness and casting speed on the thermal and mechanical behaviors of the center of the hot face of the casting wheel were discussed in detail.In each rotation,the casting wheel passes through four different spray zones.The results show that the temperature distribution of the casting wheel in different spray zones is similar,the temperature of the hot face is the highest and the temperature reaches the peak in the spray zoneⅢ.The stress and distortion depend on the temperature distribution,and the maximum stress and distortion of the hot face are 358.2 MPa and 1.82 mm,respectively.The temperature at the center of the hot face decreases with increasing grinding thickness and increases with increasing casting speed.

关键词： casting wheel finite element model grinding thickness casting speed hot face spray zones

The late Early-Paleozoic granitic magmatism in Northwestern Fujian, China: constraints on intraplate orogeny in the South China block

在线全文

学校读者我要写书评

暂无评论

Acta Geochimica 2024年第1期43卷 134-149页

作者： WanLi gao ZongXiu Wang Institute of Geomechanics Chinese Academy of Geological ScienceBeijing 100081People’s Republic of China Key Laboratory of Paleomagnetism and Tectonic Reconstruction of Ministry of Natural Resources Beijing 100081People’s Republic of China

The Early Paleozoic tectono-thermal event was a significant orogenic activity during the Phanerozoic era,which had a profound impact on the early crust of the South China Block(SCB) and established the foundation for later tectonic activity.The Wuyi-Yunkai orogenic belt in Southeastern China was extensively exposed to Early Paleozoic magmatism,the genetic mechanism of which remains controversial.To shed light on this issue,detailed petrological,geochemical,and zircon U-Pb-Hf isotopic studies were carried out on two granitoids,namely the Yuntongshan pluton and the gaoqiao pluton,identified in the central Wuyishan.Zircon U-Pb chronology of the Yuntongshan and gaoqiao bodies yielded ages of437±4 Ma(MSWD=2.2) and 404±2 Ma(MSWD=12),respectively,indicating that they were emplaced during the Early Silurian and Early Devonian periods.These granitoids are primarily composed of biotite-granite and biotite-monzonitic-granites,with high concentrations of S_(i)O_(2)(73.59-75.91 wt%),K_(2)O+Na_(2)O(8.31-8.73wt%),and low contents of MgO,CaO,Cr,Ni.They are classified as high-K calc-alkaline and weakly metaluminous-strongly peraluminous S-type granites.These granitoids are enriched in light rare earth elements(LREEs) and large ion lithophile elements(LILEs) and depleted in heavy rare earth elements(HREEs) and high field strength elements(HFSEs) with arc affinity.The εHf(t) values of-3.3 to-15.4 with two-stage Hf model ages ranging from 2829 to 1644 Ma,combined with the presence of Neoproterozoic inherited zircons,suggest that the primary magma of these granitoids was derived from the partial melting of Neoproterozoic crust with a Paleoproterozoic crustal model age.These findings,combined with the spatio-temporal distribution of regional magmatism,reveal that the late Early-Paleozoic granitoids formed in the intraplate orogenic background originating from the subduction of the proto-Tethys Ocean and proto-Pacific Ocean around the margin of the east Gondwana supercontinent.

关键词： Late Early-Paleozoic Granites Intraplate orogeny Cathysian block Zircon U-Pb-Hf Isotopic composition