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World Journal of Gastroenterology 2024年第20期30卷 2689-2708页

作者： Lian-Meng Huang ming-jin zhang Department of General Surgery The 901st Hospital of PLAHefei 230031Anhui ProvinceChina

BACKGROUND The regulatory effects of KIF26B on gastric cancer(GC)have been confirmed,but the specific mechanism still needs further ***-cancer analysis shows that the KIF26B expression is highly related to immune infiltration of cancerassociated fibroblasts(CAFs),and CAFs promote macrophage M2 polarization and affect cancers’*** To investigate the regulatory functions of KIF26B on immune and metastasis of *** We analyzed genes’mRNA levels by quantitative real-time polymerase chain *** levels of target proteins were detected by immunohistochemistry,ELISA,and Western *** injected AGS cells into nude mice for the establishment of a xenograft tumor model and observed the occurrence and metastasis of *** degree of inflammatory infiltration in pulmonary nodes was observed through hematoxylin-eosin *** and wound healing assays were performed for the evaluation of cell invasion and migration *** formation assay was used for detecting angiogenesis.M2-polarized macrophages were estimated by immunofluorescence and flow *** KIF26B was significantly overexpressed in cells and tissues of GC,and the higher expression of KIF26B was related to GC metastasis and *** to in vivo experiments,KIF26B promoted tumor formation and metastasis of ***26B expression was positively associated with CAFs’degree of ***,CAFs could regulate M2-type polarization of macrophages,affecting GC cells’migration,angiogenesis,invasion,and epithelial-mesenchymal transition *** KIF26B regulated M2 polarization of macrophage through activating CAFs,regulating the occurrence and metastasis of GC.

关键词： metastasis invasion macrophage

Elastodynamic analysis of synergistic oscillation system driven by double servomotors for continuous casting mold

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Journal of Iron and Steel Research(International) 2022年第1期29卷 115-123页

作者： Da-wei Liu Chen Lv jin-ming zhang Xin jin College of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina National Engineering Technology Research Center of Cold Rolling Strip Equipment and Technology Yanshan UniversityQinhuangdao 066004HebeiChina

Based on the principle of speed superposition,the oscillation system for continuous casting mold synchronously driven by double servomotors can adjust all parameters online with high reliability and high bearing *** elastodynamic model of the oscillation system was presented to analyze the oscillation characteristics affected by multiple ***,the working principle of the system was illustrated,with the kinematic model of the system *** the elastic deformation of mechanical components,the lumped parameter method was used to establish the equivalent component and elastodynamic model of the oscillation *** on Runge–Kutta method,the oscillation response of the system was *** validity of the elastodynamic model was validated by comparing the simulated solution and experimental data,and the oscillation characteristics of the system were analyzed emphatically with model *** results showed that the first three harmonic frequencies of the eccentric shafts are the main cause of harmonic resonance,which has a strong relationship with the system *** increase in the fluctuation coefficients and the decrease in the phase difference enhanced the elastic oscillation of the *** elastic error tends to show linear growth with the increase in the friction force of the slab.

关键词： Continuous casting Mold Non-sinusoidal oscillation Elastic response

Functional Cellulose Materials Fabricated by Using Ionic Liquids as the Solvent

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Chinese Journal of Polymer Science 2023年第4期41卷 483-499,I0005页

作者： Yi-Rong Wang Chun-Chun Yin jin-ming zhang jin Wu Jian Yu Jun zhang CAS Key Laboratory of Engineering Plastics and CAS Research/Education Center for Excellence in Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing100190China College of Chemistry University of Chinese Academy of SciencesBeijing100049China

Cellulose is one of the most abundant natural polymers in the nature,which has many attractive advantages,such as renewability,biodegradability,and ***,due to the strong hydrogen bond network and hierarchical structure,cellulose is extremely difficult to be dissolved and *** recently,a class of novel eco-friendly solvents,ionic liquids,have been found to be able to efficiently dissolve cellulose,providing a versatile platform for cellulose processing and ***,we highlight recent advances in efficiently fabricating functional cellulose derivatives via the homogeneous chemical modification and developing all-biomass materials via controlling the dissolution-regeneration process in ionic *** effective and environmentally-friendly utilization of cellulose not only reduces dependence on fossil resources but also protects the environment.

关键词： Cellulose Ionic liquids Homogeneous modification Functional materials Cellulose derivatives

Value of Chuanjin Qinggan decoction in improving the depressive state of patients with herpes zoster combined with depression

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World Journal of Psychiatry 2023年第12期13卷 1037-1045页

作者： Yi-Nan Wang Meng-Meng Shi jin-ming zhang Department of Dermatology Yantai Hospital of Traditional Chinese MedicineYantai 264000Shandong ProvinceChina Department of Geriatrics Yantai Traditional Chinese Medicine HospitalYantai 264000Shandong ProvinceChina

BACKGROUND Western medicine is beneficial for the recovery of neurological function in patients with depression,but some patients experience side effects such as headaches,dizziness,nausea,gastrointestinal symptoms,insomnia,and cardiac *** recent years,integrative medicine has achieved positive results in the treatment of various *** To study Chuanjin Qinggan decoction combined with selective serotonin reuptake inhibitors(SSRIs)in patients with herpes zoster complicated by *** Patients with herpes zoster complicated by depression who were treated at the Yantai Hospital of Traditional Chinese Medicine from January 2021 to December 2022 were retrospectively selected as research *** them,43 patients with herpes zoster complicated by depression who received SSRI treatment between January and December 2021 were assigned to the Western medicine group,while those who received combined treatment of traditional Chinese and Western medicine between January and December 2022 were assigned to the combined *** groups were treated for eight *** degree of pain,effect of herpes zoster treatment,degree of improvement in depressive symptoms,serum neurotransmitter levels,sleep quality,and occurrence of adverse reactions were compared between the two *** We found that after eight weeks of drug treatment,the two treatment schemes achieved differing *** further comparison,we found that,compared with patients treated with SSRIs alone,patients treated with Chuanjin Qinggan decoction combined with SSRIs showed more significant improvement in depression and a greater increase in dopamine and 5-hydroxytryptamine levels after treatment(Pjin Qinggan decoction combined with SSRIs also experienced lower pain,better treatment efficacy for herpes zoster,better sleep quality,and a lower incidence of adverse reactions compared to those treated with SSRIs alone(P<0.05).All minor adverse

关键词： Chuanjin Qinggan decoction Selective 5-hydroxytryptamine reuptake inhibitor Herpes zoster Depression Sleep quality Adverse reaction

ERF4 interacts with and antagonizes TCP15 in regulating endoreduplication and cell growth in Arabidopsis

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Journal of Integrative Plant Biology 2022年第9期64卷 1673-1689页

作者： An-ming Ding Chuan-Tao Xu Qiang Xie ming-jin zhang Ning Yan Chang-Bo Dai jing Lv Meng-Meng Cui Wei-Feng Wang Yu-He Sun Key Laboratory of Tobacco Gene Resources Tobacco Research InstituteChinese Academy of Agricultural Sciences(CAAS)Qingdao266101 China College of Plant Protection Shenyang Agricultural UniversityShenyang110866 China Luzhou Tobacco Company of Sichuan Province Luzhou646000 China

Endoreduplication is prevalent during plant growth and development,and is often correlated with large cell and organ *** its prevalence,the transcriptional regulatory mechanisms underlying the transition from mitotic cell division to endoreduplication remain ***,we characterize ETHYLENE-RESPONSIVEELEMENTBINDING FACTOR 4(ERF4)as a positive regulator of endoreduplication through its function as a transcriptional ***4 was specifically expressed in mature tissues in which the cells were undergoing expansion,but was rarely expressed in young *** overexpressing ERF4 exhibited much larger cells and organs,while plants that lacked functional ERF4 displayed smaller organs than the ***4 was further shown to regulate cell size by controlling the endopolyploidy level in the ***,ERF4 physically associates with the class I TEOSINTE BRANCHED 1/CYCLOIDEA/PCF(TCP)protein TCP15,a transcription factor that inhibits endoreduplication by activating the expression of a key cell-cycle gene,CYCLIN A2;3(CYCA2;3).A molecular and genetic analysis revealed that ERF4promotes endoreduplication by directly suppressing the expression of CYCA2;***,this study demonstrates that ERF4 and TCP15 function as a module to antagonistically regulate each other?s activity in regulating downstream genes,thereby controlling the switch from the mitotic cell cycle to endoreduplication during leaf *** findings expand our understanding of how the control of the cell cycle is fine-tuned by an ERF4–TCP15 transcriptional complex.

关键词： Arabidopsis cell growth CYCA2 3 endoreduplication ERF4 TCP15

Even Search in a Promising Region for Constrained Multi-Objective Optimization

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 474-486页

作者： Fei ming Wenyin Gong Yaochu jin School of Computer Science China University of GeosciencesWuhan 430074China IEEE Faculty of Technology Bielefeld UniversityNorth Rhine-Westphalia 33619Germany School of Engineering Westlake UniversityHangzhou 310030China

In recent years, a large number of approaches to constrained multi-objective optimization problems(CMOPs) have been proposed, focusing on developing tweaked strategies and techniques for handling constraints. However, an overly finetuned strategy or technique might overfit some problem types,resulting in a lack of versatility. In this article, we propose a generic search strategy that performs an even search in a promising region. The promising region, determined by obtained feasible non-dominated solutions, possesses two general ***, the constrained Pareto front(CPF) is included in the promising region. Second, as the number of feasible solutions increases or the convergence performance(i.e., approximation to the CPF) of these solutions improves, the promising region shrinks. Then we develop a new strategy named even search,which utilizes the non-dominated solutions to accelerate convergence and escape from local optima, and the feasible solutions under a constraint relaxation condition to exploit and detect feasible regions. Finally, a diversity measure is adopted to make sure that the individuals in the population evenly cover the valuable areas in the promising region. Experimental results on 45 instances from four benchmark test suites and 14 real-world CMOPs have demonstrated that searching evenly in the promising region can achieve competitive performance and excellent versatility compared to 11 most state-of-the-art methods tailored for CMOPs.

关键词： Constrained multi-objective optimization even search evolutionary algorithms promising region real-world problems

Electrochemical Reduction of Benzo[b]thiophene 1,1-Dioxides with HFIP as Hydrogen Donor

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Chinese Journal of Chemistry 2024年第6期42卷 585-591页

作者： ming-Zhong Guo Mei-jin Mou Zhuo Chen Shao-Fei Ni ming Li Li-Rong Wen Lin-Bao zhang State Key Laboratory Base of Eco-Chemical Engineering College of Chemistry and Molecular EngineeringQingdao University of Science & TechnologyQingdaoShandong266042 China Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantouGuangdong515063 China

A straightforward electrochemical reduction of benzo[b]thiophene 1,1-dioxides with HFIP as the hydrogen donor has been reported in an undivided cell under metal-free ***,the tolerance of various functional groups and ... 详细信息

关键词： Electrochemistry Reduction Benzo[b]thiophene 1,1-dioxides Deuterium Hydrogen source

Global Zero-relaxation Limit Problem of the Electro-diffusion Model Arising in Electro-Hydrodynamics

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 241-268页

作者： ming-hua Yang Si-ming Huang jin-yi Sun Department of Mathematics Jiangxi University of Finance and EconomicsNanchang330032China School of Public Administration Guangdong University of Foreign StudiesGuangzhou510006China College of Mathematics and Statistics Northwest Normal UniversityLanzhou730070China

In this paper,we study a global zero-relaxation limit problem of the electro-diffusion model arising in electro-hydrodynamics which is the coupled Planck-Nernst-Poisson and Navier-Stokes *** is,the paper deals with a singular limit problem of{u^(∈)_(t)+u^(∈)·▽u^(∈)-Δu^(∈)+▽P^(∈)=Δφ^(∈)▽φ^(∈),in R^(3)×(0,∞),▽·u^(∈)=0,in R^(3)×(0,∞),n^(∈)_(t)+u^(∈)·▽n^(∈)-Δn^(∈)=-▽·(n^(∈)▽φ^(∈)),in R^(3)×(0,∞),ct+u^(∈)·▽c^(∈)-Δc^(∈)=▽·(c^(∈)▽φ^(∈)),in R^(3)×(0,∞),∈^(-1)φ^(∈)_(t)=Δφ^(∈)-n^(∈)+c^(∈),in R^(3)×(0,∞),(u^(∈),n^(∈),c^(∈),φ^(∈))|t=0=(u0,n0,c0,φ0),in R^(3) involving with a positive,large parameter^(∈).The present work show a case that(u^(∈),n^(∈),c^(∈))stabilizes to(u^(∞),n∞,c∞):=(u,n,c)uniformly with respect to the time variable as^(∈)→+∞with respect to the strong topology in a certain Fourier-Herz space.

关键词： fourier-Herz space littlewood-Paley decomposition stability limit dissipative system

Scalable graphene foam with ultrahigh conductivity for stabilizing Pt towards efficient hydrogen evolution

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Nano Research 2024年第8期17卷 6968-6976页

作者： ming Zhao Meng Huang Huihui jin Dayin He Wei Qian Zixin zhang Daping He State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hubei Engineering Research Center of RF-Microwave Technology and Application Wuhan University of TechnologyWuhan 430070China School of Information Engineering Wuhan University of TechnologyWuhan 430070China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China Sanya Science and Education Innovation Park of Wuhan University of Technology Sanya 572000China

For the carbon-based catalyst to be active and stable,especially in harsh electrochemical environments,the key is to decrease the concentration of defects and raise the degree of graphitization of the carbon ***,we develop a highly graphitized graphene foam with multiplicated structure to fabricate self-supporting Pt-based catalysts for efficient and stable hydrogen evolution reaction(HER)*** foam(GO-2850)is obtained through an ultra-high temperature treatment at 2850℃,with perfect graphene structure and extremely low defect,ensuring high electrical conductivity and corrosion ***,its multiplicated structure provides an inherently favorable environment for the dispersion of Pt nanoparticles(Pt NPs)and offers abundant channels for electrolyte infiltration during the catalytic *** a result,the as-prepared Pt/GO-2850 is far active and stable than the Pt NPs supported on commercial carbon paper(Pt/CP)counterpart toward catalyzing HER,exhibiting an outstanding activity and long-term durability(300 h@10 mA·cm^(−2))in acidic/alkaline/seawater *** can be attributed to the stronger interaction between the lower-defect GO-2850 substrate and Pt,as evidenced by characterization and theoretical *** work extends further insight into the design self-supporting catalysts of high activity and stability with promising prominent application toward green energy devices.

关键词： graphene foam high graphitization Pt nanoparticles hydrogen evolution reaction long-term stability

Constrained Multi-Objective Optimization With Deep Reinforcement Learning Assisted Operator Selection

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 919-931页

作者： Fei ming Wenyin Gong Ling Wang Yaochu jin the School of Computer Science China University of GeosciencesWuhan 430074China the Department of Automation Tsinghua UniversityBeijing 100084China the Faculty of Technology Bielefeld UniversityNorth Rhine-Westphalia33619 BielefeldGermany

Solving constrained multi-objective optimization problems with evolutionary algorithms has attracted considerable *** constrained multi-objective optimization evolutionary algorithms(CMOEAs)have been developed with the use of different algorithmic strategies,evolutionary operators,and constraint-handling *** performance of CMOEAs may be heavily dependent on the operators used,however,it is usually difficult to select suitable operators for the problem at ***,improving operator selection is promising and necessary for *** work proposes an online operator selection framework assisted by Deep Reinforcement *** dynamics of the population,including convergence,diversity,and feasibility,are regarded as the state;the candidate operators are considered as actions;and the improvement of the population state is treated as the *** using a Q-network to learn a policy to estimate the Q-values of all actions,the proposed approach can adaptively select an operator that maximizes the improvement of the population according to the current state and thereby improve the algorithmic *** framework is embedded into four popular CMOEAs and assessed on 42 benchmark *** experimental results reveal that the proposed Deep Reinforcement Learning-assisted operator selection significantly improves the performance of these CMOEAs and the resulting algorithm obtains better versatility compared to nine state-of-the-art CMOEAs.

关键词： Constrained multi-objective optimization deep Qlearning deep reinforcement learning(DRL) evolutionary algorithms evolutionary operator selection