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International Journal of Minerals,Metallurgy and Materials 2014年第6期21卷 544-555页

作者： Jing Zhou Bao-yu Wang ming-dong huang dong Cui School of Mechanical Engineering University of Science and Technology Beijing

Thermomechanical experiments were carried out to reproduce the hot stamping process and to investigate the effects of process parameters on the microstructure and mechanical properties of stamped parts. The process parameters, such as austenitizing temperature, soaking time, initial deformation temperature and cooling rate, are studied. The resulting microstructures of specimens were observed and analyzed. To evaluate the mechanical properties of specimens, tensile and hardness tests were also performed at room temperature. The op-timum parameters to achieve the highest tensile strength and the desired microstructure were acquired by comparing and analyzing the results. It is indicated that hot deformation changes the transformation characteristics of 22MnB5 steel. Austenite deformation promotes the austen-ite-to-ferrite transformation and elevates the critical cooling rate to induce a fully martensitic transformation.

关键词： boron steel strip metal stamping mechanical properties microstructure phase transitions

Hot Stamping Parameters Optimization of Boron Steel Using a Response Surface Methodology Based on Central Composite Design

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Journal of Iron and Steel Research International 2015年第6期22卷 519-526页

作者： ming-dong huang Bao-yu WANG Jing ZHOU School of Mechanical Engineering University of Science and Technology Beijing

The effect of hot stamping parameters on the mechanical properties of 22MnB5 steel sheet with thickness of 1.1 mm is studied. The considered parameters are austenization temperature （800- 1 000 ℃ ）, austenitizing soa king time （60-540 s）, initial deformation temperature （560-800 C） and tool temperature （20-220 ℃）. In order to obtain hot stamped parts with optimal mechanical properties, response surface methodology based on the central composite design has been employed to design the experiment matrix. Tensile strength of hot stamped parts is deter- mined as the relation in the mathematical model. The optimal condition and objective effects of parameters are deter mined via this relation. The statistical analysis showed that all four factors significantly affect the tensile strength of the hot stamped parts. The optimum austenization temperature is found to be 918.89 ℃ with the austenitizing soa- king time, initial deformation temperature and tool temperature of 279.45 s, 684.69 C and 21.85 ℃, respectively. These optimal hot stamping parameters prove to have high tensile strength （1 631.84 MPa） where deviation between predicted and actual response falls within 2 %.

关键词： hot stamping advanced high strength steel response surface method optimization

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期68卷 204-218页

作者： Chen Xiong Hong Ling Yingdan huang Hanzhi dong Bangxiang Xie Qian Hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

The reactivities of Mo cluster——A selective substitution reaction of the bridging(dtp)ligand and the crystal structure of{Mo_3S_4(μ-O_2CR)(dtp)_3(Py)}

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Acta Chimica Sinica English Edition 1989年第1期7卷 24-36页

作者： EU Shao-Fang huang Jian-Quan huang ming-dong huang Jin-Lin Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou,Fujian Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian

The reaction of trinuclear molybdenum cluster{Mo_3S_4(μ-dtp)(dtp)_3(H_2O)}1[dtp= S_2P(OEt)_2]with RCO_2Na(R=H,CH_3)in the presence of Py gave the black compounds{Mo_3S_4(μ- O_2CR)(dtp)_3(Py)}(2,R=H,3,R=CH_3).Both compounds are characterized by X-ray crystallo- *** is shown that crystals 2 and 3 belong to space group P with Z=2 and a=10.519(2),b= 12.121(2),c=15.757(2),α=93.27(1),β=94.63(1),γ=105.22(1)°,V=1925~3 for crystal 2,whereas a=9.556(2),b=14.067(7),c=15.914(9),α=101.41(4),β=101.44(4),γ=74.26(3)°,V=1994~3 for crystal *** final R factors are 0.041 and 0.048 for crystal 2 and 3 *** structure analysis indicates that(O_2CR)^- ligand selectively substitutes the bridging(dtp)*** type of Mo_3 cluster molecule where structure contains two species of bidentate ligand is for the first time to be obtained by us.

关键词： Mo A selective substitution reaction of the bridging dtp)ligand and the crystal structure of{Mo3S4 O2CR

Long noncoding RNA LINC01106 promotes lung adenocarcinoma progression via upregulation of autophagy

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Oncology Research 2025年第1期33卷 171-184页

作者： GENGYUN SUN YIPING ZHENG JIANFENG CAI JIE GAO LIE dong XIANGBIN ZHANG YINGHUI huang Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Respiratory and Critical Care Medicine Nanping First Hospital Affiliated to Fujian Medical UniversityNanping353006China

Background:Long noncoding RNA,LINC01106 exhibits high expression in lung adenocarcinoma(LUAD)tumor tissues,but its functional role and regulatory mechanism in LUAD cells remain ***:LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was *** cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor *** downstream transcription factors and molecular mechanism were determined using the Human transcription factor database(TFDB)database and Gene Expression Profiling Interactive Analysis(GEPIA)***,the impact of linc01106 on autophagy was analyzed by determining the expression of autophagy-related genes(ATGs)in LUAD ***:Our results showed that LINC01106 exhibited upregulation in both LUAD tissues and cell *** silencing of LINC01106 demonstrated a suppressive effect on tumorigenesis in a xenograft mouse model of ***,LINC01106 was found to recruit TATA-binding protein-associated factor 15(TAF15),an RNA-binding protein,thereby enhancing the mRNA stability of TEA domain transcription factor 4(TEAD4).In turn,TEAD4 served as a transcription factor that bound to the LINC01106 promoter and regulated its *** assays indicated that LINC01106 promoted autophagy in LUAD cells by upregulating the expression of autophagy-related genes(ATGs).The silencing of LINC01106 in LUAD cells inhibited autophagy,and cell proliferation,and promoted apoptosis,which all were effectively reversed by ATG5 ***:Overall,LINC01106,transcriptionally activated by TEAD4,interacts with TAF15 to promote the stability of TEAD4 and upregulates the expression of ATGs,promoting malignancy of LUAD cells.

关键词： LINC01106 TAF15 TEAD4 ATG5 Lung adenocarcinoma(LUAD) Non-small cell lung cancer(NSCLC)

Effect of friction coefficient in deep drawing of AA6111 sheet at elevated temperatures

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Transactions of Nonferrous Metals Society of China 2015年第7期25卷 2342-2351页

作者：马闻宇王宝雨傅垒周靖黄鸣东北京科技大学机械工程学院北京100083 苏州有色金属研究院苏州215026

The effect of friction coefficient on the deep drawing of aluminum alloy AA6111 at elevated temperatures was analyzed based on the three conditions using the finite element analysis and the experimental *** indicate that the friction coefficient and lubrication position significantly influence the minimum thickness,the thickness deviation and the failure mode of the formed *** the hot forming process,the failure modes are draw mode,stretch mode and equi-biaxial stretch mode induced by different lubrication *** terms of formability,the optimal value of friction coefficient determined in this work is *** the same time,the good agreement is performed between the experimental and simulated *** often occurs at the center of cup bottom or near the cup corner in a ductile mode or ductile-brittle mixed mode,respectively.

关键词： aluminum alloy deep drawing friction coefficient formability fracture surface

A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang Wei Kang Zhou Xin huang Xing Zhou Jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

Modeling tactile perceived intensity for vibration from a coin eccentric rotating mass motor

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Science China Technological Sciences 2025年

作者： Yun FANG Jingchen huang Yujun WU Jiaqi dong Weichao GUO Xinjun SHENG State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University Meta Robotics Institute Shanghai Jiao Tong University

Establishing the relationship between vibrotactile parameters and perceived intensity（PI） is of great significance in the regulation of desired sensations, which contribute to haptic interfaces in practical applications. Coin eccentric rotating mass（ERM） motors are routinely utilized due to their lightweight design and efficient ability to evoke strong tactile sensations. By adjusting input voltages, ERMs can yield different stimuli, but the effects of their physical properties on PI remain ***, we developed the physical model of the ERM-skin system and optimized the parameters affecting PI. Moreover, the relationship between stimulus and perception was derived based on Fechner?s law. Three experiments were conducted on fifteen subjects（ten males and five females, aged 24.40 ± 2.87 years） to identify the vibration parameters and corresponding PI to verify the proposed PI model. ERMs in this study were attached to phantom skin/forearm with slim adhesive tape to minimize the interference. Experiment 1 performed vibration calibration with ERM attached to the skin phantom to simulate the actual configuration. Then, the relative and absolute PI of subjects on specific stimuli were acquired in Experiments 2 and *** fitting reliability of the proposed PI model was evaluated on fifteen subjects with R2of 0.73 ± 0.07 and root mean squared error（RMSE） of 1.35 ± 0.28. Overall, the proposed PI model established the quantitative relationship between stimulus parameters（vibration parameters and physical parameters） and subjective PI, which provided theoretical support for ERM optimization and vibrotactile modulation.

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期68卷 369-376页

作者： Song-Meng Wang Hao Nian Yan-Fang Wang Li-Shuo Zheng Yu-Tao Zheng Yi-Wei dong Liping huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

关键词： host-guest interaction hydrophobic effect endo-functionalized cavity mutation pyridine

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比格犬上颌窦的应用解剖

解剖学报 2016年第5期47卷 652-657页

作者：游冬冬戴霖霖陈永辉林兆楠付小明吴东黄文秀福建医科大学附属口腔医院福州350002 中山大学孙逸仙纪念医院广州510120 福建省漳州市医院口腔科福建漳州363000 重庆医科大学附属口腔医院重庆401147

目的探讨比格犬上颌窦正常解剖,为与上颌窦有关的动物实验提供解剖学依据。方法收集16个比格犬上颌窦,利用锥形束投照计算机重组断层影像（CBCT）扫描,并完成局部解剖,详细观察上颌窦形态、位置、容积、自然窦口位置及与周围组织的毗邻... 详细信息

目的探讨比格犬上颌窦正常解剖,为与上颌窦有关的动物实验提供解剖学依据。方法收集16个比格犬上颌窦,利用锥形束投照计算机重组断层影像（CBCT）扫描,并完成局部解剖,详细观察上颌窦形态、位置、容积、自然窦口位置及与周围组织的毗邻关系。另购买2只健康成年比格犬,利用CBCT确定上颌窦窦底,经腭侧开窗,显露软组织,夹取该位点黏膜行组织学检查,光学显微镜下验证所夹取黏膜是否为上颌窦黏膜。结果比格犬上颌窦形状略似锥形,前部较窄,后部宽大,位于上颌第3前磨牙与第1磨牙之间的腭侧,四周均有骨壁包绕。于第4前磨牙远中牙尖腭侧,距腭中缝约17~18mm处可见上颌窦最低点。同一个体双侧对比,差异无统计学意义。结论比格犬双侧上颌窦无明显差异,有利于上颌窦相关研究进行随机分组;窦腔内无明显骨嵴或分隔,降低窦黏膜穿孔的危险;行上颌窦外提升时,结合CBCT于上颌窦最低点经腭侧骨板开窗是最佳的术式。

关键词：上颌窦放射测量局部解剖苏木素-伊红染色锥形束投照计算机重组断层影像比格犬