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Magnetic resonance imaging-based radiomics model for preoperative assessment of risk stratification in endometrial cancer

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World Journal of Clinical Cases 2024年第26期12卷 5908-5921页

作者： Zhi-Yao Wei zhe Zhang Dong-Li Zhao Wen-ming Zhao Yuan-Guang Meng Department of Obstetrics and Gynecology Seventh Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100700China National Genomics Data Center and Chinese Academy of Sciences Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100700China

BACKGROUND Preoperative risk stratification is significant for the management of endometrial cancer(EC)*** based on magnetic resonance imaging(MRI)in combination with clinical features may be useful to predict the risk grade of *** To construct machine learning models to predict preoperative risk stratification of patients with EC based on radiomics features extracted from *** The study comprised 112 EC *** participants were randomly separated into training and validation groups with a 7:3 *** regression analysis was applied to uncover independent clinical *** predictors were then used to create a clinical *** radiomics features from the T2-weighted imaging and diffusion weighted imaging sequences of MRI images,the Mann-Whitney U test,Pearson test,and least absolute shrinkage and selection operator analysis were employed to evaluate the relevant radiomic features,which were subsequently utilized to generate a radiomic *** machine learning strategies were used to construct radiomic models that relied on the screening *** logistic regression method was used to construct a composite nomogram that incorporated both the radiomic signature and clinical independent risk *** Having an accuracy of 0.82 along with an area under the curve(AUC)of 0.915[95%confidence interval(CI):0.806-0.986],the random forest method trained on radiomics characteristics performed better than *** predictive accuracy of radiomics prediction models surpassed that of both the clinical nomogram(AUC:0.75,95%CI:0.611-0.899)and the combined nomogram(AUC:0.869,95%CI:0.702-0.986)that integrated clinical parameters and radiomic *** The MRI-based radiomics model may be an effective tool for preoperative risk grade prediction in EC patients.

关键词： Endometrial cancer Risk stratification Radiomics Machine learning Nomogram

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Dajianzhong decoction:a review of its phytochemistry and therapeutic potential for gastrointestinal disease

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Integrative Medicine Discovery 2024年第25期8卷 1-9页

作者： Huan-Qing Gao zhe Lu ming Dang Yao Li Meng-Meng Zhang Li Ou College of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China.

Dajianzhong decoction(DJZD)is one of the traditional herbal prescriptions originated from Synopsis of Golden Chamber,which clinically used for the treatment of various gastrointestinal(GI)*** paper was aimed to provide a systematic review on the phytochemistry of DJZD and its therapeutic potential for GI disease and the ***,the possible development and perspectives for future research on this prescription were also *** date,over 60 compounds have been identified form DJZD,including unsaturated fatty acid,saponins,and polyphenols,with hydroxy-sanshool and ginsenoside compounds as the predominant *** possessed widely pharmacological activities on the GI disease from the Eastern Han Dynasty to the present,such as intestinal obstruction,colitis,and irritable bowel *** for the intestinal obstruction,it had demonstrated the efficacy of DJZD treatment for relief of postoperative ileus in patients undergoing surgery for GI *** detailed mechanism was mainly related with NF-ᴋB signaling ***,further research elucidating the protective effects of DJZD on GI disease,exploring new clinical effects,as well as establishing criteria for quality control for DJZD should be studied.

关键词： Dajian zhong decoction gastrointestinal diseases intestinal obstruction sanshool NF-ᴋB pathway

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二次碳化物特征调控及其对高碳高合金马氏体钢耐磨性的影响

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东北大学学报（自然科学版） 2024年第4期45卷 490-498页

作者：蒋金哲刘越刘春明东北大学材料科学与工程学院辽宁沈阳110819

二次碳化物的尺寸、含量对高碳高合金马氏体钢的力学性能及耐磨性有着重要影响.本文采用扫描电子显微镜、透射电子显微镜和磨粒磨损实验等手段,研究了高碳高合金马氏体钢锻造及球化退火过程中二次碳化物的演变行为及其对高碳高合金马氏... 详细信息

二次碳化物的尺寸、含量对高碳高合金马氏体钢的力学性能及耐磨性有着重要影响.本文采用扫描电子显微镜、透射电子显微镜和磨粒磨损实验等手段,研究了高碳高合金马氏体钢锻造及球化退火过程中二次碳化物的演变行为及其对高碳高合金马氏体钢力学性能及耐磨性的影响.结果表明:球化退火显著增加了锻造空冷态实验钢中二次碳化物的含量及尺寸;在奥氏体化过程中,二次碳化物通过钉扎晶界显著细化了奥氏体晶粒,同时二次碳化物的存在降低了马氏体中合金元素固溶量,进而有效提升了实验钢的冲击韧性.高硬度的微米级二次碳化物配合高韧性马氏体基体可有效阻碍磨粒切削并减轻磨损表面的微观断裂,进而提升实验钢的耐磨性.

关键词：高碳高合金马氏体钢二次碳化物硬度冲击韧性耐磨性

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1500 V超结功率MOS器件优化与电容特性研究

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电子学报 2024年第7期52卷 2271-2278页

作者：种一宁李珏乔明电子科技大学电子薄膜与集成器件全国重点实验室四川成都611731 电子科技大学广东电子信息工程研究院广东东莞523950 电子科技大学(深圳)高等研究院广东深圳518110

本文利用半超结结构进行高压超结功率金属氧化物半导体(Metal Oxide Semiconductor,MOS)器件的设计,基于Sentaurus TCAD(Technology Computer Aided Design)仿真平台设计超结元胞结构并优化高压超结功率MOS器件的击穿电压与导通电阻,随... 详细信息

本文利用半超结结构进行高压超结功率金属氧化物半导体(Metal Oxide Semiconductor,MOS)器件的设计,基于Sentaurus TCAD(Technology Computer Aided Design)仿真平台设计超结元胞结构并优化高压超结功率MOS器件的击穿电压与导通电阻,随后探究了寄生电容的特性.最后,基于多次外延工艺自主设计出一款器件结构仿真击穿电压1658 V、工艺仿真击穿电压1598 V、比导通电阻值303 mΩ·cm^(2)的高压超结功率MOS器件,与相同耐压值器件相比,比导通电阻值下降约50%.同时探究了超结掺杂浓度与厚度以及电压支持层掺杂浓度与厚度4个主要结构参数对器件寄生电容特性的影响.

关键词：超结VDMOS 元胞击穿电压比导通电阻寄生电容

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针刺调控脑卒中后轴突再生的机制研究进展

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针刺研究 2024年第7期49卷 767-776页

作者：吴哲焦明媛邹伟黑龙江中医药大学哈尔滨150040 金华市妇幼保健院浙江金华321000 黑龙江中医药大学附属第一医院哈尔滨150040

脑卒中后脑组织病理改变如血肿形成或缺血缺氧状态会导致神经细胞死亡和轴突变性。脑神经细胞损伤后的轴突再生主要受到损伤周围微环境和相关蛋白的调控,主要包括胶质瘢痕、髓鞘相关抑制因子、轴突导向分子、神经营养因子,它们通过调节... 详细信息

脑卒中后脑组织病理改变如血肿形成或缺血缺氧状态会导致神经细胞死亡和轴突变性。脑神经细胞损伤后的轴突再生主要受到损伤周围微环境和相关蛋白的调控,主要包括胶质瘢痕、髓鞘相关抑制因子、轴突导向分子、神经营养因子,它们通过调节生长锥的形态和方向、突触稳定性、神经干细胞增殖与分化来影响轴突生长。本文梳理了针刺调控脑卒中后轴突再生的作用机制,结果显示针刺可通过抑制胶质瘢痕形成、减轻其物理屏障和化学屏障对轴突生长的抑制作用,逆转髓鞘相关抑制因子对轴突生长的抑制作用,调节轴突导向分子水平进而促进神经干细胞的增殖分化和损伤轴突的再生,上调神经营养因子促进神经细胞轴突重塑,从而改善脑卒中后的神经损伤。

关键词：针刺脑卒中轴突再生

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石英挠性加速度计力矩器仿真建模与优化设计

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中国惯性技术学报 2024年第5期32卷 492-498,510页

作者：许哲徐啸韩志强陈崇陈泓玮上海机电工程研究所上海201109

石英挠性加速度计中磁场性能直接影响加速度计输出精度,而力矩器是影响加速度计内部磁场的关键。因此,以石英挠性加速度计中力矩器为研究对象,采用等效磁路方法建立含补偿环元件的力矩器工作气隙磁场数学模型,以此为基础分析工作气隙磁... 详细信息

石英挠性加速度计中磁场性能直接影响加速度计输出精度,而力矩器是影响加速度计内部磁场的关键。因此,以石英挠性加速度计中力矩器为研究对象,采用等效磁路方法建立含补偿环元件的力矩器工作气隙磁场数学模型,以此为基础分析工作气隙磁场均匀性和磁场强度等性能,并采用多参数优化方法对力矩器系统进行整体优化。仿真结果表明,优化模型有效提升力矩器工作气隙磁场均匀性,磁场轴向极差ΔB_(R)由386.3396 mT缩小至108.2755 mT,端点极差ΔB_(D)由217.8894 mT缩小至2.1934 mT,线圈位置气隙轴向磁场几乎保持对称,从而降低加速度计输出非线性,验证了优化方案的可行性。

关键词：石英挠性加速度计力矩器等效磁路磁场均匀性多参数优化

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习近平关于优秀传统文化的重要论述的国际系统层次分析

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周易研究 2024年第2期 5-16页

作者：张起铭任者春齐鲁师范学院科研处山东济南250200 山东师范大学马克思主义学院山东济南250014

国际系统层次分析分为国家、区域和全球三个层面,习近平战略思维定位模式分为功能、性质和目标三个方面,两相结合,构成了对习近平总书记关于优秀传统文化的重要论述的分析框架。在国家层面上,习近平总书记基于建设中华民族现代文明论述... 详细信息

国际系统层次分析分为国家、区域和全球三个层面,习近平战略思维定位模式分为功能、性质和目标三个方面,两相结合,构成了对习近平总书记关于优秀传统文化的重要论述的分析框架。在国家层面上,习近平总书记基于建设中华民族现代文明论述优秀传统文化,其功能即优秀传统文化的六大时代价值,性质是国家的文化软实力,目标是担负新时代新的文化使命;在区域层面上,习近平总书记基于造就中国式现代化的文化形态论述优秀传统文化,其功能是为社会主义核心价值观奠定深厚基础,性质是马克思主义中国化时代化的根脉,目标是铸就社会主义文化新辉煌;在全球层面上,习近平总书记基于创造人类文明新形态论述优秀传统文化,其功能是为人类提供正确精神指引,性质是中华文明拥有文化主体性,目标是深化文明交流互鉴。

关键词：习近平文化思想优秀传统文化中华民族现代文明中国式现代化人类文明新形态国际系统层次分析

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Continuous age-and sex-specific reference ranges of liver enzymes in Chinese children and application in pediatric non-alcoholic fatty liver disease

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World Journal of Pediatrics 2024年第9期20卷 949-956页

作者： Zhao-Yuan Wu Si-Wei Chi Liu-Jian Ouyang Xiao-Qin Xu Jing-Nan Chen Bing-Han Jin Rahim Ullah Xue-Lian Zhou Ke Huang Guan-Ping Dong zhe-ming Li Ying Shen Jie Shao Yan Ni Jun-Fen Fu Qiang Shu Wei Wu Department of Endocrinology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadHangzhou310051China Department of Data and Information Children’s HospitalZhejiang University School of MedicineHangzhouChina Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Thoracic&Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children’s Regional Medical Center3333 Binsheng RoadHangzhou310051China

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(<50 U/L)were developed by laboratories and have not been validated in populations with a large number of healthy *** This study collected venous blood and anthropometric data from a total of 13,287 healthy children aged 3 months to 18 years who underwent routine physical examinations in the Department of Pediatric *** applied the least mean square algorithm to establish age-and sex-related reference percentiles of serum levels of *** validation,we recruited 4276 children and adolescents with obesity/overweight who underwent evaluation and metabolic tests in the *** receiver operating characteristic curves,we determined age-and sex-specific upper limit percentiles of liver enzymes for fatty liver *** This study revealed a significant correlation between serum transaminase levels and age and sex(P<0.01).These transaminase levels exhibited age-and sex-specific *** individuals in the non-alcoholic fatty liver disease(NAFLD)cohort,elevated ALT levels displayed a positive association with clinical markers of disease severity,including homeostatic model assessment of insulin resistance,waist-hip ratio,and serum uric acid levels(P<0.01).According to the receiver operating characteristic curves,ALT levels at the 92.58th percentile for boys and the 92.07th percentile for girls yielded the highest accuracy and *** This study provides age-and sex-specific reference ranges for ALT,aspartate aminotransferase,andγ-glutamyltransferase in Chinese children and adolescents,making it the largest population study to ***,the study establishes a precise upper limit for ALT levels,facilitating their use in NAFLD screening.

关键词： Alanine aminotransferase Childhood Fatty liver diseases

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Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing

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Biomedical and Environmental Sciences 2024年第3期37卷 294-302页

作者： ZHANG Ya Li SU Wen zhe WANG Rui Chen LI Yan ZHANG Jun Feng LIU Sheng Hui HU Dan He XU chong Xiao YIN Jia Yu YIN Qi Kai HE Ying LI Fan FU Shi Hong NIE Kai LIANG Guo Dong TAO Yong XU Song Tao MA Chao Feng WANG Huan Yu Shaanxi University of Chinese Medicine Xianyang 712000ShaanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Guangzhou Center for Disease Control and Prevention Guangzhou 510000GuangdongChina Shandong Center for Disease Control and Prevention Jinan 250000ShandongChina Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Xi'an Center for Disease Control and Prevention Xi’an 710054ShaanxiChina

Objective Viral encephalitis is an infectious disease severely affecting human *** is caused by a wide variety of viral pathogens,including herpes viruses,flaviviruses,enteroviruses,and other *** laboratory diagnosis of viral encephalitis is a worldwide ***,high-throughput sequencing technology has provided new tools for diagnosing central nervous system ***,In this study,we established a multipathogen detection platform for viral encephalitis based on amplicon *** We designed nine pairs of specific polymerase chain reaction(PCR)primers for the 12 viruses by reviewing the relevant *** detection ability of the primers was verified by software simulation and the detection of known positive *** sequencing was used to validate the samples,and consistency was compared with Sanger *** The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×,and the sequence lengths were consistent with the sizes of the predicted *** sequences were verified using the National Center for Biotechnology Information BLAST,and all results were consistent with the results of Sanger *** Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral *** is also a useful tool for the high-volume screening of clinical samples.

关键词： Viral encephalitis Amplicon sequencing High-throughput sequencing Multipathogen detection

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Inhibitory effect of saffron on head and neck squamous cell carcinoma via targeting of ESR1 and CCND1 by its active compound crocetin

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Traditional Medicine Research 2024年第7期9卷 25-34页

作者： Xiao-Jie Wang ming-Jun Zhang Li-Mei Cui zhe-Ying Song Ya-Qi Wang Yu-Teng Yang Xiang-Kun Zhao Ya-Kui Mou Yu-Mei Li Xi-Cheng Song School of Clinical Medicine Weifang Medical UniversityWeifang 261042China. Department of Otorhinolaryngology Head and Neck SurgeryYantai Yuhuangding HospitalQingdao UniversityYantai 264000China. Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases Yantai 264000China. Yantai Key Laboratory of Otorhinolaryngologic Diseases Yantai Yuhuangding HospitalYantai 264000China. The 2nd Medical College of Binzhou Medical University Yantai 264000China.

Background:Traditional Chinese medicine is promising for managing challenging and complex disorders,including cancer,and in particular,saffron is applied in treating various cancer ***,its potential therapeutic efficacy and active components in managing squamous cell carcinoma of the head and neck(HNSCC)remain unclear ***:Using network pharmacology approaches,active ingredients of saffron,their target genes,and HNSCC-related genes were *** analyses were conducted for determining molecular functions and pathways enriched by genes that overlapped between the saffron target gene set and the HNSCC gene *** the four known active ingredients of saffron,crocetin was found to have the strongest inhibitory impact on HNSCC,based on the findings of cell viability and migration ***,the potential target genes of crocetin in HNSCC cells were examined using molecular docking experiments and were confirmed by *** s:Four active ingredients of saffron and 184 of their target genes were ***,a total of 34 overlapping saffron-/HNSCC-associated targets related to the four active ingredients were screened,and crocetin was chosen for further investigation because it had the strongest inhibitory effect on HNSCC *** docking experiments indicated that ESR1 and CCND1 were the target genes of *** results were confirmed through qPCR analysis,in which crocetin was found to lower the expression of the ESR1 and CCND1 genes in AMC-HN-8 and FaDu ***:According to our results,crocetin is a primary active anti-cancer component of saffron that may have potential in the development of novel HNSCC-treating ***,more thorough molecular research is necessary for confirming these results and elucidating the anti-cancer mechanism underlying saffron.

关键词： saffron hub genes crocetin network pharmacology analysis HNSCC ESR1 CCND1

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