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Correlation analysis of human papillomavirus E6/E7 mRNA detection with diagnosis,prognosis and recurrence risk in patients with cervical epithelioma

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World Journal of Clinical Cases 2024年第20期12卷 4146-4153页

作者： Ling-Li Zhang ming-yan du Xin du Jie duan Dong-Mei Yao Jing Jing Chun Feng Lin Song Department of Gynaecology Maternal and Child Health Hospital of Hubei ProvinceWuhan 430075Hubei ProvinceChina Department of Gynaecology China Resources WISCO General HospitalWuhan 430080Hubei ProvinceChina Department of Surgery Maternal and Child Health Hospital of Hubei ProvinceWuhan 430075Hubei ProvinceChina

BACKGROUND Cervical intraepithelial neoplasia(CIN)is an important precursor of cervical *** detection and treatment can reduce the incidence of cervical *** To investigate the detection rate of human papillomavirus(HPV)E6/E7 mRNA in cervical tissue of patients with different types of epithelial cell neoplasia(CIN)and its relationship with CIN progression and *** One hundred women with HPV infection detected by cervical exfoliation cytology between January 2022 and January 2023 were retrospectively *** patients were graded CIN based on colposcopy and cervical *** positive expression rates of HPV E6/E7 mRNA and HPV[polymerase chain reaction(PCR)-reverse dot crossing]were compared among all *** with HPV E6/E7 mRNA expression in the grade 1 CIN group were followed up for 1 *** relationship between atypical squamous epithelium and high malignant epithelial neoplasia was investigated by univariate and multivariate *** The diagnostic sensitivity,specificity,and sensitivity of PCR-reverse point hybrid ization technology for secondary CIN were 70.41%,70.66%,and 0.714,*** and specificity for secondary CIN were 752%and 7853%,respectively,the area under the curve value was *** Multifactorial model analysis revealed that the HPV positive rates and the HPV E6/E7 mRNA positive rates were independent risk factors of CIN grade I(P<0.05).In CIN grade I patients with positive for HPV E6/E7 mRNA,in its orientation to grade CIN patients,in its orientation to grade CIN patients,at 69.2%,compared with patients negative for HPV E6/E7 mRNA(30.8%),significant difference(P<0.05).CONCLUSION HPV E6/E7 mRNA and HPV(PCR-reverse dot hybrid)positive expression have a close relationship with CINgrade disease progression and is an independent risk factor for high-grade CIN lesions.

关键词： Cervical epithelial neoplasia Human papilloma change with virus E6/E7 mRNA Cervical cancer Correlation analysis

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Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway

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World Journal of Stem Cells 2024年第5期16卷 591-603页

作者： Jin-Bo Wang ming-Wei du yan Zheng Internal Medicine of Traditional Chinese Medicine Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Institute of Cardiovascular Disease Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Key Laboratory of Molecular Medical Mycology Second Affiliated Hospital of Naval Medical UniversityShanghai 200003China Shanghai Key Laboratory of Traditional Chinese Clinical Medicine Shanghai 201203China Department of Hepatic The Xixi Hospital of Hangzhou Affiliated to Zhejiang University of Traditional Chinese MedicineHangzhou 310023Zhejiang ProvinceChina

BACKGROUND Aplastic anemia(AA)presents a significant clinical challenge as a life-threatening condition due to failure to produce essential blood cells,with the current the-rapeutic options being notably *** To assess the therapeutic potential of ginsenoside Rg1 on AA,specifically its protective effects,while elucidating the mechanism at *** We employed a model of myelosuppression induced by cyclophosphamide(CTX)in C57 mice,followed by administration of ginsenoside Rg1 over 13 *** invest-igation included examining the bone marrow,thymus and spleen for pathological changes via hematoxylin-eosin ***,orbital blood of mice was collected for blood routine *** cytometry was employed to identify the impact of ginsenoside Rg1 on cell apoptosis and cycle in the bone marrow of AA ***,the study further evaluated cytokine levels with enzyme-linked immunosorbent assay and analyzed the expression of key proteins in the MAPK signaling pathway via western *** Administration of CTX led to significant damage to the bone marrow’s structural integrity and a reduction in hematopoietic cells,establishing a model of *** Rg1 successfully reversed hematopoietic dysfunction in AA *** comparison to the AA group,ginsenoside Rg1 provided relief by reducing the induction of cell apoptosis and inflammation factors caused by ***,it helped alleviate the blockade in the cell *** with ginsenoside Rg1 significantly alleviated myelosuppression in mice by inhibiting the MAPK signaling *** This study suggested that ginsenoside Rg1 addresses AA by alleviating myelosuppression,primarily through modulating the MAPK signaling pathway,which paves the way for a novel therapeutic strategy in treating AA,highlighting the potential of ginsenoside Rg1 as a beneficial intervention.

关键词： Aplastic anemia Ginsenoside Rg1 Myelosuppression MAPK signaling pathway Bone marrow Hematopoietic stem cells

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Sparse Modal Decomposition Method Addressing Underdetermined Vortex-Induced Vibration Reconstruction Problem for Marine Risers

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China Ocean Engineering 2024年第2期38卷 285-296页

作者： du Zun-feng ZHU Hai-ming YU Jian-xing State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation School of Civil EngineeringTianjin UniversityTianjin 300350China

When investigating the vortex-induced vibration(VIV)of marine risers,extrapolating the dynamic response on the entire length based on limited sensor measurements is a crucial step in both laboratory experiments and fatigue monitoring of real *** problem is conventionally solved using the modal decomposition method,based on the principle that the response can be approximated by a weighted sum of limited vibration ***,the method is not valid when the problem is underdetermined,i.e.,the number of unknown mode weights is more than the number of known *** study proposed a sparse modal decomposition method based on the compressed sensing theory and the Compressive Sampling Matching Pursuit(Co Sa MP)algorithm,exploiting the sparsity of VIV in the modal *** the validation study based on high-order VIV experiment data,the proposed method successfully reconstructed the response using only seven acceleration measurements when the conventional methods failed.A primary advantage of the proposed method is that it offers a completely data-driven approach for the underdetermined VIV reconstruction problem,which is more favorable than existing model-dependent solutions for many practical applications such as riser structural health monitoring.

关键词： motion reconstruction vortex-induced vibration(VIV) marine riser modal decomposition method compressed sensing

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Bifurcations,chaos analysis and control in a discrete predator-prey model with mixed functional responses

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International Journal of Biomathematics 2024年第3期17卷 185-210页

作者： Yajie Sun ming Zhao Yunfei du School of Science China University of Geosciences(Beijing)Beijing100083P.R.China School of Basic Education Beijing Institute of Graphic Communication Beijing102600P.R.China

Many discrete systems have more distinctive dynamical behaviors compared to continuous ones,which has led lots of researchers to investigate *** discrete predatorprey model with two different functional responses(Holling type I and II functional responses)is discussed in this paper,which depicts a complex population *** local dynamical behaviors of the interior fixed point of this system are *** detailed analysis reveals this system undergoes flip bifurcation and Neimark-Sacker ***,we prove the existence of Marotto's chaos by analytical *** addition,the hybrid control method is applied to control the chaos of this *** simulations are presented to support our research and demonstrate new dynamical behaviors,such as period-10,19,29,39,48 orbits and chaos in the sense of Li-Yorke.

关键词： Predator-prey model flip bifurcation Neimark-Sacker bifurcation Marotto's chaos chaos control

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Comprehensive Exergoeconomic Analysis and Optimization of a Novel Zero-Carbon-Emission Multi-Generation System based on Carbon Dioxide Cycle

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Journal of Thermal Science 2024年第3期33卷 1065-1081页

作者： SUN yan LI Hongwei WANG Di du Changhe School of Energy and Power Engineering Northeast Electric Power UniversityJilin132012China School of Automation Engineering Northeast Electric Power UniversityJilin132012China Xi’an Institute of Electromechanical Information Technology Xi’an710065China

This paper aims to conduct a comprehensive exergoeconomic analysis of a novel zero-carbon-emission multi-generation system and propose a fast optimization method combined with machine *** detailed exergoeconomic analysis of a novel combined power,freshwater and cooling multi-generation system is performed in this *** exergoeconomic analysis model is established by exergy flow theory.A comprehensive exergy,exergoeconomic and environmental analysis is carried *** critical decision variables are researched to bring out effects on the multi-generation system exergoeconomic performance.A novel fast optimization method combining genetic algorithm and Bagging neural network is *** advanced nature comparison is made between the proposed system and four similar *** display that increasing the turbine inlet temperature can improve exergy efficiency and decrease the total product unit *** multi-generation system exergy destruction directly determines exergy efficiency and total exergy destruction cost *** total product unit cost in the cost optimal design case is reduced by 7.7%and 25%,respectively,compared with exergy efficiency optimal design case and basic design *** with four similar cases,the proposed multi-generation system has great advantages in thermodynamic performance and exergoeconomic *** paper can provide research methods and ideas for performance analysis and fast optimization of multi-generation system.

关键词： waste heat recovery exergoeconomic analysis supercritical carbon dioxide optimization machine learning

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Transfer relation between subgrade frost heave and slab track deformation and vehicle dynamic response in seasonally frozen ground

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第2期25卷 130-146页

作者： Juanjuan REN Junhong du Kaiyao ZHANG Bin yan Jincheng TIAN MOE Key Laboratory of High-speed Railway Engineering Southwest Jiaotong UniversityChengdu610031China School of Civil Engineering Southwest Jiaotong UniversityChengdu610031China School of Civil Engineering Central South UniversityChangsha410075China Airport Planning and Design Institute POWERCHINA Kunming Engineering Corporation LimitedKunming650051China

Subgrade frost heave in seasonally frozen ground can greatly influence the safety and smooth running of high-speed trains and the service performance of track *** this study,we used a static model to:(1)investigate track-subgrade frost heave and develop a dynamic model of vehicle-track-subgrade frost heave;(2)explore the transfer relation between subgrade frost heave and track structure deformation;(3)examine the characteristics of interlayer debonding;(4)study the influence of subgrade frost heave on the dynamic response of vehicles in high-speed railways in seasonally frozen regions.A Fourier series was used to fit the frost heave waveform and simulate the behavior of subgrade uneven frost heave using data collected *** results show:(i)The position of frost heave significantly affects the transfer of deformation to a slab *** largest deformation of the track slab,with the amplitude transfer ratio reaching 20%,was recorded when the frost heave occurred near the joint of the base plate.(ii)At the same frost heave amplitude,long-wave frost heave causes smaller deformation and debonding of the track structure than short-wave frost *** the wavelength range of 10-30 m,the main frequency of the acceleration spectral density was concentrated between 3.5 and 3.7 Hz,with larger frost heave wavelengths producing smaller superposition on the vertical acceleration of the vehicle.(ii)The maximum wheel-rail force occurs when the front bogie passes the frost heave peak,with greater frost heave amplitudes producing greater wheel-rail *** these results,we conclude there is a clear need to control the frost heave deformation of the track to reduce the dynamic response of the vehicle and in turn improve train operatSubgrade frost heave in seasonally frozen ground can greatly influence the safety and smooth running of high-speed trains and the service performance of track *** this study,we used a static model to:(1)investigate track`-subgr

关键词： Slab track Subgrade frost heave Transfer relation Vehicle-track-subgrade coupling Dynamic response

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Research on the Encapsulation Device for Lunar Samples

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 104-117页

作者： Yonggang du Chunyong Wang Haoling Li Ying Zhou ming Ji Xuesong Wang Lanzhou Institute of Physics CASTLanzhou 730000China

The encapsulation of lunar samples is a core research area in the third phase of the Chinese Lunar Exploration *** seal assembly,opening and closing mechanism(OCM),and locking mechanism are the core components of the encapsulation device of the lunar samples,and the requirements of a tight seal,lightweight,and low power make the design of these core components *** this study,a combined sealing assembly,OCM,and locking mechanism were investigated for the *** sealing architecture consists of rubber and an Ag-In alloy,and a theory was built to analyze the *** of the electroplate Au coating on the knife-edge revealed that the hermetic seal can be significantly *** driving principle for coaxial double-helical pairs was investigated and used to design the ***,a locking mechanism was created using an electric initiating explosive device with orifice *** optimizing the design,the output parameters were adjusted to meet the requirements of the lunar *** experimental results showed that the helium leak rate of the test pieces were not more than 5×10^(-11) Pa·m^(3)·s^(-1),the minimum power of the OCM was 0.3 W,and the total weight of the principle prototype was 2.9 *** explosive driven locking mechanism has low *** investigation solved the difficulties in achieving tight seal,light weight,and low power for the lunar explorer,and the results can also be used to explore other extraterrestrial objects in the future.

关键词： Lunar samples Encapsulation Vacuum seal Mechanism

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Dynamic multifunctional metasurfaces:an inverse design deep learning approach

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Photonics Research 2024年第1期12卷 123-133页

作者： ZHI-DAN LEI YI-duO XU CHENG LEI yan ZHAO du WANG The Institute of Technological Sciences Wuhan UniversityWuhan 430072China College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

Optical metasurfaces(OMs)offer unprecedented control over electromagnetic waves,enabling advanced optical *** emergence of deep learning has opened new avenues for designing ***,existing deep learning methods for OMs primarily focus on forward design,which limits their design capabilities,lacks global optimization,and relies on prior ***,most OMs are static,with fixed functionalities once *** overcome these limitations,we propose an inverse design deep learning method for dynamic *** approach comprises a forward prediction network and an inverse retrieval *** forward prediction network establishes a mapping between meta-unit structure parameters and reflectance *** inverse retrieval network generates a library of meta-unit structure parameters based on target requirements,enabling end-to-end design of *** incorporating the dynamic tunability of the phase change material Sb2Te3with inverse design deep learning,we achieve the design and verification of dynamic multifunctional *** results demonstrate OMs with multiple information channels and encryption capabilities that can realize multiple physical field optical modulation *** Sb2Te3is in the amorphous state,near-field nano-printing based on meta-unit amplitude modulation is achieved for X-polarized incident light,while holographic imaging based on meta-unit phase modulation is realized for circularly polarized *** the crystalline state,the encrypted information remains secure even with the correct polarization input,achieving double *** research points towards ultra-compact,high-capacity,and highly secure information storage approaches.

关键词： polarization inverse approach

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Base-controlled NHC-Ru-catalyzed transfer hydrogenation andα-methylation/transfer hydrogenation of ketones using methanol

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Chinese Chemical Letters 2024年第7期35卷 276-280页

作者： ming Huang Xiuju Cai yan Liu Zhuofeng Ke School of pharmacy School of clinical pharmacyGuangdong Pharmaceutical UniversityGuangzhou 510006China School of Materials Science&Engineering PCFM LabSchool of ChemistrySun Yat-sen UniversityGuangzhou 510275China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China

Herein,we report the NHC-Ru catalyst system that realizes the chemo-selective transformation of ketones with *** simply changing the base,a broad range of structurally diverse ketones,could be selectively and efficiently converted to the correspondingβ-methylated secondary alcohols or secondary ***,this catalytic system was very effective for the synthesis of bio-related molecules and deuterated alcohols,as well as the three-component coupling between methyl ketones,primary alcohols,and *** reaction mechanism was further revealed by experiment and DFT mechanistic investigations.

关键词： Ru complexes Methanol Ketones β-Methylated secondary alcohols Transfer hydrogenation

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Distributed Cooperative Secondary Voltage Control in an Unbalanced Microgrid

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 222-234页

作者： Xiangzhen yang Haixi Zhao Mengke duan yan du Haining Wang Jian Zhang School of Electrical Engineering and Automation Hefei University of TechnologyHefei 23009China

The negative-sequence reactive power-conductance(Q^(−)-G) droop control strategy is a conventional method to compensate for the output unbalanced voltages in an islanded ***, the conflict between unbalanced voltage compensation and negative-sequence reactive power sharing, caused bythe impedance mismatching of distribution lines and distributedgenerators, has not been solved only by Q^(−)-G droop *** this paper, a distributed cooperative secondary unbalancedvoltage control strategy is proposed to decrease the outputvoltage unbalance factor (VUF) of each droop-controlled DG,as well as to further enhance the negative-sequence reactivepower sharing effectiveness among DGs by properly shiftingup and down the Q^(−)-G droop characteristics of each *** algorithm for adaptive VUF weight coefficient is proposedto better suppress VUF under severe imbalance ***, a negative-sequence small-signal model of an MGunder an unbalanced condition, considering the communicationdelay time of the proposed SUVC, is established to analyze thesystem’s stability and transient performance under the influenceof some critical parameters. Finally, the effectiveness of theproposed strategy is validated by the simulation results froma real-time emulator of StarSim HIL.

关键词： Distributed cooperative control MG negativesequence reactive power starsim real-time platform time delay voltage unbalance compensation

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