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Bioenergetic alteration in gastrointestinal cancers:The good,the bad and the ugly

World Journal of Gastroenterology 2023年第29期29卷 4499-4527页

作者： Yu-De Chu Chun-wei Chen ming-wei lai Siew-Na Lim Wey-Ran Lin Liver Research Center Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina Department of Gastroenterology and Hepatology Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina Department of Pediatrics Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina Department of Neurology Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina Department of Medicine Chang Gung UniversityTaoyuan 333TaiwanChina

Cancer cells exhibit metabolic reprogramming and bioenergetic alteration,utilizing glucose fermentation for energy production,known as the Warburg ***,there are a lack of comprehensive reviews summarizing the metabolic reprogramming,bioenergetic alteration,and their oncogenetic links in gastrointestinal(GI)***,the efficacy and treatment potential of emerging anticancer drugs targeting these alterations in GI cancers require further *** review highlights the interplay between aerobic glycolysis,the tricarboxylic acid(TCA)cycle,and oxidative phosphorylation(OXPHOS)in cancer cells,as well as hypotheses on the molecular mechanisms that trigger this *** role of hypoxia-inducible transcription factors,tumor suppressors,and the oncogenetic link between hypoxia-related enzymes,bioenergetic changes,and GI cancer are also *** review emphasizes the potential of targeting bioenergetic regulators for anti-cancer therapy,particularly for GI *** the potential of targeting bioenergetic regulators for GI cancer therapy,the review categorizes these regulators into aerobic glycolysis/lactate biosynthesis/transportation and TCA cycle/coupled *** also detail various anti-cancer drugs and strategies that have produced pre-clinical and/or clinical evidence in treating GI cancers,as well as the challenges posed by these *** we highlight that understanding dysregulated cancer cell bioenergetics is critical for effective treatments,although the diverse metabolic patterns present challenges for targeted *** research is needed to comprehend the specific mechanisms of inhibiting bioenergetic enzymes,address side effects,and leverage high-throughput multi-omics and spatial omics to gain insights into cancer cell heterogeneity for targeted bioenergetic therapies.

关键词： Energy metabolism Mitochondria Hypoxia Oxidative phosphorylation Glycolysis Gastrointestinal neoplasms

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Probiotic Bio-Three induces Th1 and anti-inflammatory effects in PBMC and dendritic cells

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World Journal of Gastroenterology 2010年第28期16卷 3529-3540页

作者： Man-Chin Hua Tzou-Yien Lin Chien-Chang Chen ming-wei lai Man-Shan Kong Hung-Ju Chang Department of Pediatrics Chang Gung Memorial Hospital Keelung 204 Taiwan China Graduate Institute of Clinical Medical Sciences College of Medicine Chang Gung University Taoyuan 333 Division of Infectious Disease Division of Gastroenterology Department of Pediatrics Chang Gung Memorial HospitalTaoyuan 333TaiwanChina

AIM:To investigate the immune response of peripheral blood mononuclear cells(PBMCs)and dendritic cells (DCs)that were stimulated by probiotic preparations. METHODS:PBMCs were isolated,cultured,and stimulated with Bio-Three(a mixture of Bacillus mesentericus, Clostridium butyricum and Enterococcus faecalis;105, 10 6 and 10 7 CFU/mL for 24 h).Cytokine production of (1)circulating PBMCs;(2)PBMCs stimulated by probiotic preparation;(3)monocyte-derived DCs;and(4)DC andT cell co-culture was determined by enzyme-linked immunosorbent *** analysis of circulating PBMCs was also investigated by flow *** was obtained from individuals who consumed Bio-Three (10 9 CFU/d ***,*** and ***) for 2 wk,or those who did not take probiotics orally. RESULTS:In culture supernatants,interferon-γ(IFN-γ) and interleukin(IL)-10 production increased,but IL-4 and tumor necrosis factor-α(TNF-α)production by PBMCs decreased after 1 and 2 wk of probiotic *** cytometry was also performed on day 14 and detected enhanced expression of CD11b,HLA-DR, CD4,CD45RA,CD25,CD44 and CD69 in response to ***,IL-10 and IL-12 were upregulated in supernatants of monocyte-derived DCs,and IFN-γand IL-10 were enhanced in supernatants of CD4 + T cells co-cultured with DCs. CONCLUSION:Bio-Three appeared to stimulate the Th1 immune response,downregulate pro-inflammatory cytokines(TNF-α)and upregulate anti-inflammatory cytokine(IL-10).Probiotics could be effective in activation of PBMCs and DCs.

关键词： Probiotics Bio-Three Peripheral blood mono- nuclear cells Dendritic cells

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Usefulness of fecal lactoferrin in predicting and monitoring the clinical severity of infectious diarrhea

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World Journal of Gastroenterology 2011年第37期17卷 4218-4224页

作者： Chien-Chang Chen Chee-Jen Chang Tzou-Yien Lin ming-wei lai Hsun-Chin Chao Man-Shan Kong Division of Gastroenterology Department of Pediatrics Chang Gung Memorial Hospital Taoyuan 333 Taiwan China Department of Medicine Chang Gung University College of Medicine Taoyuan 333 Taiwan China Graduate Institute of Clinical Medical Sciences Clinical Informatics and Medical Statistics Research Center Chang Gung Memorial Hospital Taoyuan 333 Taiwan China

AIM:To explore the value of fecal lactoferrin in predicting and monitoring the clinical severity of infectious ***:Patients with acute infectious diarrhea ranging from 3 mo to 10 years in age were enrolled,and one to three stool samples from each subject were *** parameters,including white blood cells /differential count,C-reactive protein,fecal mucus,fecal pus cells,duration of fever,vomiting,diarrhea and severity(indicated by Clark and Vesikari scores),were recorded and *** lactoferrin was determined by enzyme-linked immunosorbent assay and compared in different pathogen and disease *** estimating equations(GEE) were also used for ***:Data included 226 evaluations for 117 individuals across three different time *** lactoferrin was higher in patients with Salmonella(11.17 μg/g ± 2.73 μg/g) or Campylobacter(10.32 μg/g ± 2.94 μg/g) infections and lower in patients with rotavirus(2.82 μg/g ± 1.27 μg/g) or norovirus(3.16 μg/g ± 1.18 μg/g) *** of fecal lactoferrin were significantly elevated in patients with severe(11.32 μg/g ± 3.29 μg/g) or moderate(3.77 μg/g ± 2.08 μg/g) disease activity compared with subjects with mild(1.51 μg/g ± 1.36 μg/g) disease activity(P < 0.05).GEE analysis suggests that this marker could be used to monitor the severity and course of gastrointestinal infections and may provide information for disease ***:Fecal lactoferrin increased during bacterial infection and with greater disease severity and may be a good marker for predicting and monitoring intestinal inflammation in children with infectious diarrhea.

关键词： Lactoferrin Diarrhea Generalized estimating equations Vesikari scores Clark scores

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济宁市环境空气PM10和PM2.5污染特征及其影响因素分析

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工程建设与设计 2017年第20期 107-108页

作者：李峰安伟铭赖锡柳济宁市环境保护监测站山东济宁272000 北京国环清华环境工程设计研究院有限公司北京100084 柳州市气象局广西柳州545000

利用山东省济宁市2014—2016年的空气质量监测值和7个环境大气常规监测站点资料,研究和分析了济宁市近3年的空气质量的时间和空间变化特征及其影响因素。结果表明,济宁市采取的大气污染防治措施已取得一定成效,其发生空气污染天数逐年减... 详细信息

利用山东省济宁市2014—2016年的空气质量监测值和7个环境大气常规监测站点资料,研究和分析了济宁市近3年的空气质量的时间和空间变化特征及其影响因素。结果表明,济宁市采取的大气污染防治措施已取得一定成效,其发生空气污染天数逐年减少,但由于区域传送和气象条件的影响,其发生空气污染的程度有所加重。济宁市整体区域PM10和PM2.5浓度水平基本一致,主要与城市的开发建设、工业排放、交通排放以及大气污染物的区域传送有关。

关键词：大气污染特征影响因素济宁市

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关于无形资产的特征、基本概念及范围

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武汉冶金科技大学学报（社会科学版） 1999年第4期1卷 34-38页

作者：谢明香梁炜来武汉科技大学管理学院湖北武汉430081

无形资产属于企业资产的一部分。在知识经济时代 ,无形资产内容极大丰富 ,无形资产的界定亦是见仁见智。本文从会计学资产概念入手 ,通过分析得出无形资产的本质特征 ,通过对无形资产与知识产权 ,会计学上无形资产与无形的经济资源这些... 详细信息

无形资产属于企业资产的一部分。在知识经济时代 ,无形资产内容极大丰富 ,无形资产的界定亦是见仁见智。本文从会计学资产概念入手 ,通过分析得出无形资产的本质特征 ,通过对无形资产与知识产权 ,会计学上无形资产与无形的经济资源这些概念的区分 ,联系会计界有关无形资产定义 ,总结出无形资产在会计学上的概念 ,使我们更进一步理解无形资产 ,为会计处理打下基础。

关键词：无形资产定义知识产权土地使用权商标权非专利技术企业商誉会计处理

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao lai Xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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Asymmetric hydrogenation of aromatic ketones using new chiral-bridged diphosphine/diamine-Ru(Ⅱ) complexes

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Chinese Chemical Letters 2010年第12期21卷 1403-1406页

作者： Yu ming Cui lai lai Wang Fuk Yee Kwong wei Sun State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical technology The Hong Kong Polytechnic University Hong Kong China Graduate University of Chinese Academy of Sciences Beijing 100039 China

A series of chiral secondary alcohols were easily prepared by means of asymmetric hydrogenation of prochiral aromatic ketones using a new（（Rax）-BuP）/（R,R）-DPEN-Ru（Ⅱ） complex catalyst *** hydrogenation of 2-methylacetophenone in n-butanol （t-BuOK/Ru =45.6/1,S/C = 500,20 *** H2,20℃,48 h） afforded（S）-1-（2＇-methylphenyl）ethanol in 92%ee and〉99% conversion.

关键词： Asymmetric hydrogenation Chiral alcohols Diphosphine ligand Ruthenium complexes Diamine

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Preheating-assisted solid-state friction stir repair of Al-Mg-Si alloy plate at different rotational speeds

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 725-736页

作者： Hui Wang Yidi Li ming Zhang wei Gong Ruilin lai Yunping Li State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Research Institute of Light Alloy Central South UniversityChangsha 410083China

Additive friction stir deposition(AFSD)is a novel structural repair and manufacturing technology has become a research hotspot at home and abroad in the past five *** this work,the microstructural evolution and mechanical performance of the Al-Mg-Si alloy plate repaired by the preheating-assisted AFSD process were *** evaluate the tool rotation speed and substrate preheating for repair quality,the AFSD technique was used to additively repair 5 mm depth blind holes on 6061 aluminum alloy *** results showed that preheat-assisted AFSD repair significantly improved joint bonding and joint strength compared to the control non-preheat substrate ***,increasing rotation speed was also beneficial to improve the metallurgical bonding of the interface and avoid volume *** preheating conditions,the UTS and elongation were positively correlated with rotation *** the process parameters of preheated substrate and tool rotation speed of 1000 r/min,defect-free specimens could be obtained accompanied by tensile fracture occurring in the substrate rather than the repaired *** UTS and elongation reached the maximum values of 164.2MPa and 13.4%,which are equivalent to 99.4%and 140%of the heated substrate,respectively.

关键词： additive friction stir deposition structural repair tool rotation speed Al alloy

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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： minghuang Gao Xinyue Wang Shijie Su weicheng Feng Yaona lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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Genetic dissection of ear-related traits using immortalized F2 population in maize

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Journal of Integrative Agriculture 2022年第9期21卷 2492-2507页

作者： GAO Ri-xin HU ming-jian ZHAO Hai-ming lai Jin-sheng SONG wei-bin State Key Laboratory of Plant Physiology and Biochemistry&National Maize Improvement Center Department of Plant Genetics and BreedingChina Agricultural UniversityBeijing 100193P.R.China Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100193P.R.China

Ear-related traits are often selection targets for maize improvement. This study used an immortalized F(IF) population to elucidate the genetic basis of ear-related traits. Twelve ear-related traits(namely, row number(RN), kernel number per row(KNPR), ear length(EL), ear diameter(ED), ten-kernel thickness(TKT), ear weight(EW), cob diameter(CD),kernel length(KL), kernel width(KW), grain weight per ear(GW), 100-kernel weight(HKW), and grain yield per plot(GY)),were collected from the IFpopulation. The ear-related traits were comprised of 265 crosses derived from 516 individuals of the recombinant inbred lines(RILs) under two separated environments in 2017 and 2018, respectively. Quantitative trait loci(QTLs) analyses identified 165 ear traits related QTLs, which explained phenotypic variation ranging from 0.1 to 12.66%. Among the 165 QTLs, 19 underlying nine ear-related traits(CD, ED, GY, RN, TKT, HKW, KL, GW, and KNPR)were identified across multiple environments and recognized as reliable QTLs. Furthermore, 44.85% of the total QTLs showed an overdominance effect, and 12.72% showed a dominance effect. Additionally, we found 35 genomic regions exhibiting pleiotropic effects across the whole maize genome, and 17 heterotic loci(HLs) for RN, EL, ED and EW were identified. The results provide insights into genetic components of ear-related traits and enhance the understanding of the genetic basis of heterosis in maize.

关键词： maize(Zea mays L.) QTL mapping genotyping by sequencing immortalized F2 population ear-related traits

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