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Immunosuppressive and immunodulatory effects of anti-inflammatory protein,Sj16,of ***

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Immunosuppressive and immunodulatory effects of anti-inflamm...

Gene-switch therapy for beta-hemoglobinopathies a genetic disease linked with malaria

全国寄生虫学与热带医学学术研讨会

作者： ming chiu fung Nai Ki MAK Department of Biology the Chinese University of Hong Kong Department of Biology Hong Kong Baptist University

Schistosoma japonicum is the parasite causing schistosomiasis in *** with schistosome does not arouse significant inflammatory response in *** the parasite can escape from the host immune attack and inhibit dermatitis is the major focus of many *** we have reported the molecular cloning and characterization of the anti-inlfammatory protein, Sj16,of *** recombinant Sj16,rSj16,can inhibit thioglycollate-induced inflammation in mice and suppress the expression of the pro-inflammatory cytokine IL-1 beta and chemokine MIP-2 in peritoneal exudes *** we report on the studies of the effects of rSj16 on host immune system and hematopoiesis.

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Gene-switch therapy for beta-hemoglobinopathies a genetic di...

A prospective cohort of men with localized prostate cancer on active surveillance protocol in Hong Kong,China:what did we learn?

全国寄生虫学与热带医学学术研讨会

作者： ming chiu fung~1,Ki Wai Chik~2 and Hong Tao XING~1 1 Department of Biology,2 Department of Paediatrics,The Chinese University of Hong Kong,Shatin,Hong Kong

The long history of epidemic of malaria forcing the selection of a mutated beta-globin gene in ***-nopathies such as the sickle cell anemia and thalassemias become the most prevalent serious genetic disorders affecting human populations and represent a major health burden *** sickle cell anmeia is not common in China, the prevalence of beta-thalassemia is 3.4%in Hong Kong and 2.16%in *** of defected globin genes results in a clinical *** red cell transfusions and iron chelating therapy remain the basis of therapy for this disease for the majority of ***,in most of these patients,the upstream globin genes are intact and fully *** these could be reactivated,functional hemoglobin synthesis could be maintained during adulthood, ameliorating the severity of the *** many years,the search for treatment aimed at reduction of globin chain imbalance in patients with thalassemia has focused on the pharmacological manipulation of fetal hemoglobin(22;HbF).

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan Ching-Ho Ko Cindy Yeuk-Lam Hong Samuel Chi-Hang Yee Jeremy Yuen-Chun Teoh Samson Yun-Sang Chan Ho-Man Tam Chi-Kwok Chan Chi-Fai Ng Peter Ka-fung chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,Hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian Shutian Zhang Ning Dai Hoon Jai Chun Chengtang chiu Chui fung Chong Nobuo Funao Yuuichi Sakurai Jessica D.Eisner Li Xie Minhu Chen Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China Department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda Development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South Korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CI<0%)was also *** 12 weeks,endoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

Relationship between left-behind status and cognitive function in older Chinese adults: a prospective 3-year cohort study

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General Psychiatry 2023年第3期36卷 148-157页

作者： Hong-Guang Zhang Fang Fan Bao-Liang Zhong Helen fung-Kum chiu Department of Psychiatry Affiliated Wuhan Mental Health CenterTongji Medical College of Huazhong Universityof Science&TechnologyWuhanHubeiChina Department of Psychiatry Wuhan Mental Health CenterWuhanHubeiChina Department of Clinical Psychology Wuhan Hospital for PsychotherapyWuhanHubeiChina Department of Psychiatry The Chinese University of Hong KongHong KongChina

Background Due to the inaccuracy of the traditional geographical distance-based definition of left-behind status,data on the negative effect of left-behind status on cognitive function among older adults are *** This study examined the cross-sectional and longitudinal associations of left-behind status with cognitive function in older Chinese *** left-behind status definition was based on the frequency of face-to-face parent-child *** Data from a nationally representative sample of 8682 older adults(60+years)in 2015(5658 left behind and 3024 non-left behind),of which 6933 completed the follow-up in 2018,were obtained from the China Health and Retirement Longitudinal ***-behind older adults werebroadlydefined as those aged 60+years who had living adult children and saw their children less than once per *** cognitive function was assessed with a composite cognitive test with higher total scores indicating better cognitive *** Left-behind older adults had significantly lower cognitive test scores than non-left-behind older adults in both 2015(11.1(6.0)vs 13.2(5.9),t=15.863,p<0.001)and 2018(10.0(6.6)vs 12.4(6.7),t=14.177,p<0.001).After adjusting for demographic factors,lifestyle factors,chronic medical conditions and the baseline cognitive test score(in the longitudinal analysis only),on average,the cognitive test score of left-behind older adults was 0.628 lower than their non-left-behind counterparts in 2015(t=5.689,p<0.001).This difference in cognitive test scores attenuated to 0.322 but remained significant in 2018(t=2.733,p=0.006).Conclusions Left-behind older Chinese adults have a higher risk of poor cognitive function and cognitive decline than their non-left-behind *** efforts targeting left-behind older adults,such as encouraging adult children to visit their parents more regularly,are warranted to maintain or delay the progression of cognitive decline.

关键词： function cognitive maintain

Transurethral resection of prostate for acute urinary retention is linked to shorter survival in younger men

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Asian Journal of Andrology 2019年第5期21卷 468-472页

作者： Jeremy Yuen-Chun Teoh Chi-Kwok Chan Maggie Haitian Wang Chi-Ho Leung Eddie Shu-Yin Chan Peter Ka-fung chiu Chi-Hang Yee Hon-ming Wong Simon See-ming Hou Chi-Fai Ng S.H.Ho Urology Centre Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Division of Biostatistics JC School of Public Health and Primary CareThe Chinese University of Hong KongHong KongChina Division of Urology Department of SurgeryNorth District HospitalHong KongChina Division of Urology Department of SurgeryAlice Ho Miu Ling Nethersole HospitalHong KongChina

It is largely unknown whether lower urinary tract symptoms(LUTS)or acute retention of urine(AROU)is linked to shorter life expectancy in *** conducted a multicenter,retrospective database analysis of patients undergoing transurethral resection of prostate(TURP)to study their *** Cox regression analysis and Kaplan-Meier analysis with stratification to age and indication of TURP were *** further performed an age-and sex-matched survival analysis with the general population using data from the Census and Statistics Department of the Hong Kong Special Administrative Region(Hong Kong,China).From January 2002 to December 2012,3496 patients undergoing TURP were included in our study,with 1764 patients in the LUTS group and 1732 patients in the AROU *** age,ischemic heart disease,cerebrovascular accident,and AROU were risk factors of *** aged80 *** to the general population,younger patients in the LUTS group appeared to have better survival(80 years,survival was similar with the general population in both the LUTS and AROU *** conclusion,AROU at young age was associated with mortality,while early detection and management of LUTS may improve survival.

关键词： acute retention of urine lower urinary tract symptoms mortality transurethral resection of prostate

Recurrent pyogenic cholangitis:An indication for liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 396-398页

作者： Wong Hoi She Wing chiu Dai James YY fung Tan To Cheung Albert CY Chan Chung Mau Lo Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina

To the Editor:Recurrent pyogenic cholangitis(RPC),also known as Hong Kong disease[1],is an unique disease entity with a decreasing *** is characterized by the formation of intrahepatic biliary pigmented stones,which r... 详细信息

关键词： cholangitis obstruction liver

Emergency ABO-incompatible living donor liver transplant for patients with ultrahigh MELD scores

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Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 87-89页

作者： Kevin KW Chu Kenneth SH Chok James YY fung Albert CY Chan Wing chiu Dai Chung Mau Lo Department of Surgery Queen Mary Hospital The University of Hong Kong Department of Medicine Queen Mary Hospital The University of Hong Kong

To the Editor:A 49-year-old Chinese man with treatment-naive chronic hepatitis B presented with a one-week history of jaundice when admitted to our *** admission,his bilirubin was 704μmol/L,alanine aminotransferase 180 U/L,international normalized ratio 2.4,creatinine 140μmol/L,and Model for End-stage Liver Disease(MELD)score *** serum HBV DNA was 64.7 IU/mL,and he was commenced on ***,he developed acute-onchronic liver failure on day 28 with grade 2 hepatic encephalopathy and a MELD score of 40(bilirubin 709μmol/L,international normalized ratio 3.3,creatinine 181μmol/L).

关键词： Editor hospital

MULTIPHOTON MICROSCOPY:A NEW APPROACH IN PHYSIOLOGICAL STUDIES AND PATHOLOGICAL DIAGNOSIS FOR OPHTHALMOLOGY

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Journal of Innovative Optical Health Sciences 2009年第1期2卷 45-60页

作者： chiu-MEI HSUEH WEN LO SUNG-JAN LIN TSUNG-JEN WANG fung-RUNG HU HSIN-YUAN TAN CHEN-YUAN DONG Department of Physics National Taiwan University Taipei 106 Taiwan Institute of Biomedical Engineering National Taiwan University Taipei 106 Taiwan Department of Dermatology National Taiwan University Hospital Taipei 100 Taiwan Department of Ophthalmology Taipei Medical University Hospital Taipei 100 Taiwan Department of Ophthalmology National Taiwan University College of Medicine and Hospital Taipei 100Taiwan Department of Ophthalmology Chang-Gung University Linko 333 Taiwan Institute of Biomedical Engineering National Taiwan University Taipei 100 Taiwan

Multiphoton microscopy(MPM),with the advantages of improved penetration depth,decreased photo-damage,and optical sectioning capability,has become an indispensable tool for biomedical *** combination of multiphoton fluorescence(MF)and second-harmonic generation(SHG)microscopy is particularly effective in imaging tissue structures of the ocular *** work is intended to be a review of advances that MPM has made in ophthalmic *** MPM not only can be used for the label-free imaging of ocular structures,it can also be applied for investigating the morphological alterations in corneal pathologies,such as keratoconus,infected keratitis,and corneal ***,the corneal wound healing process after refractive surgical procedures such as conductive keratoplasty(CK)can also be studied with ***,qualitative and quantitative SHG microscopy is effective for characterizing corneal thermal *** additional development,multiphoton imaging has the potential to be developed into an effective imaging technique for in vivo studies and clinical diagnosis in ophthalmology.

关键词： Multiphoton microscopy fluorescence second harmonic generation cornea sclera