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Journal of Computational Mathematics 2002年第6期20卷 653-672页

作者： Feng, MF Ming, PB Yang, rk Sichuan Univ Dept Math Chengdu 610064 Peoples R China

In this paper, HFEM is proposed to investigate the circular arch problem. Optimal error estimates are derived, some superconvergence results are established, and an asymptotic exactness posteriori error estimator is presented. In contrast with the classical displacement variational method, the optimal convergence rate for displacement is uniform to the small parameter. In contrast with classical mixed finite element methods, our results are free of the strict restriction on h(the mesh size) which is preserved by all the previous papers. Furtheremore we introduce an asymptotic exactness posteriori error estimator based on a global superconvergence result which is discovered in this kind of problem for the first time.

关键词： HFEM arch superconvergence asymptotic exactness posteriori error estimator

Condenser Optimization in Steam Power Plant

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Journal of Thermal Science 2003年第2期12卷 176-178,192页

作者： SükrüBekdemir Recepztürk ZehraYumurtac Yildiz Technical University Mechanical Engineering DepartmentIstanbulTurkeyYildiz Technical UniversityMechanical Engineering DepartmentIstanbulTurkeyYildiz Technical UniversityMechanical Engineering DepartmentIstanbulTurkey

In this paper the effects of the condenser design parameters(such as turbine inlet *** power and condenser pressure) on heat transfer area,cooling water *** cost and specific energy generation cost are studied for sur... 详细信息

关键词： condensers steam power plants energy cost.

Efficacy of Bee Products(Anzer Honey,Pollen and Propolis)in Detection and Healing of Damage Induced by Antidiabetic Drug Vildagliptin/Metformin Hydrochloride in Healthy Human Pancreatic Cells:Cytotoxic,Genotoxic and Biochemical Studies

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Current Medical Science 2023年第6期43卷 1173-1182页

作者： ÖzlemÖzdemir ZinetÇöl Ömer Ertürk Department of Internal Medicine Faculty of MedicineOrdu UniversityOrdu52200Turkey Department of Molecular Biology and Genetics Faculty of Sciences and LettersOrdu UniversityOrdu52200Turkey

Background and Objective Although drugs are powerful therapeutic agents,they have a range of side *** side effects are sometimes cellular and not clinically ***/metformin hydrochloride is one of the most widely used oral antidiabetic drugs with two active *** this study,we investigated its harmful effects on the metabolic activation system in healthy human pancreatic cells“hTERT-HPNE”,and we aimed to improve these harmful effects by natural *** benefit from the healing effect,we used the unique natural products produced by the bees of the Anzer Plateau in the Eastern Black Sea Region of *** Cytotoxic and genotoxic effects of the drug were investigated by different tests,such as MTT,flow cytometry-apoptosis and comet *** honey,pollen and propolis were analyzed by gas chromatography/mass spectrometry(G/C-MS).A total of 19 compounds were detected,constituting 99.9%of the *** The decrease in cell viability at all drug concentrations was statistically significant compared to the negative control(P<0.05).A statistically significant decrease was detected in the apoptosis caused by vildagliptin/metformin hydrochloride with the supplementation of Anzer honey,pollen and propolis in hTERT-HPNE cells(P<0.05).Conclusion This study can contribute to other studies testing the healing properties of natural products against the side effects of oral antidiabetics in human *** particular,Anzer honey,pollen and propolis can be used as additional foods to maintain cell viability and improve heal damage and can be evaluated against side effects in other drug studies.

关键词： cell viability hTERT-HPNE Anzer bee products drug side effect diabetes mellitus

美国25~64岁成年人的心血管疾病住院率及死亡率

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中华高血压杂志 2024年第1期32卷 96-96页

作者： Henry CM Oseran AS Zheng Z Dong H Wadhera rk 袁源(译) 郑武洪(审校) 不详

自2011年以来,美国心血管死亡率并未减少。人们越来越担心这样的形势反映了年轻人心血管健康的恶化。然而,该人群中急性心血管疾病住院率及死亡率负担的变化尚不明确。本研究从总体及不同社区收入水平,评估了25~64岁成年人心血管住院率... 详细信息

自2011年以来,美国心血管死亡率并未减少。人们越来越担心这样的形势反映了年轻人心血管健康的恶化。然而,该人群中急性心血管疾病住院率及死亡率负担的变化尚不明确。本研究从总体及不同社区收入水平,评估了25~64岁成年人心血管住院率及死亡率变化。方法:采用国家住院样本,在25~64岁成年人中,评估急性心肌缺血(acute myocardial infarction,AMI)、心力衰竭和缺血性脑卒中的年龄标准化年住院率及住院死亡率。

关键词：住院率心血管健康住院死亡率急性心血管疾病急性心肌缺血缺血性脑卒中心力衰竭收入水平

Association of complementary and integrative therapy use and symptoms among Turkish patients with familial Mediterranean fever

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Journal of Integrative Medicine 2021年第4期19卷 340-346页

作者： Sibel Sentürk Dilek Efe Arslan Adil Cetinkaya Department of Nursing Bucak Health SchoolBurdur Mehmet Akif Ersoy UniversityBurdur 15300Turkey Department of Medical Services and Techniques Vocational School of Health ServicesErciyes UniversityKayseri 38000Turkey Children's Emergency Service Istanbul Education and Research HospitalIstanbul 34000Turkey

Objective: This study explored the correlations between the use of complementary and integrative therapies(CITs) and symptoms among Turkish patients with familial Mediterranean fever(FMF).Methods: This is a cross-sectional and descriptive study. The study was conducted with 1119 FMF patients who were registered to the social networking site for Behcet’s and the FMF Patients Association(Befemder) in Turkey, between January 2018 and February 2019. Data were collected using an online survey, for which a three-part questionnaire was created using a Google form. Descriptive statistics, chi-square test and logistic regression analysis were used to analyze the ***: It was determined that 53.2% of the individuals who participated in the research used various forms of CITs and that 32.8% used vitamin and mineral supplements(calcium, iron, and vitamin B12, C and D), 25.0% used nutritional supplements(fish oil and honey), and 24.6% used oral herbs(ginger, turmeric, green tea and rosemary) and mind–body methods(relaxation, respiration exercise and meditation). It was determined that the percentage of participants that used CITs was higher among women(odds ratio [OR] = 1.825;95% confidence interval [CI] 1.421–2.344), those with joint pain(OR = 1.385;95% CI 1.047–1.832), those with difficulty breathing(OR = 1.323;95% CI 1.031–1.697), those with gastrointestinal symptoms(OR = 1.405;95% CI 1.089–1.814) and those who had a family member with FMF(OR = 1.437;95% CI 1.115–1.851).Conclusion: More than half of the individuals used at least one type of CIT for symptom control.

关键词： Familial Mediterranean fever Complementary and integrative medicine Nursing Turkey

First Evidence of Lamprophyric Magmatism from the Konya Region, Turkey:a Genetic Link to High-K Volcanism

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Acta Geologica Sinica(English Edition) 2013年第6期87卷 1617-1629页

作者： Kürsad ASAN M. Ali ERTürk Seluk University Department of Geological Engineering Frat University Department of Geological Engineering

In the vicinity of Konya （Turkey）,mafic,micro-porphyritic sub-volcanic rocks intrude into the Mesozoic units,which represents the only example of such a rock type in the region.40Ar/39Ar dating of two whole rock samples from the sub-volcanics gave ages of 13.72±0.13 and 12.40±0.11 Ma,suggesting temporal association to the Late Miocene-Pliocene high-K calc-alkaline volcanism in the *** mineral chemistry and geochemical data permit us to classify the rocks as ＂minette＂ *** include diopside and phlogopite phenocrysts in a microcrystalline groundmass composed of sanidine,phlogopite,diopside and *** and ocelli-like globular structures occur commonly in the *** terms of major elements,the lamprophyres are calcalkaline,and potassic to ultrapotassic *** the lamprophyres display strong enrichments in LILE （Rb,Ba,K,Sr）,radiogenic elements （Th,U） and LREE （La,Ce） and prominent negative Nb,Ta,and Ti anomalies on primordial mantle-normalized trace element *** data suggest that the lamprophyres and high-K calc-alkaline rocks in the region derived from a subduction-modified lithospheric mantle source affected by different metasomatic *** magmatism sourced phlogopite-bearing veins generated by sediment-related metasomatism via subduction,but high-K calc-alkaline magmas are possibly derived from a mantle source affected by fluid-rich metasomatism.

关键词： Turkey Konya calc-alkaline lamprophyre minette metasomatism

Evaluation of response to gemcitabine plus cisplatin-based chemotherapy using positron emission computed tomography for metastatic bladder cancer

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World Journal of Clinical Cases 2023年第36期11卷 8447-8457页

作者： HakanÖztürk İnançKarapolat Department of Urology Izmir University of EconomicsKarsiyaka Izmir 35330Turkey Department of Nuclear Medicine School of Medicineİzmir Tınaztepe UniversityIzmir 35000Turkey

BACKGROUND The purpose of the present study was to examine retrospectively the contribution of 18Fluorodeoxyglucose positron emission tomography computed tomography(18FDG-PET/CT)to the evaluation of response to first-line gemcitabine plus cispla-tin-based chemotherapy in patients with metastatic bladder *** To evaluate the response to Gemcitabine plus Cisplatin-based chemotherapy using 18FDG-PET/CT imaging in patients with metastatic bladder *** Between July 2007 and April 2019,79 patients underwent 18FDG-PET/CT imaging with the diagnosis of Metastatic Bladder Carcinoma(M-BCa).A total of 42 pa-tients(38 male,4 female)were included in the study,and all had been admi-nistered Gemcitabine plus Cisplatin-based *** completion of the therapy,the patients underwent a repeat 18FDG-PET/CT scan and the results were compared with the PET/CT findings before chemotherapy according to European Organisation for the Research and treatment of cancer *** age was 66.1 years and standard deviation was 10.7 years(range:41–84 years).RESULTS Of the patients,seven(16.6%)were in complete remission,17(40.5%)were in partial remission,six(14.3%)had a stable disease,and 12(28.6%)had a pro-gressive *** overall response rate was 57.1 *** 18FDG-PET/CT can be considered as a successful imaging tool in evaluating response to first-line chemotherapy for metastatic bladder *** and functional data obtained from PET/CT scans may be useful in the planning of secondline and thirdline chemotherapy.

关键词： Metastatic bladder cancer Response to chemotheraphy Positron emission tomography computed tomography 18FDG-PET/CT

Taurolithocholate impairs bile canalicular motility and canalicular bile secretion in isolated rat hepatocyte couplets

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World Journal of Gastroenterology 2006年第33期12卷 5320-5325页

作者： Norihito Watanabe Tatehiro Kagawa Sei-ichiro Kojima Shinji Takashimizu Naruhiko Nagata Yasuhiro Nishizaki Tetsuya mine Division of Gastroenterology Department of In-ternal Medicine Tokai University School of Medicine Japan

AIM: To investigate the effects of taurolithocholate (TLC)on the canalicular motility in isolated rat hepatocyte cou-plets (IRHC).METHODS: TLC was added to IRHC at concentrationsof 10 and 50 μmol/L, respectively. In each group, fi vetime-lapse movies containing 3 representative bile cana-liculi were taken under phase-contrast microscopy for12 h. The number of bile canalicular contractions andthe intervals between consecutive canalicular contrac-tions were calculated. Furthermore, the effects of TLC onIRHC were examined by transmission electron ***: The bile canalicular contractions were spon-taneous and forceful in the controls. Active vesicularmovement was observed in the pericanalicular *** after the addition of TLC, the bile canaliculiwere deformed, and canalicular bile was incorporatedinto the vacuoles. The canaliculi were gradually dilated,and canalicular contractions were markedly inhibited byTLC. The vesicular movements became extremely slowin the pericanalicular region. The number of canalicularcontractions significantly decreased in the TLC-treatedgroups, as compared with that in the controls. The timeintervals were prolonged, as the TLC dosage increased,indicating that bile secretion into the canaliculi wasimpaired with TLC. Transmission electron microscopyrevealed the lamellar transformation of the canalicularmembranes in IRHC treated with ***: TLC impairs both the bile canalicularcontractions and the canalicular bile secretion, possiblyby acting directly on the canalicular membranes in TLC-induced cholestasis.

关键词： Taurolithocholate Bile canaliculi Canalicularcontraction Bile secretion Isolated rat hepatocyte couplets Canalicular membrane Contractile protein

Amenorrhea as a rare drug-related adverse event associated with everolimus for pancreatic neuroendocrine tumors

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World Journal of Gastroenterology 2014年第42期20卷 15920-15924页

作者： Yoshiaki Kawaguchi Atsuko Maruno Yohei Kawashima Hiroyuki Ito Masami Ogawa Tetsuya mine Department of Gastroenterology Tokai University School of Medicine

The patient was an asymptomatic 43-year-old woman. Abdominal ultrasonography and enhanced computed tomography showed a tumor lesion accompanied by multiple cystic changes in the liver and the pancreatic tail. Endoscopic ultrasound-fine needle aspiration was performed on the pancreatic tumor lesion and revealed pancreatic neuroendocrine tumor(PNET). As it was unresectable due to multiple liver metastases, the decision was made to initiate treatment with everolimus and transcatheter arterial chemoembolization. The patient ceased menstruating after the start of everolimus administration. When the administration was discontinued due to interstitial lung disease, menstruation resumed, but then again stopped with everolimus resumption. An association between everolimus and amenorrhea was highly suspected. Amenorrhea occurred as a rare adverse event of everolimus. As the younger women might be included in PNETs patients, we should put this adverse event into consideration.

关键词： Amenorrhea Everolimus Neuroendocrine tumor Pancreas Adverse event

A Study on the Estimation of Prefabricated Glass Fiber Reinforced Concrete Panel Strength Values with an Artificial Neural Network Model

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Computers, Materials & Continua 2016年第4期52卷 41-52页

作者： S.A.Yıldızel A.U.Öztürk Manisa Celal Bayar University Engineering FacultyTurkey

In this study,artificial neural networks trained with swarm based artificial bee colony optimization algorithm was implemented for prediction of the modulus of rapture values of the fabricated glass fiber reinforced concrete *** the application of the ANN models,143 different four-point bending test results of glass fiber reinforced concrete mixes with the varied parameters of temperature,fiber content and slump values were introduced the artificial bee colony optimization and conventional back propagation *** and the testing results of the corresponding models showed that artificial neural networks trained with the artificial bee colony optimization algorithm have remarkable potential for the prediction of modulus of rupture values and this method can be used as a preliminary decision criterion for quality check of the fabricated products.

关键词： Neural network glass fiber reinforced concrete glass fiber