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Omadacycline in the treatment of scrub typhus:Three case reports

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World Journal of Clinical Cases 2024年第25期12卷 5832-5838页

作者： Xue-Mei Lang Yun qiu Ya-Juan Jia Hong Sun Su-min Gao Hong-Mei Zhao Department of Emergency Medicine The Affiliated Huaian No.1 People's Hospital of Nanjing Medical UniversityHuai’an 223000Jiangsu ProvinceChina

BACKGROUND Scrub typhus is a naturally occurring acute infectious disease that is primarily transmitted through the bites of chiggers or larval mites infected by Orientia tsutsugamushi(***).Omadacycline,a novel tetracycline,exhibits potent antibacterial efficacy against both typical bacteria and atypical ***,omadacycline application in the treatment of scrub typhus remains *** SUMMARY In the present work,we report several cases of scrub typhus,with the main clinical symptoms being fever,the formation of eschars or ulcers,local or systemic lymphadenopathy,headache,myalgia and *** samples were collected before omadacycline was administered,and *** infection was confirmed through targeted next-generation sequencing(tNGS).After two days of treatment,the patients’symptoms,including fever,were alleviated,with no adverse drug *** tNGS is an effective method for diagnosing scrub *** can be considered an alternative option for antiinfective therapy in patients with *** infections.

关键词： Omadacycline Scrub typhus Orientia tsutsugamushi Targeted nextgeneration sequencing Eschar Case report

Prevalence and serotype distribution of nasopharyngeal carriage of Streptococcus pneumoniae among healthy children under 5 years of age in Hainan Province, China

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Infectious Diseases of Poverty 2024年第1期13卷 42-52页

作者： Jian Wang Li qiu Shuang Bai Wei Zhao Ao Zhang Jing Li Jun-Nan Zhang Shan-Shan Zhou Ren qiu Zhu Huang Jv-Xia Liu Ting-Bin Wang Xue Sun Jiang Wu Qun Zheng Bin He min Lv Beijing Center for Disease Prevention and Control BeijingChina Beijing Research Center for Respiratory Infectious Diseases BeijingChina Hainan Provincial Center for Disease Control and Prevention HaikouChina Haikou Center for Disease Control and Prevention HaikouHainanChina Wanning Center for Disease Control and Prevention WanningHainanChina Baisha County Center for Disease Control and Prevention BaishaHainanChina Qiongzhong County Center for Disease Control and Prevention QiongzhongHainanChina

Background The thirteen-valent pneumococcal conjugate vaccine(PCV13)is not included in the national immu-nization program and is administered voluntarily with informed consent in *** preparation for assessing the impact of pilot introduction in Hainan Province,we conducted a carriage study among children under 5 years of age from four locations in Hainan Province,*** From March to June 2022,nasopharyngeal(NP)swabs,collected from healthy children aged younger than 59 months who lived in the 4 different locations(Haikou,Wanning,Baisha and Qiongzhong)in Hainan Province,were tested for pneumococcus using conventional *** isolates were serotyped using the Quel-lung *** factors associated with pneumococcal colonization were assessed using univariate analysis and multivariable logistic regression adjusting for age,daycare attendance and other *** Pneumococcus was isolated in 710(30.4%)of the 2333 children *** 737 pneumococci,29 serotypes were identifed;60.9%were PCV13 serotypes;the most common vaccine serotypes were 6B(20.4%),19F(13.0%),6A(11.9%)and 23F(6.1%);and the most common nonvaccine serotypes were 23A(12.9%),34(6.1%)and nontypeable(NT)pneumococci(5.6%).Children vaccinated with PCV13 had lower carriage(17.7%vs 32.5%;P=0.0001)and fewer PCV13 serotypes(41.9%vs 62.7%;P=0.0017)compared to unimmunized *** adjustment,NP carriage Was higher among children attending daycare(aOR=2.3,95%CI:1.7-3.2),living in rural areas(aOR=1.4,95%CI:1.1-1.8),living with siblings(aOR=1.3,95%CI:1.0-1.6)and whose mothers had completed senior high/technical sec-ondary school(aOR=1.5,95%CI:1.1-2.0).In contrast,completion of 3-4 doses of PCV13 were associated with a lower carriage rate(aOR=0.6,95%CI:0.4-0.9).Conclusions We established the baseline of pneumococcal carriage,serotype distribution and PCV13 immuni-zation rates among healthy children under 5 years of age in Hainan Province,prior to the introduction of PCV13 into th

关键词： Pneumococcus Nasopharyngeal carriage Serotypes distribution Children Hainan Province China

无蜂窝大规模MIMO系统接入点动态选择算法

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电讯技术 2024年第3期64卷 416-422页

作者：申敏裘德市重庆邮电大学通信与信息工程学院重庆400065

在无蜂窝大规模多输入多输出(Multiple-Input Multiple-Output,MIMO)系统中,所有接入点(Access Point,AP)为用户提供服务的方式会造成较大的功率消耗和增加前传链路压力。以“用户为中心”的AP选择方案为每个用户选择最佳的AP集合,使系... 详细信息

在无蜂窝大规模多输入多输出(Multiple-Input Multiple-Output,MIMO)系统中,所有接入点(Access Point,AP)为用户提供服务的方式会造成较大的功率消耗和增加前传链路压力。以“用户为中心”的AP选择方案为每个用户选择最佳的AP集合,使系统频谱效率和能量效率得以提升。为了给每个用户选择最佳的AP集合,提出了一种基于反向传播(Back Propagation,BP)神经网络的接入点动态选择算法。将AP与用户之间的大尺度衰落向量作为输入,AP与用户之间的连接关系作为BP神经网络输出的预测向量,同时,针对BP神经网络初始化权值,提出了一种改进的自适应遗传算法以提高算法的收敛速度和收敛性能。仿真结果表明,改进后的BP神经网络预测结果更接近于实际值,并且比全连接和启发式的AP选择方案具有更高的系统和速率。

关键词：无蜂窝大规模MIMO 接入点选择遗传算法 BP神经网络

Optimized online filter stack spectrometer for ultrashort X-ray pulses

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Nuclear Science and Techniques 2024年第5期35卷 85-98页

作者： Jia-Xing Wen Ge Ma ming-Hai Yu Yu-Chi Wu Yong-Hong Yan Shao-Yi Wang Huai-Zhong Gao Lu-Shan Wang Yu-Gang Zhou Qiang Li Yue Yang Fang Tan Xiao-Hui Zhang Jie Zhang Wen-Bo Mo Jing-Qin Su Wei-min Zhou Yu-qiu Gu ming Zeng Zong-Qing Zhao Science and Technology on Plasma Physics Laboratory Laser Fusion Research CenterCAEPMianyang 621900China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China School of Information Engineering Southwest University of Science and TechnologyMianyang 621010China

Currently,with the advent of high-repetition-rate laser-plasma experiments,the demand for online diagnosis for the X-ray spectrum is increasing because the laser-plasma-generated X-ray spectrum is very important for characterizing electron dynamics and *** this study,scintillators and silicon PIN(P-type–intrinsic-N-type semiconductor)diodes were used to construct a wideband online filter stack *** X-ray sensor and filter arrangement was optimized using a genetic algorithm to minimize the condition number of the response ***,the unfolding error was significantly reduced based on numerical *** detector responses were quantitatively calibrated by irradiating the scintillator and PIN diode with various nuclides and comparing the measuredγ-ray peaks.A prototype 15-channel spectrometer was developed by integrating an X-ray detector with front-and back-end *** prototype spectrometer could record X-ray pulse signals at a repetition rate of 1 ***,an optimized spectrometer was employed to record the real-time spectra of laser-driven bremsstrahlung *** optimized spectrometer offers a compact solution for spectrum diagnostics of ultrashort X-ray pulses,exhibiting improved accuracy in terms of spectrum measurements and repetition rates,and could be widely used in next-generation high-repetition-rate high-power laser facilities.

关键词： Filter stack spectrometer Laser plasma diagnostics X-ray diagnostics Scintillator PIN diode

Iron–doped bismuth oxybromides as visible-light-responsive Fenton catalysts for the degradation of atrazine in aqueous phases

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Journal of Environmental Sciences 2024年第3期137卷 321-332页

作者： Yong-Li Cai Yu-Hang Xu Ji-Zun Xiang Zhi-Qiang Zhang qiu-Xiang He Ya-Feng Li Jian Lü Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou UniversityFuzhou 350116China

Pesticides and its degradation products,being well–known residues in soil,have recently been detected in many water bodies as pollutants of emerging concerns,and thus there is a contemporary demand to develop viable and cost–effective techniques for the removal of related organic pollutants in aqueous ***,a visible-light-responsive Fenton system was constructed with iron–doped bismuth oxybromides(Fe–BiOBr)as the *** the advantage of sustainable Fe(Ⅲ)/Fe(Ⅱ)conversion and optimized H_(2)O_(2)utilization,the optimal Fe–BiOBr–2 catalyst showed an excellent atrazine removal efficiency of 97.61%in 120 min,which is superior than the traditional homogeneous Fenton and the majority of heterogeneous processes documented in the *** this photo–Fenton system,hydroxyl(·OH)and superoxide(·O_(2)^(-))radicals were dominant active species contributed to the oxidative degradation of *** to the production of various active radicals,five degradation pathways were proposed based on the identification of intermediates and degradation ***,this work not only demonstrates a fundamental insight into creating highly efficient and atom economic photo-Fenton systems,but also provides a complementary strategy for the treatment of organic pollutants in water.

关键词： Bismuth oxybromide Photo–Fenton Atrazine Catalytic degradation

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哈达门沟金矿床地质特征及其形成时代研究

地质找矿论丛 1999年第4期14卷 76-82页

作者：苗来成 Yu-min.qiu 关康 NealMcNaughton 裘有守罗镇宽 DavidGroves 天津地质研究院天津300061 CentreforStrategicmineralDeposits DepartmentofGeologyandGeophysicstheUniversityofWestemAustralia

哈达门沟金矿床位于华北地台北缘西段,产于新太古代乌拉山岩群变质岩系中。矿床以发育一系列含金钾长石-石英脉为特征,这些钾长石-石英脉沿近东西向的韧、脆性叠加断裂成群产出。钾长石化是最发育的近矿围岩蚀变。采用离子探针(SHRIMP)... 详细信息

哈达门沟金矿床位于华北地台北缘西段,产于新太古代乌拉山岩群变质岩系中。矿床以发育一系列含金钾长石-石英脉为特征,这些钾长石-石英脉沿近东西向的韧、脆性叠加断裂成群产出。钾长石化是最发育的近矿围岩蚀变。采用离子探针(SHRIMP)对矿体边部的钾长石化蚀变岩锆石U-Pb 定年结果表明:矿化钾长石化蚀变岩的年龄为132±2 Ma。由于钾长石化蚀变岩本身被金矿化,因此金矿化年龄小于或接近于132±2 Ma,应为燕山晚期成矿。

关键词：哈达门沟金矿床成矿时代锆石地质特征

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高中自然地理野外观察要义

地理教学 2024年第4期 22-26页

作者：王敏邱维理贵阳市第一中学贵州贵阳550081 北京师范大学地理科学学部北京100875

野外观察能力是地理实践力的重要组成部分,也是地理实践教学的重点与难点。本文从“观察”的含义入手,阐明自然地理野外观察的本质就是找差别,即通过提取、比较现象特征以识别其类型,据此列举了比较现象特征的四种途径和两种方法;以科... 详细信息

野外观察能力是地理实践力的重要组成部分,也是地理实践教学的重点与难点。本文从“观察”的含义入手,阐明自然地理野外观察的本质就是找差别,即通过提取、比较现象特征以识别其类型,据此列举了比较现象特征的四种途径和两种方法;以科学研究的视角看待探究性学习,介绍了在野外综合分析自然地理现象成因与演化的主要环节和基本方法;结合实际教学,举例分析了野外观察的教学难点并提出相应的对策建议,以期为高中自然地理实践教学提供参考。

关键词：高中地理自然地理野外观察地理实践力

白酒上市公司知识产权信息披露对企业价值的影响

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中国酿造 2024年第3期43卷 255-259页

作者：童俊仇敏王凯茅台学院工商管理系贵州遵义564500 湖北工程学院经济与管理学院湖北孝感432100

该研究探讨了中国白酒上市公司的知识产权信息披露对其企业价值的影响。基于信号理论,分析了知识产权披露的方法和内容,以及不同行业在知识产权信息披露方面的差异。采用托宾Q值作为企业价值的衡量标准,分析知识产权信息披露对企业价值... 详细信息

该研究探讨了中国白酒上市公司的知识产权信息披露对其企业价值的影响。基于信号理论,分析了知识产权披露的方法和内容,以及不同行业在知识产权信息披露方面的差异。采用托宾Q值作为企业价值的衡量标准,分析知识产权信息披露对企业价值的影响。数据源自2010-2021年13家白酒上市公司,通过专家评分法评估其知识产权信息披露的质量。研究结果显示,知识产权信息披露的质量与企业价值呈正相关。这表明知识产权信息披露的质量越高,企业的价值越高。为了提升上市公司知识产权信息披露水平,从不同角度提出相关建议对策,统一披露术语和具体内容、制定白酒行业披露规则和建立官方信息共享平台;提高监管机构的监管质量和提高中介服务机构道德素养;加强企业知识产权管理和提高企业知识产权保护意识。

关键词：白酒行业知识产权信息披露企业价值

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连翘苷对呼吸道合胞病毒感染小鼠的治疗作用

中国临床药理学杂志 2024年第15期40卷 2202-2206页

作者：胡秋芳李凡敏乐山职业技术学院基础医学教研室四川乐山614000 乐山市人民医院呼吸科四川乐山614000

目的探讨连翘苷对呼吸道合胞病毒(RSV)感染小鼠Toll样受体4(TLR4)/髓样分化因子88(MyD88)信号通路的影响。方法用RSV滴鼻感染法构建呼吸道感染模型,将RSV感染小鼠随机分为模型组、实验组及阳性对照组,另对照组小鼠给予等量的DMEM培养基... 详细信息

目的探讨连翘苷对呼吸道合胞病毒(RSV)感染小鼠Toll样受体4(TLR4)/髓样分化因子88(MyD88)信号通路的影响。方法用RSV滴鼻感染法构建呼吸道感染模型,将RSV感染小鼠随机分为模型组、实验组及阳性对照组,另对照组小鼠给予等量的DMEM培养基滴鼻。实验组小鼠灌胃给予200 mg·kg^(-1)·d^(-1)连翘苷,阳性对照组小鼠灌胃给予27.6 mg·kg^(-1)·d^(-1)利巴韦林,对照组与模型组均灌胃给予等量0.9%NaCl,连续干预14 d。用酶联免疫吸附试验法检测肺泡灌洗液(BALF)中白细胞介素-4(IL-4)、IL-13及γ-干扰素(INF-γ)水平,用实时荧光定量聚合酶链反应法检测肺组织TLR4、MyD88 mRNA的转录水平,用免疫组织化学法检测肺组织TLR4、MyD88蛋白的阳性表达情况。结果对照组、模型组、实验组及阳性对照组小鼠BALF中IL-4水平分别为(490.63±27.45)、(1382.37±41.28)、(970.32±36.01)和(738.41±30.27)pg·mL^(-1),IL-13水平分别为(4.02±2.63)、(18.33±5.62)、(12.97±3.73)和(7.51±2.74)pg·mL^(-1),INF-γ水平分别为(54.42±2.68)、(30.26±4.68)、(42.80±3.36)和(45.01±3.82)pg·mL^(-1),肺组织TLR4 mRNA相对表达水平分别为0.43±0.06、1.63±0.12、0.98±0.10和0.86±0.06,肺组织MyD88 mRNA相对表达水平分别为0.56±0.09、1.78±0.15、1.02±0.07和0.75±0.06,肺组织TLR4蛋白平均光密度值分别为0.02±0.00、0.11±0.02、0.06±0.01和0.03±0.00,MyD88蛋白平均光密度值分别为0.01±0.00、0.09±0.02、0.05±0.01和0.03±0.01。模型组的上述指标与对照组比较,实验组和阳性对照组的上述指标与模型组比较,在统计学上差异均有统计学意义(均P<0.05)。结论连翘苷可减轻RSV感染小鼠的肺损伤,可能与调节免疫细胞的平衡,抑制TLR4/MyD88信号通路有关。

关键词：连翘苷呼吸道合胞病毒 Toll样受体4 髓样分化因子88 炎症反应