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Astragali Radix-Notoginseng Radix et Rhizoma medicine pair prevents cardiac remodeling by improving mitochondrial dynamic balance

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Chinese Journal of Natural Medicines 2025年第1期23卷 54-63页

作者： Pingping Lin hong Chen Zekun Cui Boyang Yu Junping Kou Fang Li Jiangsu Key Laboratory of TCM Evaluation and Translational Research Research Center for Traceability and Standardization of TCMs School of Traditional Chinese PharmacyChina Pharmaceutical University

Astragali Radix(AR) and Notoginseng Radix et Rhizoma(NR) are frequently employed in cardiovascular disease treatment. However, the efficacy of the AR-NR medicine pair(AN) in improving cardiac remodeling and its underlying mechanism remains unclear. This study aimed to evaluate AN's cardioprotective effect and potential mechanism on cardiac remodeling using transverse aortic constriction(TAC) in mice and angiotensin II(Ang II)-induced neonatal rat cardiomyocytes(NRCMs) and fibroblasts in vitro. High-performance liquid chromatography-quadrupole-time of flight tandem mass spectrometry(HPLC-Q-TOF-MS/MS) characterized 23 main components of AN. AN significantly improved cardiac function in the TAC-induced mice. Furthermore, AN considerably reduced the serum levels of N-terminal pro-B-type natriuretic peptide(NT-pro BNP), cardiac troponin T(CTn-T), and interleukin-6(IL-6) and mitigated inflammatory cell infiltration. Post-AN treatment, TAC-induced heart size approached normal. AN decreased cardiomyocyte cross-sectional area and attenuated the upregulation of cardiac hypertrophy marker genes(ANP, BNP, and MYH7) in vivo and in ***, AN alleviated collagen deposition in TAC-induced mice. AN also reduced the expression of fibrosis-related indicators(COL1A1 and COL3A1) and inhibited the activation of the transforming growth factor-β1(TGF-β1)/mothers against decapentaplegic homolog 3(Smad3) pathway. Thus, AN improved TAC-induced cardiac remodeling. Moreover, AN downregulated p-dynamin-related protein(Drp1)(Ser616) expression and upregulated mitogen 2(MFN-2) and optic atrophy 1(OPA1) expression in vivo and in vitro, thereby restoring mitochondrial fusion and fission balance. In conclusion, AN improves cardiac remodeling by regulating mitochondrial dynamic balance, providing experimental data for the rational application of Chinese medicine prescriptions with AN as the main component in clinical practice.

关键词： Astragali Radix−Notoginseng Radix et Rhizoma medicine pair Cardiac fibrosis Cardiac hypertrophy Mitochondrial dynamics Transforming growth factor-β1/Smad3 pathway

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Iron scrap derived nano zero-valent iron/biochar activated persulfate for p-arsanilic acid decontamination with coexisting microplastics

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Journal of Environmental Sciences 2025年第5期151卷 733-746页

作者： Zihan Shu Hailan Yang Shujing Ye hong Li Zhiming Yang Chuang Li Xiaofei Tan Shaobo Liu Hou Wang College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control(Hunan University)Ministry of EducationChangsha 410082China Shenzhen Research Institute of Hunan University Shenzhen 518055China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China College of Resources and Environment University of Chinese Academy of SciencesBeijing 101408China School of Architecture and Art Central South UniversityChangsha 410083China School of Metallurgy and Environment Central South UniversityChangsha 410083China

P-arsanilic acid(AA)has received widespread attention because of its conversion to more toxic inorganic arsenic compounds(arsenate and arsenite)in the natural *** removal process and mechanisms with co-existence of microplastics remain *** this study,biochar loaded with nano zero-valent iron(nZVI)particles(ISBC)was prepared by using iron scrap obtained from a steel works and wood chips collected from a wood processing *** advanced oxidation system of sodium persulfate(PDS)activated by ISBC was applied for AA degradation and inorganic arsenic control in aqueous *** than 99%of the AA was completely degraded by the ISBC/PDS system,and the As(III)on AA was almost completely oxidized to As(V)and finally removed by ***_(3)−inhibited the removal of AA by the ISBC/PDS system,while Cl^(−)had a dual effect that showing inhibition at low concentrations yet promotion at high *** effect of microplastics on the degradation of AA by the ISBC/PDS system was further investigated due to the potential for combined microplastic and organic arsenic contamination in rural/remote *** were found to have little effect on AA degradation in the ISBC/PDS system,while affect the transport of inorganic arsenic generated from AA ***,this study provides new insights and methods for efficient removal of p-arsanilic acid from water with coexisting microplastics.

关键词： P-arsanilic acid Biochar Arsenate and arsenite Microplastics

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An association analysis of lipidome and transcriptome highlights the involvement of MmGDPD1 in regulating low phosphorus tolerance in Malus mandshurica

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Horticultural Plant Journal 2025年第1期11卷 85-104页

作者： hong Zhao Yawei Wu Luonan Shen Zhengchun Li Lin Deng Xiaopeng Wen Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region(ministry of Education) Institute of Agro-bioengineering/College of Life SciencesGuizhou UniversityGuiyangGuizhou 550025China Institute of Pomology Science Guizhou Academy of Agricultural SciencesGuiyangGuizhou 550006China College of Forestry/Institute for Forest Resources&Environment of Guizhou Guizhou UniversityGuiyangGuizhou 550025China

Phosphorus(Pi)plays a crucial role in the growth and development of *** lipid regulation is one of the main mechanisms underlying plant adaptation to Pi ***,the high tolerance to low-Pi stress was justified in an elite line,MSDZ 109,which was obtained from Malus *** better understand the mechanism underlying high adaptation to low-Pi stress,currently,lipidomic and transcriptomic analysis,as well as CRISPR/Cas9 and MmGDPD1-overexpressing methodologies were comprehensively integrated into a strategy for elucidating the high tolerance to low-Pi ***,770 differential metabolites were identified from the roots between the low-Pi and stress-free,belonging to 21 sub-classes of lipid *** acids(FA)constituted the predominant lipid component,accounting for approximately 50%-60%of the total lipids,and triglycerides(TAG)ranked the second,comprising around 12%of the total,consecutively followed by phosphatidylcholine(PC)and diacylglycerol(DAG)with approximately 10%and 8%of the total,*** synchronous transcriptomic analysis revealed a significant up-regulation of genes related to glycerophospholipid and glycerolipid metabolism,specifically those(e.g.,MmGDPD1,MmDGDG1,MmMGDG1,MmSQDG,etc.)involved in phospholipid and galactosyl synthesis in response to low-Pi *** fusing reporter assay showed that MmGDPD1 promoter induced GUS gene expression and demonstrated initiation *** on expression analysis,a dual-luciferase reporter assay,as well as yeast one-hybrid(Y1H)identification,MmPHR1 was justified to bind with the MmGDPD1 promoter and positively regulate plant tolerance to low-Pi *** further elucidate the role of MmGDPD1,CRISPR/Cas9 and MmGDPD1-overexpressing vectors were successfully introduced into apple(‘Royal Gala')***,the MmGDPD1-KO line calli exhibited the remarkable decreases in the contents of phosphodiesterase(PDE),activity,as well as the contents of total Pi,and P

关键词： Malus mandshurica Lipidome profiling Transcription profiles Low phosphorus stress MmGDPD1

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Health risks of rare earth elements exposure:Impact on mitochondrial DNA copy number and micronucleus frequency

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Journal of Environmental Sciences 2025年第5期151卷 150-160页

作者： Shiyi hong Yali Zhang Qiaojian Zhang Zekang Su Guiping Hu Li Wang Shanfa Yu Xiaojun Zhu Guang Jia Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100083China School of Engineering Medicine and Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang UniversityBeijing 100083China Department of Toxicology School of Public HealthBaotou Medical CollegeBaotouInner Mongolia 014040China Henan Institute for Occupational Medicine Zhengzhou 450052China National Center for Occupational Safety and Health Beijing 102308China Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety School of Public HealthPeking UniversityBeijing 100083China

Toxic effects in terms of mitochondria and hereditary substances have been characterized in vitro for individual rare earth elements,while,the joint effects of mixed elements exposure in the population remain *** on the Occupational Chromate Exposure Dynamic Cohort of China,this study investigated the relationship between 15 blood rare earth elements(cerium,dysprosium,erbium,europium,gadolinium,holmium,lanthanum,lutetium,neodymium,praseodymium,samarium,terbium,thulium,yttrium,and ytterbium)and mitochondrial DNA copy number(MtDNACN)as well as peripheral blood lymphocyte micronucleus frequency(MNF).The elastic net was used to select elements highly correlated with effect indicators,whose dose-response relationships were further illustrated by restricted cubic *** kernel regressionwas employed to explore the combined effects of elements and the contributions of single *** results showed that most rare earth elementswere positively correlatedwith effect indicators,with yttrium showing the strongest association(β(95%CI):0.139(0.1089–0.189)for MtDNACN,0.937(0.345–1.684)for MNF).In the mixed exposure model,with the exposure level fixed at the 50th percentile as the reference,the effect estimates on MtDNACN and MNF increased by 0.228 and 0.598 units,respectively,at the 75th *** single effect analysis implied that yttrium,lanthanum and terbium contributed the most to the elevation of MtDNACN,while yttrium posed the highest risk for genetic damage,accordingly,we provided recommendations to prioritize these elements of *** addition,we observed a chief mediating effect of MtDNACN on the elevation of MNF caused by lanthanum,whereas further mechanistic exploration is required to confirm this finding.

关键词： Rare earth elements Mitochondrial DNA copy number Micronucleus frequency Mixed effect

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Development and application of an intelligent thermal state monitoring system for sintering machine tails based on CNN-LSTM hybrid neural networks

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Journal of Iron and Steel Research International 2025年第1期32卷 52-63页

作者： Da-lin Xiong Xin-yu Zhang Zheng-wei Yu Xue-feng Zhang hong-ming Long Liang-jun Chen Anhui Province Key Laboratory of Metallurgical Engineering&Resources Recycling Anhui University of TechnologyMa’anshan243002AnhuiChina School of Metallurgical Engineering Anhui University of TechnologyMa’anshan243032AnhuiChina School of Computer Science Anhui University of TechnologyMa’anshan243032AnhuiChina

Real-time prediction and precise control of sinter quality are pivotal for energy saving,cost reduction,quality improvement and efficiency enhancement in the ironmaking *** advance,the accuracy and comprehensiveness of sinter quality prediction,an intelligent flare monitoring system for sintering machine tails that combines hybrid neural networks integrating convolutional neural network with long short-term memory(CNN-LSTM)networks was *** system utilized a high-temperature thermal imager for image acquisition at the sintering machine tail and employed a zone-triggered method to accurately capture dynamic feature images under challenging conditions of high-temperature,high dust,and *** feature images were then segmented through a triple-iteration multi-thresholding approach based on the maximum between-class variance method to minimize detail loss during the segmentation *** the advantages of CNN and LSTM networks in capturing temporal and spatial information,a comprehensive model for sinter quality prediction was constructed,with inputs including the proportion of combustion layer,porosity rate,temperature distribution,and image features obtained from the convolutional neural network,and outputs comprising quality indicators such as underburning index,uniformity index,and FeO content of the *** accuracy is notably increased,achieving a 95.8%hit rate within an error margin of±*** the system is applied,the average qualified rate of FeO content increases from 87.24%to 89.99%,representing an improvement of 2.75%.The average monthly solid fuel consumption is reduced from 49.75 to 46.44 kg/t,leading to a 6.65%reduction and underscoring significant energy saving and cost reduction effects.

关键词： Sinter quality Convolutional neural network Long short-term memory Image segmentation FeO prediction

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Recycling technologies of spent lithium-ion batteries and future directions:A review

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 271-295页

作者： Xue-song GAO Meng WU Guang-jin ZHAO Kun-hong GU Jia-jia WU hong-bo ZENG Wen-qing QIN Jun-wei HAN School of minerals Processing&Bioengineering Central South UniversityChangsha 410083China Department of Chemical and Materials Engineering University of AlbertaEdmonton T6G 1H9Canada Electric Power Research Institute Henan Electric Power CompanySTATE GRID Corporation of ChinaZhengzhou 450052China

Lithium-ion batteries(LIBs)are the most popular energy storage devices due to their high energy density,high operating voltage,and long cycle ***,green and effective recycling methods are needed because LIBs contain heavy metals such as Co,Ni,and Mn and organic compounds inside,which seriously threaten human health and the *** this work,we review the current status of spent LIB recycling,discuss the traditional pyrometallurgical and hydrometallurgical recovery processes,and summarize the existing short-process recovery technologies such as salt-assisted roasting,flotation processes,and direct ***,we analyze the problems and potential research prospects of the current recycling process,and point out that the multidisciplinary integration of recycling will become the mainstream technology for the development of spent LIBs.

关键词： spent lithium battery short-process recycling secondary resources pretreatment metal recovery

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Research on Object Detection and Combination Clustering for Railway Switch Machine Gap Detection

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Chinese Journal of Electronics 2025年第1期34卷 186-203页

作者： Qingsheng Feng Shuai Xiao Wangyang Liu hong Li School of Automation and Electrical Engineering Dalian Jiaotong University School of Software Dalian Jiaotong University

Turnouts and switch machines play a crucial role in facilitating train line operations and establishing routes, making them vital for ensuring the safety and efficiency of railway transportation. Through the gap detection system of switch machines, the real-time working status of turnouts and switch machines on railway sites can be quickly known. However, due to the challenging working environment and demanding conversion tasks of switch machines, the current gap detection system has often experienced the issues of fault detection. To address this, this study proposes an automatic gap detection method for railway switch machines based on object detection and combination clustering. Firstly, a lightweight object detection network, specifically the MobileNetV3-YOLOv5s model, is used to accurately locate and extract the focal area. Subsequently, the extracted image undergoes preprocessing and is then fed into a combination clustering algorithm to achieve precise segmentation of the gap area and background,the algorithm consists of simple linear iterative clustering, Canopy and kernel fuzzy c-means clustering. Finally, the Fisher optimal segmentation criterion is utilized to divide the data sequence of pixel values, determine the classification nodes and calculate the gap size. The experimental results obtained from switch machine gap images captured in various scenes demonstrate that the proposed method is capable of accurately locating focal areas, efficiently completing gap image segmentation with a segmentation accuracy of 93.55%, and swiftly calculating the gap size with a correct rate of 98.57%. Notably, the method achieves precise detection of gap sizes even after slight deflection of the acquisition camera, aligning it more closely with the actual conditions encountered on railway sites.

关键词： Image segmentation Accuracy Clustering algorithms Transportation Switches Object detection Cameras Rail transportation Classification algorithms Safety

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Advances in regional-scale crop growth and associated process modeling

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Science China Earth Sciences 2025年第3期68卷 653-668页

作者： Wenfeng LIU Yawei BAI Taisheng DU Mengxue LI hong YANG Shichao CHEN Chuanbin LIANG Shaozhong KANG State Key Laboratory of Efficient Utilization of Agricultural Water Resources China Agricultural University National Field Scientific Observation and Research Station on Efficient Water Use of Oasis Agriculture in Wuwei of Gansu Province Center for Agricultural Water Research in China China Agricultural University 2w2e Environmental Consulting GmbH

In the context of global change, ensuring national food security and achieving sustainable development of agricultural production systems have become major challenges worldwide. To address these issues, regional-scale crop growth and associated process(CROP-AP) models, with their robust simulation and predictive capabilities, have emerged as important tools for studying a wide range of issues relating to agricultural production at river basin, national, and even global scales. Here, we provide a systematic review of the advances of regional-scale CROP-AP models. First, regional-scale CROP-AP models are categorized based on model characteristics: statistical models, crop growth models, hydrology-crop coupling models, and ecosystem models. The origin, development, principle, structure, and application of each model type are introduced. Then, the main functions of regional-scale CROP-AP models are critically reviewed from five aspects: crop yield prediction, crop water consumption, agricultural non-point source pollution, greenhouse gas emissions, and climate change impact and ***, the future development trends and research priorities of regional-scale CROP-AP models are explored from six key perspectives: model validation and calibration, the ability to simulate the coupling of crop physiology and human activities,enhancing model scalability, multi-model ensembles, data and code sharing, and the integration of artificial intelligence. This review aims to provide comprehensive references and insights for the further development and application of large-scale, high-precision CROP-AP models.

关键词： Regional scale Crop model Biophysical processes Model functions Global change

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The formation,development and classification of rail corrugation:a survey on Chinese metro

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Railway Engineering Science 2025年第1期33卷 43-61页

作者： Yang Wang hong Xiao Zhihai Zhang Xuhao Cui Yihao Chi Mahantesh M.Nadakatti School of Civil Engineering Beijing Jiaotong UniversityBeijing 100044China Beijing Key Laboratory of Track Engineering Beijing Jiaotong UniversityBeijing 100044China Faculty of Architecture Civil and Transportation EngineeringBeijing University of TechnologyBeijing 100124China Department of Mechanical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

Investigations into rail corrugation within metro systems have traditionally focused on specific mechanisms,thereby limiting the generalizability of proposed *** the commonalities in rail corrugation across diverse metro lines remains pivotal for elucidating its underlying *** present study conducted extensive field surveys and tracking tests across 14 Chinese metro *** employing t-distributed stochastic neighbor embedding(t-SNE)for dimensional reduction and employing the unsupervised clustering algorithm DBSCAN,the research redefines the classification of metro rail corrugation based on characteristic *** analysis encompassed spatial distribution and temporal evolution of this *** revealed that floating slab tracks exhibited the highest proportion of rail corrugation at 47%.Notably,ordinary monolithic bed tracks employing damping fasteners were more prone to inducing rail *** primarily manifested in curve sections with radii between 300 and 500 m,featuring ordinary monolithic bed track and steel-spring floating slab track structures,with wavelengths typically between 30 and 120 ***–slip vibrations of the wheel–rail system maybe led to short-wavelength corrugations(40–60 mm),while longer wavelengths(200–300 mm)exhibited distinct fatigue damage characteristics,mainly observed in steel-spring floating slab tracks and small-radius curve sections of ordinary monolithic bed tracks and ladder sleeper tracks.A classification system comprising 57 correlated features categorized metro rail corrugation into four distinct *** research outcomes serve as critical benchmarks for validating various theories pertaining to rail corrugation formation.

关键词： Metro Rail corrugation Formation mechanism Development law Field test

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Outcomes of men aged≤50 years treated with radical prostatectomy:a retrospective analysis

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Asian Journal of Andrology 2019年第2期21卷 150-155页

作者： Byeongdo Song Hakmin Lee min Seung Lee sung Kyu hong Department of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Seoul National University College of MedicineSeoul 03080Korea

Previous studies inv estigating prostate can cer(PCa)features in youn ger men have reported con flicting fin *** study aimed to investigate pathologic outcomes and biochemical recurrenee(BCR)status in younger men who underwent radical prostatectomy(RP)for *** of 2057 patients who underwent RP at Seoul National University Bundang Hospital(Seongnam,Korea)between 2006 and 2015 were reviewed;patients were divided according to age into the younger and older groups(men aged50 years,respectively).Postoperative BCR status and functional outcomes and clinicopathologic features were compared betwee n both *** an alyses were repeated after propensity score matchi *** men were more likely to have lowrisk disease(P<0.001),lower pathologic Gleason score(P<0.001)and pathologic stages(P<0.001)than older *** pathologic Gleason score(P=0.002)and rates of extracapsular extension(P=0.004)were lower in younger men after propensity score *** multivariate analysis,age at RP was not an independent predictor of BCR-free survival after RP(P=0.669).Moreover,at 1 year after RP,younger men with preoperative 5?item International Index of Erectile Function score≥22(n=228)showed more favorable results for urinary con tine nee(defi ned as nonuse of pads daily)(99.4%vs 95%,P=0.009)and erections sufficie nt for vaginal in tercourse(81.8%vs 55.5%,P=0.001).Youn ger men had more favorable clinicopathologic features at RP than their older *** age was not an independent predictor of BCR status outcome,younger men had better functional outcomes following RP.

关键词： age group prostate cancer prostatectomy

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