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Analysis of liver metastasis after resection for pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2012年第5期4卷 109-114页

作者： Kwang Yeol Paik Seong Ho choi Jin seok Heo Dong Wook choi Department of Surgery Yeouido St.Mary's HospitalCatholic UniversityCollege of Medicine# 62 Yeouido-dongYeongdeungpo-gu150-713 SeoulSouth Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of Medicine135-710 SeoulSouth Korea

AIM:To investigate the risk factors affecting the liver metastasis(LM) of pancreatic ductal adenocarcinoma(PDAC) after ***:We retrospectively analyzed 101 PDAC patients who underwent surgical resection at the Samsung Medical Center between January 2000 and December *** one patients with LM were analyzed for the time of metastasis,prognostic factors affecting LM,and ***:LM was found in 40.6%.The median time of the LM(n = 41) was 6.0 ± 4.6 mo and most LM occurred within 1 *** univariate analysis,tumor size,preoperative carbohydrate antigen 19-9,and perineural invasion were factors affecting LM after *** multivariate analysis,tumor size was the most important factor for *** univariate analysis,tumor cell differentiation was significant to LM in low-risk ***:LM after resection of PDAC occurs early and shows poor *** size is the key indicator for LM after resection.

关键词： Pancreatic ductal adenocarcinoma Liver metastasis Recurrence

Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Phlebovirus in Domesticated Deer in South Korea

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Virologica Sinica 2019年第5期34卷 501-507页

作者： min-Ah Yu Kwang-min Yu Su-Jin Park Young-ll Kim Norbert John Robles Young-Jae Si Eun-Ha Kim Hyeok-ll Kwon Hye Won Jeong min-Suk Song seok-Yong Kim Young Ki choi Department of Microbiology College of Medicine and Medical Research InstituteChungbuk National UniversityCheongju 28644Republic of Korea Zoonotic Infectious Diseases Research Center Chungbuk National UniversityCheongju 28644Republic of Korea Department of Internal Medicine College of Medicine and Medical Research InstituteCheongju 28644Republic of Korea Department of Internal Medicine Chungbuk National University HospitalCheongju 28644Republic of Korea

Severe fever with thrombocytopenia syndrome phlebovirus(SFTSV)has a wide host *** only has it been found in humans,but also in many wild and domesticated *** infection of breeding deer on farms is a particularly worrisome public health concern due to the large amount of human contact and the diverse use of deer products,including raw *** investigate the prevalence of breeding domesticated deer,we examined the SFTSV infection rate on deer farms in South Korea from 2015 to *** the 215 collected blood samples,0.9%(2/215)were found to be positive for viral RNA by PCR,and sequence analysis showed the highest homology with the KADGH human *** SFTSVspecific recombinant N and Gn protein-based ELIS As revealed that 14.0%(30/215)and 7.9%(17/215)of collected blood specimens were positive for SFTSV *** results demonstrate that the breeding farm deer are exposed to SFTSV and could be a potential infection source for humans through direct contact or consumption of byproducts.

关键词： Severe fever with thrombocytopenia syndrome phlebovirus(SFTSV) Breeding deer•Seroprevalence South Korea

Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials

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Acta Pharmaceutica Sinica B 2016年第4期6卷 297-307页

作者： Eun Ji Hong Dae Gun choi min Suk Shim Division of Bioengineering Incheon National University

Photodynamic therapy(PDT) is an emerging, non-invasive therapeutic strategy that involves photosensitizer(PS) drugs and external light for the treatment of diseases. Despite the great progress in PS-mediated PDT, their clinical applications are still hampered by poor water solubility and tissue/cell specificity of conventional PS drugs. Therefore, great efforts have been made towards the development of nanomaterials that can tackle fundamental challenges in conventional PS drug–mediated PDT for cancer treatment. This review highlights recent advances in the development of nano-platforms, in which various functionalized organic and inorganic nanomaterials are integrated with PS drugs, for significantly enhanced efficacy and tumor-selectivity of PDT.

关键词： Organic nanomaterials Inorganic nanomaterials Nanoparticles Photodynamic therapy Photosensitizer Targeted therapy Cancer therapy Near-infrared light

Massive retroperitoneal hematoma as an acute complication of retrograde intrarenal surgery:A case report

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World Journal of Clinical Cases 2021年第16期9卷 3914-3918页

作者： Taesoo choi Jeonghyouk choi Gyeong Eun min Dong-Gi Lee Department of Urology School of MedicineKyung Hee UniversitySeoul 05278South Korea

BACKGROUND Retrograde intrarenal surgery(RIRS)has been proven to be a safe and effective treatment modality in large-scale quantitative ***,although its safety profile has been established,it also has a potential risk of life-threatening *** here describe our experience with a patient who developed a huge periureteral hematoma after RIRS with holmium laser *** SUMMARY A 73-year-old woman visited our center with a complaint of gross *** enhanced computed tomography(CT)scan revealed a 1.5-cm left renal pelvis stone with *** patient underwent *** the surgery,a 12/14-Fr ureteral access sheath was applied and a 6-Fr ureteral catheter was indwelled *** postoperative day 1,she experienced aggravated left flank pain and left lower-quadrant tenderness without rebound tenderness.A follow-up CT scan was taken,which revealed a huge hematoma in the periureteral space,not in the perirenal space,with suspicious contrast medium *** angiography was performed;however,it showed no evidence of active *** was conservatively managed with hydration and antibiotic and nonsteroidal anti-inflammatory drug therapy,and was discharged on postoperative day ***,she visited our outpatient department with recurrent left flank pain at 5 d from *** confirmed that the double J-stent was *** rule out stent malfunction,the stent was *** size of the hematoma was observed in the imaging studies,and conservative management for candiduria was performed for 1 *** Although RIRS is an effective and safe procedure for the management of renal stones,clinicians should be aware of its potential complications.

关键词： Retroperitoneal hematoma Ureteral access sheath Retrograde intrarenal surgery Acute complication Case report

Dietary sophorolipid accelerates growth by modulation of gut microbiota population and intestinal environments in broiler chickens

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Journal of Animal Science and Biotechnology 2022年第1期13卷 256-264页

作者： min-Jin Kwak min-Young Park Yong-Soon choi Junghwan Cho Duleepa Pathiraja Jonggun Kim Hanbae Lee In-Geol choi Kwang-Youn Whang Department of Biotechnology Korea University145 Anam-roSeoul 02841Republic of Korea Pathway Intermediates Seoul 02841Republic of Korea

Background:Gut is a crucial organ for the host’s defense system due to its filtering action of the intestinal membrane from hazardous foreign *** strategy to strengthen the gut epithelial barrier function is to upregulate beneficial microflora populations and their ***(SPL),which is a glycolipid biosurfactant,could increase beneficial microflora and decrease pathogenic bacteria in the gastrointestinal ***,herein,we conducted an experiment with broiler chickens to investigate the fortifying effects of SPL on the host’s gut defense system by modulating the microbiota ***:A total of 5401-day-old chicks(Ross 308)were used,and they were immediately allotted into three treatment groups(6 replications with 30 chicks/pen)according to their initial body *** dietary treatments consisted of CON(basal diet),BAM(10 mg/kg bambermycin),and SPL(10 mg/kg SPL).During the experiment,birds freely accessed feed and water,and body weight and feed intake were measured at the end of each *** d 35,birds(one bird/pen)were sacrificed to collect jejunum and cecum ***:Dietary SPL and BAM supplementation significantly accelerated birds’growth and also significantly improved feed efficiency compared to *** microbial community was significantly separated by dietary SPL supplementation from that of CON,and dietary SPL supplementation significantly increased Lactobacillus *** Akkermansia ***,birds fed with dietary SPL also showed the highest concentration of cecal butyrate among all treatment *** morphological analysis showed that dietary SPL significantly increased villus height,ratio of villus height to crypt depth,goblet cell numbers,and the gene expression levels of claudin-1 and mucin ***,dietary SPL significantly decreased the mRNA expression level of pro-inflammatory cytokine,interleukin-6,and increased that of anti-inflammatory cytokine,interleukin-10,compared

关键词： Broilers Gut microbiota Gut morphology Local inflammation Mucus barrier Sophorolipids

Relation between etching profile and voltage-current shape of sintered SiC etching by atmospheric pressure plasma

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Plasma Science and Technology 2019年第4期21卷 137-144页

作者： D C seok S R YOO K I LEE Y S choi Y H JUNG Plasma Technology Research Center National Fusion Research InstituteGunsan City 54004Republic of Korea

Sintered silicon carbide(SiC)was etched by a dielectric barrier discharge source.A high voltage bipolar pulse was used with helium gas for the plasma *** stable filament plasma was generated and could be used for SiC *** the processing gas(NF3)mixing rate increased,the width and depth of the etching profile became narrower and *** differentiated V-Q Lissajous method was used for measuring the capacitances(Ceq)of the electrode after the plasma turned *** width of the etching profile was proportional to *** the current peak value/smx of the substrate current in creased,the volume removal rate of SiC *** etch depth was proportional to the ratio of/smx to ***,because of the different characteristics of the plasma disks on SiC substrate by the voltage polarity,the etching profile was ***,in high NF3 mixing process,the etching profile became stable and deeper.

关键词： dielectric barrier discharge silicon carbide plasma etching、filament discharge,surface charge

Long-term outcomes of penetrating keratoplasty in keratoconus: analysis of the factors associated with final visual acuities

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 517-521页

作者： Jin A choi min A Lee Man-Soo Kim Department of Ophthalmology St. Vincent's HospitalCollege of Medicine the Catholic University of Korea #93 Jungbudae-ro Paldal-gu Suwon-si Kyunggi-do 442-723Korea Department of Ophthalmology and Visual Science Seoul St.Mary's Hospital College of Medicine Catholic University of Korea #505 Banpo-dong Seocho-ku Seoul 137-701 Korea

AIM:To investigate the long-term results of penetrating keratoplasty(PK)in patients with keratoconus(KC)and to evaluate factors that might influence the final visual ***:We retrospectively reviewed the data of all patients with clinical KC who had undergone PK by a single corneal surgeon in a single center from May 1980to December *** age of the patients,preoperative best-corrected visual acuity(BCVA),corneal thickness,death to preservation time,and preservation to transplantation time were ***,postoperative complications such as graft rejection,development of glaucoma and specular microscopy were checked during the ***:Sixty-nineeyesfrom69patientswerefinally *** follow-up period was 8.64±*** rejection occurred in 4 eyes of 69 cases(5.8%),and the time to graft rejection was 2.1±1.3y.A Kaplan-Meier survival analysis showed that the estimated cumulative probability of graft rejection at 6,13,and 17y after PK were 95.6%,90.0%,and 78.8%,*** we evaluated factors that might influence final BCVA in eyes,no disparity donor-host trephine size(same graft size)as well as higher spherical equivalent,and average Kvalue were associated with higher final BCVA.(P=0.006,0.051,0.092,and 0.021 in eyes with follow-up<8y;P=0.068,0.065,and 0.030 in eyes with follow-up≥8y,respectively).CONCLUSION:The long-term results of PK in patients with KC were favorable with a high percentage of good *** myopic change and low average K-reading,as well as a surgical technique using the same size donor-recipient button may provide better visual outcomes particularly in patients with KC.

关键词： keratoconus penetrating keratoplasty visual outcome

Identification of Aristolactam Derivatives That Act as Inhibitors of Human Immunodeficiency Virus Type 1 Infection and Replication by Targeting Tat-Mediated Viral Transcription

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Virologica Sinica 2021年第2期36卷 254-263页

作者： Young Hyun Shin Chul min Park Hong Gi Kim Dong-Eun Kim min Suk choi Jeong-ah Kim Byeong-Sun choi Cheol-Hee Yoon Division of Viral Disease Research Center for Infectious Disease ResearchKorea National Institute of HealthHeungdeok-guCheongju-siShungbuk 28159Republic of Korea Center for Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea

Despite the success of antiretroviral therapy(ART),efforts to develop new classes of antiviral agents have been hampered by the emergence of drug ***-indole-bearing aristolactams are compounds that have been isolated from various plants species and which show several clinically relevant effects,including anti-inflammatory,antiplatelet,and antimycobacterial ***,the effect of these compounds on human immunodeficiency virus type 1(HIV-1)infection has not yet been *** this study,we discovered an aristolactam derivative bearing dibenzo[cd,f]indol-4(5 H)-one that had a potent anti-HIV-1 effect.A structure-activity relationship(SAR)study using nine synthetic derivatives of aristolactam identified the differing effects of residue substitutions on the inhibition of HIV-1 infection and cell *** the compounds tested,1,2,8,9-tetramethoxy-5-(2-(piperidin-1-yl)ethyl)-dibenzo[cd,f]indol-4(5 H)-one(Compound 2)exhibited the most potent activity by inhibiting HIV-1 infection with a half-maximal inhibitory concentration(IC50)of 1.03 lmol/L and a half-maximal cytotoxic concentration(CC50)of 16.91 lmol/L(selectivity index,16.45).The inhibitory effect of the compounds on HIV-1 infection was linked to inhibition of the viral replication ***-of-action studies showed that the aristolactam derivatives did not affect reverse transcription or integration;instead,they specifically inhibited Tat-mediated viral *** together,these findings show that several aristolactam derivatives impaired HIV-1 infection by inhibiting the activity of Tat-mediated viral transcription,and suggest that these derivatives could be antiviral drug candidates.

关键词： Human immunodeficiency virus type 1(HIV-1) Aristolactam Antiviral activity HIV-1 transcription

State-of-the-art preoperative staging of gastric cancer by MDCT and magnetic resonance imaging

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World Journal of Gastroenterology 2014年第16期20卷 4546-4557页

作者： Joon-Il choi Ijin Joo Jeong min Lee Department of Radiology Seoul St. Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 137-701South Korea Department of Radiology and Institute of Radiation Medicine Clinical Research InstituteSeoul National University HospitalSeoul National University College of MedicineSeoul 110-744South Korea

Gastric cancer is one of the most common and fatal cancers. The importance of accurate staging for gastric cancer has become more critical due to the recent introduction of less invasive treatment options, such as endoscopic mucosal resection or laparoscopic surgery. The tumor-node-metastasis staging system is the generally accepted staging system for predicting the prognosis of patients with gastric cancer. Multidetector row computed tomography (MDCT) is a widely accepted imaging modality for the preoperative staging of gastric cancer that can simultaneously assess locoregional staging, including the gastric mass, regional lymph nodes, and distant metastasis. The diagnostic performance of MDCT for T- and N-staging has been improved by the technical development of isotropic imaging and 3D reformation. Although magnetic resonance imaging (MRI) was not previously used to evaluate gastric cancer due to the modality’s limitations, the development of high-speed sequences has made MRI a feasible tool for the staging of gastric cancer.

关键词： Gastric cancer Multidetector row computed tomography Magnetic resonance imaging Preoperative staging The tumor-node-metastasis staging