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Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity

Bioactive Materials 2021年第9期6卷 2801-2819页

作者： Rick Xing Ze Lu milica radisic Institute of Biomedical Engineering University of TorontoTorontoONCanada Department of Chemical Engineering and Applied Chemistry University of TorontoTorontoONCanada Toronto General Research Institute University Health NetworkTorontoONCanada The Heart and Stroke/Richard Lewar Centre of Excellence TorontoONCanada

Despite showing a great promise in the field of nanomedicine,nanoparticles have gained a significant attention from regulatory agencies regarding their possible adverse health effects upon environmental *** those nanoparticles are generated through intentional or unintentional means,the constant exposure to nanomaterials can inevitably lead to unintended consequences based on epidemiological data,yet the current understanding of nanotoxicity is insufficient relative to the rate of their emission in the environment and the lack of predictive platforms that mimic the human *** calls for a development of more physiologically relevant models,which permit the comprehensive and systematic examination of toxic properties of *** the advancement in microfabrication techniques,scientists have shifted their focus on the development of an engineered system that acts as an intermediate between a well-plate system and animal models,known as *** ability of organ-on-a-chip models to recapitulate in vivo like microenvironment and responses offers a new avenue for nanotoxicological *** this review,we aim to provide overview of assessing potential risks of nanoparticle exposure using organ-on-a-chip systems and their potential to delineate biological mechanisms of epidemiological findings.

关键词： Organ-on-a-chip Toxicity Nanoparticles

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Automated fabrication of a scalable heart-on-a-chip device by 3D printing of thermoplastic elastomer nanocomposite and hot embossing

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Bioactive Materials 2024年第3期33卷 46-60页

作者： Qinghua Wu Ruikang Xue Yimu Zhao Kaitlyn Ramsay Erika Yan Wang Houman Savoji Teodor Veres Sarah H.Cartmell milica radisic Institute of Biomedical Engineering University of TorontoTorontoOntarioM5S 3G9Canada Toronto General Research Institute University Health NetworkTorontoOntarioM5G 2C4Canada Department of Materials School of Natural SciencesFaculty of Science and Engineering and The Henry Royce InstituteRoyce Hub BuildingThe University of ManchesterManchesterUK Koch Institute for Integrative Cancer Research Massachusetts Institute of TechnologyCambridgeMA02139USA Department of Chemical Engineering and Applied Chemistry University of TorontoTorontoOntarioM5S 3E5Canada Institute of Biomedical Engineering and Department of Pharmacology and Physiology University of MontrealMontrealQuebecH3T 1J4Canada Research Center Centre Hospitalier Universitaire Sainte-JustineMontrealQuebecH3T 1C5Canada Montreal TransMedTech Institute MontrealQuebecH3T 1J4Canada National Research Council of Canada BouchervilleQCJ4B 6Y4Canada Department of Mechanical and Industrial Engineering University of TorontoTorontoOntarioM5S 3G8Canada Terrence Donnelly Centre for Cellular&Biomolecular Research University of TorontoTorontoONM5S 3E1Canada

The successful translation of organ-on-a-chip devices requires the development of an automated workflow for device fabrication, which is challenged by the need for precise deposition of multiple classes of materials in micro-meter scaled configurations. Many current heart-on-a-chip devices are produced manually, requiring the expertise and dexterity of skilled operators. Here, we devised an automated and scalable fabrication method to engineer a Biowire II multiwell platform to generate human iPSC-derived cardiac tissues. This high-throughput heart-on-a-chip platform incorporated fluorescent nanocomposite microwires as force sensors, produced from quantum dots and thermoplastic elastomer, and 3D printed on top of a polystyrene tissue culture base patterned by hot embossing. An array of built-in carbon electrodes was embedded in a single step into the base, flanking the microwells on both sides. The facile and rapid 3D printing approach efficiently and seamlessly scaled up the Biowire II system from an 8-well chip to a 24-well and a 96-well format, resulting in an increase of platform fabrication efficiency by 17,5000-69,000% per well. The device’s compatibility with long-term electrical stimulation in each well facilitated the targeted generation of mature human iPSC-derived cardiac tissues, evident through a positive force-frequency relationship, post-rest potentiation, and well-aligned sarcomeric apparatus. This system’s ease of use and its capacity to gauge drug responses in matured cardiac tissue make it a powerful and reliable platform for rapid preclinical drug screening and development.

关键词： Heart-on-a-chip Additive manufacturing Electrical stimulation Cardiomyocyte Drug testing

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Biomaterials for immunomodulation in wound healing

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Regenerative Biomaterials 2024年第5期3卷 1-22页

作者： Ying Wang Katrina Vizely Chen Yu Li Karen Shen Amid Shakeri Ramak Khosravi James Ryan Smith Eugene Alfonzo II Alteza Yimu Zhao milica radisic Institute of Biomedical Engineering University of TorontoTorontoON M5S 3G9Canada Toronto General Research Institute University Health NetworkTorontoON M5G 2C4 Canada Department of Chemical Engineering and Applied Chemistry University of TorontoTorontoON M5S 3E5Canada Division of Cardiovascular and Thoracic Surgery Department of SurgeryDuke University Medical CenterDurhamNC 27710USA Terrence Donnelly Centre for Cellular&Biomolecular Research University of TorontoTorontoON M5S 3E1Canada

The substantial economic impact of non-healing wounds,scarring,and burns stemming from skin injuries is evident,resulting in a financial burden on both patients and the healthcare *** review paper provides an overview of the skin’s vital role in guarding against various environmental challenges as the body’s largest protective organ and associated developments in biomaterials for wound *** first introduce the composition of skin tissue and the intricate processes of wound healing,with special attention to the crucial role of immunomodulation in both acute and chronic *** highlights how the imbalance in the immune response,particularly in chronic wounds associated with underlying health conditions such as diabetes and immunosuppression,hinders normal healing ***,this review distinguishes between traditional wound-healing strategies that create an optimal microenvironment and recent peptide-based biomaterials that modulate cellular processes and immune responses to facilitate wound ***,we highlight the importance of considering the stages of wounds in the healing *** integrating advanced materials engineering with an in-depth understanding of wound biology,this approach holds promise for reshaping the field of wound management and ultimately offering improved outcomes for patients with acute and chronic wounds.

关键词： immunomodulation peptide-based biomaterials innate immunity angiogenesis for wound healing cellular response

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