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Decoding bone-inspired and cell-instructive cues of scaffolds for bone tissue engineering

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Engineered Regeneration 2024年第1期5卷 21-44页

作者： Zahid Hussain shah Mehmood Xingzhu Liu Yuanshan Liu Guocheng Wang Renjun Pei School of Nano-Tech and Nano-Bionics University of Science and Technology of China(USTC)Hefei 230026PR China CAS Key Laboratory for Nano-Bio Interface Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123PR China Research Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced Technology(SIAT)Chinese Academy of ScienceShenzhen 518055PR China

Bone fractures are common occurrence in clinical settings,creating a high demand for effective repair ***,limited graft availability,donor site morbidities,unpredictable clinical outcomes,immunologic reactions,infection risks,and geometrical mismatching concerns hampered tissue graft use and underscored the need for scaffolds for more effective bone reconstructions due to their tunable *** progress has been carried out in past decade in the fields of nanoceramics synthesis,bioconjugate chemistry,and composite material *** review outlines hierarchical structures and biology of bone tissue,materialistic compo-nents of scaffolds(bioceramics,polymers,bioactive drugs),featured scaffolding strategies(nanofibers,hydrogels,aerogels,bioprinting,and fiber-reinforced composite),and emphasis that hierarchical and physiochemical char-acteristics of bone should be used as an inspiration for scaffold *** review discussed how differences in materiobiological aspects of scaffolds,such as polymer/bioceramic nanocomposite,mineralized nanocomposite,matrix-rich nanocomposite,3D microenvironmental cues,pore space cues,mechanical cues,usage of physical stimulation(magnetic,electroactive,and photoactivated cues),surface cues(wettability,roughness,textured,and surface charge),and biointerface cues(cell-biomaterial interactions,cell-selective homing,and cell regula-tory strategies)modulate cellular and biological response for bone tissue *** study further outlines the challenges and benefits of integrating materiobiological cues of scaffolds for bone tissue engineering.

关键词： Bone substitute Scaffolds Mineralization Materiobiology Bone tissue engineering

Accelerated Particle Swarm Optimization Algorithm for Efficient Cluster Head Selection in WSN

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Computers, Materials & Continua 2024年第6期79卷 3585-3629页

作者： Imtiaz Ahmad Tariq Hussain Babar shah Altaf Hussain Iqtidar Ali Farman Ali Institute of Computer Sciences and Information Technology The University of AgriculturePeshawarPakistan School of Computer Science and Technology Zhejiang Gongshang UniversityHangzhouChina College of Technological Innovation Zayed UniversityDubaiUnited Arab Emirates School of Computer Science and Technology Chongqing University of Posts and TelecommunicationsChongqing400065China Department of Applied AI School of ConvergenceCollege of Computing and InformaticsSungkyunkwan UniversitySeoul03063South Korea

Numerous wireless networks have emerged that can be used for short communication ranges where the infrastructure-based networks may fail because of their installation and *** of them is a sensor network with embedded sensors working as the primary nodes,termed Wireless Sensor Networks(WSNs),in which numerous sensors are connected to at least one Base Station(BS).These sensors gather information from the environment and transmit it to a BS or gathering *** have several challenges,including throughput,energy usage,and network lifetime *** strategies have been applied to get over these *** may,therefore,be thought of as the best way to solve such ***,it is crucial to analyze effective Cluster Head(CH)selection to maximize efficiency throughput,extend the network lifetime,and minimize energy *** paper proposed an Accelerated Particle Swarm Optimization(APSO)algorithm based on the Low Energy Adaptive Clustering Hierarchy(LEACH),Neighboring Based Energy Efficient Routing(NBEER),Cooperative Energy Efficient Routing(CEER),and Cooperative Relay Neighboring Based Energy Efficient Routing(CR-NBEER)*** the help of APSO in the implementation of the WSN,the main methodology of this article has taken *** simulation findings in this study demonstrated that the suggested approach uses less energy,with respective energy consumption ranges of 0.1441 to 0.013 for 5 CH,1.003 to 0.0521 for 10 CH,and 0.1734 to 0.0911 for 15 *** sending packets ratio was also raised for all three CH selection scenarios,increasing from 659 to *** number of dead nodes likewise dropped for the given combination,falling between 71 and *** network lifetime was deemed to have risen based on the results found.A hybrid with a few valuable parameters can further improve the suggested APSO-based *** to underwater,WSN can make use of the proposed *** overall results have been evaluated and

关键词： Wireless sensor network cluster head selection low energy adaptive clustering hierarchy accelerated particle swarm optimization

Linkages among leaf nutrient concentration,resorption efficiency, litter decomposition and their stoichiometry to canopy nitrogen addition and understory removal in subtropical plantation

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Ecological Processes 2024年第2期13卷 90-102页

作者： Jawad Ali shah Wenfei Liu Saif Ullah Honglang Duan Fangfang Shen Yingchun Liao Guomin Huang Jianping Wu Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest China Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology and Institute of Biodiversity School of Ecology and Environmental Science Yunnan University Laboratory of Soil Ecology and Health in Universities of Yunnan Province Yunnan University Jiangxi Key Laboratory for Restoration of Degraded Ecosystems & Watershed Ecohydrology Nanchang Institute of Technology Key Laboratory of Forest Cultivation in Plateau Mountain of Guizhou Province Institute for Forest Resources and Environment of Guizhou College of ForestryGuizhou University

Background The prevalence of understory removal and anthropogenic nitrogen(N) deposition has significantly altered the ecological processes of forest ecosystems at both regional and global scales. However, it remains a pressing challenge to understand how N deposition and understory removal affect leaf nutrient dynamics, nutrient resorption, litter decomposition, and their linkages for better managing forest ecosystems under nutrient imbalances induced by N enrichment. To address this research gap, a field manipulation experiment was carried out in a subtropical Cunninghamia lanceolata plantation with four treatments including: control(CK), canopy N addition(CN), understory removal(UR), and canopy N addition plus understory removal(CN × UR). Green and senesced leaf N and phosphorus(P) concentrations, N and P resorption efficiencies, litter decomposition, and their correlations were *** The results revealed that the average N concentrations of green early and late leaves in UR were increased by 6.61 and 18.89% compared to CK. UR had the highest whereas CN had the lowest P concentrations in green leaves across the two sampling seasons. Following this, UR, leaf type, season, and their interactions significantly affected leaf N, P, and N:P(P < 0.05). The highest leaf N resorption(32.68%) and P resorption efficiencies(63.96%) were recorded in UR. Litter decomposition was significantly retarded in UR(P < 0.01) relative to CN. The regression analysis demonstrated that leaf nutrient status was significantly interconnected with leaf nutrient resorption efficiencies. In addition, leaf nutrient dynamics were strongly correlated with litter nutrients, indicating that both were *** These findings can deepen our knowledge of biogeochemical cycling and reveal contrasting nutrientacquisition strategies on N and P limitation in response to UR and CN. Considering the P limitation, it is important to note that P was resorbed more efficiently, illustrating a

关键词： Nutrient resorption Nitrogen deposition Litter decomposition Stoichiometry Understory removal Subtropical plantation

Morphological and molecular description of a new species of sandfly,Sergentomyia(Neophlebotomus)ashwanii ***.(Diptera:Psychodidae)from Western Ghats,India

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Asian Pacific Journal of Tropical Medicine 2024年第5期17卷 226-234页

作者： Prasanta Saini Harish Kumar shah Mathew Jessu Sonia T Tom Anns KP Amju ICMR-Vector Control Research Centre(Field Station) KottayamKeralaIndia

Objective:To report a new species of sandfly,Sergentomyia(Neophlebotomus)ashwanii ***.(Diptera:Psychodidae)from Western Ghats,***:A systematic sandfly survey was conducted in the Thrissur and Kollam districts of Kerala,India using mechanical aspirators,light and sticky traps,both indoor and outdoor habitats,for a period of one *** acid barcoding of samples was performed targeting mitochondrial cytochrome oxidase I(COI)gene and sequence generated was subjected to phylogenetic ***:Sergentomyia(Neophlebotomus)ashwanii,a new sandfly species is recorded and described in this communication.A single row of 10-12 pointed teeth in the cibarium with 4-6 small denticles or fore-teeth are the key characteristics that is distinctive from other members of the subgenus *** COI barcode followed by phylogenetic analysis of the nucleotide sequence confirms that specimens of the species belong to the same taxonomic group while the genetic distance(14.2%)with the congeners established it to be a different ***:The Western Ghats'being an important biodiversity hotspot and has dearth of systematic entomological surveys on *** current study tried to fill the void and also report a new sandfly species.

关键词： Sergentomyia(Neophlebotomus)ashwanii COI barcode Western Ghats Phlebotomine sandflies

Deep Learning Based Efficient Crowd Counting System

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Computers, Materials & Continua 2024年第6期79卷 4001-4020页

作者： Waleed Khalid Al-Ghanem Emad Ul Haq Qazi Muhammad Hamza Faheem Syed shah Amanullah Quadri Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadh12372Saudi Arabia Centre of Excellence in Cybercrime and Digital Forensics Naif Arab University for Security SciencesRiyadh14812Saudi Arabia Center of Excellence for Information Assurance(COEIA) King Saud UniversityRiyadh12372Saudi Arabia

Estimation of crowd count is becoming crucial nowadays,as it can help in security surveillance,crowd monitoring,and management for different *** is challenging to determine the approximate crowd size from an image of the crowd’s *** in this research study,we proposed a multi-headed convolutional neural network architecture-based model for crowd counting,where we divided our proposed model into two main components:(i)the convolutional neural network,which extracts the feature across the whole image that is given to it as an input,and(ii)the multi-headed layers,which make it easier to evaluate density maps to estimate the number of people in the input image and determine their number in the *** employed the available public benchmark crowd-counting datasets UCF CC 50 and ShanghaiTech parts A and B for model training and testing to validate the model’s *** analyze the results,we used two metrics Mean Absolute Error(MAE)and Mean Square Error(MSE),and compared the results of the proposed systems with the state-of-art models of crowd *** results show the superiority of the proposed system.

关键词： Crowd counting EfficientNet multi-head attention convolutional neural network transfer learning

Classification and Comprehension of Software Requirements Using Ensemble Learning

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Computers, Materials & Continua 2024年第8期80卷 2839-2855页

作者： Jalil Abbas Arshad Ahmad Syed Muqsit shaheed Rubia Fatima Sajid shah Mohammad Elaffendi Gauhar Ali School of Computer Science and Technology Anhui UniversityHefei230039China School of Computing Sciences Pak Austria FachhochschuleInstitute of Applied Sciences and TechnologyHaripur22620Pakistan Department of Computer Science and IT University of LahoreLahore55150Pakistan Department of Computer Science Emerson UniversityPunjabMultan60000Pakistan EIAS(Emerging Intelligent Autonomous Systems)Data Science Lab Prince Sultan UniversityRiyad12435Saudi Arabia

The software development process mostly depends on accurately identifying both essential and optional ***,user needs are typically expressed in free-form language,requiring significant time and human resources to translate these into clear functional and non-functional *** address this challenge,various machine learning(ML)methods have been explored to automate the understanding of these requirements,aiming to reduce time and human ***,existing techniques often struggle with complex instructions and large-scale *** our study,we introduce an innovative approach known as the Functional and Non-functional Requirements Classifier(FNRC).By combining the traditional random forest algorithm with the Accuracy Sliding Window(ASW)technique,we develop optimal sub-ensembles that surpass the initial classifier’s accuracy while using fewer *** results demonstrate that our FNRC methodology performs robustly across different datasets,achieving a balanced Precision of 75%on the PROMISE dataset and an impressive Recall of 85%on the CCHIT *** datasets consistently maintain an F-measure around 64%,highlighting FNRC’s ability to effectively balance precision and recall in diverse *** findings contribute to more accurate and efficient software development processes,increasing the probability of achieving successful project outcomes.

关键词： Ensemble learning machine learning non-functional requirements requirement engineering accuracy sliding window

Contemporary Study for Detection of COVID-19 Using Machine Learning with Explainable AI

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Computers, Materials & Continua 2024年第7期80卷 1075-1104页

作者： Saad Akbar Humera Azam Sulaiman Sulmi Almutairi Omar Alqahtani Habib shah Aliya Aleryani Department of Computer Science University of KarachiKarachi75270Pakistan Department of Computing Faculty of Engineering Science and TechnologyHamdard UniversityKarachi75540Pakistan Department of Health Informatics College of Applied Medical SciencesQassim UniversityQassim51452Saudi Arabia Department of Computer Science College of Computer ScienceKing Khalid UniversityAbha61421Saudi Arabia

The prompt spread of COVID-19 has emphasized the necessity for effective and precise diagnostic *** this article,a hybrid approach in terms of datasets as well as the methodology by utilizing a previously unexplored dataset obtained from a private hospital for detecting COVID-19,pneumonia,and normal conditions in chest X-ray images(CXIs)is proposed coupled with Explainable Artificial Intelligence(XAI).Our study leverages less preprocessing with pre-trained cutting-edge models like InceptionV3,VGG16,and VGG19 that excel in the task of feature *** methodology is further enhanced by the inclusion of the t-SNE(t-Distributed Stochastic Neighbor Embedding)technique for visualizing the extracted image features and Contrast Limited Adaptive Histogram Equalization(CLAHE)to improve images before extraction of ***,an AttentionMechanism is utilized,which helps clarify how the modelmakes decisions,which builds trust in artificial intelligence(AI)*** evaluate the effectiveness of the proposed approach,both benchmark datasets and a private dataset obtained with permissions from Jinnah PostgraduateMedical Center(JPMC)in Karachi,Pakistan,are *** 12 experiments,VGG19 showcased remarkable performance in the hybrid dataset approach,achieving 100%accuracy in COVID-19 *** classification and 97%in distinguishing normal ***,across all classes,the approach achieved 98%accuracy,demonstrating its efficiency in detecting COVID-19 and differentiating it fromother chest disorders(Pneumonia and healthy)while also providing insights into the decision-making process of the models.

关键词： COVID-19 detection deep neural networks support vector machine CXIs InceptionV3 VGG16 VGG19 t-SNE embedding CLAHE attention mechanism XAI

Outcomes and variables that impact pneumatic retinopexies

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 564-569页

作者： Maria V.Castanos Daniel Vail Oscar Otero-Marquez Yash shah Avnish Deobhakta New York Eye and Ear Infirmary of Mount Sinai New York 10003New YorkUSA

●AIM:To evaluate the efficacy of pneumatic retinopexy(PR)in patients undergoing PR as primary treatment for rhegmatogenous retinal detachment(RRD)and analyze the factors associated with success and failure in the studied population.●METHODS:A retrospective chart review was done of patients with RRD treated with PR as primary management method treated at New York Eye and Ear Infirmary of Mount Sinai between January 2017 and December *** outcome measured success or failure of *** outcome measured best corrected visual acuity(BCVA)after PR.A separate risk analysis was done to identify and stratify risks associated with success and failure of PR.●RESULTS:A total of 179 eyes from 179 patients were included for final *** 83 patients(46.37%)achieved anatomical reattachment of the retina after primary PR with no need for additional *** 96 patients(53.63%)had a failed primary PR and required a PPV and 6 of them required pars plana vitrectomy(PPV)with scleral buckle(SB).In total,19 cases(10.61%)were done as temporizing pneumatics,18(94.74%)underwent PPV,and 1(5.26%)did not require further *** visual acuities at postoperative month 1(POM1)for patients who underwent primary PR successfully and for those that underwent PPV after,were 0.58(20/80)and 1.03(20/200)*** who met Pneumatic Retinopexy Versus Vitrectomy for the Management of Primary Rhegmatogenous Retinal Detachment Outcomes Randomized Trial(PIVOT)criteria had a statistically significant decreased risk of primary PR failing(hazard ratio 0.29,P=0.00).Majority of missed or new breaks were found superotemporally.●CONCLUSION:PR is a good treatment option for treating RRDs in patients that meet PIVOT criteria and can be conducted as a temporizing *** criteria and fovea on status decrease the risk of PR failure.

关键词： retina pneumatic retinopexy rhegmatogenous retinal detachment

Current updates on the epidemiology,pathogenesis and development of small molecule therapeutics for the treatment of Ebola virus infections

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Asian Pacific Journal of Tropical Medicine 2024年第7期17卷 285-298,I0001-I0007页

作者： shah Alam Khan Neelima Shrivastava MdJawaid Akhtar Aftab Ahmad Asif Husain Department of Pharmaceutical Chemistry College of PharmacyNational University of Science and TechnologyPO Box 620Postal code 130MuscatSultanate of Oman Centre of Molecular Medicine and Diagnostics(COMMAND) Saveetha Dental College&HospitalsSaveetha Institute of Medical&Technical SciencesSaveetha UniversityChennai 600077India Department of Pharmaceutical Chemistry School of Pharmaceutical Education and ResearchJamia HamdardNew Delhi-110062India Department of Health Information Technology the Applied CollegeKing Abdulaziz UniversityJeddah-21589Kingdom of Saudi Arabia

Ebola virus disease(EVD)is a rare,highly contagious and a deadly disease with a variable fatality rate ranging from 30%to 90%.Over the past two decades,Ebola pandemic has severely affected the sub-Sahara region including Democratic Republic of the Congo(DRC),and *** causative agents of the most EVD cases are three distinct species out of six Ebolaviruses namely Zaire Ebolavirus(ZEBOV),Sudan Ebolavirus(SUDV)and Bundibugyo Ebolavirus(BDBV).In recent years,significant strides have been made in therapeutic ***,the US Food and Drug Administration has approved two monoclonal antibodies:InmazebTM(REGN-EB3)and Ansuvimab or ***,many small molecules are currently in the developmental stage,promising further progress in medical *** the critical need for preventive measures,this review provides an in-depth analysis of the licensed Ebola vaccines-Ervebo and the combination of Zabdeno(***)and Mvabea(MVA-BN-Filo)as well as the vaccines which are currently being tested for their efficacy and safety in clinical *** vaccines might play an important role in curbing the spread and mitigating the impact of this lethal *** current treatment landscape for EVD encompasses both nutritional(supportive)and drug *** review comprehensively details the origin,pathogenesis,and epidemiology of EVD,shedding light on the ongoing efforts to combat this devastating *** explores small molecules in various stages of the development,discusses patents filed or granted,and delves into the clinical and supportive therapies that form the cornerstone of EVD *** review aims to provide the recent developments made in the design and synthesis of small molecules for scientific community to facilitate a deeper understanding of the disease and fostering the development of effective strategies for prevention,treatment,and control of EVD.

关键词： Ebola Epidemic Vaccine Ebola virus diseas