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Inflammation/bioenergetics-associated neurodegenerative pathologies and concomitant diseases:a role of mitochondria targeted catalase and xanthophylls

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Neural Regeneration Research 2021年第2期16卷 223-233页

作者： mikhail A.Filippov Olga G.Tatarnikova Natalia V.Pozdnyakova Vasily V.Vorobyov Sistema-BioTech LLCMoscowRussia Institute of Cell Biophysics Russian Academy of SciencesPushchinoRussia

Various inflammatory stimuli are able to modify or even"re-program"the mitochondrial metabolism that results in generation of reactive oxygen *** noncommunicable chronic diseases such as atherosclerosis and other cardiovascular pathologies,type 2 diabetes and metabolic syndrome,these modifications become systemic and are characterized by chronic inflammation and,in particular,"neuroinflammation"in the central nervous *** processes associated with chronic inflammation are frequently grouped into"vicious circles"which are able to stimulate each other constantly amplifying the pathological *** circles are evidently observed in Alzheimer's disease,atherosclerosis,type 2 diabetes,metabolic syndrome and,possibly,other associated ***,chronic inflammation in peripheral tissues is frequently concomitant to Alzheimer's *** is supposedly associated with some common genetic polymorphisms,for example,Apolipoprotein-Eε4 allele carriers with Alzheimer's disease can also develop ***,in the transgenic mice expressing the recombinant mitochondria targeted catalase,that removes hydrogen peroxide from mitochondria,demonstrates the significant pathology amelioration and health *** addition,the beneficial effects of some natural products from the xanthophyll family,astaxanthin and fucoxanthin,which are able to target the reactive oxygen species at cellular or mitochondrial membranes,have been demonstrated in both animal and human *** propose that the normalization of mitochondrial functions could play a key role in the treatment of neurodegenerative disorders and other noncommunicable diseases associated with chronic inflammation in ***,some prospective drugs based on mitochondria targeted catalase or xanthophylls could be used as an effective treatment of these pathologies,especially at early stages of their development.

关键词： algae xanthophylls Alzheimer's disease atherosclerosis depression type 2 diabetes metabolic syndrome mitochondria-targeted catalase noncommunicable chronic diseases stress

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观测与最小二乘法第1版

观测与最小二乘法

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丛书名：书名原文:Observations and least squares

1984年

作者： E.m.mikhail等

本书介绍了观测和模型的概念.观测误差的性质.传播的原理和方法.最小二乘平差引论等内容。

ISBN: (纸本)15039·新276

本书介绍了观测和模型的概念.观测误差的性质.传播的原理和方法.最小二乘平差引论等内容。

关键词：观测最小二乘法平差

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Anatomical basis for pancreas transplantation via isolated splenic artery perfusion:A literature review

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World Journal of Clinical Cases 2022年第35期10卷 12844-12853页

作者： Ilya Dmitriev marine Oganesyan Antonina Popova Egor Orlov mikhail Sinelnikov Yury Zharikov Department of Pancreas and Kidney Transplantation N.V.Sklifosovsky Research Institute for Emergency CareMoscow 107045Russia Department of Human Anatomy Sechenov First Moscow State Medical University(Sechenov University)Moscow 125009Russia Department of Oncology Radiotherapy and Reconstructive SurgerySechenov First Moscow State Medical University(Sechenov University)Moscow 119048Russia Laboratory of clinical morphology Research Institute of Human MorphologyMoscow 117418Russia

The variability of vascular anatomy of the pancreas underlines the difficulty of its *** regarding the consistency of anatomical variations shows splenic arterial dominance in most *** can significantly improve transplantation success.A systematic literature review was performed according to the quality standards described in the AmSTAR measurement tool and the PRISmA *** valuated existing literature regarding the vascularization and blood perfusion patterns of the pancreas in terms of dominance and *** collected data was independently analyzed by two *** of vascular anatomy was seen to be underreported in literature,though significant findings have been included and discussed in this study,providing valuable insight into the dynamics of pancreatic perfusion and feasibility of transplantation on several different supplying *** splenic artery(SA)has a high percentage of consistency in all found studies(over 90%).High frequency of anastomoses between arterial pools supplying the pancreas can mediate sufficient blood supply through a dominant vessel,such as the SA,which is present in most *** transplantation with isolated SA blood supply can provide sufficient arterial perfusion of the pancreas for stable transplant viability due to high anatomical consistency of the SA and vast communications with other arterial systems.

关键词： Pancreas transplantation Isolated splenic artery supply Pancreas anatomy pancreatic perfusion minireview

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Use of the reported Edmonton frail scale in the assessment of patients for transcatheter aortic valve replacement： a possible selection tool in very high-risk patients？

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Journal of Geriatric Cardiology 2018年第6期15卷 463-466页

作者： Louis Koizia Sarosh Khan Angela Frame Ghada W mikhail Sayan Sen Neil Ruparelia Geriatric medicine St Mary's Hospital Praed Street London UK Department of Cardiology Western Sussex Hospitals NHS Foundation Trust West Sussex UK Department of Cardiology lmperial College Healthcare NHS Trust London UK

Transcatheter aortic valve replacement （TAVR） has revolutionised the treatment of patients with aortic stenosis （AS） over the last 15 *** is a well-established procedure for the treatment of patients considered high risk for open surgery. Results from the PARTNER （Placement of AoRTic traNscathetER） trial showed that inoperable patients randomly assigned to TAVR, had a 20% reduction in all-cause mortality, as well as hospitalisation, at one year compared to best medical management.

关键词： Edmonton frail scale Frailty Transcatheter aortic valve replacement

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Self-cleaning property of AZ31 mg alloy during plasma electrolytic oxidation process

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Progress in Natural Science:materials International 2019年第1期29卷 94-102页

作者： Jiaping Han Carsten Blawert Junjie Yang Xiaopeng Lu Jin Hu mikhail L.Zheludkevich National Key Laboratory for Precision Hot Processing of metals School of Materials Science and Engineering Harbin Institute of Technology magnesium Innovation Centre-magIC Institute of Materials Research Helmholtz-Zentrum Geesthacht Corrosion and Protection Division Shenyang National Laboratory for Materials Science Northeastern University

The rolling of metal sheet often leads to strong contamination of the resulting surface. The present work reports the effects of the surface contamination remaining after rolling of AZ31 mg alloy on plasma electrolytic oxidation(PEO) treatment of the resulting sheet material. Results indicate that most of the contaminants on the surface of as-rolled AZ31 mg alloy are removed in the early stages of PEO process. The contaminations slightly influence the phase composition of PEO coating. Non-uniform distribution of contaminations results in aggregation of pores on the surface of PEO samples. On the bare substrate the contaminations are responsible for poor wear and corrosion resistance but final PEO coatings reveals similar performance on contaminated substrate compared to the abraded one. A self-cleaning property of the PEO and possibility of one step process,avoiding pre-cleaning stages, is suggested.

关键词： Intermetallics mechanochemical processing Corrosion Electrochemical impedance spectroscopy Scanning electron microscopy

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A detailed reconstruction of changes in the factors and parameters of soil erosion over the past 250 years in the forest zone of European Russia(moscow region)

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International Soil and Water Conservation Research 2022年第1期10卷 149-160页

作者： Andrey Zhidkin Daria Fomicheva Nadezhda Ivanova Tomas Dostal Alla Yurova mikhail Komissarov Josef Krasa V.V.dokuchaev soil science institute pyzhevskiy pereulok 7moscow119017russian federation Faculty of geography lomonosov moscow state universityleninskie gorygsp-1moscow119991russian federation Department of landscape water conservation faculty of civil engineeringczech technical university in praguethakurova 7prague16629czech republic Ufa institute of biology ufrc russian academy of sciencespr.oktyabrya 69ufa450054russian federation

Accelerated soil erosion is a major threat to soil,and there are great variations in the rate of soil erosion over time due to natural and human-induced *** temperate forest zone of Russia is character-ized by complex stages of land-use history(*** urbanization,agricultural development,land abandonment,etc.).We have for the first time estimated the rates of soil erosion by the WaTEm/SEDEm model(rainfall erosion)and by a regional model(snowmelt erosion)over the past 250 years(from 1780 to 2019)for a 100-km2 study site in the moscow region of *** calculations were made on the basis of a detailed historical reconstruction of the following factors:the location of the arable land,crop rotation,the rain erosivity factor,and the maximum snow water *** area of arable land has decreased more than 3.5-fold over the past 250 *** the end of the 20th century,the rates of gross erosion had declined more than 5.5-fold(from 28×10^(3) to 5×10^(3) t·ha^(-1)yr^(-1))in comparison with the end of the 18th *** in the boundaries of arable land and also the relief features had led to a significant intra-slope accumulation of *** a result of sediment redeposition within the arable land,the variation in net soil erosion was significantly lower than the variation in gross soil *** changes in arable land area and in crop composition are the factors that have to the greatest extent determined the changes in soil erosion in this territory.

关键词： Anthropogenic soil erosion Soil erosion history Crop rotation magnetic tracer method WaTEm/SEDEm

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A Laboratory Investigation into the Fuel Atomization Process in a Diesel Engine for Different Configurations of the Injector Nozzles and Flow Conditions

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Fluid Dynamics & materials Processing 2020年第4期16卷 747-760页

作者： mikhail G.Shatrov Valery I.malchuk Andrey Y.Dunin Ishlinsky Institute for Problems in mechanics RAS Moscow119526Russia moscow Automobile and Road Construction State Technical University(mADI) Moscow125319Russia

This paper reports a laboratory investigation of the fuel injection process in a diesel *** atomization process of the considered fuel(a hydrocarbon liquid)and the ensuing mixing with air is studied experimentally under high-pressure *** types of injector nozzles are examined,including(two)new configurations,which are compared in terms of performances to a standard injector manufactured by the Bosch *** the two alternate configurations,the intake edges of one atomizing hole(hole No.1)are located in the sack volume while for the other(hole No.2)they are located on the locking cone of the needle *** injection process,the fuel atomization fineness and fuel supply speed characteristics are studied as functions of high-pressure fuel pump camshaft speed and rotation *** results obtained show that a decrease in the high-pressure fuel pump camshaft speed can produce fuel redistribution depending on the injector *** general,however,the hole No.1 can ensure fuel flow with higher speed with respect to the hole No.2 for all the operation modes of the *** on such an analysis,we conclude that the use of certain injectors can enable a fine tuning of the propagation process of fuel sprays into various areas of the diesel engine combustion chamber.

关键词： Injection atomization injector nozzle channel injection characteristic flow coefficient

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西伯利亚北极地区含油气盆地的水文地球化学特征

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石油勘探与开发 2017年第5期44卷 737-744页

作者： DmITRY Novikov Anatolievich SARAEV mikhail mikhailovich Trofimuk Institute of Petroleum Geology and Geophysics Siberian Branch of the RAS Novosibirsk 630090 Russia Novosibirsk State University Faculty of Geology Novosibirsk 630090 Russia

通过对过去40年收集的西伯利亚北极地区水文地球化学数据进行分析及综合解释,对数据进行了分类、评价和统计分析,评估区域背景值和异常值,估算水源之间接近程度的各种相关系数。西伯利亚沉积盆地的古水文地质重建表明,油气藏的水体有3... 详细信息

通过对过去40年收集的西伯利亚北极地区水文地球化学数据进行分析及综合解释,对数据进行了分类、评价和统计分析,评估区域背景值和异常值,估算水源之间接近程度的各种相关系数。西伯利亚沉积盆地的古水文地质重建表明,油气藏的水体有3种成因类型:(1)海相沉积过程中形成的水体;(2)渗入盆地内并经历了各个地质时期表生作用的大气降水成因的水体;(3)烃类混合物冷凝形成的水体。油气藏的水文地球化学模式受控于水-岩-气-有机质体系漫长的地质演化过程。西伯利亚北极地区沉积盆地内分布总矿化度为0.2~350.0 g/L的含氯化钠-碳酸氢盐、氯化钠、氯化钙地下水和其他类型的地下水。通过对西伯利亚北极地区地下水的对比分析,发现含有氯化钠组分的样品总矿化度超过250 g/L,表明卤水的形成与蒸发岩的浸出有关。水文地球化学数据分析显示,地下水的成分随其演化而发生非常大的变化,阿纳巴尔—拉普帖夫、西西伯利亚等盆地中生界的地下水处于其化学演化的初始阶段。

关键词：北极地区西伯利亚含油气盆地水文地质含水层水文地球化学模式地下水演化

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Platinum single-atom catalyst with self-adjustable valence state for large-current-density acidic water oxidation

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eScience 2022年第1期2卷 102-109页

作者： Hui Su mikhail A.Soldatov Victor Roldugin Qinghua Liu National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei230029AnhuiPR China The Smart materials Research Institute Southern Federal University344090Sladkova 178/24Rostov-on-DonRussia

The design of active acidic oxygen evolution reaction(OER)catalysts is of paramount importance to achieve efficient large-current-density industrial hydrogen fuel production via water ***,we develop a Pt-based catalyst with high electrochemical activity for the OER in acidic conditions under a large *** achieve this by modulating the electronic structure of Pt into a high-valence,electron-accessible Pt1^((2.4+δ)+)(δ=0-0.7)state during the *** electron-accessible Pt1^((2.4+δ)+)single-site catalyst can effectively maintain a large OER current density of 120 mA cm^(-2)for more than 12 h in 0.5 m H_(2)SO_(4) at a low overpotential of 405 mV,and it shows a high mass activity of~3350 A gmetal^(-1)at 10 mA cm^(-2) current density and 232 mV *** in situ synchrotron radiation infrared and X-ray absorption spectroscopies,we directly observe in an experiment that a key(*O)-Pt_(1)-C_(2)N_(2) intermediate is produced by the potential-driven structural optimization of square pyramidal Pt_(1)-C_(2)N_(2) moieties;this highly favors the dissociation of H_(2)O over Pt1^(2.4+δ)^(+)sites and prevents over-oxidation and dissolution of the active sites.

关键词： Oxygen evolution reaction Acidic electrolyte In situ characterization

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Bond-selective transient phase imaging via sensing of the infrared photothermal effect

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Light(Science & Applications) 2019年第1期8卷 70-81页

作者： Delong Zhang Lu Lan Yeran Bai Hassaan majeed mikhail E.Kandel Gabriel Popescu Ji-Xin Cheng Department of Biomedical Engineering Boston UniversityBostonMA 02215USA Department of Physics Zhejiang UniversityHangzhou 310028China National Laboratory on High Power Laser and Physics Shanghai 201800China Key Laboratory of High Power Laser and Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Department of Bioengineering University of Illinois at Urbana-ChampaignChampaignIL 61801USA Department of Electrical and Computer Engineering University of Illinois at Urbana-ChampaignChampaignIL 61801USA Department of Electrical&Computer Engineering Boston UniversityBostonMA 02215USA Photonics Center Boston UniversityBostonMA 02215USA

Phase-contrast microscopy converts the phase shift of light passing through a transparent specimen,e.g.,a biological cell,into brightness variations in an *** ability to observe structures without destructive fixation or staining has been widely utilized for applications in materials and life *** these advantages,phase-contrast microscopy lacks the ability to reveal molecular *** address this gap,we developed a bond-selective transient phase(BSTP)imaging technique that excites molecular vibrations by infrared light,resulting in a transient change in phase shift that can be detected by a diffraction phase *** developing a time-gated pump-probe camera system,we demonstrate BSTP imaging of live cells at a 50 Hz frame rate with high spectral fidelity,sub-microsecond temporal resolution,and sub-micron spatial *** approach paves a new way for spectroscopic imaging investigation in biology and materials science.

关键词： transient phase utilized

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