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Clinical significance of molecular subtypes of gastrointestinal tract adenocarcinoma

World Journal of Gastrointestinal Oncology 2022年第3期14卷 628-645页

作者： Ekaterina Olegovna Ignatova Evgenii Kozlov Maxim Ivanov Vladislav Mileyko Sofia Menshikova Henian Sun mikhail Fedyanin Alexey Tryakin Ivan Stilidi Department of Second Chemotherapy Federal State Budgetary Institution“N.N.Blokhin National Medical Research Center of Oncology”of the Ministry of Health of the Russian FederationMoscow 115478MoscowRussia Department of Oncogenetics Research Centre for Medical Genetics Research Centre for Medical GeneticsMoscow 115522MoscowRussia OncoAtlas LLC Moscow 121069MoscowRussia Department of Biological and Medical Physics Moscow Institute of Physics and TechnologyMoscow 141700MoscowRussia Department of Anticancer Drug Treatment AO K31 CityMoscow 121552MoscowRussia Pirogov Russian National Research Medical University(Pirogov Medical University) Moscow 117997MoscowRussia

Adenocarcinomas of the gastrointestinal tract(esophagus,stomach,and colon)represent a heterogeneous group of diseases with distinct etiology,clinical features,treatment approaches,and *** are ongoing to isolate molecular genetic subtypes,perform complete biological characterization of the tumor,determine prognostic groups,and find predictive markers to the effectiveness of *** molecular genetic classifications were created for esophageal adenocarcinoma[The Cancer Genome Atlas(TCGA)],stomach cancer(TCGA,Asian Cancer Research Group),and colon cancer(Colorectal Cancer Subtyping Consortium).In 2018,isolation of TCGA molecular genetic subtypes for adenocarcinomas of the gastrointestinal tract(esophagus,stomach,and colon)highlighted the need for further studies and clinical validation of subtyping of gastrointestinal ***,this approach has *** aim of our work was to critically analyze integration of molecular genetic subtyping of gastrointestinal adenocarcinomas in clinical practice.

关键词： Esophageal adenocarcinoma Gastric cancer Colon cancer Gene sequencing,Gene expression profiling Molecular subtypes

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Accelerated procedure to solve kinetic equation for neutral atoms in a hot plasma

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第5期9卷 233-246页

作者： mikhail Z.Tokar Institute for Energy and Climate Research—Plasma Physics(IEK-4)Research Center J¨ulich J¨ulich52428Germany

By reaching the first wall of a fusion reactor, charged plasma particles, electrons and ionsare recombined into neutral molecules and atoms of hydrogen isotopes. These speciesrecycle back into the plasma volume and participate, in particular, in charge–exchange(cx) collisions with ions. As a result, hot atoms with chaotically directed velocities aregenerated and some of them hit the wall. Statistical Monte Carlo methods often usedto model the behavior of cx atoms are too time-consuming for comprehensive parameter studies. Recently1 an alternative iteration approach to solve one-dimensional kineticequation2 has been significantly accelerated, by a factor of 30–50, by applying a passmethod to evaluate the arising integrals from functions, involving the ion velocity distribution. Here, this approach is used by solving a two-dimensional kinetic equation,describing the transport of cx atoms in the vicinity of an opening in the wall, e.g.,the entrance of a duct guiding to a diagnostic installation. To assess the erosion rateand lifetime of the installation, one need to know the energy spectrum of hot cx atomsescaping from the plasma into the duct. Calculations are done for a first mirror of molybdenum under plasma conditions expected in a fusion reactor like DEMO.3,4 The resultsof kinetic modeling are compared with those found by using a diffusion approximation5relevant for cx atoms if the time between cx collisions with ions is much smaller thanthe time till the ionization of atoms by electrons. The present more exact kinetic consideration predicts a mirror erosion rate by a factor of 2 larger than the approximatediffusion approach.

关键词： Kinetic equation numerical solution neutrals plasma.

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Effect of support modification on the characterization and catalytic activity of Mo/Al_2O_3 catalysts

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Journal of Energy Chemistry 2015年第4期24卷 520-528页

作者： M.Riad S.mikhail Egyptian Petroleum Research Institute

Molybdenum catalysts（15 wt% Mo O3loading） supported on alumina,alumina–magnesia,and alumina–chromia were prepared via impregnation technique and studied for the reaction of methyl-cyclohexane dehydrogenation. The catalysts were evaluated by means of FT-IR,XRD,DSC,TPR,and N2adsorption–desorption isotherms. The results clarified that Mo/alumina–magnesia catalyst possesses small crystallite size and high surface area（240 m2/g） and is selective toward the formation of dehydrogenated product（96.5%）. The yield to ring-opening products is higher on Mo/alumina–chromia catalyst due to its higher acidity and larger metal crystals,which favor the ring-opening reaction and lower metallic activity with selectivity toward ringopening products（32%）.

关键词： Metal oxide Infrared spectroscopy Hysteresis Dehydrogenation Methyl-cyclohexane

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GNSS-based BiSAR imaging using modified range migration algorithm

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Science China(Information Sciences) 2015年第8期58卷 144-156页

作者： ZENG Tao LIU FeiFeng ANTONIOU Michail CHERNIAKov mikhail Beijing Key Laboratory of Embedded Real-time Information Processing Technology Beijing Institute of Technology School of Electronic Electrical and Systems Engineering University of Birmingham

This paper proposed a new focusing approach for the bistatic SAR systems with a GNSS(Global Navigation Satellite System) satellite as the transmitter. Because of the long integration time the inherited curvature of the transmitter’s trajectory was adopted and the spatial variance of the equivalent velocity was derived under the principal of equivalent slant range model in the system signal model. The proposed focusing approach consists of two-step processing. Firstly, the general Doppler phase from constant velocity of the echo data is focused by modified Stolt mapping. Secondly, the residual nonlinear Doppler phase due to velocity variation is compensated by means of block-processing-based adaptive phase compensation to achieve large scene focusing. The simulation and experimental results validate the proposed algorithm in GNSS-based Bi SAR systems.

关键词： GNSS-based Bi SAR equivalent slant range model curvature of trajectory two-step processing modified Stolt mapping

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E-beam generation in discharges initiated by voltage pulses with a rise time of 200 ns at an air pressure of 12.5-100 kPa

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Plasma Science and Technology 2019年第4期21卷 52-60页

作者： Victor TARASENKO Dmitry BELOPLOTov mikhail LOMAEV Dmitry SOROKIN Institute of High Current Electronics Siberian Bran ch.Russian Academy of Sciences.Tomsk&34055.Russia National Research Tomsk State University.Tomsk 634050 Russia

The effect of air pressure(12.5,25,50,and 100 kPa)on the gen eration of runaway electron beams in a non-uniform electric field when applying voltage pulses(~35 kV)with a rise time of?200 ns has been *** results show that the discharge has various stages:streamer,diffuse,and ***,a wide streamer develops in the gap and a diffuse discharge is formed.A spark is formed u 100 ns after the *** current pulse of a supershort avalanche electron beam(SAEB)was measured with a collector at various pressures of *** show that there are two modes of generation of run away *** an air pressure of 25-100 kPa,a single SAEB current pulse with a full width at half-maximum(FWHM)of 120-140 ps is *** the air pressure of 12.5 kPa,two current pulses of the electron beam are *** of the first and second current pulses are ul40ps and u300 ps,*** current pulse amplitude of the second electron beam is higher than that of the first one,but the electron energy is less.

关键词： diffuse discharge runaway electrons streamer breakdown displacement current

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Kinetics of oxidative coupling of methane:Bridging the gap between comprehension and description

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Journal of Natural Gas Chemistry 2009年第3期18卷 273-287页

作者： mikhail Sinev Zukhra Fattakhova Vladimir Lomonosov Yurii Gordienko Semenov Institute of Chemical Physics ZAO "SCHAG" Company

The development of notions about the mechanism of the oxidative coupling of methane （OCM） over oxide catalysts and corresponding progress in its kinetic description are reviewed and discussed. The latter becomes essential at the stage of scaling up and optimization of the process in pilot and industrial reactors. It is demonstrated that the main achievements in the development of kinetic models can be reached by combining the approaches conventionally used in homogeneous gas-phase kinetics and in heterogeneous catalysis. In particular, some important features of the OCM process can be described if several elementary reactions of free radical species （formation and transformation） with surface active sites are included into the detailed scheme of methane oxidation in gas. However, some important features, such as a non-additive character of the reciprocal influence of methane and ethane in the case of their simultaneous presence in the reaction mixture, cannot yet be described and comprehended in the framework of schemes developed so far. Possible ways towards an advanced kinetic model, accounting the main principles of catalyst functioning （redox nature of active sites） and pathways of product formation （via free radicals） are traced.

关键词： natural gas methane oxidative coupling of methane ethane ethylene kinetics mechanism rate equations

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Non-classical solutions of a continuum model for rock descriptions

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Journal of Rock Mechanics and Geotechnical Engineering 2014年第3期6卷 180-185页

作者： mikhail A.Guzev Institute for Applied Mathematics Far Eastern Branch of the Russian Academy of Sciences

The strain-gradient and non-Euclidean continuum theories are employed for construction of non- classical solutions of continuum models. The linear approximation of both models＇ results in identical structures in terms of their kinematic and stress characteristics. The solutions obtained in this study exhibit a critical behaviour with respect to the external loading parameter. The conclusions are obtained based on an investigation of the solution for the scalar curvature in the non-Euclidean continuum theory, The proposed analysis enables us to use different theoretical approaches for description of rock critical behaviour under different loading conditions.

关键词： Zonal disintegrationStrain-gradient theoryNon-Euclidean continuum model

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Anisotropy effect on strengths of metamorphic rocks

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第1期10卷 164-175页

作者： Ahmet ?zbek Murat Gül Ergun Karacan ovünc Alca Department of Geological Engineering Kahramanmaras Sutcu Imam UniversityAvsar CampusKahramanmarasTurkey Department of Geological Engineering Mugla Sltkl Kocman UniversityMuglaTurkey

This paper aims to study the effect of anisotropy on strengths of several metamorphic rocks of southern(Cine) submassif of Menderes metamorphic massif in southwest Turkey. Four different metamorphic rocks including foliated phyllite, schist, gneiss and marble(calcschist) were selected and *** surveys were made along lines for each rock and evaluated with DIPS program. L-type Schmidt hammer was applied in the directions parallel and perpendicular to foliation during the field study. Several hand samples and rock blocks were collected during the field study for measurements of dry and saturated densities, dry and saturated unit weights and porosity, and for petrographic analysis and strength determination in laboratory. L-and N-type Schmidt hammers were applied in the directions perpendicular(anisotropy angle of 0°) and parallel(anisotropy angle of 90) to the foliation on selected blocks of phyllite, schist, gneiss and marble(calcschist). The phyllite and schist have higher porosity and lower density values than the other rocks. However, coarse crystalline gneiss and marble(calcschist) have higher rebound values and strengths, and they are classified as strong-very strong rocks. Generally, the rebound values in the direction perpendicular to the foliation are slightly higher than that in the direction parallel to foliation. Rebound values of N-type Schmidt hammer are higher than the L-type values except for phyllite. Sometimes, the rebound values of laboratory and field applications gave different results. This may result from variable local conditions such as minerals differentiation,discontinuities, water content, weathering degree and thickness of foliated structure.

关键词： Rock anisotropy Field survey Schmidt hammer rebound values Southwest Turkey

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Machine learning-based method to adjust electron anomalous conductivity profile to experimentally measured operating parameters of Hall thruster

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Plasma Science and Technology 2022年第6期24卷 148-156页

作者： Andrey SHASHKov mikhail TYUSHEV Alexander LovTSov Dmitry TOMILIN Dmitrii KRAVCHENKO JSC'Keldysh Research Center' 8 Onezhskaya St.Moscow 125438Russia

The problem of determining the electron anomalous conductivity profile in a Hall thruster,when its operating parameters are known from the experiment,is *** solve the problem,we propose varying the parametrically set anomalous conductivity profile until the calculated operating parameters match the experimentally measured ones in the best *** axial 1D3V hybrid model was used to calculate the operating parameters with parametrically set *** of the conductivity profile was performed using Bayesian optimization with a Gaussian process(machine learning method),which can resolve all local minima,even for noisy *** calculated solution corresponding to the measured operating parameters of a Hall thruster in the best way proved to be unique for the studied operating modes of *** local plasma parameters were calculated and compared to the measured ones for four different operating *** results show the qualitative *** agreement between calculated and measured local parameters can be improved with a more accurate model of plasma-wall interaction.

关键词： Hall thruster anomalous conductivity machine learning Bayesian optimization Gaussian process electric propulsion

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Multilayered organic semiconductors for high performance optoelectronic stimulation of cells

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Nano Research 2023年第4期16卷 5809-5816页

作者： Aleksandr Markov Alexander Gerasimenko Annie-Kermen Boromangnaeva Sofia Shashova Elena Iusupovskaia Ulyana Kurilova Vita Nikitina Irina Suetina Marina Mezentseva mikhail Savelyev Peter Timashev Dmitry Telyshev Xing-Jie Liang Institute for Bionic Technologies and Engineering I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Institute of Biomedical Systems National Research University of Electronic TechnologyZelenogradMoscow 124498Russia Chemistry Department Lomonosov Moscow State UniversityLeninskie Gory1/3Moscow 119991Russia Ivanovsky Institute of Virology N.F.Gamaleya National Center of Epidemiology and MicrobiologyMoscow 123098Russia World-Class Research Center“Digital Biodesign and Personalized Healthcare” I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Laboratory of Clinical Smart Nanotechnologies I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Institute for Regenerative Medicine I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The efficiency of devices for bioelectronic applications,including cell and tissue stimulation,is heavily dependent on the scale and the performance *** miniaturization of stimulation electrodes,achieving a sufficiently high current pulse to elicit action potentials becomes an *** we report on our approach of vertically stacking organic p-n junctions to create highlyefficient multilayered organic semiconductor(MOS)photostimulation device.A tandem arrangement substantially increases the photovoltage and charge density without sacrificing lateral area,while not exceeding 200-500 nm of *** devices generate 4 times higher voltages and at least double the charge densities over single p-n junction devices,which allow using lower light intensities for *** devices show an outstanding stability in the electrolyte that is extremely important for forthcoming in vivo ***,we have validated MOS devices performance by photostimulating fibroblasts and neuroblasts,and found that using tandem devices leads to more effective action potential *** a result,we obtained up to 4 times enhanced effect in cell growth density using 3 p-n layered *** results corroborate the conclusion that MOS technology not only can achieve parity with state-of-the-art silicon devices,but also can exceed them in miniaturization and performance for biomedical applications.

关键词： bioelectronics organic semiconductors wireless stimulation fibroblasts neuroblastoma cells

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