检索结果-南通市图书馆

Alzheimer’s Disease Aβ-Amyloid Plaque Morphology Varies According to APOE Isotype

World Journal of Neuroscience 2023年第3期13卷 118-133页

作者： Ina Caesar K. Peter R. Nilsson Per Hammarström mikael lindgren Stefan Prokop James Schmeidler Vahram Haroutunian David M. Holtzman Patrick R. Hof Sam Gandy Department of Neurology Icahn School of Medicine at Mount Sinai New York NY USA Department of Physics Chemistry and Biology Link&#246ping University Link&#246ping Sweden Department of Physics Norwegian University of Science and Technology Trondheim Norway Department of Neuropathology Charité Universit&#228tsmedizin Berlin Berlin Germany Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA Alzheimer’s Disease Research Center Icahn School of Medicine at Mount Sinai New York NY USA James J. Peters VA Medical Center Bronx NY USA Nash Family Department of Neuroscience and Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York NY USA Department of Neurology Hope Center for Neurological Disorders Knight Alzheimer’s Disease Research Center Washington University St. Louis MO USA Ronald M. Loeb Center for Alzheimer’s Disease Icahn School of Medicine at Mount Sinai New York NY USA

Background: The apolipoprotein E (APOE, gene;apoE, protein) ε4 allele is the most commonly identified genetic risk factor for typical late-onset sporadic Alzheimer’s disease (AD). Each APOE ε4 allele roughly triples the relative risk for AD compared to that of the reference allele, APOE ε3. Methods: We have employed hyperspectral fluorescence imaging with an amyloid-specific, conformation-sensing probe, p-FTAA, to elucidate protein aggregate structure and morphology in fresh frozen prefrontal cortex samples from human postmortem AD brain tissue samples from patients homozygous for either APOE ε3 or APOE ε4. Results: As expected APOE ε4/ε4 tissues had a significantly larger load of CAA than APOE ε3/ε3. APOE isoform-dependent morphological differences in amyloid plaques were also observed. Amyloid plaques in APOE ε3/ε3 tissue had small spherical cores and large coronas while amyloid plaques in APOE ε4/ε4 tissues had large irregular and multi-lobulated plaques with relatively smaller coronas. Despite the different morphologies of their cores, the p-FTAA stained APOE ε3/ε3 amyloid plaque cores had spectral properties identical to those of APOE ε4/ε4 plaque cores. Conclusions: These data support the hypothesis that one mechanism by which the APOE ε4 allele affects AD is by modulating the macrostructure of pathological protein deposits in the brain. APOE ε4 is associated with a higher density of amyloid plaques (as compared to APOE ε3). We speculate that multilobulated APOE ε4-associated plaques arise from multiple initiation foci that coalesce as the plaques grow.

关键词： Alzheimer’s Disease Amyloid Apolipoprotein Luminescent Conjugated Oligothiophenes Hyperspectral Separation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Alzheimer’s Disease Aβ -Amyloid Plaque Morphology Varies According to APOE Isotype

引用

World Journal of Neuroscience（神经科学国际期刊） 2023年第3期

作者： Ina Caesar K. Peter R. Nilsson Per Hammarström mikael lindgren Stefan Prokop James Schmeidler Vahram Haroutunian David M. Holtzman Patrick R. Hof Sam Gandy

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Integrating Functional Status Information into Knowledge Graphs to Support Self-Health Management

引用

Data Intelligence 2023年第3期5卷 636-662页

作者： Mauro Dragoni Tania Bailoni Ivan Donadello Jean-Claude Martin Helena lindgren Fondazione Bruno Kessler TrentoItaly Free University of Bolzano BolzanoItaly LISN-CNRS Universite Paris SaclayParisFrance Umea University UmeaSweden

Functional Status Information(FSI)describes physical and mental wellness at the whole-person *** includes information on activity performance,social role participation,and environmental and personal factors that affect the well-being and quality of *** and analyzing this information is critical to address the needs for caring for an aging global population,and to provide effective care for individuals with chronic conditions,multi-morbidity,and *** knowledge graphs(PKGs)represent a suitable way for meaning in a complete and structured way all information related to people's FSI and reasoning over them to build tailored coaching solutions supporting them in daily life for conducting a healthy *** this paper,we present the development process related to the creation of a PKG by starting from the HeLis ontology in order to enable the design of an Al-enabled system with the aim of increasing,within people,the self-awareness of their own functional *** particular,we focus on the three modules extending the HeLis ontology aiming to represent(i)enablers and(ii)barriers playing potential roles in improving(or deteriorating)own functional status and(iii)arguments driving the FSI collection ***,we show how these modules have been instantiated into real-world scenarios.

关键词： Knowledge Graph Personal Healthcare Functional Status Enablers Barriers Arguments

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Atomistic learning in the electronically grand-canonical ensemble

引用

npj Computational Materials 2023年第1期9卷 1619-1627页

作者： Xi Chen Muammar El Khatib Per lindgren Adam Willard Andrew J.Medford Andrew A.Peterson School of Engineering Brown UniversityProvidenceRI 02912USA Department of Chemistry Massachussetts Institute of TechnologyCambridgeMAUSA School of Chemical and Biomolecular Engineering Georgia Institute of TechnologyAtlantaGA 30318USA

A strategy is presented for the machine-learning emulation of electronic structure calculations carried out in the electronically grand-canonical *** approach relies upon a dual-learning scheme,where both the system charge and the system energy are predicted for each *** scheme is shown to be capable of emulating basic electrochemical reactions at a range of potentials,and coupling it with a bootstrap-ensemble approach gives reasonable estimates of the prediction *** method is also demonstrated to accelerate saddle-point searches,and to extrapolate to systems with one to five water *** anticipate that this method will allow for larger length-and time-scale simulations necessary for electrochemical simulations.

关键词： canonical ensemble electronic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Management of vascular complications following calcium hydroxylapatite filler injections:a systemic review of cases and experimental studies

引用

Plastic and Aesthetic Research 2022年第1期9卷 503-528页

作者： Aleksandra L.lindgren Kathleen M.Welsh University of Queensland-Ochsner Clinical School New OrleansLA 70121USA Bay Area Cosmetic Dermatology San FranciscoCA 94115USA

Aim:Dermal fillers are increasingly popular *** intraarterial injection of fillers,particularly with calcium hydroxylapatite(CaHA),can result in devastating consequences.A systemic review was performed to summarize management strategies to treat CaHA-associated vascular ***:The methodology of this review was derived from The Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA).In addition,this paper presents a previously unreported case of a CaHA-associated vascular ***:There were 32 articles describing 42 cases,plus our case included in this *** were 15 cases of vision complications,23 cases of non-vision complications,and 5 experimental *** most common injection sites reported were nasal region for vision complications(45%)and nasolabial folds for non-vision complications(40%).Of the 38 human cases,the most prevalent treatment choice was steroids(24 cases,63%).Complete or near complete improvement was reported in 83%of non-vision complications and 40%of vision *** was no noticeable homogeneity in the management strategies and outcomes of the *** the 5 experimental studies,no clear consensus on treatments was ***:Vascular complications of CaHA are seemingly uncommon,but it is widely suspected that this is due to *** best management is prevention,preparation for a potential complication is equally *** from CaHA literature,hyaluronic acid filler complication protocols,findings of this review,and personal experiences,this report proposes management strategies for CaHA-associated vascular *** hope these strategies provide a much-needed framework for injectors to refer to and utilize as needed.

关键词： Filler-associated intravascular complications filler-associated blindness vascular occlusion management calcium hydroxylapatite Radiesse

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ETV2 expression increases the efficiency of primitive endothelial cell derivation from human embryonic stem cells

引用

Cell Regeneration 2015年第1期4卷 1-7页

作者： Anne G lindgren Matthew B Veldman Shuo Lin Department of Molecular Cellular and Developmental Biology University of California615 Charles E.Young Drive SouthLos AngelesCA 90095USA

Background:Endothelial cells line the luminal surface of blood vessels and form a barrier between the blood and other tissues of the *** variant 2(ETV2)is transiently expressed in both zebrafish and mice and is necessary and sufficient for vascular endothelial cell *** of this gene in early zebrafish and mouse embryos results in ectopic appearance of endothelial *** expression of ETV2 in later development results in only a subset of cells responding to the ***:We have examined the expression pattern of ETV2 in differentiating human embryonic stem cells(ESCs)to determine when the peak of ETV2 expression *** show that overexpression of ETV2 in differentiating human ESC is able to increase the number of endothelial cells generated when administered during or after the endogenous peak of gene ***:Addition of exogenous ETV2 to human ESCs significantly increased the number of cells expressing angioblast genes without arterial or venous *** may be a viable solution to generate in vitro endothelial cells for use in research and in the clinic.

关键词： Human embryonic stem cells Endothelium ETV2 Differentiation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis

引用

World Journal of Gastroenterology 2016年第17期22卷 4389-4396页

作者： Tarja Ruuska Peter Küster Lena Grahnquist Fredrik lindgren Anne Vibeke Wewer Department of Pediatrics Tampere University Hospital 33521 Tampere Finland Department of Pediatrics and Adolescent Medicine Clemenshospital 48153 Munster Germany Karolinska University Hospital Astrid Lindgren Children's Hospital 17176 Solna Sweden Department of Pediatrics Karolinska University Hospital Huddinge 14186 Stockholm Sweden Department of Pediatrics Hvidovre Hospital 2650 Hvidovre Denmark

AIM: To investigate efficacy and safety for granulocyte, monocyte apheresis in a population of pediatric patients with ulcerative ***: The ADAPT study was a prospective, open-label, multicenter study in pediatric patients with moderate, active ulcerative colitis with pediatric ulcerative colitis activity index (PUCAI) of 35-64. Patients received one weekly apheresis with Adacolumn® granulocyte, monocyte/macrophage adsorptive (GMA) apheresis over 5 consecutive weeks, optionally followed by up to 3 additional apheresis treatments over 3 consecutive weeks. The primary endpoint was the change in mean PUCAI between baseline and week 12; the secondary endpoint was improvement in PUCAI categorized as (Significant Improvement, PUCAI decrease of ≥ 35), Moderate Improvement (PUCAI decrease of 20 ® GMA apheresis treatment was effective in ped

关键词： Granulocyte-monocyte apheresis Pediatric Ulcerative colitis Inflammatory bowel disease Therapy Steroids Clinical trial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anthropogenic Heat Flux Will Affect Global Warming

引用

Atmospheric and Climate Sciences 2021年第3期11卷 563-568页

作者： Mats lindgren KTH Royal Institute of Technology Stockholm Fellow of the Royal Swedish Academy of Engineering Sciences Stockholm Sweden

Examination of 420,000 years old ice cores shows a close relation between temperature increase and CO2-concentration increase. During the industrial era a new energy component appears, Anthropogenic Heat Flux, and a p... 详细信息

关键词： Global Warming Anthropogenic Heat Flux Earth Climate System

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Use of Fossil Energy Will Increase Atmosphere and Earth Land Temperature

引用

Atmospheric and Climate Sciences 2022年第2期12卷 264-269页

作者： Mats lindgren KTH Royal Institute of Technology Stockholm Fellow of the Royal Swedish Academy of Engineering Sciences Stockholm Sweden

Energy used for industrial production, buildings and transport will be accumulated in Atmosphere and Earth land. Global use of energy is known and documented for a long period of time and proportion of fossil and renewable energy is also known. Calculated accumulated energy in Earth land from 1971 to 2018 corresponds to 40% of IPCC Global Energy Inventory and calculated Atmosphere temperature increase from 1971 to 2018 corresponds to 100% of actual measurements.

关键词： Use of Energy Accumulated Energy in Atmosphere and Earth Land Global Energy Inventory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Perinatal mental health in China:views of health system professionals in Shanghai

引用

Global Health Journal 2019年第3期3卷 73-78页

作者： Simone Schwank Helena lindgren Birgitta Wickberg Yan Ding Ewa Andersson Department of Women's and Children's Health Reproductive HealthKarolinska InstitutetTomtebodavagen 18a17177 StockholmSweden Center for Psychoanalytic Training and Research Columbia University1051 Riverside DriveUnit 63New York 10032USA Department of Psychology University of GothenburgPO Box 500Haraldsgatan 141314 GoteborgSweden School of Nursing Fudan University305 Fenglin RoadShanghai 200032China Nursing Department Obstetrics and Gynecology HospitalFudan University419 Fangxie RoadShanghai 200011China

Background:Mental health has recently been receiving a growing amount of attention in China's Mainland,with mental disorders increasingly being recognized as a major public health ***,the treatment gap for mental health care is markedly high in *** research and clinical practice have focused on high-risk physical disorders but overlooked psychosocial factors,especially during the perinatal ***:To explore Chinese professionals'perception and attributions of perinatal mental health in ***:The study was conducted in Shanghai,China,in 2018,drawing on interviews with 15 key informants including health professionals,government officials,and policymakers recruited through snowball *** analysis of the semi-structured interviews was ***:The study yielded insights into the perceptions of perinatal mental health among health professionals in *** themes emerged from the informants'reports:(1)mental health influenced by tradition—describing traditions affecting the perception of mental health at both the societal and individual level;(2)societal changed contributing perinatal mental health problems—referring to a rapidly changing cultural and economic backdrop as a source of stress leading to mental health problems;and(3)existing and required resources—demonstrating a lack of professional training,staff shortages,and inadequacy of resources to provide the required mental health ***:Our results provide new insights into key health professionals'perceptions of mental health problems in *** to seek care owing to a lack of knowledge,and resource shortages in health care systems are obstacles to improve mental health among women in urban China.

关键词： Mental health problems Urban Chinese traditions Public health Perinatal Health care policies Depression Anxiety

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：