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Varicocele repair in severe oligozoospermia: A case report of post-operative azoospermia

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World Journal of Clinical Cases 2014年第4期2卷 94-96页

作者： Marco Milone Mario Musella miguel Emilio Sosa fernandez Paola Maietta Annarita Sasso Loredana Maria Sosa fernandez Laura Virginia Sosa fernandez Francesco Milone Department of Advanced Biomedical Science University of Naples "Federico Ⅱ"80131 Naples Italy Embryos IVF Center in Battipaglia84100 Salerno Italy

Varicocele has been implicated as a cause in 35%-50% of patients with primary infertility and up to 81% of men with secondary infertility. Although a large number of reports have shown improvement in the semen parameters after correction of varicocele, other studies have suggested no benefit. We report the first case of azoospermia after surgery in a young infertile male patient with left-sided varicocele and severe oligozoospermia undergoing laparoscopic varicocelectomy. A pregnancy was only achieved with assisted reproductive technology because semen cryopreservation was performed before surgery. In the light of the above, the deterioration of sperm count after varicocele repair in patients with severe oligozoospermia could be due to irreversible impairment of spermatogenesis of such patients, together with the possible temporary damage of the surgical repair. This possible complication could therefore turn the severe oligozoospermia into an indication to perform cryopreservation before surgery, on both clinical and medico-legal grounds. Further research is needed before drawing definitive conclusions regarding the management of varicocele-related severe oligozoospermia.

关键词： Varicocele Fertility Semen Cryopreservation Oligozoospermia

A vaginal drain of a pelvic abscess due to colonic diverticulitis

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World Journal of Clinical Cases 2013年第2期1卷 82-83页

作者： Marco Milone miguel Emilio Sosa fernandez Piero Venetucci Paola Maietta Loredana Maria Sosa fernandez Caterina Taffuri Francesco Milone Department of Advanced Biomedical Science University "Federico Ⅱ" of Naples

Although well recognized for tubo-ovarian abscesses, we report, in our best knowledge, the first case of a vaginal drain of a pelvic abscess due to colonic diverticulitis. A 78-year-old patient presented with abdominal and pelvic pain, fever(39.3 ℃) and an elevated white blood cell count(18500/mL). After abdominopelvic computed tomography the patient was presumed to have a pelvic abscess, which developed as a complication of the sigmoid diverticulitis. Due to the numerous intervening structures that create obstacles to safe percutaneous access, we planned a trans-vaginal drain. A rapid recovery was obtained within 2 d from the procedure and, at present, the follow-up was uneventful after 18 mo. We believe that transvaginal drain of pelvic abscess could be a useful alternative, when percutaneous approach is not feasible.

关键词： Vaginal Drain Diverticulitis Pelvic abscess Echography

Buchbesprechung Von Christoph Horns Nichtideale Normativitit:Ein neuer Blick auf Kants politische Philosophie

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德国哲学 2022年第2期 303-310,325页

作者： Jose miguel fernandez Perez und Teng He Promovierende an der Universität Bonn mit dem Schwerpunkt auf So-zialphilosophie.Teng He Promovierende an der Universität Bonn mit dem Schwerpunkt auf Au-gustins Philosophie.

Das Thema des Buches ist die besondere Art von Normativität des Politischen bei *** des Buches ist es,eine mittlere Position zwischen zwei hauptsächlichen konkurrierenden Auslegungsthesen zu Kants *** erste These(Unabhängigkeitsthese oder Trennungsthese)besagt,dass Kants Rechtphilosophie im Wesentlichen unabhängig von seiner Moralphilosophie *** bedeutet unter an-derem,dass die Rechtslehre bei Kant eine besondere Art der Normativität bein-haltet,die nicht von der Normativität der Moral abgeleitet wird.

关键词： des Das Ein

Effectiveness and safety of first-generation protease inhibitors in clinical practice:Hepatitis C virus patients with advanced fibrosis

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World Journal of Gastroenterology 2015年第30期21卷 9163-9174页

作者： Javier Salmeron Carmen Vinaixa Ruben Berenguer Juan Manuel Pascasio Juan Jose Sanchez Ruano miguel angel Serra Ana Gila Moises Diago Manuel Romero-Gomez Jose Maria Navarro Milagros Testillano Conrado fernandez Dolores Espinosa Isabel Carmona Jose Antonio Pons Francisco Jorquera Francisco Javier Rodriguez Ramon Perez Jose Luis Montero Rafael Granados miguel fernandez Ana Belen Martin Paloma Munoz de Rueda Rosa Quiles CIBERehd Instituto de Salud Carlos Ⅲ28029 MadridSpain Unit for Clinical Management of Digestive Diseases Complejo Hospitalario Universitario de Granada Instituto de Investigacion Biosanitaria de Granada University Hospital Politecnico La Fe Unit for Clinical Management of Digestive Diseases University Hospital Virgen Del Rocio Hospital Toledo University Clinic Hospital of Valencia University General Hospital of Valencia Unit for Clinical Management of Digestive Diseases University Hospital Nuestra Senora de Valme Department of Gastroenterology and Hepatology Agencia Sanitaria Costa del Sol University Hospital Cruces Gastroenterology Unit University Hospital Fundacion Alcorcon University Hospital Virgen Macarena University Hospital Virgen de la Arrixaca Hospital of Leon University General Hospital Reina Sofia Department Gastroenterology and Hepatology University Hospital Central de Asturias University Hospital Reina Sofia University Hospital De Gran Canaria Dr. Negrin Hospital San Pedro de Alcantara

AIM:To evaluates the effectiveness and safety of the first generation,NS3/4A protease inhibitors(PIs) in clinical practice against chronic C virus,especially in patients with advanced fibrosis. METHODS:Prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis C genotype 1,treatment-na?ve(TN) or treatment-experienced(TE),who underwent triple therapy with the first generation NS3/4A protease inhibitors,boceprevir(BOC) and telaprevir(TVR),in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow ***:One thousand and fifty seven patients were included,405(38%) were treated with BOC and 652(62%) with TVR. Of this total,30%(n = 319) were TN and the remaining were TE:28%(n = 298) relapsers,12%(n = 123) partial responders(PR),25%(n = 260) null-responders(NR) and for 5%(n = 57) with prior response unknown. The rate of sustained virologic response(SVR) by intention-to-treatment(ITT) was greater in those treated with TVR(65%) than in those treated with BOC(52%)(P < 0.0001),whereas by modified intention-to-treatment(m ITT) no were found significant differences. By degree of fibrosis,56% of patients were F4 and the highest SVR rates were recorded in the non-F4 patients,both TN and TE. In the analysis by groups,the TN patients treated with TVR by ITT showed a higher SVR(P = 0.005). However,by m ITT there were no significant differences between BOC and TVR. In the multivariate analysis by m ITT,the significant SVR factors were relapsers,IL28 B CC and non-F4; the type of treatment(BOC or TVR) was not significant. The lowest SVR values were presented by the F4-NR patients,treated with BOC(46%) or with TVR(45%). 28% of the patients interrupted the treatment,mainly by non-viral response(51%):this outcome was

关键词： Hepatitis C Boceprevir Telaprevir First-generation protease inhibitors Advanced fibrosis

Analysis of the therapeutic evolution in the management of airway infantile hemangioma

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World Journal of Clinical Pediatrics 2016年第1期5卷 95-101页

作者： Grecia V Vivas-Colmenares Israel fernandez-Pineda Juan Carlos Lopez-Gutierrez miguel Angel fernandez-Hurtado Maria Antonia Garcia-Casillas Jose Antonio Matute de Cardenas Department of Pediatric Surgery Virgen del Rocio Children’s Hospital Department of Pediatric Surgery La Paz’s Children’s Hospital Department of Pediatric Surgery Gregorio Mara?on Children’s Hospital

AIM: To analyze the evolution in the management of airway infantile hemangioma(AIH) and to report the results from 3 pediatric tertiary care ***: A retrospective study of patients with diagnosis of AIH and treated in 3 pediatric tertiary care institutions from 1996 to 2014 was performed. RESULTS: Twenty-three patients with diagnosis of AIH were identified. Mean age at diagnosis was 6 mo(range, 1-27). Single therapy was indicated in 16 patients and 7 patients received combined therapy. Two therapeutic groups were identified: Group A included 14 patients who were treated with steroids, interferon, laser therapy and/or surgery; group B included 9 patients treated with oral propranolol. In group A, oral corticosteroids were used in 9 patients with a good response in 3 cases(no requiring other therapeutic option), the other patients required additional treatment options. Cushing syndrome was observed in 3 patients. One patient died of a fulminant sepsis. Open surgical excision and endoscopic therapy were performed in 11 patients(in 5 of them as a single treatment) with a response rateof 54.5%. Stridor persisted in 2 cases, and one patient died during the clinical course of bronchial aspiration. In group B, oral propranolol was used in 9 patients(in 8 of them as a single treatment) with a response rate of 100%, with an mean treatment duration of 7 mo(range, 5-10); complications were not observed. CONCLUSION: Our experience and the medical literature support the use of propranolol as a first line of treatment in AIH.

关键词： Infantile hemangioma Propranolol Surgery Airway Fibrobronchoscopy

Selective Fetal Growth Restriction in Monochorionic Diamniotic Twins: Diagnosis and Management

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Maternal-Fetal Medicine 2022年第4期4卷 268-275页

作者： Alicia Mazer Zumaeta Maria Mar Gil miguel Rodriguez-fernandez Pilar Carretero JoséHector Ochoa Maria Cristina Casanova Francisca Sonia Molina Department of Obstetrics and Gynecology Hospital Universitario Clinico San CecilioGranada 18016Spain Department of Obstetrics and Gynecology Hospital Matemo Provincial Dr.Raul Felipe LuciniCordoba 500oArgentina Diagnus SA Prenatal Diagnosis and Fetal Medicine CenterCordoba 5000Argentina Obstetrics and Gynecology Department Hospital Universitario de TorrejonTorrejon de Ardoz 28223MadridSpain School of Medicine Universidad Francisco de VitoriaPozuelo de Alarcon 28223MadridSpain Instituto de Investigacion Biosanitaria lbs.GRANADA Granada 18016Spain

Selective fetal growth restriction (sFGR) is a severe condition that complicates 10% to 15% of all monochorionic diamniotic (MCDA) twin pregnancies. Pregnancies complicated with sFGR are at high risk of intrauterine demise or adverse perinatal outcome for the twins. Three clinical types have been described according to the umbilical artery (UA) Doppler pattern observed in the smaller twin: type I, when the UA Doppler is normal;type II, when there is persistent absent or reversed end-diastolic blood flow in the UA Doppler;and type III, when there is intermittent absent and/or reversed end-diastolic blood flow in the UA Doppler. Clinical evolution and management options mainly depend on the type of sFGR. Type I is usually associated with a good prognosis and is managed conservatively. There is no consensus on the management of types II and III, but in earlier and more severe presentations, fetal interventions such as selective laser photocoagulation of placental anastomoses or selective fetal cord occlusion of the smaller twin may be considered. This review aims to provide updated information about the diagnosis, evaluation, follow-up, and management of sFGR in MCDA twin pregnancies.

关键词： Twins Monochorionic diamniotic twins Selective fetal growth restriction Birthweight discordance Fetal therapy Placenta

Giant and thrombosed left ventricular aneurysm

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World Journal of Cardiology 2015年第7期7卷 431-433页

作者： Jose Alberto de Agustin Jose Juan Gomez de Diego Pedro Marcos-Alberca Jose Luis Rodrigo Carlos Almeria Patricia Mahia Maria Luaces miguel Angel Garcia-fernandez Carlos Macaya Leopoldo Perez de Isla Instituto Cardiovascular Hospital Universitario San Carlos

Left ventricular aneurysms are a frequent complication of acute extensive myocardial infarction and are most commonly located at the ventricular apex. A timely diagnosis is vital due to the serious complications that can occur,including heart failure,thromboembolism,or tachyarrhythmias. We report the case of a 78-yearold male with history of previous anterior myocardial infarction and currently under evaluation by chronic heart failure. Transthoracic echocardiogram revealed a huge thrombosed and calcified anteroapical left ventricular aneurysm. Coronary angiography demonstrated that the left anterior descending artery was chronically occluded,and revealed a big and spherical mass with calcified borders in the left hemithorax. Left ventriculogram confirmed that this spherical mass was a giant calcified left ventricular aneurysm,causing very severe left ventricular systolic dysfunction. The patient underwent cardioverter-defibrillator implantation for primary prevention.

关键词： Myocardial infarction Echocardiography Coronary artery disease Left ventricular aneurysm Coronary angiography

Piling up multidecker pyrgos[n]cages as antibacterial materials

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Science China Materials 2025年第01期 314-316页

作者： miguel A.Liuzzi-Vaamonde Jackson B.Lancaster Samantha A.Mason Yuanning Feng Department of Chemistry and Biochemistry The University of Oklahoma

The development of antibiotics is regarded as one of the most significant scientific advances in modern medicine. Before the commercialization of antibiotics, infectious diseases were catastrophic throughout history [1]. Penicillin was used to treat serious infections in the 1940s, but unfortunately, with the introduction of antibiotics came the emergence of antibiotic resistance [2,3]. Evolved and adapted methicillin-resistant Staphylococcus aureus (MRSA) strains are presently impacting community and healthcare systems across the globe [4].

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Selective Fetal Growth Restriction in MonochorionicDiamniotic Twins: Diagnosis and Management:Erratum

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Maternal-Fetal Medicine 2023年第1期5卷 57-57页

作者： Zumaeta, Alicia Mazer Mar Gil, Maria Rodriguez-fernandez, miguel Carretero, Pilar Hector Ochoa, Jose Cristina Casanova, Maria Sonia Molina, Francisca Hosp Univ Clin San Cecilio Dept Obstet & Gynecol Granada 18016 Spain Hosp Materno Prov Dr Raul Felipe Lucini Dept Obstet & Gynecol RA-5000 Cordoba Argentina Diagnus SA Prenatal Diag & Fetal Med Ctr RA-5000 Cordoba Argentina Hosp Univ Torrejon Obstet & Gynecol Dept Madrid 28223 Spain Univ Francisco Vitoria Sch Med Madrid 28223 Spain Inst Invest Biosanitaria Ibs GRANADA Granada 18016 Spain

Following the original article’s publication,1the authors identified an error in the published *** authors and institution section should be corrected as follows:Alicia Mazer Zumaeta1,2,3,MaríaMarGil4,5,*,miguel Rod... 详细信息

关键词： institution corrected Management