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A prototype for on-site generation of chlorinated disinfectant for use in rural aqueducts

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Water Science and Engineering 2024年第1期17卷 33-40页

作者： Diana Marcela Cuesta Parra Felipe Correa Mahecha Andrés Felipe Rubio pinzon Davidcamilo Ramirez Bustos Leonel Alveyro Teran Llorente miguel Fernando Jimenez Jimenez Chemical and Environmental Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia Chemical Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia Mecanical Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia

Sodium hypochlorite has significant potential as a sanitation solution in hard-to-reach *** studies have investigated the optimal electrolysis parameters for its production with volumes greater than 1o *** study evaluated sodium hypochlorite production through electrolysis in a 22-L prototype and identified the optimal operating *** were performed using graphite electrodes with areas of 68.4 cm^(2) at the laboratory scale and 1865.0 cm^(2) at the prototype scale.A design for experiments with different operating times,chloride concentrations,and electric current intensities was *** optimal operating time,sodium chloride concentration,and current intensity at the laboratory scale were 120 min,150 g of chloride per liter,and 3 A,respectively,leading to the production of 5.02 g/L of the disinfectant with an energy efficiency of 12.21 mg of Cl_(2) per *** the prototype scale,the maximum sodium hypochlorite concentration of 3.99 g of chloride per liter was achieved with an operating time of 120 min,a sodium chloride concentration of 100 g of chloride per liter,and a current intensity of 70 A,reaching an energy efficiency of 42.56 mg of Cl_(2) per *** addition,this study evaluated the influences of the chloride concentration,current intensity,and operating time on the production of sodium hypochlorite at the two scales,and formulated the equations showing the trends of sodium hypochlorite production and energy efficiency in the electrochemical *** 22-L prototype model for production of this oxidizing substance is promising for disinfection of large volumes of water in areas that are difficult to access.

关键词： Disinfection Electrolysis Energy efficiency Optimization Sodium hypochlorite

超声辅助乙醇提取富硒金花葵花朵中的硒及抗氧化活性分析

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食品工业科技 2024年第16期45卷 201-208页

作者：张文开鲍征宇 Diego Armando pinzon NUNEZ 邵玲玲徐峰张宏宇赵月华田欢中国地质大学(武汉)材料与化学学院湖北武汉430000 安康国硒源科技有限公司陕西安康725000 紫阳中地大硒科技有限公司陕西安康725000 西北大学地质学系陕西西安710000 武汉测绘研究院湖北武汉430000

为促进优质天然富硒植物资源的科学开发利用,本文选取富硒金花葵为研究对象,采用氢化物发生-原子荧光光谱法(Hydride Generation-Atomic Fluorescence Spectrometry,HG-AFS)检测不同植物器官样品中的硒含量,超声波辅助乙醇提取金花葵花... 详细信息

为促进优质天然富硒植物资源的科学开发利用,本文选取富硒金花葵为研究对象,采用氢化物发生-原子荧光光谱法(Hydride Generation-Atomic Fluorescence Spectrometry,HG-AFS)检测不同植物器官样品中的硒含量,超声波辅助乙醇提取金花葵花朵中的含硒有机活性组分并使用响应面法优化获得最佳提取工艺,同时对含硒提取物开展抗氧化活性研究。结果显示,金花葵各器官中硒含量从高到低依次为叶、果、花、根和茎,分别为21.99、14.29、12.93、10.90和10.23 mg/kg。响应面优化结果表明,含硒有机活性成分最佳提取参数为提取温度40℃、固液比1:60、提取时间40 min、超声功率350 W、乙醇浓度50%(V/V)和提取次数1次。在最佳提取参数下,硒的提取率为35.65%±0.65%。DPPH抗氧化活性测定结果显示,含硒有机活性成分的半抑制浓度(IC_(50))为0.048 mg/mL(硒元素浓度为0.79μg/mL),羟基自由基清除实验显示样品浓度为8 mg/mL时达到最大清除率97%,IC_(50)为0.56 mg/mL,还原力实验表明样品的还原能力随样品浓度的增大而增强。证明金花葵的含硒乙醇提取物具有良好的抗氧化能力。本研究可以为合理利用富硒金花葵和研发加工富硒农副作物提供一些理论依据。

关键词：金花葵硒含硒活性成分提取工艺优化响应面抗氧化活性

Geological setting, mining and reduction of mercury vapor contamination in the gold-silver district of Vetas-Calofornia （Santander, Colombia）

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Episodes 2005年第4期28卷 252-256页

作者： Erwin Wolff Carreno Juan Manuel pinzon Angel Rodolfo Contreras Moreno Christoph Bernardy Corporacion Autonoma Regional Para la Defensa de la Mescta de Bucaramanga Carrera 23 N°37-63 Bucaramanga Colombia Formely with Corporacidn Autonoma Regional Para la Defensa de la Mescta de Bucaramanga Carrera 23 N°37-63 Bucaramanga Colombia. Formerly with Federal Institute for Geosciences and Natural Resources Stilleweg 2 30655 Hannover Germany

Bucaramanga, with a population of about one million, is the capital of the Department of Santander （Colombia）, and has the Rio Surata as its main source of drinking water. In the upper reaches of the river, small-scale gold mining has been going onfor many centuries （Vetas-California mining district）. Geologically, the Vetas-California mining district is part of the Santander Massif which is composed of pre-Devonian metamorphic rocks and Mesozoic igneous rocks. The mineralisation is restricted to structurally controlled veins and is often associated with hydrothermal alteration. There is also disseminated mineralisation, but presently only the vein-type is mined. The processing residues are discharged into the nearby watercourses, contaminating the waters of the Surata river basin. As part of a joint Colombian-German technical cooperation project, with the purpose of controlling the negative environmental effects of gold mining pollution, an integrated distillation system for the recovery of mercuury. has been designed and tested.

关键词：地质条件矿床哥伦比亚蒸发作用金银

Green Method, Optical and Structural Characterization of ZnO Nanoparticles Synthesized Using Leaves Extract of M. oleifera

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Journal of Renewable Materials 2022年第3期10卷 833-847页

作者： Jose Vulfrano Gonzalez-Fernandez Diego David pinzon-Moreno Antony Alexander Neciosup-Puican Maria Veronica Carranza-Oropeza Facultad de Quimica e Ingenieria Quimica Universidad Nacional Mayor de San MarcosLima15081Peru Centro de Investigaciones Tecnologicas Biomedicas y MedioambientalesUniversidad Nacional Mayor de San MarcosLima15081Peru

ZnO nanoparticles(ZnO-NP)present innovative optical,electrical,and magnetic properties that depend on spe-cific characteristics,e.g.,size,distribution,and ***,these properties are essential to address various applications in areas such as electronics,medicine,energy,and *** addition,the performance of this ZnO-NP depends of their preparation which can be done by chemical,physical,and biological ***,nowadays,the main interest in developing ZnO-NP synthesis through biological methods bases on the decrease of use of toxic chemicals or energy applied to the procedures,making the process more cost-effective and environ-mentally ***,the large-scale production of nanoparticles by green synthesis remains a big challenge due to the complexity of the biological extracts used in chemical *** being the case,the preparation of ZnO-NP using Moringa oleifera extract as an alternative biological agent for capping and reduction in synthesis was evaluated in this ***,the results based on the analysis of the optical and structural characterization of the ZnO-NP obtained by employing UV-Vis,DLS,zeta potential,XRD,ATR-FTIR,and FE-SEM indicate mostly the presence of spherical nanosized material with a mean hydrodynamic diameter of 47.2 nm measured by DLS and a mean size diameter of 25 nm observed with FE-SEM ***,in FE-SEM images a homo-geneous dispersion and distribution is observed in the absence of agglutination,agglomeration,or generation of significant lumps of the *** XRD analysis showed that heat annealing induced the crystallite size favor-ing their *** obtained data confirm the synthesis of ZnO-NP and the absence of impurities associated with organic compounds in the annealed ***,those results and low-cost production pre-sent to the synthesized ZnO-NP by this biological method as a useful material in several applications.

关键词： ZnO nanoparticles green chemistry Moringa oleifera extract optical characterization structural characterization

Laser Wavelength Estimation Method Based on a High-Birefringence Fiber Loop Mirror

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Photonic Sensors 2019年第1期9卷 89-96页

作者： Ricardo I.ALVAREZ-TAMAYO Patricia PRIETO-CORTES Manuel DURAN-SANCHEZ Baldemar IBARRA-ESCAMILLA Antonio BARCELATA-pinzon Evgeny A.KUZIN Faculty of Physical-Mathematical Sciences CONACYT-Universidad Autonoma de Nuevo LeonSan Nicolas de los Garza 66451Mexico Faculty of Physical-Mathematical Sciences Universidad Autonoma de Nuevo LednSan Nicolas de los Garza 66451 Mexico Optics department CONA CYT-Instituto Nacional de AstrofisieaOptica y EleetronieaTonantzintla 72480Mexico Optics department Instituto Nacional de AstrofisicaOptica y ElectronicaTonantzintla 72480Mexico Mechatronics division Universidad Tecnologica de PueblaPuebla 72300Mexico

A simple method for the estimation of the wavelength of a fiber laser system is proposed. The method is based on the use of a high-birefringence-fiber loop mirror(HBFLM).The HBFLM exhibits a periodic transmission/reflection spectrum whose spectral characteristics are determined by the length and temperature of the high-birefringence fiber(HBF).Then,by the previous characterization of the HBFLM spectral transmission response,the central wavelength of the generated laser line can be *** using a photodetector,the *** of the laser line is estimated during an HBF temperature scanning by measuring the temperature at which the maximum transmitted power of the HBFLM is *** proposed method is demonstrated in a linear cavity tunable Er/Yb fiber *** method is a reliable and low-cost alternative for laser wavelength determination in short wavelength ranges without the use of specialized and expensive equipment.

关键词： Wavelength meter fiber lasers fiber optical loop mirror high-birefringence fiber

Importance of ROS1 gene fusions in non-small cell lung cancer

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Cancer Drug Resistance 2023年第2期6卷 332-344页

作者： Meri Muminovic Carlos Rodrigo Carracedo Uribe Andres Alvarez-pinzon Khine Shan Luis E.Raez Department of Hematology-Oncology Memorial Cancer Institute/Memorial Health Care SystemFlorida International UniversityPembroke PinesFL 33028USA Department of Internal Medicine Memorial Health Care SystemFlorida International UniversityPembroke PinesFL 33028USA Office of Human Research Memorial Healthcare SystemPembroke PinesFL 33028USA

Targeted therapy has become one of the standards of care for advanced lung *** than 10 genetic aberrations have been discovered that are actionable and several tyrosine kinase inhibitors(TKIs)have been approved to target each of *** several genetic aberrations that are actionable in non-small cell lung cancer(NSCLC),ROS1 translocations also known as gene fusion proteins,are found in only 1%-2%of the patient ***1 mutations can usually be detected using a combination of techniques such as immunohistochemistry(IHC),Fluorescence in-situ testing(FISH),polymerase chain reaction(PCR),and nextgeneration sequencing(NGS).However,RNA NGS and ctDNA NGS(liquid biopsies)also contribute to the *** are currently numerous FDA-approved agents for these tumors,including crizotinib and entrectinib;however,there is in-vitro sensitivity data and clinical data documenting responses to ceritinib and *** responses and survival rates with these agents are frequently among the best compared to other TKIs with genetic aberrations;however,intrinsic or extrinsic mechanisms of resistance may develop,necessitating research for alternative treatment *** combat the mechanisms of resistance,novel agents such as repotrectenib,cabozantinib,talotrectinib,and others are being *** this article,we examine the literature pertaining to patients with ROS1 tumors,including epidemiology,clinical outcomes,resistance mechanisms,and treatment options.

关键词： ROS1 targeted therapy non-small cell lung cancer

Arginine Metabolism in Cancer:A Valid Therapeutic Target?

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Journal of Nutritional Oncology 2017年第1期2卷 7-15页

作者： Vance L. Albaugh Carolina pinzon-Guzman Adrian Barbul Division of General Surgery Department of Surgery Vanderbilt University School of Medicine Nashville TN 37232 USA

Arginine is a conditionally essential amino acid that has been identified as an important player in a number of biologic processes,including normal functions of the cardiovascular and immune *** studies have demonstrated that arginine is necessary for cellular growth and can become limiting in states of rapid growth like *** this requirement for arginine in malignant cells,investigators have examined the potential for arginine deprivation therapy as an adjuvant treatment for cancers that are unable to synthesize arginine de ***,arginine has been identified as being critically important for immune surveillance that targets and destroys malignant ***,paradoxically,arginine has been identified as being both necessary for cancer growth and normal immune destruction of malignant cells.A number of factors,including the type of cancer,expression of arginine synthetic genes,tumor microenvironment and host immune cell-cancer cell interactions,can affect the progression of *** we review the data supporting arginine deprivation and supplementation in cancer therapies and the currently registered trials that aim at understanding which of these strategies may lead to advances in cancer therapy.

关键词： Tumors Arginine metabolism Anti-cancer activity

Antinociceptive and Anti-inflammatory Activities of Methanol Extract of Ormosia coccinea （Aubl,） Jacks in vivo

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Journal of Pharmacy and Pharmacology 2017年第6期5卷 289-298页

作者： miguel Angel Diaz C. Lorena H. Cruz M. Mahabir P. Gupta Dionisio Olmedo Jose Luis Lopez-Perez Estela Guerrero De Leon Juan Antonio Moran-pinzon Direccidn Nacional de Farmacia y Drogas Ministerio de Salud Panama Apartado 06812-0816 Republica de Panama Centro de lnvestigaciones Farmacognosticas de la Flora Panamena (CIFLORPAN) Facultad de Farmacia Universidad de Panama Panama Apartado 0824-00172 Republica de Panama Departamento de Quimica FarmacOutica Facultad de Farmacia Universidad de Salamanca Salamanca Apartado 37007 Spain Departamento de Farmacologla Facultad de Medicina Universidad de Panama Panama Apartado 0824 Panama

The present study was conducted to evaluate the antinociceptive and anti-inflammatory activities of methanol extract of rachis of Ormosia coccinea （Aubl.） Jacks （MEOC） using animal models of nociception and inflammation. The antinociceptive activity of the extract was assessed using acetic acid-induced abdominal writhing, hot-plate, and formalin tests. Oral administration of MEOC （500 mg/kg） produced significant （t7 〈 0.05） antinociceptive effects when tested in mice using acetic acid-induced abdominal writhing test and on the inflammatory phase of the formalin test. It was also demonstrated that MEOC had no significant effect on the response latency time to the heat stimulus in the thermal model of the hot plate test. The anti-inflammatory activity of the extract was assessed using carrageenan, histamine and serotonin induced oedema in rat paw. The oral administration of MEOC showed maximum inhibition （64.29%） at 1 h on carrageenan edema, but it did not modify the edema induced by histamine and serotonin. The present results suggest that MEOC has a peripheral antinoeiceptive and anti-inflammatory action.

关键词： Ormosia coccinea antinociceptive anti-inflammatory fabaceae.

Toehold switch based biosensors for sensing the highly trafficked rosewood Dalbergia maritima

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Synthetic and Systems Biotechnology 2022年第2期7卷 791-801页

作者： Paul Soudier Daniel Rodriguez pinzon Tristan Reif-Trauttmansdorff Hassan Hijazi Maeva Cherriere Catia Goncalves Pereira Doriane Blaise Maxime Pispisa Angelyne Saint-Julien William Hamlet Melissa Nguevo Eva Gomes Sophia Belkhelfa Anna Niarakis Manish Kushwaha Ioana Grigoras Evry Paris-Saclay 2020 iGEM team France Universite Paris-Saclay INRAEAgroParisTechMicalis Institute78352Jouy-en-JosasFrance Universite Paris-Saclay Univ EvryLaboratoire Europeen de Recherche pour la Polyarthrite Rhumatoïde-GenhotelEvryFrance Universite Paris-Saclay Univ EvryCNRSCEAGenomique MetaboliqueEvryFrance DNA Script Le Kremlin-BicetreFrance SYNMIKRO Center of Synthetic Microbiology MarburgGermany Universite Grenoble Alpes CEAInsermEDyP-BGEGrenobleFrance National Institute of Industrial Property(INPI) CourbevoieFrance

Nucleic acid sensing is a 3 decades old but still challenging area of application for different biological sub-domains,from pathogen detection to single cell transcriptomics *** many applications of nucleic acid detection and identification are mostly carried out by PCR techniques,sequencing,and their derivatives used at large ***,these methods’limitations on speed,cost,complexity and specificity have motivated the development of innovative detection methods among which nucleic acid biosensing technologies seem *** switches are a particular class of RNA sensing devices relying on a conformational switch of secondary structure induced by the pairing of the detected trigger RNA with a de novo designed synthetic sensing mRNA *** we describe a streamlined methodology enabling the development of such a sensor for the RNA-mediated detection of an endangered plant species in a cell-free reaction *** applied this methodology to help identify the rosewood Dalbergia maritima,a highly trafficked wood,whose protection is limited by the capacity of the authorities to distinguish protected logs from other unprotected but related *** streamlined pipeline presented in this work is a versatile framework enabling cheap and rapid development of new sensors for custom RNA detection.

关键词： Toehold switch Riboregulator Biosensor Rosewood