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Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors

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World Journal of Gastroenterology 2015年第8期21卷 2450-2459页

作者： Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer michelle k kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder Department of Gastrointestinal Oncology H. Lee Moffitt Cancer Center and Research Institute Department of Medicine Division of Oncology Stanford University Medical Center Stanford Robert H. Lurie Comprehensive Cancer Center of Northwestern University Department of Internal Medicine Division of Medical Oncology University of Kentucky Markey Cancer Center Rush University Medical Center Department of Surgery University at Buffalo - State University of New York Department of Medicine Division of Hematology Oncology and Transplantation University of Minnesota Department of Medical Oncology Roswell Park Cancer Institute Department of Medicine Gastroenterology Mount Sinai School of Medicine Mission Health System Asheville Department of Oncology Karmanos Cancer Institute Partnership for Health Analytic Research LLC

AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment ***:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic *** this time,there is little data to guide treatment selection and *** therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment *** appropriateness ratings were collected using the RAND/UCLA modified Delphi *** studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 *** were done both before and after an extended discussion of the *** measurements of agreement were made and consensus statements developed from the second round ***:Specialties represented were medical and surgical oncology,interventional radiology,and *** had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)*** the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were *** statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be *** patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated u

关键词： Unresectable Neuroendocrine carcinomas Neuroendocr

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Age, socioeconomic features, and clinical factors predict receipt of endoscopic retrograde cholangiopancreatography in pancreatic cancer

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World Journal of Gastrointestinal Endoscopy 2019年第2期11卷 133-144页

作者： Sheila D Rustgi Sunil P Amin michelle k kim Satish Nagula Nikhil A kumta Christopher J DiMaio Paolo Boffetta Aimee L Lucas Henry D. Janowitz Division of Gastroenterology Department of Medicine Icahn School of Medicine at Mount Sinai Division of Gastroenterology Virginia Mason Medical Center Tisch Cancer Institute Icahn School of Medicine at Mount Sinai

BACkGROUND Endoscopic retrograde cholangiopancreatography(ERCP) is the recommended technique for biliary decompression in pancreatic cancer. Previous studies have suggested racial, socioeconomic and geographic differences in diagnosis,treatment and outcomes of pancreatic cancer *** To examine geographic, racial, socioeconomic and clinical factors associated with utilization of *** Surveillance, Epidemiology and End Results and linked Medicare claims data were used to identify pancreatic cancer patients between 2000-2011. Claims data were used to identify patients who had ERCP and other treatments. The primary outcome was receipt of ERCP. Chi-squared analyses were used to compare demographic information. Trends in use of ERCP over time were assessed using Cochran Armitage test. Adjusted odds ratios(aORs) and 95% confidence intervals(CIs) for receipt ERCP were calculated using logistic regression,controlling for other *** Among 32510 pancreatic cancer patients, 14704(45.2%) underwent *** who had cancer located in the head of the pancreas(aOR 3.27, 95%CI:2.99-3.57), had jaundice(aOR 7.59, 95%CI: 7.06-8.17), cholangitis(aOR 4.22,95%CI: 3.71-4.81) or pruritus(aOR 1.42, 95%CI: 1.22-1.66) and lived in lower education zip codes(aOR 1.14, 95%CI: 1.04-1.24) were more likely to receive ERCP. In contrast, patients who were older(aOR 0.88, 95%CI: 0.83, 0.94), not married(aOR 0.92, 95%CI: 0.86, 0.98), and lived in a non-metropolitan area(aOR0.89, 95%CI: 0.82, 0.98) were less likely to receive ERCP. Compared to white patients, non-white/non-black patients(aOR 0.83, 95%CI: 0.70-0.97) were less likely to receive ERCP. Patients diagnosed later in the study period were less likely to receive ERCP(aOR 2004-2007 0.85, 95%CI: 0.78-0.92; aOR 2008-2011 0.76,95%CI: 0.70-0.83). After stratifying by indications for ERCP including jaundice,racial differences persisted(aOR black patients 0.80, 95%CI: 0.67-0.95,nonwhite/nonblack patients 0.73, 95%C

关键词： Pancreatic cancer Endoscopic retrograde cholangiopancreatography Socioeconomic disparities Racial disparities Jaundice Outcomes research

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Practice patterns in FNA technique: A survey analysis

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World Journal of Gastrointestinal Endoscopy 2014年第10期6卷 499-505页

作者： Christopher J DiMaio Jonathan M Buscaglia Seth A Gross Harry R Aslanian Adam J Goodman Sammy Ho michelle k kim Shireen Pais Felice Schnoll-Sussman Amrita Sethi Uzma D Siddiqui David H Robbins Douglas G Adler Satish Nagula Division of Gastroenterology Icahn School of Medicine at Mount Sinai Mount Sinai Medical CenterNew York NY 10029 United States Division of Gastroenterology and Hepatology Stony Brook University School of MedicineStony BrookNew YorkNY 11794 United States Division of Gastroenterology NYU School of Medicine New York NY 10016 United States Section of Digestive Diseases Yale School of Medicine New Haven Connecticut CT 06510 United States Division of Digestive and Liver Diseases Montefiore Medical Center Bronx New York NY 10467 United States Division of Gastroenterology and Hepatobiliary Diseases New York Medical College Valhalla New York NY 10595 United States Division of Gastroenterology and Hepatology Weill Cornell Medical College New York NY 10065 United States Division of Digestive and Liver Diseases Columbia University Medical Center New York NY 10032 United States Section of Gastroenterology Hepatology and Nutrition University of Chicago Medicine Chicago Illinois IL 60637 United States Division of Gastroenterology Lenox Hill Hospital New York NY 10075 United States Division of Gastroenterology and Hepatology University of Utah School of Medicine Salt Lake City Utah UT 84132 United States

AIM: To ascertain fine needle aspiration(FNA) tech-niques by endosonographers with varying levels of ex-perience and ***: A survey study was performed on United States based endosonographers. The subjects complet-ed an anonymous online electronic survey. The main outcome measurements were differences in needle choice, FNA technique, and clinical decision making among endosonographers and how this relates to years in practice, volume of EUS-FNA procedures, and prac-tice ***: A total of 210(30.8%) endosonographers completed the survey. Just over half(51.4%) identified themselves as academic/university-based practitioners. The vast majority of respondents(77.1%) identified themselves as high-volume endoscopic ultrasound(EUS)(> 150 EUS/year) and high-volume FNA(> 75 FNA/year) performers(73.3). If final cytology is non-diagnostic, high-volume EUS physicians were more likely than low volume physicians to repeat FNA with a core needle(60.5% vs 31.2%; P = 0.0004), and low volume physicians were more likely to refer patients for either surgical or percutaneous biopsy,(33.4% vs 4.9%, P kely to repeat FNA with a core needle(66.7%) compared to community physicians(40.2%, P < 0.001). CONCLUSION: There is significant variation in EUS-FNA practices among United States endosonographers. Differences appear to be related to EUS volume and practice environment.

关键词： Endoscopic ultrasound Diagnostic procedures and techniques Fine needle biopsy Fine needle aspiration

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Analysis of the Oscillatory Flows of Multiple Shock Waves in a Constant Area Duct

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Journal of Thermal Science 2024年第3期33卷 794-806页

作者： k JAMES Jintu kim Heuy Dong Department of Mechanical Engineering Andong National UniversityAndong36729Republic of Korea CAD-IT korea Co. Ltd.Seoul08591Republic of Korea

The oscillatory response of multiple shock waves to downstream perturbations in a supersonic flow is studied numerically in a rectangular *** shock waves are formed inside the duct at a shock Mach number of *** duct has an exit height of H,and the effect of duct resonance on multiple shock oscillations is investigated by attaching exit ducts of lengths 0H,50H,and *** downstream disturbance frequency varied from 10 Hz to 200 Hz to explore the oscillation characteristics of the multiple shock *** oscillatory response of shock waves under self-excited and forced oscillation conditions are analyzed in terms of wall static pressure,shock train leading-edge location,shock train length,and the size of the separation *** extent of the initial shock location increases with an increase in exit duct length for the self-excited oscillation *** analysis of the shock train leading edge and the spectral analysis of wall static pressure variations are *** variation in the shock train length is analyzed using the pressure ratio method for self-excited as well as forced *** RMS amplitude of the normalized shock train length(ζ_(ST))increases with an increase in the exit duct length for the self-excited oscillation *** the downstream perturbation frequency is increased,ζ_(ST)is decreased for exit duct *** all exit duct designs and downstream forcing frequencies,the size of the separation bubble grows and shrinks during the shock oscillations,demonstrating the dependence on duct resonance and forced oscillations.

关键词： shock train downstream disturbance supersonic flow shock wave boundary layer interaction duct resonance flow separation

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INVERTING GENERATING FUNCTIONS WITH INCREASED NUMERICAL PRECISION-A COMPUTATIONAL EXPERIENCE

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Journal of Systems Science and Systems Engineering 2011年第4期20卷 475-494页

作者： Nam k. kim Mohan L. CHAUDHRY Bong k. YOON kilhwan kim Department of Industrial Engineering Chonnam National University Department of Mathematics and Computer Science Royal Military College of Canada Defense Management College Korea National Defense University Internet Research Lab. Electronics and Telecommunications Research Institute

In this paper, we consider the numerical inversion of a variety of generating functions （GFs） that arise in the area of engineering and non-engineering fields. Three classes of GFs are taken into account in a comprehensive manner： classes of probability generating functions （PGFs） that are given in rational and non-rational forms, and a class of GFs that are not PGFs. Among others, those PGFs that are not explicitly given but contain a number of unknowns are largely considered as they are often encountered in many interesting applied problems. For the numerical inversion of GFs, we use the methods of the discrete （fast） Fourier transform and the Taylor series expansion. Through these methods, we show that it is remarkably easy to obtain the desired sequence to any given accuracy, so long as enough numerical precision is used in computations. Since high precision is readily available in current software packages and programming languages, one can now lift, with little effort, the so-called Laplacian curtain that veils the sequence of interest. To demonstrate, we take a series of representative examples： the PGF of the number of customers in the discrete-time Geo^X/Geo/c queue, the same in the continuous-time M^X/D/c queue, and the GFs arising in the discrete-time renewal process.

关键词： Queuing applied probability numerical inversion generating function

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Laboratory investigation of the anisotropic confinement-dependent brittle-ductile transition of a Utah coal

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International Journal of Mining Science and Technology 2021年第1期31卷 51-57页

作者： Bo-Hyun kim Mark k.Larson Mine Safety Branch CDC/NIOSH/SMRDSpokaneWA 99207USA

This paper was developed as part of an effort by the National Institute for Occupational Safety and Health(NIOSH)to identify risk factors associated with bumps in the prevention of fatalities and accidents in highly stressed,bump-prone ground *** of failure mechanism with increasing confinement,from extensional-to shear-dominated failure,are widely observed in the rupture of intact specimens at the laboratory scale and in rock *** the previous analysis conducted in 2018,both unconfined and triaxial compressive tests were conducted to investigate the strength characteristics of some specimens of a Utah coal,including the spalling limits,the ratio of apparent unconfined compressive strength(AUCS)to unconfined compressive strength(UCS),the damage characteristics,and the postyield *** mechanical characteristics were found to be strongly anisotropic as a function of the orientation of the cleats relative to the loading ***,the transition from extensional to shear failure at the given confinements was not clearly *** this study,a total of 20 specimens were additionally prepared from the same coal sample used in the previous study and then tested under both unconfined and triaxial compressive *** different confining stresses are used as analogs for different width-to-height(W/H)ratios of pillar *** the W/H ratios of the specimens were not directly considered during testing,the equivalent W/H ratios of a pillar as a function of the confining stresses were estimated using an existing empirical *** to this relationship,theW/H atwhich in-situ pillar behavior would be expected to transition from brittle to ductile is identified.

关键词： Bump-prone ground conditions A Utah coal Anisotropic Equivalent W/H ratios of a pillar

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Photoluminescence enhancement of red-emitting GdVO_4:Eu and YVO_4:Eu phosphors by adding zinc

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Journal of Rare Earths 2013年第1期31卷 13-17页

作者： k.Park J.kim k.Y.kim J.Y.kim Y.kim S.J.Dhoble Faculty of Nanotechnology and Advanced Materials Engineering Sejong University Department of Advanced Materials Engineering Hoseo University Department of Chemistry and Institute of Basic Sciences Dankook University Department of Physics R.T.M. Nagpur University

We synthesized the rare-earth activated Ro.94_xEuo.06ZnxVO4 （R： Gd and Y; 0〈_x〈_0.08） phosphors with a spherical mor- phology and a smooth surface by the ultrasonic spray pyrolysis. The annealed Ro.94_xEuo.06ZnxVO4 crystallized in the tetragonal zircon type structure, belonging to the space group of I41/amd. The incorporation of a small amount of Zn to Ro.94Euo.06VO4 improved the emission characteristics. The emission intensities of the Gdo.88EUo.06Zno.06VO4 and Yo.9Euo.06Zno.04VO4 phosphors at 619 nm were 72% and 2 1% stronger than those of the Gdo,94Euo.06VO4 and Yo.94Euo.06VO4 phosphors, respectively. We demonstrated that the addi- tion of Zn to Ro.94Euo.06VO4 was quite effective for improving the photoluminescent properties.

关键词： rare earths photolurninescence vanadate ultrasonic spray pyrolysis

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ESTIMATE OF THE UPPER CRITICAL FIELD AND CONCENTRATION FOR SUPERCONDUCTOR

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Chinese Annals of Mathematics,Series B 2004年第2期25卷 183-198页

作者： k．I．kim LIUZUHAN DepanmentofMathematics，PohangUniVersityofScienceandTechnology，Pohang，790-784，korea. DepanmentofMathematics，XuzhouNormalUniVersityXuzhOu221116，Jiangsu，China．

The effect of an applied magnetic field on an inhomogeneous superconductor is studied and the value of the upper critical magnetic field Hc3 at which superconductivity can nucleate is estimated. In addition, the authors locate the concentration of the order parameter, which depends on the inhomogeneous term a(x). Unlikely to the homogeneous case, the order parameter may concentrate in the interior of the superconducting material, due to the influence of the inhomogeneous term a(x).

关键词： Superconductor Critical field Nucleation Ginzburg-Landau

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An in situ monitoring method for PECVD process equipment condition

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Plasma Science and Technology 2019年第6期21卷 15-22页

作者： G kANG S AN k kim S HONG Department of Electronic Engineering Myongji University Yongin 17058 Republic of Korea

A key to successful consistent plasma processing is maintaining a consistent process chamber condition over a certain production *** alleviate the concern,in situ process monitoring sensors are employed to investigate the plasma chamber conditions of both the deposition step with direct plasma and the cleaning step with a remote plasma *** situ sensors are optical emission spectroscopy (OES),optical plasma monitoring sensors (OPMS),voltage current probes (Ⅵ-probes),and self-plasma OES (SP-OES).During the deposition,we perform the monitoring of a plasma condition associated with the applied RF power via OES,OPMS,and a Ⅵ-*** the chamber cleaning step using a remote plasma system does not allow plasma monitoring through the sidewall because the plasma is not formed in the process chamber,thus we employed SP-OES to monitor the by-product gas chemistry during the chamber cleaning process *** monitoring results with some useful applications,such as arc detection,part failure detection,and cleaning process chemistry analysis,are presented in this *** use of in situ sensors with proper combination can help to understand the plasma process better,to achieve more precise control of plasma processing.

关键词： in situ monitoring sensor advanced equipment control

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Development of a fault-rupture environment in 3D: A numerical tool for examining the mechanical impact of a fault on underground excavations

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International Journal of Mining Science and Technology 2019年第1期29卷 105-111页

作者： Bo-Hyun kim Mark k.Larson Spokane Mining Research Division CDC/NIOSH

While faults are commonly simulated as a single planar or non-planar interface for a safety or stability analysis in underground mining excavation, the real 3D structure of a fault is often very complex, with different branches that reactivate at different times. Furthermore, these branches are zones of nonzero thickness where material continuously undergoes damage even during interseismic periods. In this study, the initiation and the initial evolution of a strike-slip fault was modeled using the FLAC3D software program. The initial and boundary conditions are simplified, and mimic the Riedel shear experiment and the constitutive model in the literature. The FLAC3D model successfully replicates and creates the 3D fault zone as a strike-slip type structure in the entire thickness of the model. The strike-slip fault structure and normal displacement result in the formation of valleys in the model. Three panels of a longwall excavation are virtually placed and excavated beneath a main valley. The characteristics of stored and dissipated energy associated with the panel excavations are examined and observed at different stages of shear strain in the fault to evaluate bump potential. Depending on the shear strain in the fault, the energy characteristics adjacent to the longwall panels present different degrees of bump potential, which is not possible to capture by conventional fault simulation using an interface.

关键词： 3D fault zone Strike-slip fault FLAC3D Bump potential Energy characteristics

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