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Matching traditional Chinese medicine and western medicine-based research:Advanced nutraceutical development for proactive gastric cancer prevention

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3798-3819页

作者： Matteo Micucci Bian-Zhao Xiang Chen-Min Ting Hiu-Yee Kwan michele Mari michele retini Sabrina Burattini Riham Osman Udodinma Jude Okeke Fuad Othman Abdullah Federico Gianfanti Michela Battistelli Department of Biomolecular Sciences University of Urbino Carlo BoUrbino 61029Italy Hong Kong Chinese Medicine Clinical Study Centre Chinese EQUATOR CentreSchool of Chinese MedicineChinese Clinical Trial Registry(Hong Kong)Hong Kong Baptist UniversityHong Kong 999077China Centre for Chinese Herbal Medicine Drug Development Hong Kong Baptist UniversityHong Kong 999077China Centre for Cancer and Inflammation Research School of Chinese MedicineHong Kong Baptist UniversityHong Kong 999077China Department of Chemistry College of ScienceSalahaddin University-ErbilErbil 44001Iraq Department of Pharmacognosy Faculty PharmacyTishk International UniversityErbil 44001Iraq Institute of Oncology Research Bellinzona CH6500Switzerland Universitàdella Svizzera Italiana Lugano CH6900Switzerland

Gastric cancer(GC),the third leading cause of cancer-related death globally,is complex and *** review explores multidisciplinary investigations of traditional Chinese medicine(TCM)combined with Western medical practices,emphasizing the development of nutraceuticals for cancer *** advanced analytical chemistry and food chemistry techniques,this study investigated how TCM components may be optimized for nutraceutical *** on molecular interactions with GC pathways,particularly the NF-κB,PI3K/Akt,and Wnt/β-catenin pathways,we examined the effects of TCM polyherbal formulas,extracts,and isolated *** agents modulate apoptosis and cellular proliferation,underscoring their potential in preventive *** convergence of nutraceutical and medicine food homology studies highlights a significant shift towards integrating TCM-derived compounds in a preventive health *** approach aims not only to enhance efficacy and reduce side effects but also to champion a preventive paradigm using personalized medicine to advance proactive health maintenance and disease *** combination of TCM and western medical practices offers promising avenues for future research and practical applications in GC prevention.

关键词： Traditional Chinese medicine Precision medicine Molecular network Phytochemistry Food chemistry Nutraceuticals Gastric cancer

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Angiotensin-converting enzyme 2 and AMPK/mTOR pathway in the treatment of liver fibrosis:Should we consider further implications?

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World Journal of Gastroenterology 2024年第18期30卷 2391-2396页

作者： michele Barone Section of Gastroenterology Department of Precision and Regenerative Medicine-Jonian Area-University of BariBari 70124Italy

This editorial contains comments on the article by Zhao et al in print in the World Journal of *** mechanisms responsible for hepatic fibrosis are also involved in ***,we recapitulated the complexity of the renin-angiotensin system,discussed the role of hepatic stellate cell(HSC)autophagy in liver fibrogenesis,and analyzed the possible implications in the development of hepatocarcinoma(HCC).Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers definitively contribute to reducing hepatic fibrogenesis,whereas their involvement in HCC is more evident in experimental conditions than in human ***-converting enzyme 2(ACE2),and its product Angiotensin(Ang)1-7,not only regulate HSC autophagy and liver fibrosis,but they also represent potential targets for unexplored applications in the field of ***,ACE2 overexpression inhibits HSC autophagy through the AMP-activated protein kinase(AMPK)/mammalian target of rapamycin(mTOR)*** this case,Ang 1-7 acts binding to the MasR,and its agonists could modulate this ***,since AMPK utilizes different targets to suppress the mTOR downstream complex mTOR complex 1 effectively,we still need to unravel the entire pathway to identify other potential targets for the therapy of fibrosis and liver cancer.

关键词： Renin-angiotensin system Liver fibrosis Hepatic stellate cells Autophagy Hepatocellular carcinoma

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Risk of hepatic decompensation from hepatitis B virus reactivation in hematological malignancy treatments

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World Journal of Gastroenterology 2024年第25期30卷 3147-3151页

作者： michele Barone Section of Gastroenterology Department of Precision and Regenerative Medicine-Jonian Area-University of BariBari 70124Italy

In this editorial,we discussed the apparent discrepancy between the findings described by Colapietro et al,in their case report and data found in the *** et al reported a case of hepatitis B virus(HBV)-related hepatic decompensation in a patient with chronic myeloid leukemia and a previously resolved HBV infection who was receiving Bruton’s tyrosine kinase(BTK)inhibitor *** of all,we recapitulated the main aspects of the immune system involved in the response to HBV infection in order to underline the role of the innate and adaptive response,focusing our attention on the protective role of *** then carefully analyzed literature data on the risk of HBV reactivation(HBVr)in patients with previous HBV infection who were treated with either tyrosine kinase inhibitors or BTK inhibitors for their hematologic *** on literature data,we suggested that several factors may contribute to the different risks of HBVr:The type of hematologic malignancy;the type of therapy(BTK inhibitors,especially second-generation,seem to be at a higher risk of HBVr than those with tyrosine kinase inhibitors);previous exposure to an anti-CD20 as first-line therapy;and ethnicity and HBV ***,the warning regarding HBVr in the specific setting of patients with hematologic malignancies requires further investigation.

关键词： Hematological malignancy Hepatitis Hepatitis B virus-DNA Bruton’s tyrosine kinase Previously resolved hepatitis B virus infection

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Metabolomic evidence of independent biotransformation pathways for terpenes in two specialist mammalian herbivores (genus Neotoma)

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Integrative Zoology 2024年第1期19卷 143-155页

作者： Katharina SCHRAMM michele SKOPEC Denise DEARING Department of Biology University of UtahSalt Lake CityUtahUSA Department of Zoology Weber State UniversityOgdenUtahUSA

Herbivory is common in mammals,yet our understanding of detoxification processes used by mammals to biotrans-form plant secondary compounds(PSCs)is *** herbivores are thought to have evolved detoxifica-tion mechanisms that rely more heavily on energetically cheap Phase I biotransformation reactions to process high levels of PSCs in their *** explored this hypothesis by comparing the urinary metabolite patterns of two spe-cialist herbivores(genus Neotoma).Neotoma stephensi is an obligate specialist on one-seeded juniper(Juniperus monosperma).Neotoma lepida is a generalist forager across its range,yet populations in the Great Basin specialize on Utah juniper(***).While both juniper species have high levels of terpenes,the terpene profiles and quantities differ between the *** from both woodrat species were fed diets of each juniper in a cross-over ***,collected over a 24-h period,was extracted and analyzed in an untargeted metabolomics approach using both GC-MS and HPLC-MS/*** obligate specialist *** excreted a unique pattern of Phase I metabolites when fed its native juniper,while *** excreted a unique pattern of Phase II metabolites when fed its native *** woodrat species utilized the Phase II metabolic pathway of glucuronidation more heavily when consuming the more chemically diverse ***,and *** utilized less glucuronida-tion than *** when consuming *** results are consistent with the hypothesis that obligate specialists may have evolved unique and efficient biotransformation mechanisms for dealing with PSCs in their diet.

关键词： dietary specialization herbivory juniper metabolomics Neotoma

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Colon and rectal cancer:An emergent public health problem

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World Journal of Gastroenterology 2024年第7期30卷 644-651页

作者： Marina Pinheiro David Nascimento Moreira michele Ghidini LAQV REQUIMTEDepartment of ChemistryFaculty of PharmacyUniversity of Porto4050-313 PortoPortugal Unidade de Saúde Pública Unidade Local de Saúde Barcelos/EsposendeBarcelinhos 4755-069BragaPortugal Medical Oncology Unit Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilan 20122Italy

Colorectal cancer ranks third globally,with a high mortality *** the United States,and different countries in Europe,organized population screenings exist and include people between 50 and 74 years of *** screenings have allowed an early diagnosis and consequently an improvement in health *** and rectal cancer(CRC)is a disease of particular interest due to the high global burden associated with it and the role attributed to prevention and early diagnosis in reducing morbidity and *** study is a review of CRC pathology and includes the most recent scientific evidence regarding this pathology,as well as a diagnosis of the epidemiological situation of ***,the recommendation from a public health perspective will be discussed in detail taking into account the context and the most current recommendations.

关键词： Colon and rectal neoplasia Colon and rectal tumor Mortality Morbidity

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Therapeutic advances in neural regeneration for Huntington’s disease

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Neural Regeneration Research 2024年第9期19卷 1991-1997页

作者： Francesco D’Egidio Vanessa Castelli Giorgia Lombardozzi Fabrizio Ammannito Annamaria Cimini michele d’Angelo Department of Life Health and Environmental SciencesUniversity of L’AquilaL’AquilaItaly

Huntington’s disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the HTT gene which is responsible for the production of the huntingtin (Htt) protein. In physiological conditions, Htt is involved in many cellular processes such as cell signaling, transcriptional regulation, energy metabolism regulation, DNA maintenance, axonal trafficking, and antiapoptotic activity. When the genetic alteration is present, the production of a mutant version of Htt (mHtt) occurs, which is characterized by a plethora of pathogenic activities that, finally, lead to cell death. Among all the cells in which mHtt exerts its dangerous activity, the GABAergic Medium Spiny Neurons seem to be the most affected by the mHtt-induced excitotoxicity both in the cortex and in the striatum. However, as the neurodegeneration proceeds ahead the neuronal loss grows also in other brain areas such as the cerebellum, hypothalamus, thalamus, subthalamic nucleus, globus pallidus, and substantia nigra, determining the variety of symptoms that characterize Huntington’s disease. From a clinical point of view, Huntington’s disease is characterized by a wide spectrum of symptoms spanning from motor impairment to cognitive disorders and dementia. Huntington’s disease shows a prevalence of around 3.92 cases every 100,000 worldwide and an incidence of 0.48 new cases every 100,000/year. To date, there is no available cure for Huntington’s disease. Several treatments have been developed so far, aiming to reduce the severity of one or more symptoms to slow down the inexorable decline caused by the disease. In this context, the search for reliable strategies to target the different aspects of Huntington’s disease become of the utmost interest. In recent years, a variety of studies demonstrated the detrimental role of neuronal loss in Huntington’s disease condition highlighting how the replacement of lost cells would be a reasonable strategy to o

关键词： cell therapy exosomes extracellular vesicles Huntingtin Huntington’s disease medium spiny neurons neurodegenerative disease neurogenesis neuronal loss stem cells

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Close relationship between mediators of inflammation and pancreatic cancer:Our experience

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World Journal of Gastroenterology 2024年第23期30卷 2927-2930页

作者： Francesca Vescio michele Ammendola Giuseppe Currò Silvia Curcio Department General Surgery UnitUniversity“Magna Graecia”Medical SchoolUniversity Hospital“R.Dulbecco”Catanzaro 88100Italy Science of Health Department Digestive Surgery UnitUniversity“Magna Graecia”Medical SchoolUniversity Hospital“R.Dulbecco”Catanzaro 88100Italy

In this editorial,we focus specifically on the mechanisms by which pancreatic inflammation affects pancreatic *** of the pancreas remains one of the deadliest cancer *** highest incidence and mortality rates of pancreatic cancer are found in developed *** of pancreatic cancer incidence and mortality vary considerably worldwide.A better understanding of the etiology and identification of the risk factors is essential for the primary prevention of this *** tumors are characterized by a complex microenvironment that orchestrates metabolic alterations and supports a milieu of interactions among various cell types within this *** this editorial,we highlight the foundational studies that have driven our understanding of these *** our experimental center,we have carefully studied the mechanisms of that link pancreatic inflammation and pancreatic *** focused on the role of mast cells(MCs).MCs contain pro-angiogenic factors,including tryptase,that are associated with increased angiogenesis in various *** this editorial,we address the role of MCs in angiogenesis in both pancreatic ductal adenocarcinoma tissue and adjacent normal *** assessment includes the density of c-Kit receptor-positive MCs,the density of tryptase-positive MCs,the area of tryptasepositive MCs,and angiogenesis in terms of microvascularization density.

关键词： Mast cells C-Kit receptor Tryptase Angiogenesis Microvascular density Endothelial area Pancreatic tumor tissue Adjacent normal tissue

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Potential of GSHP coupled with PV systems for retrofitting urban areas in different European climates based on archetypes definition

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Energy and Built Environment 2024年第3期5卷 374-392页

作者： Laura Carnieletto Antonino Di Bella Davide Quaggiotto Giuseppe Emmi Adriana Bernardi michele De Carli Department of Industrial Engineering–DII University of Padovavia Venezia 1PadovaItaly University of Ferrara Italy CNR–National Research Council PadovaItaly

According to the recent policies regarding energy use in buildings and the need of retrofit strategies,the aim of this work is to support policies concerning the installation of ground source heat exchangers in urban and historical areas,raising the awareness on the potential energy saving achievable with optimal sizing and limited impact on the urban *** have been developed distinguishing among existing and historic buildings,focusing on single-family terrace houses,which are the typical residential buildings in European historic centres.A methodology for the optimal sizing of ground source heat pumps,eventually considering dual-source system or air system has been developed combining simulations of a photovoltaic system to estimate the self-sufficiency and the self-consumption for five orientations of the *** results have been obtained for warm cli-mates,with negligible heating energy demand and possibly free cooling systems rather than traditional cooling systems needed in *** temperature was acceptable despite unbalanced energy *** proper inclination,photovoltaic systems could provide up to 40%of self-sufficiency share also in northern *** energy-economic analysis was carried out obtaining a variety of cases representing a general overview of the European building stock and the potential benefits achievable in terms of renewable energy share,energy savings and economic investments needed to be extended to simulations at urban scale.

关键词： Energy use database Ground source heat exchangers Urban context Energy retrofit Integrated renewables

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Frequency stabilization of C-band semiconductor lasers through a SiN photonic integrated circuit

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Photonics Research 2024年第8期12卷 1619-1626页

作者： A1LESSANDRO BRUGNONI ALI EMRE KAPLAN VALERIO VITALI KYLE BOTTRILL michele RE PERIKLIS PETROPOULOS COSIMO LACAVA ILARIA C1RISTIANI Photonics Group Department of Electrical Computer and Biomedical Engineering University of Pavia Optoelectronics Research Centre University of Southampton Huawei Technologies Italia S.r.l Centro direzionale Milano

Integrated semiconductor lasers represent essential building blocks for integrated optical components and circuits and their stability in frequency is fundamental for the development of numerous frontier applications and engineering tasks. When dense optical circuits are considered, the stability of integrated laser sources can be impaired by the thermal cross-talk generated by the action of neighboring components, leading to a deterioration of the long-term system performance (on the scale of seconds). In this work we show the design and the experimental characterization of a silicon nitride photonic integrated circuit (PIC) that is able to frequency stabilize 16semiconductor lasers, simultaneously. A stabilized 50 GHz-spaced two-channel system is demonstrated through the detection of the related beating note and the stability of the resulting waveform is characterized via the use of artificially induced thermal cross-talk stimuli.

关键词： Fiber optic couplers Laser sources Optical circuits Ring resonators Semiconductor lasers Silicon nitride

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Corneal collagen cross-linking in patients with keratoconus from the Dresden protocol to customized solutions:theoretical basis

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 951-962页

作者： Ciro Caruso Luca D’Andrea Mario Troisi michele Rinaldi Raffaele Piscopo Salvatore Troisi Ciro Costagliola Corneal Transplant Center Pellegrini HospitalVia Portamedina alla Pignasecca 41Napoli 80127Italy Eye Clinic Department of NeurosciencesReproductive and Odontostomatological SciencesUniversity of Naples Federico IINaples 80131Italy Public Health Department University of Naples Federico IINaples 80131Italy Salerno Hospital University Ophthalmologic UnitBaronissiCampania 84131Italy

Keratoconus is an ectatic condition characterized by gradual corneal thinning,corneal protrusion,progressive irregular astigmatism,corneal fibrosis,and visual *** therapeutic options regarding improvement of visual function include glasses or soft contact lenses correction for initial stages,gas-permeable rigid contact lenses,scleral lenses,implantation of intrastromal corneal ring or corneal transplants for most advanced *** keratoconus cases showing disease progression corneal collagen crosslinking(CXL)has been proven to be an effective,minimally invasive and safe *** consists of a photochemical reaction of corneal collagen by riboflavin stimulation with ultraviolet A radiation,resulting in stromal crosslinks *** aim of this review is to carry out an examination of CXL methods based on theoretical basis and mathematical models,from the original Dresden protocol to the most recent developments in the technique,reporting the changes proposed in the last 15y and examining the advantages and disadvantages of the various treatment ***,the limits of non-standardized methods and the perspectives offered by a customization of the treatment are highlighted.

关键词： corneal collagen cross linking keratoconus custom fast protocol Dresden protocol lambert-beer law Bunsen-roscoe law

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