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家族性主动脉瘤／夹层动脉瘤合并动脉导管未闭的遗传机制

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上海医学 2007年第S1期30卷 65-65页

作者：朱理敏 Roger VRANCKX Philippe KHAU VAN KIEN Alain LALANDE Nicolas BOISSET Flavie MATHIEU Mark WEGMAN Luke GLANCY Jean-Marie GASC Francois BRUNOTTE Patrick BRUNEVAL Jean-Eric WOLF Jean-Baptiste michel Xavier JEUNEMAITRE 上海交通大学医学院附属瑞金医院高血压科 200025

目的在16p13-12．1位点20 cm的区域内明确致病基因,了解基因型和临床表型的关系。方法采用双向DNA直接测序法筛选候选基因;运用免疫组化和蛋白免疫印迹法等了解突变基因的表达情况。运用质粒重组及体外表达方法获得野生型和突变型蛋白,... 详细信息

目的在16p13-12．1位点20 cm的区域内明确致病基因,了解基因型和临床表型的关系。方法采用双向DNA直接测序法筛选候选基因;运用免疫组化和蛋白免疫印迹法等了解突变基因的表达情况。运用质粒重组及体外表达方法获得野生型和突变型蛋白,使用免疫共沉淀法了解这两者的结合程度。结果在两个家系中发现编码平滑肌肌球蛋白的MYH11基因突变,所有TAAD和PDA患者均为突变基因携带者。在法国家系中发现两个突变。前者为剪切点供体杂合子突变,导致编码71个氨基酸的第32外显子完全缺失:第2个突变为第37外显子上的1个点突变,导致精氨酸变为谷氨酸。在美国家系中发现1个杂合子突变,为第28外显子上编码24个氨基酸的72个碱基缺失。在法国患者的病变动脉标本上运用蛋白免疫印迹法,发现野生型和突变型肌球蛋白蛋白共存,但有异常免疫组化表现。体外实验显示重组野生型和突变型蛋白不能正常结合。结论MYH11基因突变导致家族性TAAD合并PDA,野生型和突变型平滑肌肌球蛋白不能正常结合,推论杂合子突变导致“Dominant-negative”作用。

关键词：夹层动脉瘤主动脉瘤蛋白免疫印迹法平滑肌肌球蛋白族性突变型野生型免疫共沉淀法基因突变体外表达

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用无细胞真皮基质包裹全部假体治疗包膜挛缩：一项新技术

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中国美容整形外科杂志 2014年第2期25卷 J0009-J0009页

作者： Angela Cheng Chrisovalantis Lakhiani michel Saint-Cyr 魏峰(译) 高景恒(译) 张晨(译) 德克萨斯大学西南医学中心美国德克萨斯州达拉斯埃默里大学乔治亚州亚特兰大梅约诊所整形外科中心明尼苏达州罗契斯特《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景与目的包膜挛缩是乳房再造术的常见并发症，其受累患者比例为2．8％～15．9％。已有应用无细胞真皮基质治疗包膜挛缩的报道，其复发率为6．3％，但这个比例仅限于假体局部覆盖者。笔者报道一种应用无细胞真皮基质完整覆盖假体来治... 详细信息

背景与目的包膜挛缩是乳房再造术的常见并发症，其受累患者比例为2．8％～15．9％。已有应用无细胞真皮基质治疗包膜挛缩的报道，其复发率为6．3％，但这个比例仅限于假体局部覆盖者。笔者报道一种应用无细胞真皮基质完整覆盖假体来治疗及预防包膜挛缩的新的手术技术。方法将乳房假体以无细胞真皮基质完全包裹并置入，手术由同一医师施行，对此类患者进行图表评估鉴定。记录患者的人口统计学信息、放射治疗或包膜挛缩病史、治疗前及治疗后并发症。结果对11例患者（16只乳房）进行鉴定。患者平均年龄（52．3±6．9）岁，平均体质量指数（23．6±4．4）kg／m。4例患者（5只乳房）有包膜挛缩病史，之前经包囊切除术及更换假体治疗。10例患者为新出现的Ⅲ级（n=2）和Ⅳ级（n=8）包膜挛缩的矫治，l例患者为预防包膜挛缩。无细胞真皮基质的平均尺寸为144～256eIll，平均（229．8±46．5）cm。随访2．4～18．8个月，平均9．2个月。1例患者（1只乳房）出现感染而需要取出假体。无一例患者出现包膜挛缩复发。结论通过无细胞真皮基质包裹可成功治疗包膜挛缩。该技术可作为当前治疗顽固性包膜挛缩（标准疗法下的早期复发或顽固复发）有用的附加技术。（循证医学证据等级：疗法，Ⅳ级）

关键词：无细胞真皮基质包膜挛缩放射治疗乳房假体包裹乳房再造术手术技术标准疗法

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输尿管的炎性假瘤

世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 50-50页

作者： Harper L. michel J.- L. Riviere J.- P. 李丹 Servicede Chirurgie Infantile Ctr. Hosp. Departmental Felix Guyon Bellepiere 97405 Cedex Saint- Denis France

Inflammatory myofibroblastic pseudotumors are rare solid tumors found in most soft tissue locations although mainly in the lung. Their etiology is uncertain, and they are generally considered benign although some have a potential for rec urrence and dissemination. Recent studies have suggested, however, that some of these tumors are in fact neoplastic processes that harbor chromosomal aberration s similar to those seen in certain lymphomas. The authors report a case of infla mmatory pseudotumor of the ureter in a child and discuss recent reports.

关键词：炎性假瘤淋巴瘤实体瘤染色体畸变成神经细胞病因学

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Join us on an amazing journey towards next-generation treatments for CNS disorders:Launch of Neuroprotection,a new high-quality journal in translational neuroscience

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Neuroprotection 2023年第1期1卷 5-8页

作者： Xunming Ji Piotr Walczak Heleen M.M.van Beusekom Ana I.Casas Andrew Clarkson Tracy Farr Jukka Jolkkonen Yajie Liang michel M.Modo Paulo H.Rosado-de-Castro Karsten Ruscher Yan-Jiang Wang Haitao Wu Marietta Zille Shen Li Johannes Boltze Beijing Institute of Brain Disorders Capital Medical UniversityBeijingChina Department of Diagnostic Radiology and Nuclear Medicine Center for Advanced Imaging ResearchUniversity of MarylandBaltimoreMarylandUSA Department of Cardiology Erasmus MC RotterdamUniversity Medical Center RotterdamRotterdamThe Netherlands Department of Neurology Center for Translational Neuro‐and Behavioral Sciences(C‐TNBS)University Clinics EssenEssenGermany Department of Anatomy Brain Health Research Center and Brain Research New ZealandDunedinNew Zealand Medical School Queen's Medical CentreUniversity of NottinghamNottinghamUK A.I.Virtanen Institute for Molecular Sciences University of Eastern FinlandKuopioFinland McGowan Institute for Regenerative Medicine University of PittsburghPittsburghPennsylvaniaUSA Department of Radiology University of PittsburghPittsburghPennsylvaniaUSA Department of Bioengineering University of PittsburghPittsburghPennsylvaniaUSA Department of Anatomy and Department of Radiology School of MedicineInstitute of Biomedical SciencesFederal University of Rio de JaneiroRio de JaneiroBrazil Laboratory for Experimental Brain Research University of LundLundSweden Department of Neurology Daping HospitalCenter for Clinical NeuroscienceChongqingChina Department of Neurobiology Beijing Institute of Basic Medical SciencesBeijingChina Department of Pharmaceutical Sciences Division of Pharmacology and ToxicologyUniversity of ViennaViennaAustria Department of Neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina School of Life Sciences University of WarwickCoventryUK

Translational medicine in neurodegenerative and neurovascular diseases is approaching a breakthrough *** years have led to dramatic progress in both experimental and clinical *** on a much better and continuously increasing understanding of disease mechanisms,progression and pathophysiology,new therapies with an improved translational potential to protect tissue either against acute or chronic degeneration and even approaches potentially capable of repairing damaged brain tissue are emerging.

关键词： cytoprotection nervous system repair neurodegeneration neuroprotection neurovasculardiseases translational research

压缩背斜的运动速率对尼日尔深水三角洲斜坡稳定性的影响

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海洋地质 2009年第1期25卷 51-51页

作者： Sebastien Garziglia Nabil Sultan Antonio Cattaneo michel VOISSET 杨丽娟（译）闫章存（校对）海洋开发研究院法国不详

Sultan等（2007）最近研究了深水尼日尔拆离褶皱带，揭示出现代海底存在三处滑坡。这些滑坡位于平均倾角约2°的陆坡处，全部是在-个背斜构造的脊线上。Sultan等（2007）利用柱形空腔膨胀理论模拟了压缩构造运动，评估了沉积层上部的张... 详细信息

Sultan等（2007）最近研究了深水尼日尔拆离褶皱带，揭示出现代海底存在三处滑坡。这些滑坡位于平均倾角约2°的陆坡处，全部是在-个背斜构造的脊线上。Sultan等（2007）利用柱形空腔膨胀理论模拟了压缩构造运动，评估了沉积层上部的张力。采用三维陆坡稳定性模型SAMU-3D所作的斜坡稳定性评估结果表明背斜的压缩变形可能是上述地区陆坡滑塌的触发机制（Sultan等，2007）。这些结论中还有一个悬而未决的问题，也就是压缩背斜的运动速率在滑坡易发到破坏的过程中有何影响。

关键词：背斜构造压缩变形运动速率尼日尔斜坡稳定性深水三角洲稳定性评估

Management of Complex Wounds with Dermal Substitute Assisted by a Negative Pressure System

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Modern Plastic Surgery 2023年第4期13卷 95-105页

作者： Cuahutémoc Márquez Espriella Ruiz Garza Jorge Gerardo Barbosa Villarreal Fernando Dávila Díaz Rodrigo Cuervo Vergara Marco Antonio Campollo López Ana Priscila Gutierrez Alvarez Mauricio Chama Naranjo Alfredo García Corral Jesús Ricardo Pérez Benítez Omar Alberto Pulido López Ricardo Alberto Jaimes Duran Edwing michel Garibaldi Bernot Mauro Cortes Aguilar Carlos Manuel García Córdova Carlos Emiliano Camacho Rodriguez Hayah Camacho Rodriguez Hayah Martinez Villalobos Claudia Nallely Ochoa Contreras Erick Cesar Randall Cruz Soto Herrera Lozano Luis Arturo Department of Plastic and Reconstructive Surgery Hospital Central Sur Petróleos Mexicanos Mexico City Mexico

Introduction: The standard treatment for complex wound care is autografting. The advent of dermal substitutes has provided a novel tool for the preparation of the bed to be grafted. However, most types of dermal matrices require the application of a skin graft a second time. Currently, other strategies have been developed to improve the vascularization process, such as negative pressure wound therapy (NPWT), which has been reported to reduce the time required for vascular growth and dermal matrix integration and thus achieve a shorter waiting period for autologous graft application. The present study aims to evaluate the effectiveness and safety of dermal matrix management associated with NPWT in the treatment of complex wounds. Methods: Seven patients with a diagnosis of complex wounds were enrolled in this study between July 1, 2015, and June 31, 2016. After debridement and having an adequate wound bed, patients who met the criteria for the application of combined therapy were treated with dermal substitutes and a negative pressure system. The percentage of graft integration into the wound bed, complications, length of hospital stay, and duration of therapy were analyzed. Results: The mean age was 42.5 ± 16 (39 - 54) years old;three women and four men were included in the study. The approximate size of skin loss was 120.7 ± 75 cm2 (25 - 250 cm2). The combined therapy of dermal matrix plus NPWT was instituted in all cases for a period of 14 days. There were no complications, with 100% graft integration in 6 of 7 cases. Patients were discharged after a mean hospital stay of 5.4 days. Conclusions: This study demonstrates that the utilization of combined dermal matrix plus NPWT therapy can be performed safely and effectively in patients with complex wounds with low complication rates and a short hospital stay.

关键词： Negative Pressure Wound Therapy Complex Wound Dermal Matrix Wound Therapy

Managament Wound Healing: The Importance of a Wound Clinic in Hospital Centers

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Modern Plastic Surgery 2023年第4期13卷 118-125页

作者： Alfredo Chama Naranjo Cuahutémoc Márquez Espriella Alberto Ignacio Cahuana Quispe Barbosa Villarreal Fernando Ana Priscila Campollo López Mauricio Gutiérrez Álvarez Carlos Emiliano García Córdova Jesús Ricardo García Corral Cuervo Vergara Marco Antonio Jorge Luis Rosales Becerra Dávila Díaz Rodrigo Edgar Alan Guillen Martínez Marín Canto Miguel Eduardo Luis Arturo Herrera Lozano Ochoa Contreras Erick Cesar Martinez Villalobos Claudia Nallely Cruz Soto Randall Camacho Rodriguez Hayah Ricardo Alberto Pulido López Edwing michel Jaimes Durán Department of Plastic and Restrictive Surgery Hospital Central Sur de Alta Especialidad Pemex Mexico City Mexico

Background: In clinical practice, acute and chronic wounds continue to be a challenge. Unfortunately, wound care is often inadequate or inappropriate. The implementation of wound clinics involving an interdisciplinary team for wound care and treatment yields favorable clinical outcomes as well as a reduction in economic expenses due to a higher rate of healing, a decrease in hospital stays, and a reduction in the number of readmissions. The establishment of wound clinics enhances the utilization of diagnostic, preventive, and therapeutic resources, improving the quality of life of patients and facilitating their reintegration into their normal lives. The objective is solely to describe the importance of wound clinics in the medical profession. Methods: A retrospective literature search was conducted to include articles no more than 10 years old that reported measures or results of the study in order to perform a literature review and describe the importance of wound clinics in medical practice. Results: A total of 7 articles were obtained with the inclusion criteria, the most recent being from the year 2023 and the oldest from 2013. Conclusion: An important area for improvement in the healthcare industry is the management and treatment of complex wounds. The establishment of wound clinics offers comprehensive and specialized care for both acute and chronic complex wounds with the goal of enhancing secondary illness patients’ prevention, treatment, and rehabilitation.

关键词： Wound Clinic Pressure Ulcer Chronic Wound Wound Healing Quality of Life

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盾牌座δ型变星金牛座θ~2的新光电测光

Chinese Journal of Astronomy and Astrophysics 1988年第4期 245-250页

作者：黄磷郭子和蒋世仰 M.Breger 中国科学院北京天文台奥地利维也纳大学天文研究所美国得克萨斯大学天文系

本文给出在北京天文台兴隆观测站获得的盾牌座δ型变星金牛座θ~2的新光电测光资料,它们是新近开展的一次多台站国际联合观测的一部分。以前得到的四频率解(文[1])与新资料符合得极好。单次测量的残差约±0.003星等。

关键词：恒星脉动变量盾牌座δ型变星双星光电测光

Epidemiology of Fingertip Injuries at South Central Hospital Petróleos Mexicanos “Pemex” with a Review of the Literature

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Journal of Biosciences and Medicines 2023年第6期11卷 182-195页

作者： Fernando Barbosa-Villarreal Cuahutémoc Márquez-Espriella Erika Barlandas-Quintana Ana Priscila Campollo-López Mauricio Gutiérrez-Álvarez Carlos Emiliano García-Córdova Jesús Ricardo García-Corral Alfredo Chama-Naranjo Ricardo Alberto Pulido-López Patricia Llizette López-Medellín Edgar Alan Guillen-Martínez Jonathan Steve Rodríguez-Alaníz Edwing michel Jaimes-Duran Carlos Manuel Cortes-Aguilar Mauro Garibaldi-Bernot Omar Alberto Pérez-Benítez Miguel Eduardo Marín-Canto Luis Arturo Herrera-Lozano Héctor Manuel Suarez-Ortega Alejandro Cruz-Zarate Department of Plastic and Reconstructive Surgery Hospital Central Sur Petróleos Mexicanos Mexico City Mexico

Background: The hand is an essential component for performing our daily tasks;as a result, injuries to the fingertip are frequently seen. Accurate evaluation and treatment of fingertip injuries are essential to avoiding long-term disability, job loss and psychological issues. No matter the injury classification system, maintaining finger length, regaining sensation, and improving appearance are the three main objectives of treatment. The objective of this research was to outline the epidemiology of fingertip injuries treated between 2021 and 2022 at a highly specialized referral hospital in Mexico City. Methodology: This investigation is cross-sectional, retrospective, and observational. From January 2021 to December 2022, 60 patients with a diagnosis of fingertip injury from the South Central Hospital “Pemex” were included. The descriptive statistical analysis was performed using SPSS29. Results: 60 patients were included, 27 (45%) were women and 33 (55%) were men. Allen’s classification was able to classify only 19 patients, of which 18 (94.7%) had a type 1 classification and one (5.26%) had a type 2 classification. 10% of patients experienced complications, which included 2 patients with surgical site infections (3.3%), 3 patients with persistent pain (5%), and 1 patient (1.6%) with graft rejection. Conclusions: There are currently insufficient epidemiological data on hand and wrist injuries and its effects on labor in Mexico. Fingertip injuries require particular care in order to prevent complications and long-term damage. The creation of national registries could help with the creation of reference manuals for the care of hand and wrist injuries in our nation.

关键词： Fingertip Fingertip Injuries Epidemiology