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What is the best anti-vascular endothelial growth factor agent for the treatment of diabetic macular edema？ Review of the 2-year results of Diabetic Retinopathy Clinical Research Network ProtocolT

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Eye Science 2016年第4期31卷 217-220页

作者： michal schaap-fogler Rita Ehrlich Department of Ophthalmology Rabin Medical Center Sackler School of Medicine Tel Aviv University Tel Aviv Israel

Diabetic macular edema(DME) remains a main concern in diabetic patients,due to potential visual impairment with any level of diabetic *** first study to provide a treatment option for these patients was The Early Trea... 详细信息

关键词：糖尿病视网膜病变血管内皮生长因子早期治疗病性网络协议水肿黄斑业绩

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What is new in central serous chorioretinopathy?

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World Journal of Ophthalmology 2014年第4期4卷 113-123页

作者： michal schaap-fogler Rita Ehrlich Department of Ophthalmology Rabin Medical CenterPetach Tikva 49100 Israel

Central serous chorioretinopathy(CSCR) is considered a benign, self-limiting disease. However, as many as third of the patients have recurrent episodes or chronic disease that may cause significant functional impairment. New diagnostic tools and new treatment modalities are emerging in order to improve the functional outcomes of these patients. Spectral domain optical coherence tomography(SD-OCT) has the ability to image individual layers of the retina and choroid. SD-OCT images in CSCR patients have demonstrated increased subfoveal thickness measurements, high reflective deposits in areas of subretinal precipitates and changes in the Retinal pigment epithelium layers of the asymptomatic eyes of patients with supposedly unilateral CSCR. A positive correlation was found between the level of distribution to the layer of inner segment/outer segment junction of the photoreceptors and the visual impairment. Fundus autoflouresence images show a wide variety during different stages of the disease in CSCR patients. Minimal abnormalities during the early stages are followed by hyperautofluoresence in the detached area in later stages, often in a manner of inferior gravitation and at the borders of the detachments. The chronic phase is characterized by varying degrees of atrophy and areas of decreased autofluorescence surrounding areas ofchronic leaks. These changes help differentiate an active disease from an inactive state. Multifocal electroretinography(mf ERG) has the ability to demonstrate a persistent depression despite the resolution of subretinal detachments. It is therefore being investigated as a follow up tool for patients with chronic CSCR. An excellent correlation was found between changes in mf ERG and visual function. Macular microperimetry, measuring retinal sensitivity within the central visual field, is intended to compensate for the underestimation of visual impairment in patients with macular diseases. Reduced retinal sensitivity was found in areas of prev

关键词： Central serous chorioretinopathy Optical coherence tomography Fundus autoflouresence Multifocal electroretinography Macular microperimetry

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