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用于先进光刻的混金属钛锆氧簇光刻胶（英文）

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Science China Materials 2024年第10期67卷 3132-3141页

作者：乔洋史广月张鸥李尤 michaela Vockenhuber Yasin Ekinci 罗锋张磊 School of Materials Science and Engineering Nankai University Paul Scherrer Institute Laboratory for Micro and Nanotechnology Institute of Modern Optics College of Electronic Information and Optical Engineering Nankai University

极紫外光刻（EUVL）和电子束光刻（EBL）被认为是制造纳米级半导体器件的关键光刻技术.然而,随着业界对分辨率、灵敏度和粗糙度等方面的要求日益提升,开发符合产业界需要的极紫外光刻胶仍面临着挑战.近年来,金属氧簇光刻胶因其对极紫外... 详细信息

极紫外光刻（EUVL）和电子束光刻（EBL）被认为是制造纳米级半导体器件的关键光刻技术.然而,随着业界对分辨率、灵敏度和粗糙度等方面的要求日益提升,开发符合产业界需要的极紫外光刻胶仍面临着挑战.近年来,金属氧簇光刻胶因其对极紫外光的高吸收截面和纳米级均一尺寸,在EUV光刻领域引起了广泛关注.在本研究中,我们采用混金属策略合成了四种钛锆氧簇光刻胶,并详细研究了它们的溶解性、显影剂的选择、电子束和极紫外光刻性能、复杂图案转移能力以及相比硅的蚀刻选择性.研究结果表明,R-4光刻胶在低剂量电子束下可实现25 nm的特征尺寸,而在EUV光刻测试中,19.7 mJ cm-2的灵敏度即可获得50 nm的分辨率.本研究提出了一种通过混金属策略优化金属氧簇光刻胶性能的方法,为下一代商用EUV光刻胶的开发提供了新的思路.

关键词： heterometallic nanocluster photoresists electron beam lithography extreme ultraviolet lithography

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Excess non-COVID-19-related mortality among inflammatory bowel disease decedents during the COVID-19 pandemic

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World Journal of Gastroenterology 2024年第20期30卷 2677-2688页

作者： Sarah Rotondo-Trivette Xin-Yuan He Jamil S Samaan Fan Lv Emily Truong michaela Juels Anthony Nguyen Xu Gao Jian Zu Yee Hui Yeo Fan-Pu Ji Gil Y Melmed Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Infectious Disease The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Karsh Division of Gastroenterology and Hepatology Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049Shaanxi ProvinceChina David Geffen School of Medicine University of CaliforniaLos AngelesLos AngelesCA 90095United States Division of Gastroenterology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Key Laboratory of Surgical Critical Care and Life Support(Xi’an Jiaotong University) Ministry of EducationXi’an 710004Shaanxi ProvinceChina

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic disrupted healthcare in the United *** To investigate COVID-19-related and non-COVID-19-related death and characteristics associated with excess death among inflammatory bowel disease(IBD)*** We performed a register-based study using data from the National Vital Statistics System,which reports death data from over 99%of the United States population,from January 1,2006 through December 31,***-related deaths among adults 25 years and older were stratified by age,sex,race/ethnicity,place of death,and primary cause of *** and actual age-standardized mortality rates(ASMRs)per 100000 persons were *** 49782 IBD-related deaths occurred during the study ***-COVID-19-related deaths increased by 13.14%in 2020 and 18.12%in 2021[2020 ASMR:1.55 actual vs 1.37 predicted,95%confidence interval(CI):1.26-1.49;2021 ASMR:1.63 actual vs 1.38 predicted,95%CI:1.26-1.49].In 2020,non-COVID-19-related mortality increased by 17.65%in ulcerative colitis(UC)patients between the ages of 25 and 65 and 36.36%in non-Hispanic black(NHB)Crohn’s disease(CD)*** the pandemic,deaths at home or on arrival and at medical facilities as well as deaths due to neoplasms also *** IBD patients suffered excess non-COVID-19-related death during the *** death was associated with younger age among UC patients,and with NHB race among CD *** death at home or on arrival and due to neoplasms suggests that delayed presentation and difficulty accessing healthcare may have led to increased IBD mortality.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease COVID-19 Excess death Race Sex Disparities

Fuel cell development for New Energy Vehicles (NEVs) and clean air in China

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Progress in Natural Science:Materials International 2018年第2期28卷 113-120页

作者： michaela Kendall Midlands Fuel Cell and Hydrogen Network (MFCHN) and Business Forum Birmingham City University

This paper reviews the background to New Energy Vehicles(NEV) policies in China, and the key scientific and market challenges that need to be addressed to accelerate fuel cells(FCs) in the rapidly developing NEV *** global significance of the Chinese market, key players, core FC technologies and future research priorities are discussed.

关键词： New energy vehicle(NEV) Electric vehicle(EV) Hybrid vehicle(HV) Battery electric vehicle(BEV) Fuel cell vehicle(FCV) Fuel cell bus Range extender Polymer electrolyte membrane fuel cell(PEM FC) Solid oxide fuel cell(SOFC) Hydrogen Clean air in China

Topological Transformation during Normal Grain Growth

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Journal of Materials Science & Technology 2004年第5期20卷 601-604页

作者： ChaogangLOU michaela.PLayer SchoolofElectronicEngineering SoutheastUniversitvNanjing210018China DepartmentofEngineering UniversityofAberdeenAberdeen-AB243UEUK

This paper investigates topological transformation during normal grain growth by carrying out a computer vertex simulation. Results show that topological correlation agrees with the models proposed by Blanc et al. and Weaire. Topological transformation occurs more often on grains with some topological classes instead of equal probability on each boundary. This can be qualitatively explained by topological correlation.

关键词： Topological transformation Normal grain growth Simulation

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A numerical study of prestressed high strength steel tubular members

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Frontiers of Structural and Civil Engineering 2020年第1期14卷 10-22页

作者： michaela GKANTOU Marios THEOFANOUS Charalampos BANIOTOPOULOS Department of Civil Engineering Liverpool John Moores UniversityLiverpool L33AFUK Department of Civil Engineering University of BirminghamBirmingham B152TTUK

The structural behavior of prestressed high strength steel(HSS)tubular members is investigated through the execution of advanced finite element *** models are developed and validated against published experimental data on HSS tubular members subjected to different levels of initial prestress and loaded either in tension or *** effect of the presence or absence of grouting on the strength and ductility of the members is also *** numerically replicate the structural response recorded in the tests,some key modeling features including the employed numerical solver,the adopted material models and the element types warrant careful *** developing of the finite element models,the numerically generated ultimate loads,the corresponding failure modes and the full load-deformation curves are compared to the experimental ones,indicating a successful *** anticipated,prestressing enhances the load-bearing capacity for the tensile members,whereas it is detrimental for the compressive ones.A series of parametric studies is performed to assess the influence of key factors on the structural response of prestressed HSS members and the obtained results are *** guidance for tensile and compressive prestressed tubular members is also provided.

关键词： finite element prestressing tubular members grout high strength steel

Urban Park Soil and Vegetation: Effects of Natural and Anthropogenic Factors

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Pedosphere 2015年第3期25卷 392-404页

作者： Pariente SARAH Helena michaela ZHEVELEV Atar OZ Laboratory of Geomorphology and Soil Department of Geography and EnvironmentBar-Ilan University

Various soil surface components, such as trees, shrubs and biological crusts, and human recreational activities, e.g., barbecues and trampling by visitors, may divide the area of the urban park into smaller fragments/mieroenvironments, differentiated by their microenvironmental conditions, which may differ in soil and vegetation characteristics. The spatial changes in the soil and vegetation characteristics and their causes were investigated in an urban park located south of Tel Aviv-Jaffa, Israel. The area of the park is 0.5 km^2, including groves, a lake, lawns, and rest areas. Soil was sampled in nine microenvironments, of which seven were within the park： under Ceratonia siliqua trees （CsU）, under Ficus sycomorus trees （FLU）, rest area between tables under F. sycomorus （FIB）, rest area under tables under F. sycomorus （FIT）, open area with bare soil （OaS）, open area with biological crust cover （OaC）, and open area covered by herbaceous vegetation （OaV）. Two more microenvironments, planar and sloping open areas （CoP and CoS, respectively） in the vicinity of the park, were used as the controls. Electrical conductivity, concentrations of soluble ions （Mg^2＋, Ca^2＋, Na^＋, K^＋ and HCO3）, pH, contents of organic carbon, calcium carbonate and moisture, and grain size distribution were determined. In addition, herbaceous vegetation cover, number and diversity of herbaceous vegetation species were measured. It was found that soil properties and herbaceous vegetation characteristics varied within the park. Soil organic carbon, electrical conductivity, soluble salts, penetration depth, and vegetation characteristics were affected by human activities, mainly in the rest area between the tables. In contrast, the above characteristics were affected by natural factors mainly in the rest of the microenvironments, which were subjected to low levels of anthropogenic intervention. The heterogeneous structure of the park, as represented by the various microenvironments, offered new

关键词： anthropogenic activity herbaceous vegetation microenvironment soil properties species diversity

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The ecological performance of tetra-, penta- and hexaploid geophyte Allium oleraceum in reciprocal transplant experiment may explain the occurrence of multiple-cytotype populations

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Journal of Plant Ecology 2017年第3期10卷 569-580页

作者： Martin Duchoslav Martina Fialová michaela Jandová Plant Biosystematics and Ecology RG Department of BotanyFaculty of SciencePalackýUniversityŠlechtitelů27CZ 78371 OlomoucCzech Republic

Aims Many polyploids are geographically separated from their lower-ploidy progenitors at a variety of spatial *** adaptive and non-adaptive mechanisms have been suggested to contribute to these spatial patterns.A long-standing hypothesis holds that poly-ploids are established and persist due to specialization to differ-ent ecological conditions compared to their ***,experimental approaches testing this hypothesis remain *** evidence for niche differences among ploidy levels has been found previously for the European polyploid geophyte Allium ***,we conducted a 5-year reciprocal transplant experiment with tetraploid,pentaploid and hexaploid *** to test for adaptation at the ploidy and population *** In 2006,we sowed 2160 aerial bulbils among six sites(two per cytotype,central and western Moravia,the Czech Republic)and monitored their emergence in 2007,their survival until 2011 and their performance in *** Findings The emergence of bulbils was high at all target sites,and no evi-dence for niche differentiation among cytotypes was recorded in the first *** in the following years was relatively high,but significantly better survival for plants of home ploidy than foreign ploidy was *** plant reached the reproductive stage during our *** a strict definition of local adaptation,local plants only rarely performed better than foreign plants at both sites in pairwise comparisons within a ***,our results sug-gest weak niche differentiation among cytotypes and provide limited support for the existence of local adaptation within ***,all cytotypes are able to establish in habitats typically populated by other cytotypes via aerial bulbil spread,but will likely die out gradually in non-native *** ability may explain the occur-rence of some multiple-cytotype *** complex spatial pattern of *** cytotypes is therefore t

关键词： Allium oleraceum bulbils reciprocal transplant local adaptation niche differentiation

Auto-regulatory feedback by RNA-binding proteins

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Journal of Molecular Cell Biology 2019年第10期11卷 930-939页

作者： michaela Muller-McNicoll Oliver Rossbach Jingyi Hui Jan Medenbach Institute of Cell Biology and Neuroscience Goethe University FrankfurtMax-von-Laue-Strasse 13D-60438 Frankfurt am MainGermany Institute of Biochemistry Justus-Liebig-University GiessenHeinrich-Buff-Ring 17D-35392 GiessenGermany State Key Laboratory of Molecular Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China Institute of Biochemistry I University of RegensburgUniversitaetsstrasse 31D-93053 RegensburgGermany

RNA-binding proteins(RBPs)are key regulators in post-transcriptional control of gene *** that alter their activity or abundance have been implicated in numerous diseases such as neurodegenerative disorders and various types of *** highlights the importance of RBP proteostasis and the necessity to tightly control the expression levels and activities of *** many cases,RBPs engage in an auto-regulatory feedback by directly binding to and influencing the fate oftheirown mRNAs,exerting control over their own *** this feedback control,RBPs employ a variety of mechanisms operating at all levels of posttranscriptional regulation of gene *** we review RBP-mediated autogenous feedback regulation that either serves to maintain protein abundance within a physiological range(by negative feedback)or generates binary,genetic on/off switches important for *** fate decisions(by positive feedback).

关键词： autogenous regulation protein homeostasis RNA-binding proteins post-transcriptional regulation of gene expressi on

Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials

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Bioactive Materials 2023年第9期27卷 574-593页

作者： Henry F.Duncan Yoshifumi Kobayashi michaela Kearney Emi Shimizu Division of Restorative Dentistry&Periodontology Dublin Dental University HospitalTrinity College DublinUniversity of DublinLincoln PlaceDublinIreland Department of Oral Biology Rutgers School of Dental MedicineNewarkNJUSA

This opinion-led review paper highlights the need for novel translational research in vital-pulp-treatment(VPT),but also discusses the challenges in translating evidence to *** dentistry is expensive,invasive and relies on an outmoded mechanical understanding of dental disease,rather than employing a biological perspective that harnesses cell activity and the *** research has focussed on developing minimally-invasive biologically-based‘fillings’that preserve the dental pulp;research that is shifting the paradigm from expensive high-technology dentistry,with high failure rates,to smart restorations targeted at biological *** VPTs promote repair by recruiting odontoblast-like cells in a material-dependent ***,exciting opportunities exist for development of next-generation biomaterials targeted at regenerative processes in the dentin-pulp *** article analyses recent research using pharmacological-inhibitors to therapeutically-target histone-deacetylase(HDAC)enzymes in dental-pulp-cells(DPCs)that stimulate pro-regenerative effects with limited loss of ***,HDAC-inhibitors have the potential to enhance biomaterial-driven tissue responses at low concentration by influencing the cellular processes with minimal side-effects,providing an opportunity to develop a topically-placed,inexpensive bio-inductive pulp-capping *** positive results,clinical translation of these innovations requires enterprise to counteract regulatory obstacles,dental-industry priorities and to develop strong academic/industry *** aim of this opinion-led review paper is to discuss the potential role of therapeutically-targeting epigenetic modifications as part of a topical VPT strategy in the treatment of the damaged dental pulp,while considering the next steps,material considerations,challenges and future for the clinical development of epigenetic therapeutics or other‘smart’restora

关键词： Epigenetics Vital pulp treatment Histone deacetylase inhibitors Regenerative endodontics Pulp capping