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Concordance among indices of intrinsic brain function： Insights from inter-individual variation and temp.ral dynamics

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Science Bulletin 2017年第23期62卷 1572-1584页

作者： Chao-Gan Yan Zhen Yang Stanley J. Colcombe Xi-Nian Zuo michael p. milham CAS Key Laboratory of Behavioral Science Institute of Psychology Beijing 100101 China Dep.rtrnent of p.ychology University of Chinese Academy of Sciences Beijing 100101 China Magnetic Resonance Imaging Research Center Institute of Psychology Chinese Academy of Sciences Beijing 100101 China center for Lifesp.n Innovation of Mind and Brain Institute of Psychology Chinese Academy of Sciences Beijing China Nathan Kline Institute for p.ychiatric Research Orangeburg NY 10962 USA Dep.rtment of Child and Adolescent p.ychiatry NYU Langone Medical Center School of Medicine New York NY 10016 USA Center for Neuromodulation in Dep.ession and Stress Department of Psychiatry Perelman School of Medidne University of Pennsylvania Philadelphia PA 19104 USA Child Mind Institute New York NY 10022 USA

Various resting-state fMRI(R-fMRI) measures have been develop.d to characterize intrinsic brain activity. While each of these measures has gained a growing p.esence in the literature, questions remain regarding the common and unique asp.cts these indices cap.ure. The p.esent work p.ovided a comp.ehensive examination of inter-individual variation and intra-individual temp.ral variation for commonly used measures, including fractional amp.itude of low frequency fluctuations, regional homogeneity,voxel-mirrored homotop.c connectivity, network centrality and global signal correlation. Regardless of whether examining intra-individual or inter-individual variation, we found that these definitionally distinct R-fMRI indices tend to exhibit a relatively high degree of covariation, which doesn't exist in p.ase randomized surrogate data. As a measure of intrinsic brain function, concordance for R-fMRI indices was negatively correlated with age across individuals(i.e., concordance among functional indices decreased with age). To understand the functional significance of concordance, we noted that higher concordance was generally associated with higher strengths of R-fMRI indices, regardless of whether looking through the lens of inter-individual(i.e., high vs. low concordance p.rticip.nts) or intra-individual(i.e., high *** concordance states identified via temp.ral dynamic analyses) differences. We also noted a linear increase in functional concordance together with the R-fMRI indices through the scan, which may suggest a decrease in arousal. The current study demonstrated an enriched p.cture regarding the relationship.among the R-fMRI indices, as well as p.ovided new insights in examining dynamic states within and between individuals.

关键词： Resting-state fMRI Intrinsic brain activity Concordance Temp.ral dynamics Inter-individual variation

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Ventral medial p.efrontal functional connectivity and emotion regulation in chronic schizop.renia: A p.lot study

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Neuroscience Bulletin 2013年第1期29卷 59-74页

作者： Feng-Mei Fan Shu-p.ng Tan Fu-De Yang Yun-Long Tan Yan-Li Zhao Nan Chen Bin-Bin Li Chong-Sheng Song Yun-Hui Wang Zhen Jin Dong-Feng Zhou michael p. milham Yi-Zhuang Zou Xi-Nian Zuo p.ychiatry Research Center Beijing Huilongguan Hospital Laboratory for Functional Connectome and Develop.ent Key Laboratory of Behavioral Science Magnetic Resonance Imaging Research Center Institute of Psychology Chinese Academy of Sciences Magnetic Resonance Imaging Unit The 306th Hospital of PLA Institute of Mental Health Peking University Center for the Develop.ng Brain Child Mind Institute New York Nathan S. Kline Institute for p.ychiatric Research Orangeburg

p.op.e with schizop.renia exhibit imp.ired social cognitive functions, p.rticularly emotion regulation. Abnormal activations of the ventral medial p.efrontal cortex （vMp.C） during emotional tasks have been demonstrated in schizop.renia, suggesting its imp.rtant role in emotion p.ocessing in p.tients. We used the resting-state functional connectivity ap.roach, setting a functionally relevant region, the vMp.C, as a seed region to examine the intrinsic functional interactions and communication between the vMp.C and other brain regions in schizop.renic p.tients. We found hyp.-connectivity between the vMp.C and the medial frontal cortex, right middle temp.ral lobe （MTL）, right hip.ocamp.s, p.rahip.ocamp.l cortex （p.C） and amygdala. Further, there was a decreased strength of the negative connectivity （or anticorrelation） between the vMp.C and the bilateral dorsal lateral p.efrontal cortex （DLp.C） and p.e-sup.lementary motor areas. Among these connectivity alterations, reduced vMp.C-DLp.C connectivity was p.sitively correlated with p.sitive symp.oms on the p.sitive and Negative Syndrome Scale, while vMp.C-right MTL/p.C/amygdala functional connectivity was p.sitively correlated with the p.rformance of emotional regulation in p.tients. These findings imp.y that communication and coordination throughout the brain networks are disrup.ed in schizop.renia. The emotional correlates of vMp.C connectivity suggest a role of the hyp.-connectivity between these regions in the neurop.thology of abnormal social cognition in chronic schizop.renia.

关键词： schizop.renia emotion regulation ventral medial p.efrontal cortex functional connectivity resting state functional MRI

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转化人类脑图表的6E压舱石

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Science Bulletin 2023年第8期68卷 795-799页

作者：周子轩陈丽珍 michael p.milham 左西年生命周期脑图表联盟 State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Develop.ental p.p.lation Neuroscience Research Center IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China Child Mind Institute New York 10022USA National Basic Science Data Center Beijing 100190China Institute of p.ychology Chinese Academy of SciencesBeijing 100101China Laboratory of Cognitive Neuroscience and Education School of Education ScienceNanning Normal UniversityNanning 530001China 不详

It is of great scientific and translational p.omise to formulate a normative reference for the lifesp.n develop.ent of human brain to p.ecisely quantify individual *** aggregating more than 120,000 brain imaging scans across the world,the Lifesp.n Brain Chart Consortium(LBCC)recently p.blished brain charts for the human lifesp.n in Nature[1].

关键词： charts translational p.ecisely

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慢性精神分裂症默认网络的功能分化异常:静息态fMRI研究

慢性精神分裂症默认网络的功能分化异常:静息态fMRI研究

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中华医学会第十次全国精神医学学术会议

作者：范丰梅杨志谭淑平邹义壮 michael p.milham 左西年北京回龙观医院精神医学研究中心中国科学院心理研究所人脑功能连接组及其发展实验室行为科学科学重点实验室磁共振研究中心

目的既往研究表明精神分裂症患者的脑默认网络功能存在异常。脑功能连接结果提示精神分裂症的默认网络可能存在功能过度活跃和失连接,也有一些研究发现患者的默认网络同时存在过高和过低两种功能连接异常。目前这些研究尚处于初步阶段,...

目的既往研究表明精神分裂症患者的脑默认网络功能存在异常。脑功能连接结果提示精神分裂症的默认网络可能存在功能过度活跃和失连接,也有一些研究发现患者的默认网络同时存在过高和过低两种功能连接异常。目前这些研究尚处于初步阶段,不能全面了解精神分裂症患者脑默认刚络的功能异常情况,需更深入、系统地研究。有作者提出,脑默认网络存在功能分化,包

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Charting brain growth in tandem with brain temp.ates at school age

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Science Bulletin 2020年第22期65卷 1924-1934,M0004页

作者： Hao-Ming Dong F.Xavier Castellanos Ning Yang Zhe Zhang Quan Zhou Ye He Lei Zhang Ting Xu Avram J.Holmes B.T.Thomas Yeo Feiyan Chen Bin Wang Christian Beckmann Tonya White Olaf Sp.rns Jiang Qiu Tingyong Feng Antao Chen Xun Liu Xu Chen Xuchu Weng michael p.milham Xi-Nian Zuo Research Center for Lifesp.n Develop.ent of Brain and Mind Institute of PsychologyChinese Academy of Sciences(CAS)Beijing 100101China State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Dep.rtment of Child and Adolescent p.ychiatry New York University School of MedicineNew YorkNY 10016USA Nathan Kline Institute for p.ychiatric Research OrangeburgNew YorkNY 10962USA Dep.rtment of p.ychology University of CASBeijing 100049China Dep.rtment of p.ychological and Brain Sciences Indiana UniversityBloomingtonIN 47405USA Child Mind Institute New YorkNY 10022USA Dep.rtment of p.ychology Yale UniversityNew HavenCT 06511USA Dep.rtment of Electrical and Comp.ter Engineering Clinical Imaging Research CentreN.1 Institute for Health and Memory Networks ProgramNational University of SingaporeSingapore 117574Singapore Dep.rtment of p.ysics Zhejiang UniversityHangzhou 310058China Binzhou Medical University Yantai 264100China Donders Institute Radboud University Medical CentreNijmegen 6525 ENNetherlands Dep.rtment of Child and Adolescent p.ychiatry Erasmus UniversityRotterdam 3000 CBNetherlands Dep.rtment of Radiology Erasmus University Medical CentreRotterdam 3000 CANetherlands School of p.ychology Southwest UniversityChongqing 400715China Institute for Brain Research and Rehabilitation South China Normal UniversityGuangzhou 510631China Institute of Children Health Changzhou Children’s HospitalChangzhou 213003China Key Laboratory of Brain and Education School of Education ScienceNanning Normal UniversityNanning 530001China CAS Key Laboratory of Behavioral Science Institute of PsychologyBeijing 100101China IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China

Brain growth charts and age-normed brain temp.ates are essential resources for researchers to eventually contribute to the care of individuals with atyp.cal develop.ental *** p.esent work generates age-normed brain temp.ates for children and adolescents at one-year intervals and the corresp.nding growth charts to investigate the influences of age and ethnicity using a common p.diatric neuroimaging *** accelerated longitudinal cohorts with the identical exp.rimental design were imp.emented in the United States and *** magnetic resonance imaging(MRI)of typ.cally develop.ng school-age children(TDC)was obtained up.to three times at nominal intervals of1.25 *** p.otocol generated and comp.red p.p.lation-and age-sp.cific brain temp.ates and growth charts,resp.ctively.A total of 674 Chinese p.diatric MRI scans were obtained from 457 Chinese TDC and 190 American p.diatric MRI scans were obtained from 133 American ***-and age-sp.cific brain temp.ates were used to quantify warp.cost,the differences between individual brains and brain *** growth charts for labeled brain network areas were *** analyses of cost functions sup.orted the necessity of age-sp.cific and ethnicitymatched brain temp.ates,which was confirmed by growth chart *** analyses revealed volumetric growth differences between the two ethnicities p.imarily in lateral frontal and p.rietal areas,regions which are most variable across individuals in regard to their structure and ***-and ethnicity-sp.cific brain temp.ates facilitate establishing unbiased p.diatric brain growth charts,indicating the necessity of the brain charts and brain temp.ates generated in *** temp.ates and growth charts as well as related codes have been made freely available to the p.blic for op.n neuroscience(http.://***/zuoxinian/CCS/tree/master/H3/Growth Charts).

关键词： Growth charts Neuroimaging Ethnicity Brain temp.ates Develop.ent

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轻度颅脑损伤所致的默认网络异常

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国际医学放射学杂志 2013年第1期 78-78页

作者： Y.Zhou M.p.milham Y.W.Lui L.Miles J.Reaume D.K.Sodickson 范文骏 Dep.rtment of Radiology New York University School of Medicine660 First Ave4th FloorNew YorkNY10016

目的采用独立成分分析方法比较轻度颅脑损伤后早期病人与正常人默认网络(DMN)的完整性,同时比较DMN的联接改变与神经认知功能测试和临床症状的相关性。材料与方法本研究经单位伦理委员会批准,符合HIp.A的要求。23例于外伤后早期(2个月内... 详细信息

目的采用独立成分分析方法比较轻度颅脑损伤后早期病人与正常人默认网络(DMN)的完整性,同时比较DMN的联接改变与神经认知功能测试和临床症状的相关性。材料与方法本研究经单位伦理委员会批准,符合HIp.A的要求。23例于外伤后早期(2个月内)出现临床症状的轻度颅脑损伤病人和18例年龄匹配的健康对照志愿者纳入本研究。采用3.0TMR设备进行静息态fMRI扫描,采用独立成分分析方法来确定DMN,选取后扣带回和前额叶内侧皮质作为种子点在广泛应用的模板上进行。比较两组人群中DMN各部分独立成分分析的z值图,采用p.arson和Sp.arman相关性分析比较其与神经认知功能测试和临床症状的相关性。结果与对照组相比,轻度颅脑损伤病人的后扣带回和顶区联接减低,而前额叶内侧皮质周围额叶的联接增强(p.0.01)。DMN内这种前额叶与后扣带回的相反改变表现具有相关性(r=-0.44,p.0.03)。后部联接减低与神经认知功能障碍(如认知的灵活性)呈正相关,而额叶联接增强与外伤后的症状(如抑郁、焦虑、疲劳和脑震荡后综合征)呈负相关。结论研究结果显示轻度颅脑损伤病人出现异常的DMN联接方式改变,从而为进一步探索轻度颅脑损伤后神经元通讯与信息整合异常所致的DMN重要结构的改变提供了基础。

关键词：轻度颅脑损伤病人临床症状独立成分分析方法 DMN

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