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Nuance of inward rectifying potassium(Kir)channel dysfunctions in neurodegenerative diseases

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Neural Regeneration Research 2024年第6期19卷 1195-1196页

作者： Benjamin Garland Linlin ma Griffith Institute for Drug Discovery&School of Environment and Science Griffith UniversityNathanBrisbaneQLDAustralia

Neurodegenerative disorders are highly prevalent and diverse in *** manifestation largely depends on the cell types involved,with aberrant inflammatory episodes progressively inducing a constellation of phenotypes that are classified into specific diseases based on their neuropathological *** two most prevalent neurodegenerative diseases worldwide,Alzheimer’s disease(AD)and Parkinson’s disease(PD),for example,share notable similarities,yet they differ in terms of the specific cell types lost within the central nervous system(CNS).The significant and progressive loss of cortical and certain subcortical neurons in various regions is a major defining trait of *** contrast,the specific loss of dopaminergic neurons(DA)within the substantial nigra pars compacta(SNpc)is sufficient to cause motor symptoms associated with *** devastating condition arising from neurodegeneration within the CNS,amyotrophic lateral sclerosis(ALS),results in the progressive death of upper and lower motor *** degeneration originates in oligodendrocytes,whose defective myelination abilities lead to the denervation of the anterior horn,aggravating motor neuron death.

关键词： diseases degenerative degeneration

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Endo-hepatology:An emerging field

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World Journal of Gastrointestinal Endoscopy 2021年第8期13卷 296-301页

作者： Daniel E Hogan michael ma David Kadosh Alisha Menon Kana Chin Arun Swaminath Division of Gastroenterology Lenox Hill HospitalNorthwell HealthNew YorkNY 10075United States Department of Internal Medicine Lenox Hill HospitalNorthwell HealthNew YorkNY 10075United States Department of Internal Medicine Long Island Jewish Forest HillsNorthwell HealthNew YorkNY 11375United States

Gastroenterologists have long been spearheading the care of patients with various forms of liver *** diagnosis and management of liver disease has traditionally been a combination of clinical,laboratory,and imaging findings coupled with percutaneous and intravascular procedures with endoscopy largely limited to screening for and therapy of esophageal and gastric *** the applications of diagnostic and therapeutic endoscopic ultrasound(EUS)have evolved,it has found a particular niche within hepatology now *** we discuss several EUS-guided procedures such as liver biopsy,shear wave elastography,direct portal pressure measurement,paracentesis,as well as EUSguided therapies for variceal hemorrhage.

关键词： Endoscopic ultrasound Therapeutic endoscopic ultrasound Hepatology Liver disease Liver biopsy

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生命之糖——海藻糖

中国食品添加剂 2007年第G期18卷 136-137页

作者： michael Sen Jack ma 思多励贸易（上海）有限公司

糖类作为与人们日常饮食息息相关的食品原料，始终吸引着国内外的食品工作者致力于其实用性和功能性的研究。而海藻糖由于其许多特殊的功能特性，在食品、医药等许多领域有着极为良好的应用前景，从而引起了人们的浓厚兴趣。各国纷纷投... 详细信息

糖类作为与人们日常饮食息息相关的食品原料，始终吸引着国内外的食品工作者致力于其实用性和功能性的研究。而海藻糖由于其许多特殊的功能特性，在食品、医药等许多领域有着极为良好的应用前景，从而引起了人们的浓厚兴趣。各国纷纷投入大量的人力和物力对其生产技术和应用开发进行研究，日本林原公司首次实现了以淀粉为原料工业化生产海藻糖的技术。作为充分安全性的食品原料，海藻糖通过了一系列国际性食品安全健康认证，包括美国食品药品管理局（FDA）认证、FDA安全健康食品（GRAS）称号、联合国粮农组织和食品添加剂联合委员会（JECFA）认证、中国和日本（NOVELFOODS）认证等。今天，思多励贸易（上海）有限公司将它引人中国，必将引发我国的食品工业的一次巨大变革。海藻糖是天然的糖类，在自然界中广泛存在，包括大量人们常吃的食物中，其中菌类、海藻和酵母中含量丰富，面包和啤酒等发酵食品及虾类等也含有海藻糖。与其它的食品原料相比，海藻糖有着更多的功能特性，因此在食品、医药等行业有着广泛的用途。

关键词：海藻糖美国食品药品管理局食品原料联合国粮农组织生命功能特性生产技术工业化生产

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Ns NPV杂交瘤抗体的研究

上海农学院学报 1986年第1期 1-5页

作者：陆蘋 michael ma 上海农学院牧医系美国马里兰大学

本文研究了抗纯化*** NPV的杂交瘤抗体。病毒的包涵体是通过K-系列离心而提纯,由Frank Lewis博士提供。每个BALB/C小白鼠每次用200μg抗原免疫。最后一次注射是在细胞融合之前4～7天。取2×108脾细胞与2×107骨髓瘤细胞（NS-1或P3×63）... 详细信息

本文研究了抗纯化*** NPV的杂交瘤抗体。病毒的包涵体是通过K-系列离心而提纯,由Frank Lewis博士提供。每个BALB/C小白鼠每次用200μg抗原免疫。最后一次注射是在细胞融合之前4～7天。取2×108脾细胞与2×107骨髓瘤细胞（NS-1或P3×63）在50％PEG 4000（Sigma）存在下进行融合,用HAT来选择杂交瘤细胞。用间接ELISA法来筛选阳性的杂交瘤细胞。 13个细胞系已筛选成功,并对其产生的免疫球蛋白进行了分型。选择三种Lepidopteran NPVs用于交叉保护试验。除三种杂交瘤抗体外,其他10种对这三种病毒均有不同程度的交叉反应。

关键词： Ns核多角体病毒单克隆抗体

A Tropical View on Landau-Ginzburg Models

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Acta mathematica Sinica,English Series 2024年第1期40卷 329-382页

作者： michael CARL max PUMPERLA Bernd SIEBERT Alfred-Delp-Str.2 73430 AalenGermany IU Internationale Hochschule Juri-Gagarin-Ring 15299084 ErfurtGermany AnyscaleInc.2080 Addison St Ste 7BerkeleyCA 94704USA Department of mathematics The Univ.of Texas at Austin2515 SpeedwayAustinTX 78712USA

This paper,largely written in 2009/2010,fits Landau-Ginzburg models into the mirror symmetry program pursued by the last author jointly with mark Gross since *** point of view transparently brings in tropical disks of maslov index 2 via the notion of broken lines,previously introduced in two dimensions by mark Gross in his study of mirror symmetry for P2.A ma jor insight is the equivalence of properness of the Landau-Ginzburg potential with smoothness of the anticanonical divisor on the mirror *** obtain proper superpotentials which agree on an open part with those classically known for toric *** include mirror LG models for non-singular and singular del Pezzo surfaces,Hirzebruch surfaces and some Fano threefolds.

关键词： Landau-Ginzburg model mirror symmetry tropical disk broken line wall structure scattering diagram Gross-Siebert program del Pezzo surface toric degeneration

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Statistical evaluation of 571 GaAs quantum point contact transistors showing the 0.7 anomaly in quantized conductance using cryogenic on-chip multiplexing

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Chip 2024年第3期3卷 21-28页

作者： Pengcheng ma Kaveh Delfanazari Reuben K.Puddy Jiahui Li Moda Cao Teng Yi Jonathan P.Griffiths Harvey E.Beere David A.Ritchie michael J.Kelly Charles G.Smith Cavendish Laboratory Department of PhysicsUniversity of CambridgeCambridge CB30HEUK James Watt School of Engineering University of GlasgowGlasgow G128QQUK Electrical Engineering Division University of CambridgeCambridge CB30FAUK

Themass production and the practical number of cryogenic quantum devices producible in a single chip are limited to the number of electrical contact pads and wiring of the cryostat or dilution *** is,therefore,beneficial to contrast themeasurements of hundreds of devices fabricated in a single chip in one cooldown process to promote the scalability,integrability,reliability,and reproducibility of quantum devices and to save evaluation time,cost and ***,we used a cryogenic on-chip multiplexer architecture and investigated the statistics of the 0.7 anomaly observed on the first three plateaus of the quantized conductance of semiconductor quantum point contact(QPC)*** single chips contain 256 split gate field-effect QPC transistors(QFET)each,with two 16-branch multiplexed source-drain and gate pads,allowing individual transistors to be selected,addressed and controlled through an electrostatic gate voltage process.A total of 1280 quantum transistors with nano-scale dimensions are patterned in 5 different chips of GaAs *** the measurements of 571 functioning QFETs taken at temperatures T[1.4 K and T[40 mK,it is found that the spontaneous polarisation model and Kondo effect do not fit our ***,some of the features in our data largely agreed with van Hove model with short-range *** approach provides further insight into the quantum mechanical properties and microscopic origin of the 0.7 anomaly in QFETs,paving the way for the development of semiconducting quantum circuits and integrated cryogenic electronics,for scalable quantum logic control,readout,synthesis,and processing applications.

关键词： Cryogenic chip Cryogenic quantum multiplexer Semi-conductor quantum integrated circuit Quantumﬁeld effect transistors Quantum point contacts Chip-scale cryogenic electronics

Single-cell transcriptome atlases of soybean root and mature nodule reveal new regulatory programs that control the nodulation process

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Plant Communications 2024年第8期5卷 69-91页

作者： Sergio Alan Cervantes-Perez Prince Zogli Sahand Amini Sandra Thibivilliers Sutton Tennant Md Sabbir Hossain Hengping Xu Ian Meyer Akash Nooka Pengchong ma Qiuming Yao michael J.Naldrett Andrew Farmer Olivier martin Samik Bhattacharya Jasper Klaver marc Libault Department of Agronomy and Horticulture University of Nebraska-LincolnLincolnNE 68503USA Division of Plant Science and Technology College of AgricultureFoodand Natural ResourcesUniversity of Missouri-ColumbiaColumbiaMO 65211USA Interdisciplinary Plant Group of Missouri-Columbia ColumbiaMO 65211USA School of Computing University of Nebraska-LincolnLincolnNE 68503USA Proteomics and Metabolomics Facility Center for BiotechnologyUniversity of Nebraska-LincolnLincolnNE 68588USA National Center for Genome Resources Santa FeNM 87505USA INRAE UniversiteParis-SaclayInstitut des Sciences des Plantes de Paris SaclayIPS2Batiment 630 Plateau du MoulonRue Noetzlin91192 Gif sur Yvette CedexFrance Resolve Biosciences Monheim am RheinGermany Present address:The School of Plant Sciences University of ArizonaTucsonAZ 85721USA Present address:GALY Co. 100 Hood Park Dr.BostonMA 02126USA

The soybean root system is *** addition to being composed of various cell types,the soybean root system includes the primary root,the lateral roots,and the nodule,an organ in which mutualistic symbiosis with N-fixing rhizobia occurs.A mature soybean root nodule is characterized by a central infection zone where atmospheric nitrogen is fixed and assimilated by the symbiont,resulting from the close cooperation between the plant cell and the *** date,the transcriptome of individual cells isolated from developing soybean nodules has been established,but the transcriptomic signatures of cells from the mature soybean nodule have not yet been *** single-nucleus RNA-seq and Molecular Cartography technologies,we precisely characterized the transcriptomic signature of soybean root and mature nodule cell types and revealed the co-existence of different sub-populations of ***-infected cells in the mature soybean nodule,including those actively involved in nitrogen fixation and those engaged in *** of the single-cell-resolution nodule transcriptome atlas and the associated gene co-expression network confirmed the role of known nodulation-related genes and identified new genes that control the nodulation *** instance,we functionally characterized the role of GmFWL3,a plasma membrane microdomain-associated protein that controls rhizobial *** study reveals the unique cellular complexity of the mature soybean nodule and helps redefine the concept of cell types when considering the infection zone of the soybean nodule.

关键词： soybean root nodule single-cell RNA-seq nanodomains

Tacrolimus combined with arsenic trioxide provides a three-in-one drug-eluting coronary stent integrating anti-restenosis,pro-endothelialization and anti-inflammation

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Medicine in Novel Technology and Devices 2024年第1期21卷 110-119页

作者： Yaojia Zhang Hongchi Yu Li Deng Zhe Hou Jie Yang Fei Fang michael ZMiao Wenjun Li Xin Shen Dongyun Hao Xiaoyi ma Lifeng Zhou Fugui He Xiaoheng Liu a1Institute of Biomedical Engineering West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu610041China Division of Oral&Craniofacial Health Sciences Adams School of DentistryUniversity of North Carolina at Chapel HillNC27599USA Beijing Key Laboratory of Cardiac Drug Device Technology and Evidence Based Medicine Beijing100021China

The limitations of current drug-eluting stent technologies in selectively inhibiting vascular smooth muscle cell proliferation,which often leads to inflammation,call for innovative approaches in coronary artery disease *** the present work,we propose a revolutionary solution:a three-in-one platform for vascular stents,combining arsenic trioxide(ATO)and tacrolimus(TAC)to address anti-proliferation,pro-endothelialization,and anti-inflammation *** findings demonstrate that the synergistic action of ATO and TAC effectively suppresses aberrant vascular smooth muscle cell proliferation and mitigates endothelial cell ***,the combination treatment of TAC/ATO enhances endothelial cell migration and adhesion ***,our TAC/ATO-eluting stent exhibits superior re-endothelialization and anti-restenosis effects in a rabbit and porcine stent implantation *** in vitro and in vivo results solidify the notion that the TAC/ATO-eluting stent ensures rapid re-endothelialization and significantly reduces the incidence of in-stent ***,this study represents a promising and novel multifunctional platform with immense potential in the therapy of coronary artery disease.

关键词： Tacrolimus Arsenic trioxide Drug-eluting stent

抗Spodoptera f.病毒单克隆抗体的初步研制

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上海交通大学学报（农业科学版） 1987年第1期15卷 1-5页

作者：陆苹 michael ma 上海农学院马里兰大学

本文介绍了 Spodoptera frugiperda 病毒多角体及病毒粒子的提纯方法。粗提材料先通过40%蔗糖,在10000r/min 下离心15分钟,随后悬浮于0.01M Tris 缓冲液,25～65%蔗糖的连续梯度中,于40000 r/min 下离心30分钟。取出多角体的条带,洗除游... 详细信息

本文介绍了 Spodoptera frugiperda 病毒多角体及病毒粒子的提纯方法。粗提材料先通过40%蔗糖,在10000r/min 下离心15分钟,随后悬浮于0.01M Tris 缓冲液,25～65%蔗糖的连续梯度中,于40000 r/min 下离心30分钟。取出多角体的条带,洗除游离残存的蔗糖,透析过夜。将多角体在4℃,0.01MNa_2CO_3,0.01MEDTA,0.17M NaCl,pH=1下,作用1小时,随后调节 pH 到8.5～8.9,2000g,离心10分钟。该制剂在4℃下,25～60%蔗糖梯度中,24000r/min,离心2小时。随后取出病毒粒子,重新悬浮于蒸馏水中,于—70℃下贮藏备用。每个 BALB/C 小白鼠免疫4～5次,最后一次注射是在融合前4～7天。将2×10~8脾细胞与2×10~7P_3×63或 SP-2骨髓瘤细胞混合,并用50%PEG(Sigma)融合,用间接酶联免疫法进行筛选阳性杂交瘤细胞,强阳性者进行克隆化。以多角体及病毒粒子为抗原者,均建立了10株能产生特异性单克隆抗体的杂交瘤细胞株,该抗体的效价较高,并进行了血清学的分类。

关键词： Spodoptera f.病毒多角体单克隆抗体

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