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Short, medium, and Long-Term Stroke mortality in Libreville and Associated Factors

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Neuroscience & medicine 2024年第1期15卷 39-50页

作者： Grass Aurelle mambila matsalou Jennifer Nyangui mapaga Pupchen m. Gnigone minka’a Pagbe michael Chermine mboumba mboumba Christian Allognon mahutondji Aissata Ibrahima Camara Annick A. Nsounda Nelly Diouf mbourou michel-Arnaud Saphou-Damon Elsa Ayo Bivigou Philomene Kouna Ndouongo Neurology Department University Hospital of Libreville Libreville Gabon Cardiology Department University Hospitalof Libreville Libreville Gabon

Strokes are common around the world and especially in sub-Saharan Africa. They are responsible for severe sequelae and the majority of deaths. In Gabon, no study on stroke mortality has been conducted. Objective: To determine short, medium, long-term mortality and factors associated with long-term stroke mortality. method: Our study took place in the Neurology Department of the University Hospital Center of Libreville (UHCL). It was a historical cohort study with descriptive and analytical purposes covering the period from June 1 to August 31, 2018 and taking into account hospitalized patients from January 1, 2013 to December 31, 2017. We conducted a comprehensive systematic recruitment of patients with stroke, 18 years old and more, and had been agreed to give information. We included all patients meeting the inclusion criteria. The data was gathered using Epi-Info 7 software. The CHI-2 test was used for the comparison of frequencies and the Student’s test, for comparison of means. multivariate analysis with logistic regression allowed us to look for factors associated with long-term mortality. A result was statistically significant for a p 0.05 value. Results: At 3 months, 28 patients (18.1%) died, at 6 months thirty-one patients or 20.1% died. At 5 years old, fifty-three patients or 34.4% had died. The factors associated with long-term mortality, if the lost of sight were all alive were tobacco (p = 0.01) and stroke (p = 0.008). If all those who were lost to sight had died, no factor was associated with 5-year mortality. Conclusion: Stroke mortality must not be taken for granted, it can be underestimated because of the large number of lost sight. measures must be put in place to strengthen post-stroke monitoring. .

关键词： Stroke mortality Associated Factors Libreville

BRCA mutated pancreatic cancer:A change is coming

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World Journal of Gastroenterology 2021年第17期27卷 1943-1958页

作者： michael N Rosen Rachel A Goodwin michael m Vickers Faculty of medicine The University of OttawaOttawa K1H 8L6OntarioCanada The Ottawa Hospital Cancer Center The University of OttawaOttawa K1H 8L6OntarioCanada

Pancreatic cancer remains a leading cause of cancer-related death with few available therapies for advanced ***,patients with germline BRCA mutations have received increased attention due to advances in the management of BRCA mutated ovarian and breast *** BRCA mutations significantly increase risk of developing pancreatic cancer and can be found in up to 8%of patients with sporadic pancreatic *** patients with germline BRCA mutations,platinum-based chemotherapies and poly(ADP-ribose)polymerase inhibitors are effective treatment options which may offer survival *** review will focus on the molecular biology,epidemiology,and management of BRCA-mutated pancreatic ***-more,we will discuss future directions for this area of research and promising active areas of research.

关键词： Pancreatic cancer Systemic therapy Platinum chemotherapy BRCA Deoxyribonucleic acid repair Poly(ADP-ribose)polymerase inhibitors

Data augmentation for bias correction in mapping Pm_(2.5) based on satellite retrievals and ground observations

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Geoscience Frontiers 2024年第1期15卷 17-28页

作者： Tan mi Die Tang Jianbo Fu Wen Zeng michael L.Grieneisen Zihang Zhou Fengju Jia Fumo Yang Yu Zhan College of Carbon Neutrality Future Technology Sichuan UniversityChengduSichuan 610065China Department of Environmental Science and Engineering Sichuan UniversityChengduSichuan 610065China Institute for Disaster management and Reconstruction Sichuan UniversityChengduSichuan 610200China Department of Land Airand Water ResourcesUniversity of CaliforniaDavisCA 95616United States Chengdu Academy of Environmental Sciences ChengduSichuan 610072China Sichuan Chengdu Ecological and Environment monitoring Center ChengduSichuan 610011China

As most air quality monitoring sites are in urban areas worldwide,machine learning models may produce substantial estimation bias in rural areas when deriving spatiotemporal distributions of air *** bias stems from the issue of dataset shift,as the density distributions of predictor variables differ greatly between urban and rural *** propose a data-augmentation approach based on the multiple imputation by chained equations(mICE-DA)to remedy the dataset shift *** with the benchmark models,mICE-DA exhibits superior predictive performance in deriving the spatiotemporal distributions of hourly Pm2.5 in the megacity(Chengdu)at the foot of the Tibetan Plateau,especially for correcting the estimation bias,with the mean bias decreasing from-3.4µg/m3 to-1.6µg/*** a complement to the holdout validation,the semi-variance results show that mICE-DA decently preserves the spatial autocorrelation pattern of Pm2.5 over the study *** essence of mICE-DA is strengthening the correlation between Pm2.5 and aerosol optical depth(AOD)during the data ***,the importance of AOD is largely enhanced for predicting Pm2.5,and the summed relative importance value of the two satellite-retrieved AOD variables increases from 5.5%to 18.4%.This study resolved the puzzle that AOD exhibited relatively lower importance in local or regional *** results of this study can advance the utilization of satellite remote sensing in modeling air quality while drawing more attention to the common dataset shift problem in data-driven environmental research.

关键词： Aerosol optical depth Dataset shift Spatiotemporal Distribution Air quality monitoring multiple imputation by chained equations

Taming heat with tiny pressure

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The Innovation 2024年第2期5卷 70-78页

作者： Kun Zhang Zhe Zhang Hailong Pan Haoyu Wang Xueting Zhao Ji Qi Zhao Zhang Ruiqi Song Chenyang Yu Biaohong Huang Xujing Li Huaican Chen Wen Yin Changlong Tan Weijin Hu michael Wüubbenhorst Jiangshui Luo Dehong Yu Zhidong Zhang Bing Li Shenyang National Laboratory for materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Laboratory for Soft matter and Biophysics Department of Physics and AstronomyKU Leuven3001 LeuvenBelgium Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China College of materials Science and Engineering Sichuan UniversityChengdu 610064China School of materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150080China Australian Nuclear Science and Technology Organisation Lucas HeightsNSW 2234Australia

Heat is almost *** electricity,which can be easily manipulated,the current ability to control heat is still highly limited owing to spontaneous thermal dissipation imposed by the second law of *** illumination and pressure have been used to switch endothermic/exothermic responses of materials via phase transitions;however,these strategies are less cost-effective and ***,we spectroscopically demonstrate the glassy crystal state of 2-amino-2-methyl-1,3-propanediol(AmP)to realize an affordable,easily manageable approach for thermal energy *** supercooled state of AmP is so sensitive to pressure that even several megapascals can induce crystallization to the ordered crystal,resulting in a substantial temperature increase of 48 K within 20 ***,we demonstrate a proof-of-concept device capable of programable heating with an extremely high work-to-heat conversion effi-ciency of*** delicate and efficient tuning of heat may remarkably facilitate rational utilization of waste heat.

关键词： illumination thermal rational

microRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma

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World Journal of Gastroenterology 2010年第5期16卷 531-537页

作者： Cameron m Smith David I Watson michael Z michael Damian J Hussey Department of Surgery Flinders University Room 3D211 Flinders Medical Centre Bedford Park South Australia 5042 Australia Department of Gastroenterology & Hepatology Flinders University Bedford Park South Australia 5042 Australia

Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. microRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer.

关键词： Barrett’s esophagus microRNA Esophageal adenocarcinoma Transdifferentiation Tumour suppressor

The role of estradiol in male reproductive function

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Asian Journal of Andrology 2016年第3期18卷 435-440,I0009页

作者： michael Schulster Aaron m Bernie Ranjith Ramasamy Department of Urology New York-Presbyterian Hospital Weill Cornell Medical College New York USA Department of Urology Miller School of Medicine University of Miami Miami FL USA.

Traditionally, testosterone and estrogen have been considered to be male and female sex hormones, respectively. However, estradiol, the predominant form of estrogen, also plays a critical role in male sexual function. Estradiol in men is essential for modulating libido, erectile function, and spermatogenesis. Estrogen receptors, as well as aromatase, the enzyme that converts testosterone to estrogen, are abundant in brain, penis, and testis, organs important for sexual function. In the brain, estradiol synthesis is increased in areas related to sexual arousal. In addition, in the penis, estrogen receptors are found throughout the corpus cavernosum with high concentration around neurovascular bundles. Low testosterone and elevated estrogen increase the incidence of erectile dysfunction independently of one another. In the testes, spermatogenesis is modulated at every level by estrogen, starting with the hypothalamus-pituitary-gonadal axis, followed by the Leydig, Sertoli, and germ cells, and finishing with the ductal epithelium, epididymis, and mature sperm. Regulation of testicular cells by estradiol shows both an inhibitory and a stimulatory influence, indicating an intricate symphony of dose-dependent and temporally sensitive modulation. Our goal in this review is to elucidate the overall contribution of estradiol to male sexual function by looking at the hormone＇s effects on erectile function, spermatogenesis, and libido.

关键词： estrogen testosterone spermatogenesis erectile function estrogen receptor aromatase

Comparison of L-band and X-band differential interferometric synthetic aperture radar for mine subsidence monitoring in central Utah

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International Journal of mining Science and Technology 2017年第1期27卷 159-163页

作者： Jessica m.Wempen michael K.mcCarter Department of mining Engineering University of UtahSalt Lake City 84112USA

Differential interferometric synthetic aperture radar(DIn SAR), a satellite-based remote sensing technique, has potential application for measuring mine subsidence on a regional scale with high spatial and temporal resolutions. However, the characteristics of synthetic aperture radar(SAR) data and the effectiveness of DIn SAR for subsidence monitoring depend on the radar band(wavelength). This study evaluates the effectiveness of DIn SAR for monitoring subsidence due to longwall mining in central Utah using L-band(24 cm wavelength) SAR data from the advanced land observing satellite(ALOS)and X-band(3 cm wavelength) SAR data from the Terra SAR-X mission. In the Wasatch Plateau region of central Utah, which is characterized by steep terrain and variable ground cover conditions, areas affected by longwall mine subsidence are identifiable using both L-band and X-band DIn ***, using L-band data, subsidence magnitudes are measurable. Compared to X-band, L-band data are less affected by signal saturation due to large deformation gradients and by temporal decorrelation due to changes in the surface conditions over time. The L-band data tend to be stable over relatively long periods(months). Short wavelength X-band data are strongly affected by signal saturation and temporal decorrelation, but regions of subsidence are typically identifiable over short periods(days). Additionally,though subsidence magnitudes are difficult to precisely measure in the central Utah region using X-band data, they can often be reasonably estimated.

关键词： mine subsidence DInSAR Terra SAR-X ALOS Interferometry

A novel method of quantifying the coating progress in a three-dimensional prismatic spouted bed

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Particuology 2019年第1期17卷 137-145页

作者： Swantje Pietscha Finn Ole Poppinga Stefan Heinrich michael müller michael Schonherr Frank Kleine Jager Hamburg University of Technology Institute of Solids Process Engineering and Particle TechnologyDenickestraβe 1521073 HamburgGermany BASF SE RCP/TT67056 LudwigshafenGermany

An optical method of experimentally quantifying the coating progress in a laboratory prismatic spouted bed is presented. microcrystalline cellulose particles with size dp = 0.57 mm are used as core material. Waterborne coating suspensions with methylene blue as a dye are used and sprayed via a two-fluid nozzle in bottom-spray configuration. A high-speed camera with a color filter is positioned in front of the observation window of the three-dimensional plant and records the flow pattern in the process chamber with a certain frequency. With increasing surface coverage, the particles become bluer and darker. The change in brightness is detected by digital image analysis. In the implemented algorithm, the spherical particles are detected, cut from the background and normalized regarding their lighting and area. The detection of coated pixels on the single particles allows the calculation of the coating fraction and coating uniformity after a Kalman filter has been applied to reduce noise. It is shown that the method can be used to determine the time needed to reach the maximum blue value indicating a complete coating of the particle bed. Besides the minimum coating duration, information on the spraying performance (e.g., the time point of a possibly occurring blockage of the nozzle) can be obtained from the data. Two exemplary experiments are presented, showing a connection of the slope of the coating fraction and the uniformity of the coating of the particles in the apparatus that results in the recommendation of a slow liquid injection for obtaining consistent coating layers as desired in many applications.

关键词： Spouted bed Particle coating Granulation Digital image analysis

The foraging behavior of Japanese macaques macaca fuscata in a forested enclosure: Effects of nutrient composition,energy and its seasonal variation on the consumption of natural plant foods

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Current Zoology 2010年第2期56卷 198-208页

作者： m.Firoj JAmAN michael A.HUFFmAN Hiroyuki TAKEmOTO Primate Research Institute Kyoto University Department of Zoology University of Dhaka

In the wild, primate foraging behaviors are related to the diversity and nutritional properties of food, which are affected by seasonal variation. The goal of environmental enrichment is to stimulate captive animals to exhibit similar foraging behavior of their wild counterparts, e.g. to extend foraging time. We conducted a 12-month study on the foraging behavior of Japanese macaques in a semi-naturally forested enclosure to understand how they use both provisioned foods and naturally available plant foods and what are the nutritional criteria of their consumption of natural plants. We recorded time spent feeding on provisioned and natural plant foods and collected the plant parts ingested of their major plant food species monthly, when available. We conducted nutritional analysis （crude protein, crude lipid, neutral detergent fiber-‘NDF＇, ash） and calculated total non-structural carbohydrate - ‘TNC＇ and total energy of those food items. monkeys spent 47% of their feeding time foraging on natural plant species. The consumption of plant parts varied significantly across seasons. We found that leaf items were consumed in months when crude protein, crude protein-to-NDF ratio, TNC and total energy were significantly higher and NDF was significantly lower, fruit/nut items in months when crude protein and TNC were significantly higher and crude lipid content was significantly lower, and bark items in months when TNC and total energy were higher and crude lipid content was lower. This preliminary investigation showed that the forested enclosure allowed troop members to more fully express their species typical flexible behavior by challenging them to adjust their foraging behavior to seasonal changes of plant item diversity and nutritional content, also providing the possibility for individuals to nutritionally enhance their diet .

关键词： Nutrition Food consumption Semi-natural vegetation Provisioned foods Captive primates Enrichment