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World Journal of Gastroenterology 2010年第8期16卷 973-981页

作者： Sandra Braun Christoph Berg Sandra Buck michael gregor Reinhild Klein Department of Internal Medicine University of Tuebingen Department of Internal Medicine University of Tuebingen

AIM:To search for further immunodominant peptides of the pyruvate dehydrogenase complex E2-component (PDC-E2) recognized by antimitochondrial antibodies (AMA) in primary biliary cirrhosis (PBC). METHODS:Sera from 95 patients with PBC were tested by enzyme-linked immunosorbent assay against 33 synthetic overlapping peptides (25 amino acids; aa) covering the entire length of the E2-subunit of PDC-E2. Furthermore,the inner lipoyl peptide 167-184 was used in an unlip oylated and a lipoylated form as well as coupled to ovalbumin. Sera from 11 AMA negative/ANA posit ive PBC patients,63 patients with other liver disorders and 22 healthy blood donors served as ***:Of the 95 PBC-sera,74% reacted with the peptide 475-499 and 58% with the pept ide 407-431 located within the catalytic domain of PDC-E2. Patients with other disorders or healthy controls were positive in only up to 18%. Antibodies to the unlipoylatedand lip oylated pept ide 167-184 within the inner lipoyl domain were found in only 5% and 11% of the PBC sera,respectively; using ovalbumin-coupled peptides,the incidence increased up to 57% (unlipoylated form). CONCLUSION:Peptides within the catalytic site of PDC-E2 rather than the previously reported lipoyl binding peptide 167-184 may represent major immunodomin ant epitopes recognized by AMA in PBC.

关键词： Anti-M2 Epitope mapping E2-subunit Pyruvate dehydrogenase complex Inner lipoyl domain Active site Catalytic domain Primary biliary cirrhosis

Anxiety and depression in adult patients with celiac disease on a gluten-free diet

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World Journal of Gastroenterology 2010年第22期16卷 2780-2787页

作者： Winfried Huser Karl-Heinz Janke Bodo Klump michael gregor Andreas Hinz Department of Internal Medicine I Klinikum Saarbrücken Winterberg 1 D-66119 Saarbrücken and Department of Psychosomatic Medicine and Psychotherapie Technische Universitt München Baden-Württemberg State Health Office District Government Stuttgart Gastroenterology and Gastrointestinal Cancer St. Anna Hospital Obere Waiblinger Starβe 101 D-70374 Stuttgart Germany and Department of Internal Medicine 1 Universittskliniken Tübingen Department of Internal Medicine 1 Universittskliniken Tübingen Department of Medical Psychology and Medical Sociology Universitt Leipzig

AIM: To compare anxiety and depression levels in adult patients with celiac disease (CD) on a gluten-free diet (GFD) with ***: The levels of anxiety, depression and of a probable anxiety or depressive disorder were assessed by the Hospital Anxiety and Depression Scale in 441 adult patients with CD recruited by the German Celiac Society, in 235 age-and sex-matched patients with inflammatory bowel disease (IBD) in remission or with slight disease activity, and in 441 adult persons of a representative German general population sample (GP). Potential demographic (age, sex, social class, family status) and disease-related (latency to diagnosis, duration of GFD, compliance with GFD, thyroid disease) predictors of anxiety and depression in CD were tested for by regression analyses. RESULTS: The level of anxiety in CD patients was predicted (R 2 = 0.07) by female gender (P = 0.01). Female sex (OR = 3.6, 95% CI: 1.3-9.4, P = 0.01) was associated with a probable anxiety disorder. Living alone (OR = 0.5, 95% CI: 0.2-0.9, P = 0.05) was associated with a reduced risk of an anxiety disorder. The level of depression and a probable depressive disorder were not predicted by any of the demographic and medical variables tested for. The levels of anxiety in patients with CD (6.6 ± 3.4) and with IBD (6.9 ± 3.7) were higher than those of persons in the GP (4.6 ± 3.3) (both P < 0.001). The levels of depression in persons with CD (4.2 ± 3.4), IBD (4.6 ± 3.4) and of the GP (4.2 ± 3.8) did not differ (P = 0.3). The prevalence of a probable anxiety disorder in persons with CD (16.8%) and IBD (14.0%) was higher than that of the GP (5.7%) (P < 0.001). The prevalence of a probable depressive disorder did not differ significantly between the three groups (P = 0.1). CONCLUSION: Anxiety in adult German female celiacs on a GFD is higher than in persons of the GP. Female celiacs on a GFD should be screened for anxiety.

关键词： Celiac disease Anxiety Depression Gender

Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model

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World Journal of Gastroenterology 2005年第44期11卷 6910-6919页

作者： Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A Lauer Reinhard Vonthein michael gregor Sorin Armeanu michael Bitzer Ulrich M.Lauer Department of Internal Medicine Ⅰ Section of Experimental Radiology Department of Medical Biometry

AIM： To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model. METHODS： To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine （5-FC）, we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase （YCD） and the yeast uracil phosphoribosyltransferase （YUPRT） gene. RESULTS： In vitro stably transduced Morris rat hepatoma cells （MH） expressing the bifunctional SuperCD suicide gene （MH SuperCD） showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH cells stably expressing YCD solely （MH YCD） or the cytosine deaminase gene of bacterial origin （MH BCD）, respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions （P〈0.01） under both high dose as well as low dose systemic 5-FC application, whereas MH tumors without transgene expression （MH naive） showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness （SuperCD〉〉 YCD〉〉BCD〉〉〉negative control） was defined as a result of a direct in vivo comparison of all three suicide genes. CONCLUSION： Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model, thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine.

关键词： YCD/YUPRT fusion Cytosine deaminase GDEPT Suicide gene therapy Hepatoma therapy

The penetration depth of atomic radicals in tubes with catalytic surface properties

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Plasma Science and Technology 2024年第7期26卷 157-164页

作者： Domen PAUL Miran MOZETIC Rok ZAPLOTNIK Alenka VESEL gregor PRIMC Denis DONLAGIC Jozef Stefan Institute Jamova Cesta 39Ljubljana 1000Slovenia Jozef Stefan International Postgraduate School Jamova Cesta 39Ljubljana 1000Slovenia Faculty of Electrical Engineering and Computer Science University of MariborKoroska Cesta 46Maribor 2000Slovenia

Catalysis of molecular radicals is often performed in interesting experimental *** possible configuration is tubular *** radicals are introduced into the tubes on one side,and stable molecules are exhausted on the other *** penetration depth of radicals depends on numerous parameters,so it is not always feasible to calculate *** article presents systematic measurements of the penetration depth of oxygen atoms along tubes made from nickel,cobalt,and *** source of O atoms was a surfatron-type microwave *** initial density of O atoms depended on the gas flow and was 0.7×10^(21)m^(-3),2.4×10^(21)m^(-3),and 4.2×10^(21)m^(-3)at the flow rates of 50,300,and 600 sccm,and pressures of 10,35,and 60 Pa,*** gas temperature remained at room temperature throughout the *** dissociation fraction decreased exponentially along the length of the tubes in all *** penetration depths for well-oxidized nickel were 1.2,1.7,and 2.4 cm,*** cobalt,they were slightly lower at 1.0,1.3,and 1.6 cm,respectively,while for copper,they were 1.1,1.3,and 1.7 cm,*** results were explained by gas dynamics and heterogeneous surface *** data are useful in any attempt to estimate the loss of molecular fragments along tubes,which serve as catalysts for the association of various radicals to stable molecules.

关键词： oxygen plasma penetration depth catalysis heterogeneous surface recombination atom loss

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原始的面具——奥古斯特·马克与弗朗兹·马尔克的原始主义和文化批判

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内蒙古艺术学院学报 2024年第1期21卷 47-56页

作者： [德国]gregor Wedekind() 何佳(译) 王荟(校) 美茵茨约翰内斯·古腾堡大学德国莱茵兰内蒙古艺术学院内蒙古呼和浩特010070 集美大学福建厦门361021

本文以德国表现主义艺术家奥古斯特·马克(August Macke)与弗朗兹·马尔克(Franz Marc)为例,分析论述两位艺术家在其社会文化背景下创作的艺术风格。

关键词：德国表现主义原始主义文化批判

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生产准备时间缩短一半

现代制造 2024年第8期 30-30,32页

作者： Lars Rödel Jonas Krebs gregor Müller Timo Denner 不详

在生产准备工作实现自动化之后,才能实现节约生产成本的目标。而利用弗劳恩霍夫IPA生产技术和自动化研究所开发的“设计链(Designchain)”系统可实现生产准备的自动化。当前,虽然经济形势不容乐观,但Ceratizit公司的订单合同依然比较充... 详细信息

在生产准备工作实现自动化之后,才能实现节约生产成本的目标。而利用弗劳恩霍夫IPA生产技术和自动化研究所开发的“设计链(Designchain)”系统可实现生产准备的自动化。当前,虽然经济形势不容乐观,但Ceratizit公司的订单合同依然比较充足。究其原因,是由于此前受全球疫情影响,Ceratizit公司忘记了如何快速高效地处理客户合同订单,还是因为供应链受到干扰而出现订单积压?

关键词：自动化研究所供应链设计链生产准备时间合同订单生产准备工作节约生产订单合同

Post-testing measurement of freely movable and diffusible hydrogen in context of WEC formation at cylindrical roller thrust bearings from 100Cr6

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Friction 2021年第4期9卷 876-890页

作者： Martin LINZMAYER Francisco GUTIÉRREZ GUZMÁN gregor MANKE Georg JACOBS Christopher SOUS michael POHL Institute for Machine Elements and System Engineering RWTH Aachen UniversitySchinkelstrasse 10Aachen 52062Germany Institute for Materials Material TestingRuhr University BochumUniversitatsstr 150Bochum 44801Germany

Sub-surface crack networks in areas of altered microstructure are a common cause for bearing *** to its appearance under light microscopy,the damage pattern is referred to as White Etching Cracks(WEC).The root causes leading to the formation of WEC are still under ***,it has already been shown that atomic hydrogen can have an accelerating effect on the formation and propagation of *** addition to hydrogen pre-charging,hydrogen can be released and absorbed during rolling/sliding due to the decomposing of the lubricant and *** current work focuses on the analysis of the hydrogen content of cylindrical roller thrust bearings after testing in a FE8 type test rig using two different *** the framework of this work,two different hydrogen analysis methods were used and assessed regarding their *** results show that the so-called Hydrogen Collecting Analysis(HCA)is more suitable to investigate the correlation between lubricant chemistry and hydrogen content in the test bearings than the Local Hydrogen Analysis(LHA).The measurements with the HCA show a continuously increasing freely movable and diffusible hydrogen content under tribological conditions,which leads to the formation of *** tests with an oil without hydrogen showed that the tendency of the system to fail as a result of WEC can be reduced by using a lubricant without hydride compounds.

关键词： White Etching Crack(WEC) White Etching Areas(WEA) hydrogen content Hydrogen Collecting Analysis(HCA) freely movable hydrogen diffusible hydrogen cylindrical roller thrust bearing roller bearings roller contact fatigue

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A Stochastic Modeling Approach for Interplanetary Supply Chain Planning

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Space(Science & Technology) 2023年第1期3卷 98-111页

作者： gregor Blossey Department of Information Systems Productionand Logistics ManagementUniversity of InnsbruckInnsbruckAustria Department of Business Informatics European University ViadrinaFrankfurt(Oder)Germany

The unique and complex challenges of sustainable interplanetary travel necessitate a novel space logistics paradigm,which is hereafter referred to as the interplanetary supply *** lay the groundwork for this anticipated paradigm shift,this work aims to introduce principles and methodologies of supply chain(SC)planning to the field of space *** this end,a stochastic multistage mixed integer linear programming model is proposed that explores the vision of a permanent human presence on Mars from a logistics *** model optimizes material flows,propellant production,and in-space infrastructure allocations to identify the optimal SC network ***,demand uncertainty at the Mars base is considered,which makes it the first model to investigate the effects of stochasticity in space logistics *** case studies are investigated,which incorporate data on Earth-Mars transfer windows and flight trajectories obtained through the National Aeronautics and Space Administration’s trajectory *** results reveal numerous interdependencies and,thus,highlight the need for holistic SC modeling approaches that go beyond the isolated mission planning of the extant *** instance,the findings show frequent interactions among spacecraft as they regularly engage in division of labor regarding cargo and propellant ***,complex propellant supply networks that involve strategic in-space infrastructure allocation and propellant production on celestial bodies are ***,the developed model provides valuable insights into the planning of a sustainable interplanetary travel,offers a new SC perspective,and lays the foundation for future research in this area.

关键词： travel hereafter sustainable

Study of tree shrew biology and models: A booming and prosperous field for biomedical research

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Zoological Research 2024年第4期45卷 877-909页

作者： Yong-Gang Yao Li Lu Rong-Jun Ni Rui Bi Ceshi Chen Jia-Qi Chen Eberhard Fuchs Marina Gorbatyuk Hao Lei Hongli Li Chunyu Liu Long-Bao Lv Kyoko Tsukiyama-Kohara Michinori Kohara Claudia Perez-Cruz gregor Rainer Bao-Ci Shan Fang Shen An-Zhou Tang Jing Wang Wei Xia Xueshan Xia Ling Xu Dandan Yu Feng Zhang Ping Zheng Yong-Tang Zheng Jumin Zhou Jiang-Ning Zhou Key Laboratory of Genetic Evolution and Animal Models Yunnan Key Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) and National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Mental Health Center and Psychiatric Laboratory West China HospitalSichuan UniversityChengduSichuan 610041China Sichuan Clinical Medical Research Center for Mental Disorders ChengduSichuan 610044China German Primate Center Leibniz Institute of Primate ResearchGöttingen 37077Germany Department of Optometry and Vision Science School of OptometryUniversity of Alabama at BirminghamBirminghamAL 35294USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Transboundary Animal Diseases Center Joint Faculty of Veterinary MedicineKagoshima UniversityKagoshima-cityKagoshima 890-8580Japan Department of Microbiology and Cell Biology Tokyo Metropolitan Institute of Medical ScienceTokyo 156-8506Japan Pharmacology Department CinvestavMexico City 07360Mexico Department of Medicine University of FribourgFribourg CH-1700Switzerland Beijing Engineering Research Center of Radiog

The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with *** recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain ***,the limited availability of tree shrews globally remains a substantial challenge in the ***,determining the key questions best answered using tree shrews constitutes another *** shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative *** these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical *** review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this *** emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew *** use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.

关键词： Tree shrew Animal model Neurodegenerative diseases Infectious diseases Neuroscience Phenome

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Analysis of the microstructure of superconducting YBCO foams by means of AFM and EBSD

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Journal of Advanced Ceramics 2014年第4期3卷 317-325页

作者： michael Rudolf KOBLISCHKA Anjela KOBLISCHKA-VENEVA E.S.REDDY gregor J.SCHMITZ Institute of Experimental Physics Saarland UniversityP.O.Box 151150D-66041 SaarbrückenGermany ACCESS Intzestrasse 552072 AachenGermany Nanonouvelle Pty Ltd. Marcoola QLD 4564Australia

YBa_(2)Cu_(3)O_(y)(YBCO)foam samples show an open,porous foam structure,which may have benefits for many applications of high-Tc *** the basic material of these foams is a pseudo-single crystalline material with the directional growth initiated by a seed crystal similar to standard melt-textured samples,the texture of YBCO is a very important ***,we analysed the local texture and grain orientation of the individual struts forming the foam by means of atomic force microscopy(AFM)and electron backscatter diffraction(EBSD).Due to the processing route starting with Y_(2)BaCuO_(5)(211),a two-phase analysis must be performed,so a high surface quality is necessary to enable an automated EBSD *** quality Kikuchi patterns were obtained from both the YBCO and 211 *** found an inhomogeneous distribution of the residual 211 particles,which are mainly randomly oriented and have sizes ranging between 200 nm and 15μ*** contrast to this,the YBCO matrix shows a dominating orientation with cracks with a typical distance of 1-10μ***,the analysis of strut cross-sections reveals that the entire strut is converted to the YBCO phase.

关键词： high-Tc superconductors foam microstructure atomic force microscopy(AFM) electron backscatter diffraction(EBSD) orientation