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The expanding amyloid family:Structure,stability,function,and pathogenesis

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四川生理科学杂志 2024年第1期46卷 106-106页

作者： michael R Sawaya Departments of Chemistry and Biochemistry and Biological Chemistry UCLA Los Angeles CA 90095 USA Howard Hughes Medical Institute UCLA Los Angeles CA 90095 USA UCLA-DOE Institute UCLA Los Angeles CA 90095 USA Molecular Biology Institute UCLA Los Angeles CA 90095 USA Laboratory of Physical Chemistry ETH Zurich Vladimir Prelog Weg 2 CH-8093 Zurich Switzerland

The hidden world of amyloid biology has suddenly snapped into atomic-level focus,revealing over 80 amyloid protein fibrils,both pathogenic and *** globular proteins,amyloid proteins flatten and stack into unbranched *** still,a single protein sequence can adopt wildly different two-dimensional conformations,yielding distinct fibril polymorphs.

关键词： amyloid pathogenesis expanding

China-Caribe:más cerca que nunca

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今日中国（西文版） 2024年第3期 34-35页

作者： michael ZÁRATE 不详

Improving Lives China-Africa cooperation propels space industry,drives socio-economic progress

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ChinAfrica 2024年第5期16卷 28-29页

作者： EHIZUELEN michael MITCHELL OMORUYI Centre for Nigerian Studies Institute of African StudiesZhejiang Normal University

In the past,outer space was primarily the domain of a few powerful countries and generally considered separate from broader concerns of human security and ***,in recent times,space technology development has been a dynamic arena in which the majority of the world’s countries,including countries across the continent of Africa,are actively engaged to address their most pressing socio-economic *** the turn of the millennium,countries across Africa have demonstrated growing interest in developing their space capabilities to address their most pressing challenges,including but not limited to climate change,poverty,terrorism,and forced migration.

关键词： Africa primarily challenges

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Digital Empowerment

ChinAfrica 2024年第7期16卷 14-15页

作者： EHIZUELEN michael MITCHELL OMORUYI Centre for Nigerian Studies Institute of African StudiesZhejiang Normal University

How China’s tech cooperation with Africa is boosting the continent’s industrial modernisation Given the rate at which youth population in numerous African countries is growing,the continent promises to emerge as a major consumption market in the coming *** than 70 percent of Africa’s population is under the age of 35,and by 2030,42 percent of the world’s young people are expected to reside on the continent.

关键词： boosting Africa cooperation

Promoting Human Rights Through Development

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ChinAfrica 2024年第3期16卷 32-33页

作者： EHIZUELEN michael MITCHELL OMORUYI Centre for Nigerian Studies Institute of African Studies Zhejiang Normal University

China’s human rights practice focuses on the rights of subsistence and development,China always regards rights to subsistence and development as primary and basic human *** a goal humanity has pursued for a long time,the Chinese people have worked tirelessly to protect human rights for *** with its rising global stature,the nation has moved from its traditionally more defensive posture to a more activist role in the field of global human rights protection,especially in the United Nations Human Rights Council.

关键词： Human traditionally Rights

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

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Genes & Diseases 2024年第3期11卷 155-187页

作者： michael Yu Kevin Qin Jiaming Fan Guozhi Zhao Piao Zhao Wei Zeng Connie Chen Annie Wang Yonghui Wang jiamin Zhong Yi Zhu William Wagstaff Rex C.Haydon Hue H.Luu Sherwin Ho michael J.Lee Jason Strelzow Russell R.Reid Tong-Chuan He School of Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedic Surgery The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Department of Orthopaedic Surgery Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China

The evolutionarily conserved Wnt signaling pathway plays a central role in develop-ment and adult tissue homeostasis across *** proteins are secreted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling *** behaviors such as proliferation,differ-entiation,maturation,and proper body-axis specification are carried out by the canonical pathway,which is the best characterized of the known Wnt signaling *** signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various *** includes but is not limited to embryonic,hematopoietic,mesenchymal,gut,neural,and epidermal stem *** signaling has also been implicated in tumor cells that exhibit stem cell-like *** signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone *** surprisingly,aberrant Wnt signaling is also associated with a wide variety of diseases,including *** of Wnt pathway members in cancer can lead to unchecked cell proliferation,epithelial-mesenchymal transition,and ***,advances in the understand-ing of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt *** with a brief overview of the mechanisms of canonical and non-canonical Wnt,this review aims to summarize the cur-rent knowledge of Wnt signaling in stem cells,aberrations to the Wnt pathway associated with diseases,and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.

关键词： β-Catenin Cancer Canonical Wnt Disease Non-canonical Wnt Stem cells Targeted therapy Wnt signaling

Injury and illness in short-course triathletes:A systematic review

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Journal of Sport and Health Science 2024年第2期13卷 172-185页

作者： Sara A.Guevara Melissa L.Crunkhorn michael Drew Gordon Waddington Julien D.Périard Naroa Etxebarria Liam A.Toohey Paula Charlton University of Canberra Research Institute for Sport and Exercise(UCRISE) BruceACT 2617Australia New South Wales Institute of Sport SydneyNSW 2127Australia Queensland Academy of Sport BrisbaneQLD 4111Australia Triathlon Australia Gold CoastQLD 4227Australia Australian Institute of Sport BruceACT 2617Australia

Background:Determining the incidence and prevalence of injury and illness in short-course triathletes would improve understanding of their etiologies and therefore assist in the development and implementation of prevention *** study synthesizes the existing evidence on the incidence and prevalence of injury and illness and summarizes reported injury or illness etiology and risk factors affecting short-course ***:This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** reporting health problems(injury and illness)in triathletes(all sexes,ages,and experience levels)training and/or competing in short-course distances were *** electronic databases(Cochrane Central Register of Controlled Trials,MEDLINE,Embase,APA PsychINFO,Web of Science Core Collection,and SPORTDiscus)were *** of bias was independently assessed by 2 reviewers using the Newcastle-Ottawa Quality Assessment *** authors independently completed data ***:The search yielded 7998 studies,with 42 studies eligible for ***-three studies investigated injuries,24 studies investigated illnesses,and 5 studies investigated both injuries and *** injury incidence rate ranged 15.7-24.3 per 1000 athlete exposures,and the illness incidence rate ranged 1.8-13.1 per 1000 athlete *** and illness prevalence ranged between 2%-15%and 6%-84%,*** injuries reported occurred during running(45%-92%),and the most frequently reported illnesses affected the gastrointestinal(7%-70%),cardiovascular(14%-59%),and respiratory systems(5%-60%).Conclusion:The most frequently reported health problems in short-course triathletes were:overuse and lower limb injuries associated with running;gastrointestinal illnesses and altered cardiac function,primarily attributable to environmental factors;and respiratory illness mostly caused by infection.

关键词： Athlete illnesses Athletic injuries Epidemiology Triathlon

Feeding ecology and interactions with mammal hosts in a symbiotic genus of birds(Buphagus spp.)in Namibia

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Avian Research 2024年第3期15卷 336-344页

作者： michael S.Lukubwe Daniel Velarde-Garcéz Fernando Sequeira Susana Lopes Adrian J.F.K.Craig Vanessa A.Mata Department of Zoology and Entomology Rhodes UniversityMakhandaSouth Africa Department of Wildlife Management and Tourism Studies University of NamibiaKatima Mulilo CampusNamibia Departamento de Biologia Faculdade de CiênciasUniversidade do PortoPortoPortugal CIBIO Centro de Investigação em Biodiversidade e Recursos GenéticosInBIO Laboratório AssociadoCampus de VairãoVairãoPortugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOCampus de VairãoVairãoPortugal

As the sole obligate symbiotic birds in Africa,oxpeckers offer a unique model for studying symbiotic *** to the multitrophic level they occupy and the context dependent foraging behavior they exhibit,the type of symbiotic relationship can be *** addition to providing a cleaning service to the host by removing ticks,oxpeckers frequently feed on blood,mucus,and saliva,inflicting potential damage on the ***,we used DNA metabarcoding on faecal samples to analyze the taxonomic composition of the trophic interactions of the Yellow-billed Oxpecker(Buphagus africanus)and Red-billed Oxpecker(***)in northeastern *** contrast to conventional methods,DNA metabarcoding allows for a detailed identification of dietary resources encompassing both mammal hosts and consumed arthropods within the same *** this information,we examined differences in the diet composition between oxpecker species and localities,as well as the co-occurrence between host and arthropod *** findings revealed that oxpeckers predominantly source their diet from mammals,ticks,and flies;however,ticks and flies rarely co-occur in the diet of an *** observed variability among individuals in their feeding ecology,which is strongly correlated with locality and,to a lesser extent,with the mammal *** noted a high degree of mobility between hosts within relatively short periods,with 32%of the samples showing traces of at least two mammal *** study illustrates the dynamic foraging behavior of these specialized symbiotic birds,shedding light on their potential role in pest control services and disease transmission.

关键词： Commensalism Diet DNA metabarcoding Oxpeckers Parasitism Trophic ecology

Voûtes célestes,terresfertiles La collaboration sino-africaine dynamise l'industrie spatiale et stimule le développement socio-économique

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中国与非洲（法文版） 2024年第5期16卷 28-29页

作者： EHIZUELEN michael MITCHELL OMORUYI 不详