检索结果-南通市图书馆

作者： Ming Li Siiri E.Iismaa Nawazish Naqvi Jianxin Wu Scott Kesteven Ahtesham ul Haq Andrea Y.Chan Sara R.Holman Amy Nicks michael p.feneley Ahsan Husain Robert M.Graham Cardiac Regeneration Research Institute Wenzhou Medical University Division of Molecular Cardiology and Biophysics Victor Chang Cardiac Research Institute St Vincent’s Clinical School University of New South Wales Department of Medicine Emory University School of Medicine

Aims:We have previously demonstrated that cardiomyocytes(CMs) of adult transgenic C57 BL/6 J mice with CM-restricted overexpression of the dominant negative Wv mutant(dn-c-kit-Tg) retain the ability to proliferate;a response normally restricted to fetal and early neonatal *** leads to a hyperplastic CM response to pressure overload with improved cardiac function and ***,we tested if this persistent CM proliferative competence allows complete,scar-less repair of the myocardium with normalization of cardiac morphology and function post-myocardial infarction(MI).Methods and *** to WT control non-transgenic littermates,dn-c-kit-Tg mice displayed i) persistent CM replicative capacity in adulthood,ii) a thicker left ventricular(LV) wall and a smaller LV cavity due to increased CM cell number,but no change in CM length,width,volume,pbidy or nucleation state,and iii) improved *** 24 hours after ligation of the left anterior descending coronary artery,infarct sizes were similar in adult(16 week old) WT and dn-c-kit-Tg *** weeks post-MI,infarct size in dn-c-kk-Tg was half that in WT hearts,but significant scarring was still *** infarct size in the dn-c-kit-Tg mice was associated with improved survival,increased CM cell cycle entry,attenuated left ventricular remodelling and improved cardiac ***:Extending CM replicative capacity into adulthood improves outcomes post-MI,but healing is structurally and functionally incomplete.

关键词： Cardiac regeneration cardiomyocyte proliferation myocardial infarct

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

prostate cancer： diagnosis and staging

引用

Asian Journal of Andrology 2009年第1期11卷 74-80页

作者： Nigel Borley Mark R. feneley Department of Urology University College Hospitals London NW1 2BU UK

prostate cancer represents an increasing health burden. The past 20 years, with the introduction of prostate-specific antigen （pSA）, has seen prostate cancer move increasingly from a condition that presented with locally advanced disease or metastases to one that is found upon screening. More is also known about the pathology ofpre-malignant lesions. Di- agnosis relies on trans-rectal ultrasound （TRUS） to obtain biopsies from throughout the prostate, but TRUS is not useful for staging. Imaging for staging, such as magnetic resonance imaging or computed tomography, still has a low accuracy compared with pathological specimens. Current techniques are also inaccurate in identifying lymph node and bony me- tastases. Nomograms have been developed from the pSA, Gleason score and clinical grading to help quantify the risk of extra-capsular extension in radical prostatectomy specimens. Improved clinical staging modalities are required for more reliable prediction of pathological stage and for monitoring of response to treatments.

关键词： diagnosis imaging prostate cancer pSA staging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Utility of tissue microarrays for profiling prognostic biomarkers in clinically localized prostate cancer： the expression of BCL-2, E-cadherin, Ki-67 and p53 as predictors of biochemical failure after radical prostatectomy with nested control for clinical and pathological risk factors

引用

Asian Journal of Andrology 2009年第1期11卷 109-118页

作者： Joseph Nariculam Alex Freeman Simon Bott phillipa Munson Noriko Cable Nicola Brookman-Amissah Magali Williamson Roger S. Kirby John Masters Mark feneley Institute of Urology Prostate Cancer Research Centre London W1 W 7E J UK Histopathology Diagnostics Statistics University College London London W1 W 7ET UK prostate Cancer Research Centre London W1 G 8GT UK

A cure cannot be assured for all men with clinically localized prostate cancer undergoing radical treatment. Molecular markers would be invaluable if they could improve the prediction of occult metastatic disease. This study was carried out to investigate the expression of BCL-2, Ki-67, p53 and E-cadherin in radical prostatectomy specimens. We sought to assess their ability to predict early biochemical relapse in a specific therapeutic setting. Eighty-two patients comprising 41 case pairs were matched for pathological stage, Gleason grade and preoperative prostate-specific antigen （pSA） concentration. One patient in each pair had biochemical recurrence （defined as pSA ≥ 0.2 ng mL^-1 within 2 years of surgery） and the other remained biochemically free of disease （defined as undetectable pSA at least 3 years after surgery）. Immunohistochemical analysis was performed to assess marker expression on four replicate tissue microarrays constructed with benign and malignant tissue from each radical prostatectomy specimen. Ki-67, p53 and BCL-2, but not E-cadherin, were significantly upregulated in prostate adenocarcinoma compared with benign prostate tissue （p 〈 0.01）. However, no significant differences in expression of any of the markers were observed when comparing patients who developed early biochemical relapse with patients who had no biochemical recurrence. This study showed that expression of p53, BCL-2 and Ki-67 was upregulated in clinically localized prostate cancer compared with benign prostate tissue, with no alteration in E-cadherin expression. Biomarker upregulation had no prognostic value for biochemical recurrence after radical prostatectomy, even after considering pathological stage, whole tumour Gleason grade and preoperative serum pSA level.

关键词： immunohistochemistry prostate cancer prostatectomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：