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SMXL5 attenuates strigolactone signaling in Arabidopsis thaliana by inhibiting SMXL7 degradation

Molecular Plant 2024年第4期17卷 631-647页

作者： Qingtian Li Haiyang Yu Wenwen chang Sunhyun chang michael Guzman Lionel Faure Eva-Sophie Wallner Heqin Yan Thomas Greb Lei Wang Ruifeng Yao David c.Nelson Department of Botany and Plant Sciences University of CaliforniaRiversideRiversideCA 2521USA Yazhouwan National Laboratory Sanya 572025China Hainan Seed Industry Laboratory Sanya 57205China State Key Laboratory of chemo/Biosensing and chemometrics Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental RegulationCollege of BiologyHunan UniversityChangsha 410082China Key Laboratory of Seed Innovation Center for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuangHebei 050021China University of chinese Academy of Sciences Beijing 10004China School of the Sciences Biology DivisionTexas Woman’s UniversityDentonTX 76204USA centre for Organismal Studies(cOS) Heidelberg University6120 HeidelbergGermany

Hormone-activated proteolysis is a recurring theme of plant hormone signaling *** strigolactone signaling,the enzyme receptor DWARF14(D14)and an F-box protein,MORE AXILLARY GROWTH2(MAX2),mark SUPPRESSOR OF MAX21-LIKE(SMXL)family proteins SMXL6,SMXL7,and SMXL8 for rapid *** of these transcriptional corepressors initiates downstream growth *** homologous proteins SMXL3,SMXL4,and SMXL5,however,are resistant to MAX2-mediated *** discovered that the smxl4 smxl5 mutant has enhanced responses to ***5 attenuates strigolactone signaling by interfering with AtD14-SMXL7 ***5 interacts with AtD14 and SMXL7,providing two possible ways to inhibit SMXL7 ***5 function is partially dependent on an ethylene-responsive-element binding-factor-associated amphiphilic repression(EAR)motif,which typically mediates interactions with the TOPLESS family of transcriptional ***,we found that loss of the EAR motif reduces SMXL5-SMXL7 interactions and the attenuation of strigolactone signaling by *** hypothesize that integration of SMXL5 into heteromeric SMXL complexes reduces the susceptibility of SMXL6/7/8 proteins to strigolactone-activated degradation and that the EAR motif promotes the formation or stability of these *** mechanism may provide a way to spatially or temporally fine-tune strigolactone signaling through the regulation of SMXL5 expression or translation.

关键词： Arabidopsis typically inhibiting

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The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

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Genes & Diseases 2024年第3期11卷 155-187页

作者： michael Yu Kevin Qin Jiaming Fan Guozhi Zhao Piao Zhao Wei Zeng connie chen Annie Wang Yonghui Wang jiamin Zhong Yi Zhu William Wagstaff Rex c.Haydon Hue H.Luu Sherwin Ho michael J.Lee Jason Strelzow Russell R.Reid Tong-chuan He School of Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedic Surgery The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Department of Orthopaedic Surgery Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Laboratory of craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China

The evolutionarily conserved Wnt signaling pathway plays a central role in develop-ment and adult tissue homeostasis across *** proteins are secreted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling *** behaviors such as proliferation,differ-entiation,maturation,and proper body-axis specification are carried out by the canonical pathway,which is the best characterized of the known Wnt signaling *** signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various *** includes but is not limited to embryonic,hematopoietic,mesenchymal,gut,neural,and epidermal stem *** signaling has also been implicated in tumor cells that exhibit stem cell-like *** signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone *** surprisingly,aberrant Wnt signaling is also associated with a wide variety of diseases,including *** of Wnt pathway members in cancer can lead to unchecked cell proliferation,epithelial-mesenchymal transition,and ***,advances in the understand-ing of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt *** with a brief overview of the mechanisms of canonical and non-canonical Wnt,this review aims to summarize the cur-rent knowledge of Wnt signaling in stem cells,aberrations to the Wnt pathway associated with diseases,and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.

关键词： β-catenin cancer canonical Wnt Disease Non-canonical Wnt Stem cells Targeted therapy Wnt signaling

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Evaluating for unrecognized deficits in perimetry associated with functional upper eyelid malposition

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Advances in Ophthalmology Practice and Research 2024年第1期4卷 39-44页

作者： Linyan Wang Davin c.Ashraf michael Deiner Oluwatobi O.Idowu Seanna R.Grob Bryan J.Winn M Reza Vagefi Robert c.Kersten Department of Ophthalmology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Ophthalmology University of CaliforniaSan FranciscoUSA Department of Ophthalmology Oregon Health and Science UniversityPortlandUSA Department of Ophthalmology Tufts Medical CenterBostonUSA Department of Ophthalmology University of UtahSalt Lake CityUtahUSA

Objective:To investigate whether functional upper eyelid malposition is associated with unrecognized deficits in automated perimetry among glaucoma patients by examining patients undergoing eyelid surgery who had not been identified as requiring eyelid taping during glaucoma field ***:In this retrospective pre-post study,an automated database search followed by manual chart review was used to identify eligible patients from January 2012 to March *** patients had reliable visual field testing within two years before and after functional upper blepharoplasty or ptosis repair and no comorbid ocular *** part of routine practice,glaucoma visual field technicians taped patients with pupil-obstructing eyelid malposition;taped examinations were excluded from *** and demographic characteristics,mean deviation,and pattern standard deviation were evaluated within a two year period before and after eyelid ***:The final analysis included 60 eyes of 38 *** in visual field parameters after eyelid surgery did not reach statistical significance in crude or adjusted *** patients with ptosis,the margin reflex distance-1 was not associated with change in mean deviation after surgery(Pearson R2=0.0061;P=0.700).Five of 17 eyes excluded from analysis due to unreliable pre-operative visual fields demonstrated substantial improvement after ***:Functional upper eyelid malposition does not appear to cause spurious visual field abnormalities among glaucoma patients with reliable visual fields who were determined not to require eyelid taping at the time of their visual *** visual fields could be a sign of eyelid interference in this population.

关键词： Visual field Ptosis Dermatochalasis Glaucoma Perimetry Visually significant

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Application of a simplified ADM1 for full-scale anaerobic co-digestion of cattle slurry and grass silage:assessment of input variability

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 125-139页

作者： Sofia Tisocco Sören Weinrich Gary Lyons michael Wills Xinmin Zhan Paul crosson civil Engineering College of Science and EngineeringUniversity of GalwayGalwayH91 TK33Ireland Teagasc Animal and Bioscience Research Department Animal and Grassland Research and Innovation CentreDunsanyC15 PW93Ireland Biochemical conversion Department Deutsches Biomasseforschungszentrum gemeinnützige GmbHLeipzig 04347Germany Faculty of Energy·Building Services·Environmental Engineering Münster University of Applied SciencesSteinfurt 48565Germany Agri-Food and Biosciences Institute HillsboroughBT266DRUK Ryan Institute University of GalwayGalwayH91 TK33Ireland MaREI Research centre for Energy Climate and MarineRyan InstituteUniversity of GalwayGalwayH91 TK33Ireland

Mathematical modeling of anaerobic digestion is a powerful tool to predict gas yields and optimize the *** Anaerobic Digestion Model No.1(ADM1)is a widely implemented model for this ***,modeling full-scale biogas plants is challenging due to the extensive substrate and parameter characterization *** study describes the modification of the ADM1 through a simplification of individual process phases,characteristic components and required ***,the ability of the simplified model to simulate the co-digestion of grass silage and cattle slurry was evaluated using data from a full-scale biogas *** impacts of substrate composition(crude carbohydrate,protein and lipid concentration)and variability of carbohydrate degradability on simulation results were assessed to identify the most influential *** indicated that the simplified version was able to depict biogas and biomethane production with average model efficiencies,according to the Nash-Sutcliffe efficiency(NSE)coefficient,of 0.70 and 0.67,respectively,and was comparable to the original ADM1(average model efficiencies of 0.71 and 0.63,respectively).The variability of crude carbohydrate,protein and lipid concentration did not significantly impact biogas and biomethane output for the data sets *** contrast,carbohydrate degradability seemed to explain much more of the variability in the biogas and methane ***,the application of simplified models provides a reliable basis for the process simulation and optimization of full-scale agricultural biogas plants.

关键词： ADM1 Agricultural feedstocks Biogas technology Input variability Parameter estimation

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cOVID-19 vaccination produces exercise-responsive SARS-coV-2 specific T-cells regardless of infection history

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Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany M.Zúñiga Forrest L.Baker Helena Batatinha charles R.Pedlar Shane c.Burgess michael P.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona cancer center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-coV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(cOVID-19).We sought to determine if cOVID-19 vaccination would elicit exercise-responsive SARS-coV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a cOVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-coV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TcR)-βsequencing,and SARS-coV-2 nAb ***:cOVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of cD4+and cD8+naive T-cells,as well as cD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-coV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-coV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-coV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral cOVID-19 Exercise immunology SARS-coV-2 T-cells Vaccine

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Outcomes following minimally invasive dorsal cheilectomy for hallux rigidus:A systematic review

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World Journal of Orthopedics 2024年第6期15卷 585-592页

作者： Katherine Esser James J Butler Mackenzie Roof Nathaniel P Mercer michael c Harrington Alan P Samsonov Andrew J Rosenbaum John G Kennedy Department of Orthopaedic Surgery University of Toledo Medical center University of Toledo College of Medicine and Life SciencesToledoOH 43614United States Department of Orthopedic Surgery NYU Langone HealthNew YorkNY 10002United States Department of Orthopedic Surgery Albany Medical CenterAlbanyNY 12208United States

BAcKGROUND cheilectomy of the 1^(st)metatarsophalangeal joint(MTPJ)is one of the most common procedures for the management of hallux ***,there is no consensus regarding outcomes following minimally invasive dorsal cheilectomy(MIDc)for the management of hallux *** To evaluate outcomes following MIDc for the management of hallux *** During November 2023,the PubMed,EMBASE and cochrane Library databases were systematically reviewed to identify clinical studies examining outcomes following MIDc for the management of hallux *** Six studies were *** total,348 patients(370 feet)underwent MIDc for hallux rigidus at a weighted mean follow-up of 37.9±16.5 *** distribution of patients by coughlin and Shurna's classification was recorded in 4 studies as follows:Ⅰ(58 patients,27.1%),Ⅱ(112 patients,52.3%),Ⅲ(44 patients,20.6%).Three studies performed an additional 1^(st)MTPJ arthroscopy and debridement following *** intra-articular bone debris was observed in 100%of patients in 1 *** weighted mean American orthopedic foot and ankle society score improved from a preoperative score of 68.9±3.2 to a postoperative score of *** complication rate was 8.4%,the most common of which was persistent joint pain and ***-two failures(8.7%)were ***-three secondary procedures(8.9%)were performed at a weighted mean time of 8.6±3.2 months following the index *** This systematic review demonstrated improvements in subjective clinical outcomes together with a moderate complication rate following MIDc for the management of hallux rigidus at short-term follow-up.A moderate reoperation rate at short-term follow-up was *** marked heterogeneity between included studies and paucity of high quality comparative studies limits the generation of any robust conclusions.

关键词： Minimally invasive dorsal cheilectomy Hallux rigidus The first metatarsophalangeal joint cheilectomy Minimally invasive surgery

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Numerical study of novel OME_(1-6) combustion mechanism and spray combustion at changed ambient environments

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Frontiers in Energy 2024年第4期18卷 483-505页

作者： Frederik WIESMANN Zeyan QIU Dong HAN Lukas STRAUβ Sebastian RIEβ michael WENSING Thomas LAUER Institute of Powertrains and Automotive Technology TU Wien1060 ViennaAustria Key Laboratory for Power Machinery and Engineering of Ministry of Education Shanghai Jiao Tong UniversityShanghai 200240China Professorship for Fluid Systems Technology Friedrich-AlexanderUniversität Erlangen-Nürnberg91058 ErlangenGermany

For a climate-neutral future mobility,the socalled e-fuels can play an essential ***,oxygenated e-fuels containing oxygen in their chemical formula have the additional potential to burn with significantly lower soot *** particular,polyoxymethylene dimethyl ethers or oxymethylene ethers(PODEs or OMEs)do not contain carbon-carbon bonds,prohibiting the production of soot precursors like acetylene(c_(2)H_(2)).These properties make OMEs a highly interesting candidate for future climate-neutral compression-ignition ***,to fully leverage their potential,the auto-ignition process,flame propagation,and mixing regimes of the combustion need to be *** achieve this,efficient oxidation mechanisms suitable for computational fluid dynamics(cFD)calculations must be developed and *** present work aims to highlight the improvements made by developing an adapted oxidation mechanism for OME1-6 and introducing it into a validated spray combustion cFD model for *** simulations were conducted for single-and multi-injection patterns,changing ambient temperatures,and oxygen *** results were validated against high-pressure and high-temperature constantpressure chamber ****-chemiluminescence measurements accomplished the characterization of the auto-ignition *** experiments and simulations were conducted for two different *** improvements concerning the prediction of the ignition delay time were accomplished while also retaining an excellent agreement for the flame lift-off *** spatial zones of high-temperature reaction activity were also affected by the adaption of the reaction *** showed a greater tendency to form OH^(*) radicals within the center of the spray in accordance with the experiments.

关键词： oxygenated fuels reaction kinetics oxidation mechanisms computational fluid dynamics(cFD) oxymethylene ethers(OME) e-fuels multiinjection spray-combustion

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Spark plasma sintering of tungsten-based WTaVcr refractory high entropy alloys for nuclear fusion applications

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 146-154页

作者： Yongchul Yoo Xiang Zhang Fei Wang Xin chen Xing-Zhong Li michael Nastasi Bai cui Department of Mechanical&Materials Engineering University of Nebraska-LincolnLincolnNE 68588USA Nebraska center for Materials and Nanoscience University of Nebraska-LincolnLincolnNE 68588USA Department of Nuclear Engineering Texas A&M UniversityCollege StationTX 77843USA

W-based WTaVcr refractory high entropy alloys (RHEA) may be novel and promising candidate materials for plasma facing components in the first wall and diverter in fusion reactors. This alloy has been developed by a powder metallurgy process combining mechanical alloying and spark plasma sintering (SPS). The SPSed samples contained two phases, in which the matrix is RHEA with a body-centered cubic structure, while the oxide phase was most likely Ta2VO6through a combined analysis of X-ray diffraction (XRD),energy-dispersive spectroscopy (EDS), and selected area electron diffraction (SAED). The higher oxygen affinity of Ta and V may explain the preferential formation of their oxide phases based on thermodynamic calculations. Electron backscatter diffraction (EBSD) revealed an average grain size of 6.2μm. WTaVcr RHEA showed a peak compressive strength of 2997 MPa at room temperature and much higher micro-and nano-hardness than W and other W-based RHEAs in the literature. Their high Rockwell hardness can be retained to at least 1000°c.

关键词： refractory high entropy alloy plasma-facing material fusion reactor spark plasma sintering

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Direct Pointwise comparison of FE Predictions to StereoDIc Measurements:Developments and Validation Using Double Edge-Notched Tensile Specimen

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computer Modeling in Engineering & Sciences 2024年第8期140卷 1263-1298页

作者： Troy Myers michael A.Sutton Hubert Schreier Alistair Tofts Sreehari Rajan Kattil Department of Mechanical Engineering University of South CarolinaColumbiaSC29208USA correlated Solutions Incorporated 121 Dutchman BlvdColumbiaSC29063USA

To compare finite element analysis(FEA)predictions and stereovision digital image correlation(StereoDIc)strain measurements at the same spatial positions throughout a region of interest,a field comparison procedure is *** procedure includes(a)conversion of the finite element data into a triangular mesh,(b)selection of a common coordinate system,(c)determination of the rigid body transformation to place both measurements and FEA data in the same system and(d)interpolation of the FEA nodal information to the same spatial locations as the StereoDIc measurements using barycentric *** an aluminum Al-6061 double edge notched tensile specimen,FEA results are obtained using both the von Mises isotropic yield criterion and Hill’s quadratic anisotropic yield criterion,with the unknown Hill model parameters determined using full-field specimen strain measurements for the nominally plane stress *** Hill’s quadratic anisotropic yield criterion,the point-by-point comparison of experimentally based full-field strains and stresses to finite element predictions are shown to be in excellent agreement,confirming the effectiveness of the field comparison process.

关键词： StereoDIc spatial co-registration data transformation finite element simulations point-wise comparison of measurements and FEA predictions double edge notch specimen model validation

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Improved Quantile convolutional and Recurrent Neural Networks for Electric Vehicle Battery Temperature Prediction

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Big Data Mining and Analytics 2024年第2期7卷 512-530页

作者： Andreas M.Billert Runyao Yu Stefan Erschen michael Frey Frank Gauterin Karlsruhe Institute of Technology(KIT) Institute of Vehicle System TechnologyKarlsruhe 76131Germanyand also with Bayerische Motoren Werke(BMW)AGMunich 80788Germany Technical University of Munich(TUM) Munich 80333Germany BMW AG Munich 80788Germany KIT Institute of Vehicle System TechnologyKarlsruhe 76131Germany

The battery thermal management of electric vehicles can be improved using neural networks predicting quantile sequences of the battery *** work extends a method for the development of Quantile convolutional and Quantile Recurrent Neural Networks(namely Q*NN).Fleet data of 225629 drives are clustered and balanced,simulation data from 971 simulations are augmented before they are combined for training and *** Q*NN hyperparameters are optimized using an efficient Bayesian optimization,before the Q*NN models are compared with regression and quantile regression models for four *** analysis of point-forecast and quantile-related metrics shows the superior performance of the novel Q*NN *** median predictions of the best performing model achieve an average RMSE of 0.66°c and R^(2) of *** predicted 0.99 quantile covers 98.87%of the true values in the test *** conclusion,this work proposes an extended development and comparison of Q*NN models for accurate battery temperature prediction.

关键词： deep learning battery temperature convolutional and recurrent neural network quantile forecasting

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